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VTEFLVRGRYVLSMAGLPAPAERVRTPGAHLDGVLTDAAVHVRDGAIVAVDGYAALVAAQAHLPVHGDGT GLVIPGLISTHTHLSESLATGMGSELSLFEWADAIVAPLGMVLTREDAAEGTALRAIEMLLSGVTTVNDM FCHTNIGSRASLGVVDGLTRAGMRGVVAYGAEDLPLLERSTLAPGDVIDDVLAEQHDLAAHAATAPLLDF RYGVGTLLGQSDELLAAGVEECRRAGWGVHTHLAEVREEVTTARHRWGHRTVEHSLRAGLFERPLIAGHG VWLTEADIATFARHGAAIAHNPVANMILASGVCPVPRLRAAGVPVGIGTDGAASNDSQDMLQAVKAAALL QKVHHLDALVVDALDVLTMATIDGARALGLDHLVGSLEPGKRADIVLLQDTVDVAVLHDPVAQLVYGASP RSVRDVWVDGVQVVADHRCTTVDEATQIARCRPLADRVGVKAGLVATGHSVVTG
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_3147 | - | - | 100% (474) | amidohydrolase |
| M. vanbaalenii PYR-1 | Mvan_3159 | - | 9e-91 | 42.64% (462) | amidohydrolase |
| M. vanbaalenii PYR-1 | Mvan_0863 | - | 3e-46 | 33.26% (469) | amidohydrolase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0076 | - | 2e-07 | 27.34% (417) | hypothetical protein Mb0076 |
| M. gilvum PYR-GCK | Mflv_2466 | - | 8e-08 | 27.70% (213) | amidohydrolase |
| M. tuberculosis H37Rv | Rv0074 | - | 2e-07 | 27.34% (417) | hypothetical protein Rv0074 |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_2927c | - | 1e-40 | 32.33% (430) | hydroxydechloroatrazine ethylaminohydrolase |
| M. marinum M | MMAR_2844 | - | 2e-37 | 32.01% (428) | metal-dependent hydrolase |
| M. avium 104 | - | - | - | - | - |
| M. smegmatis MC2 155 | MSMEG_1297 | - | 2e-46 | 34.48% (464) | hydroxydechloroatrazine ethylaminohydrolase |
| M. thermoresistible (build 8) | TH_3859 | - | 8e-24 | 26.53% (441) | PUTATIVE - |
| M. ulcerans Agy99 | MUL_2914 | - | 2e-36 | 31.78% (428) | hydroxydechloroatrazine ethylaminohydrolase |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_2844|M.marinum_M -MSTILLTLMLECRVPKLVIDRVSIATVDPKAAEFSEGHIIVEDDLIVAV
MUL_2914|M.ulcerans_Agy99 ---------MLECRVPKLVIDRISIATVDPKAAEFSEGHIIVEDDLIVAV
MSMEG_1297|M.smegmatis_MC2_155 --------------MPRLVIDGAAIATVDAAHTEHNRGYIVVDDNIITAV
MAB_2927c|M.abscessus_ATCC_199 -------------MNPITLIENVFAATVDKSRREIADARVVIEGGRIAAV
Mb0076|M.bovis_AF2122/97 ----MGDLSISQVSARPGRIGIRARQMFDGYRFQRGPVLVVVEDGRISAV
Rv0074|M.tuberculosis_H37Rv ----MGDLSISQVSARPGRIGIRARQMFDGYRFQRGPVLVVVEDGRISAV
Mflv_2466|M.gilvum_PYR-GCK --------------MTVTVVKAARWADVEAG-VVRSPAVIVVEGNRIRSV
Mvan_3147|M.vanbaalenii_PYR-1 MTEFLVRGRYVLSMAGLPAPAERVRTPGAHLDGVLTDAAVHVRDGAIVAV
TH_3859|M.thermoresistible__bu ------------------------VLAGDPLTAHVRAADLLIEDGRVTAI
: : .. : ::
MMAR_2844|M.marinum_M GDG----PAPEVPGATVIDGRGCLATPGLVNTHEHLYQWITRGYTQKGTL
MUL_2914|M.ulcerans_Agy99 GDG----PAPEVPGATVIDGRGCLATPGLVNTHEHLYQWITRGHTQKGTL
MSMEG_1297|M.smegmatis_MC2_155 GAG----PAPEVPGAQFIDARGCLATPGLVNTHHHLYQWITRGHAQDGTL
MAB_2927c|M.abscessus_ATCC_199 LTAGENNPWQELPGVERVDGSGCLLTPGLVNTHHHLYQWITRGLAADHTL
Mb0076|M.bovis_AF2122/97 DFAG-----SACPDMNLVDLGESTLLPGLVDAHAHLC-WDPDGRPED---
Rv0074|M.tuberculosis_H37Rv DFAG-----SACPDMNLVDLGESTLLPGLVDAHAHLC-WDPDGRPED---
Mflv_2466|M.gilvum_PYR-GCK DPA------AEPPGAEVLDLGDVTLLPGLMDMELNLLIGGPGGPEGLPSP
Mvan_3147|M.vanbaalenii_PYR-1 DGYAA--LVAAQAHLPVHGDGTGLVIPGLISTHTHLSESLATGMGSELSL
TH_3859|M.thermoresistible__bu ESD------LAGVDAEIIDATGRWVLPGFVDTHRHLWQTTMRGLTANWNL
. **::. . :* *
MMAR_2844|M.marinum_M FQWLTEMYPVWGRLDAELEFAAASAGLAGLALTGCTTTM-----DHHYVF
MUL_2914|M.ulcerans_Agy99 FQWLTEMYPVWGRLDAELEFAAASAGLAGLALTGCTTTM-----DHHYVF
MSMEG_1297|M.smegmatis_MC2_155 FEWLTTLYPLWSHLDADLEYVAASAALAALALSGCTTTT-----DHHYVF
MAB_2927c|M.abscessus_ATCC_199 FQWLTALYPVWQGIDADSLHVAAQGALSWLALSGCTTTT-----DHHYVF
Mb0076|M.bovis_AF2122/97 --LAGDPHAVLVGRARRHAAAALRSGITTIRDLGDRDYA-----ALALRE
Rv0074|M.tuberculosis_H37Rv --LAGDPHAVLVGRARRHAAAALRSGITTIRDLGDRDYA-----ALALRE
Mflv_2466|M.gilvum_PYR-GCK MHGVQDDPAYRTLRGAVNARTTLDAGFTTVRNLGLMVKTGGYLLDVALQR
Mvan_3147|M.vanbaalenii_PYR-1 FEWADAIVAPLG-MVLTREDAAEGTALRAIEMLLSGVTT---------VN
TH_3859|M.thermoresistible__bu KDYFWCIRSHFAGLHDPDDVYGGQYAGGLDALVNGVTTT-----------
. .
MMAR_2844|M.marinum_M PHAGGDMLGAEIAAAKRIGVRFHPTRGSMDLGVASGGLPPEHTVEDID--
MUL_2914|M.ulcerans_Agy99 PHAGGDMLGAEIVAAKRIGVRFHPTRGSMDLGVASGGLPPEHTVEDID--
MSMEG_1297|M.smegmatis_MC2_155 PRGGGDVLGAEIAAAQRIGLRFHPTRGSMDLGASAGGLPPDNVVEDID--
MAB_2927c|M.abscessus_ATCC_199 PSDAGDLLEAEIEAARQVGLRFDPTRGSMDLGRSAGGLPPDGLVESID--
Mb0076|M.bovis_AF2122/97 EYRQKTTVGPELVVSGPP-----LTRSGGHCWFLGG--VADSVEELVD--
Rv0074|M.tuberculosis_H37Rv EYRQKTTVGPELVVSGPP-----LTRSGGHCWFLGG--VADSVEELVD--
Mflv_2466|M.gilvum_PYR-GCK AIEQGWHPGPRIYPAGHAVTPYGGHLDPTVFQRLAPGIMPLSVAEGIANG
Mvan_3147|M.vanbaalenii_PYR-1 DMFCHTNIGSRASLGVVDGLTRAGMRGVVAYGAEDLPLLERSTLAPGD--
TH_3859|M.thermoresistible__bu IDHSHITNSPDHSDAAVRGLLDSGVRALWCYGFYPSPQADPVFTTPQH--
. .
MMAR_2844|M.marinum_M ------TILTTCQDAVREHHDPTKGSMVQISLAPCSPFSVTGELMKQSAL
MUL_2914|M.ulcerans_Agy99 ------TILTTCQDAVREHHDPTKGSMVQISLAPCSPFSVTGELMKQSAL
MSMEG_1297|M.smegmatis_MC2_155 ------AILAAGQDAVGAHHDPSFGSMCRIALAPCSPFSVSGELMRESAA
MAB_2927c|M.abscessus_ATCC_199 ------TALEASDAAIARWHDPAPGAMVRIGLAPCSPFSVSADLLRQSAL
Mb0076|M.bovis_AF2122/97 ------AVQERAARGADWIKVMATGGFVTTASDPWQPQYGSGQLA-AVVA
Rv0074|M.tuberculosis_H37Rv ------AVQERAARGADWIKVMATGGFVTTASDPWQPQYGSGQLA-AVVA
Mflv_2466|M.gilvum_PYR-GCK VDDVRACVRYQVRHGAKLIKVSASGGVMSHSTAPGAQQYSDEEFA-AIAD
Mvan_3147|M.vanbaalenii_PYR-1 ------VIDDVLAEQHDLAAHAATAPLLDFRYGVGTLLGQSDELLAAGVE
TH_3859|M.thermoresistible__bu --------RLDDARRVRSTFFPTDDGLVRMGVALTELGMQPFTETQRELQ
: .
MMAR_2844|M.marinum_M LARDLGVRLHTHLSETVEEDEFCLAQFGSRPVDYVESLGWLGSDVWMAHC
MUL_2914|M.ulcerans_Agy99 LARDLGVRLHTHLSETVEEDEFCLAQFGSRPVDYVESLGWLGSDVWMAHC
MSMEG_1297|M.smegmatis_MC2_155 LARELGVRLHTHIAETTDEEQFCLERFGARPVDYVESLGWLGDDVWFAHG
MAB_2927c|M.abscessus_ATCC_199 LARERGVRLHTHLAETKDESVYCAERFGCSPLDYMEELGWLGPDVWFAHG
Mb0076|M.bovis_AF2122/97 AAEQVGLPVTAHAHATAG-----IAAAVAAGVDGIEHCTFLS-EGSAAAS
Rv0074|M.tuberculosis_H37Rv AAEQVGLPVTAHAHATAG-----IAAAVAAGVDGIEHCTFLS-EGSAAAS
Mflv_2466|M.gilvum_PYR-GCK EAHRAGVRVAAHAVGDSA-----IRACIRAGIDCIEHGFLATDETLQMMV
Mvan_3147|M.vanbaalenii_PYR-1 ECRRAGWGVHTHLAEVREEVTTARHRWGHRTVEHSLRAGLFERPLIAGHG
TH_3859|M.thermoresistible__bu TAEDLAVPVTMHTNCVWT-------RPEFHDVELYHRAGLLRAGQIHSHA
.. . : * ::
MMAR_2844|M.marinum_M VHLSKGDIAKLAATGTGVAHCPTSNGR-----FGAGIAPIPELLAADVAV
MUL_2914|M.ulcerans_Agy99 VHLSKGYIAKLAATGTGVAHCPTSNGR-----FGAGIAPIPELLAADVAV
MSMEG_1297|M.smegmatis_MC2_155 VHLSASDIAKLAQTGTGVAHCPSSNAR-----LGAGTAPIPELLAAGVPV
MAB_2927c|M.abscessus_ATCC_199 VHFDDASIARLARTGTGIAHCPTSNGR-----LGAGIARVRELLAAGVPV
Mb0076|M.bovis_AF2122/97 PDVVEAIVAQGVWCGMTIPRVYPEMPENLVAVVQDGWRNIRRLIDAGARV
Rv0074|M.tuberculosis_H37Rv PDVVEAIVAQGVWCGMTIPRVYPEMPENLVAVVQDGWRNIRRLIDAGARV
Mflv_2466|M.gilvum_PYR-GCK DHGTFLVSTTYLTEAMAVDRIAPELRKKAEVVFPQAQAMLPKAIAAGVRI
Mvan_3147|M.vanbaalenii_PYR-1 VWLTEADIATFARHGAAIAHNPVANMI-----LASGVCPVPRLRAAGVPV
TH_3859|M.thermoresistible__bu NRCSDHELALLRDAGCAVSSTPDTELQ-----MGCGRPVFRRALATGVTA
: . : . . . . :..
MMAR_2844|M.marinum_M GLGVDGAG-AEHRGL------ANEMRQAALAARFR-------LGPQALDA
MUL_2914|M.ulcerans_Agy99 GLGVDGAG-AEHRGL------ANEMRQAALAARFR-------LGPQALDA
MSMEG_1297|M.smegmatis_MC2_155 GMGVDGVASNEHGGL------GGELRQALLMARNR-------LGPTAITA
MAB_2927c|M.abscessus_ATCC_199 GLGVDGAASNESGRL------LEEAHQALLLARAV-------GGPTALST
Mb0076|M.bovis_AF2122/97 ALSTDAGVAPGRR------------HDVLPDDLVY-------LSRHGFTS
Rv0074|M.tuberculosis_H37Rv ALSTDAGVAPGRR------------HDVLPDDLVY-------LSRHGFTS
Mflv_2466|M.gilvum_PYR-GCK ACGTDAPAVPHGQN---------------AKELCA-------LVSRGMTP
Mvan_3147|M.vanbaalenii_PYR-1 GIGTDGAASNDSQDM------LQAVKAAALLQKVHH------LDALVVDA
TH_3859|M.thermoresistible__bu GIGIDIVSNNSGDMFTAMRVLMQHERGDALQPTLEESGLTAVAEPLPVTT
. . * . .
MMAR_2844|M.marinum_M REALWMATVGGARCLGRDQDLGSLEVGKLADIALWQLDGLGHSDVEDPVW
MUL_2914|M.ulcerans_Agy99 REALWMATVGGARCLGRDQDLGSLEVGKLADIALWQLDGLGHSDVEDPVW
MSMEG_1297|M.smegmatis_MC2_155 RQVLQAGTIGGARCLGRDRELGSLEPGKLADMALWRVDGLGHADIDDPVC
MAB_2927c|M.abscessus_ATCC_199 RTALELATLGGARLLGRSDEIGSIEVGKCADLVLWDLSTLGHSGIEDPVA
Mb0076|M.bovis_AF2122/97 TEVLTGATAAAAASCGLGHRKGRIAPGYDADLLAVAAG------VDHDPA
Rv0074|M.tuberculosis_H37Rv TEVLTGATAAAAASCGLGHRKGRIAPGYDADLLAVAAG------VDHDPA
Mflv_2466|M.gilvum_PYR-GCK MQALRAATITSAELIDAEDELGRLAPGYLADIIAVDGD------VSADIA
Mvan_3147|M.vanbaalenii_PYR-1 LDVLTMATIDGARALGLDHLVGSLEPGKRADIVLLQDT-VDVAVLHDPVA
TH_3859|M.thermoresistible__bu RQILHAATLAGARALGLESVCGSIDVGKSADLLLLRHDRLHMRPVIDDID
* .* .* . * : * **: :
MMAR_2844|M.marinum_M ALIYGPPA-PLRLLLVGGNTVVEDGELRTADTETLATDAKNAAVTLRERG
MUL_2914|M.ulcerans_Agy99 ALIYGPPA-PLRLLLVGGNTVVEDGELRTADTETLATDAKNAAVTLRERG
MSMEG_1297|M.smegmatis_MC2_155 ALVFGPSA-PLRLLLVNGVPVVADDELRTADTATLAGDARDAARTLRARA
MAB_2927c|M.abscessus_ATCC_199 AVILGEVP-PIRRSWVGGRPIVADGQMLTVDTERIAVAVRAAHHGLMNRE
Mb0076|M.bovis_AF2122/97 GLCD------VKAVWRSGTQVPLQASAVGYNTPS----------------
Rv0074|M.tuberculosis_H37Rv GLCD------VKAVWRSGTQVPLQASAVGYNTPS----------------
Mflv_2466|M.gilvum_PYR-GCK TTLD------VRFVMKDGVVHKTVDVAQDASTSTV---------------
Mvan_3147|M.vanbaalenii_PYR-1 QLVYGASPRSVRDVWVDGVQVVADHRCTTVDEATQIARCRPLADRVGVKA
TH_3859|M.thermoresistible__bu SIVLQATTRDIDRVLVAGRTVVQDGRLPAAVERRGVAAIEAAHSRLAERV
: *
MMAR_2844|M.marinum_M -----------------------------------
MUL_2914|M.ulcerans_Agy99 -----------------------------------
MSMEG_1297|M.smegmatis_MC2_155 GT---------------------------------
MAB_2927c|M.abscessus_ATCC_199 R----------------------------------
Mb0076|M.bovis_AF2122/97 -----------------------------------
Rv0074|M.tuberculosis_H37Rv -----------------------------------
Mflv_2466|M.gilvum_PYR-GCK -----------------------------------
Mvan_3147|M.vanbaalenii_PYR-1 GLVATGHSVVTG-----------------------
TH_3859|M.thermoresistible__bu AAVGGWKLAVPQGLMDQLGVTFHDNVANTPAQANS