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MSNAVPDLSPYYEESQSIYDVSNEFFALFLGPTMGYTCSYFEREDMTLDEAQIAKFDLALGKLNLEPGMT LLDVGCGWGGALRRAVEKYDVNVIGITLSRKQFEYSKALMAGLDTERKAEVRLQGWEEFDEPVDRIVSIG AFEAFKAERYPLFFERAYDILPADGRMLLHTILAHTQKFFRDNGIKLTISDLKFMRFIGTEIFPGGQLPA VEDIEKLAADSGFTLERAHLLRPHYARTLDMWAANLEANRQEATRITSPEVYERYMHYLTGCADFFRRGI TNVGQFTLVKG
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_0803 | - | - | 100% (291) | cyclopropane-fatty-acyl-phospholipid synthase |
| M. vanbaalenii PYR-1 | Mvan_4949 | - | 8e-99 | 59.86% (284) | cyclopropane-fatty-acyl-phospholipid synthase |
| M. vanbaalenii PYR-1 | Mvan_3025 | - | 3e-91 | 56.69% (284) | cyclopropane-fatty-acyl-phospholipid synthase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0478 | umaA1 | 1e-121 | 71.48% (284) | mycolic acid synthase |
| M. gilvum PYR-GCK | Mflv_1800 | - | 1e-100 | 60.92% (284) | cyclopropane-fatty-acyl-phospholipid synthase |
| M. tuberculosis H37Rv | Rv0469 | umaA | 1e-121 | 71.48% (284) | mycolic acid synthase |
| M. leprae Br4923 | MLBr_01900 | mmaA1 | 1e-107 | 64.66% (283) | methyl mycolic acid synthase 1 |
| M. abscessus ATCC 19977 | MAB_4088c | - | 1e-130 | 77.00% (287) | mycolic acid synthase UmaA1 |
| M. marinum M | MMAR_0794 | umaA | 1e-126 | 75.35% (284) | mycolic acid synthase UmaA |
| M. avium 104 | MAV_4680 | - | 1e-127 | 75.97% (283) | methoxy mycolic acid synthase 1 |
| M. smegmatis MC2 155 | MSMEG_0913 | - | 1e-141 | 82.76% (290) | methoxy mycolic acid synthase 1 |
| M. thermoresistible (build 8) | TH_3763 | - | 1e-131 | 76.29% (291) | PUTATIVE Cyclopropane-fatty-acyl-phospholipid synthase |
| M. ulcerans Agy99 | MUL_4538 | umaA | 1e-126 | 75.00% (284) | mycolic acid synthase UmaA |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_0803|M.vanbaalenii_PYR-1 ---MSN--------------AVPDLSPYYEESQSIYDVSNEFFALFLG-P
MSMEG_0913|M.smegmatis_MC2_155 ---MSN--------------VESELAPYYEESQSIYDISNEFFALFLG-P
MAB_4088c|M.abscessus_ATCC_199 ---MS------------------DLKPYYEESQSIYDISDEFYGLFLDEE
Mb0478|M.bovis_AF2122/97 ---MT------------------ELRPFYEESQSIYDVSDEFFSLFLD-P
Rv0469|M.tuberculosis_H37Rv ---MT------------------ELRPFYEESQSIYDVSDEFFSLFLD-P
MMAR_0794|M.marinum_M ---MT------------------ELRPFYEESQSIYDVSDEFFALFLD-P
MUL_4538|M.ulcerans_Agy99 ---MT------------------ELRPFYEESQSIYDVSDEFFALFLD-P
MAV_4680|M.avium_104 MPRMT------------------GLEPYYEESQSIYDVSDEFFALFLD-P
MLBr_01900|M.leprae_Br4923 ---MA------------------KLRPYYEESQSAYDISDDFFALFLD-P
TH_3763|M.thermoresistible__bu ---MTN--------------TSAELEPFFEESQSIYDVSDDFFALFLG-P
Mflv_1800|M.gilvum_PYR-GCK ---MTGRTAEPPTGHDTTPPTAEDMKPHFEEVQAHYDLSDVFFGLFQD-P
*: : *.:** *: **:*: *:.** .
Mvan_0803|M.vanbaalenii_PYR-1 TMGYTCSYFEREDMTLDEAQIAKFDLALGKLNLEPGMTLLDVGCGWGGAL
MSMEG_0913|M.smegmatis_MC2_155 TMGYTCGYYEREDMTLDESQNAKFDLALGKLDLKPGMTLLDVGCGWGGAL
MAB_4088c|M.abscessus_ATCC_199 TMGYTCAYFERDDLTLAEAQIAKFDLALGKLNLEPGMTVLDIGCGWGACL
Mb0478|M.bovis_AF2122/97 TMAYTCAYFEREDMTLEEAQNAKFDLALDKLHLEPGMTLLDIGCGWGGGL
Rv0469|M.tuberculosis_H37Rv TMAYTCAYFEREDMTLEEAQNAKFDLALDKLHLEPGMTLLDIGCGWGGGL
MMAR_0794|M.marinum_M TMAYTCAYFERDDMTLEEASNAKFDLALGKLNLEPGMTLLDIGCGWGGAL
MUL_4538|M.ulcerans_Agy99 TMAYTCAYFERDDMTLEEASNAKFDLALGKLNLEPGMTLLDIGCGWGGAL
MAV_4680|M.avium_104 TMAYTCAFFERDDMTLEEAQTAKFDLALGKLNLEPGMTLLDIGCGWGGAL
MLBr_01900|M.leprae_Br4923 TWVYTCAYFERDDMTLEEAQLAKLDLALDKLNLAPGMTLLDVGCGWGGAL
TH_3763|M.thermoresistible__bu TMGYTCAYFERDDMTLDEAQIAKFDLALGKLNLEPGMTLLDIGCGWGGAL
Mflv_1800|M.gilvum_PYR-GCK SRTYSCAYYERDDMTLAEAQIAKIDLALGKLNLEPGMTLLDIGCGWGSVL
: *:*.::**:*:** *:. **:****.**.* ****:**:*****. *
Mvan_0803|M.vanbaalenii_PYR-1 RRAVEKYDVNVIGITLSRKQFEYSKALMAGL--DTERKAEVRLQGWEEFD
MSMEG_0913|M.smegmatis_MC2_155 ERAVTKYDVNVIGITLSKAQSDYARERLAKI--ETNRSVEVRLQGWEEFN
MAB_4088c|M.abscessus_ATCC_199 DRAMRKFDVNVIGITLSKNQSEYSRKRLAQVAAETGRSAEIRMQGWEEFN
Mb0478|M.bovis_AF2122/97 QRAIENYDVNVIGITLSRNQFEYSKAKLAKIP--TERSVQVRLQGWDEFT
Rv0469|M.tuberculosis_H37Rv QRAIENYDVNVIGITLSRNQFEYSKAKLAKIP--TERSVQVRLQGWDEFT
MMAR_0794|M.marinum_M QRAVEKYDVNVIGITLSRNQFEYSKAKMAKIP--TERTVEVRLQGWEEFE
MUL_4538|M.ulcerans_Agy99 QRAVEKYDVNVIGITLSRNQFDYSKAKMAKIP--TERTVEVRLQGWEEFE
MAV_4680|M.avium_104 KRALEKYDVNVIGITLSRNQFEYSKKLLAGFP--TDRNIEVRLQGWEEFD
MLBr_01900|M.leprae_Br4923 VRAVEKYDVNVIGLTLSRNHCARSKARLAEIL--TKRHAEARLQGWEEFE
TH_3763|M.thermoresistible__bu QLALEKYDVNVIGITLSRNQYEYSKARLAQID--TARTAEVRLQGWEQFD
Mflv_1800|M.gilvum_PYR-GCK QRAVEKYDVNVVGLTLSRNQCKFAQDLLDGLD--TERSRRILLRGWEQFD
*: ::****:*:***: : :: : . * * . ::**::*
Mvan_0803|M.vanbaalenii_PYR-1 EPVDRIVSIGAFEAFKAERYPLFFERAYDILPADGRMLLHTILAHTQKFF
MSMEG_0913|M.smegmatis_MC2_155 EPVDRIVSIGAFEAFKAERYPVFFERAYSILPDDGRMLLHTILAHTQKFF
MAB_4088c|M.abscessus_ATCC_199 DKVDRIVTIGAFEAFKQERYPIFFERAYDILPNDGRMLLHTILAHTQQFF
Mb0478|M.bovis_AF2122/97 DKVDRIVSIGAFEAFKMERYAAFFERSYDILPDDGRMLLHTILTYTQKQM
Rv0469|M.tuberculosis_H37Rv DKVDRIVSIGAFEAFKMERYAAFFERSYDILPDDGRMLLHTILTYTQKQM
MMAR_0794|M.marinum_M DKVDRIVTIGAFEAFKMERYAAFFERSYDILPDDGRMLLHTILTYTQKQF
MUL_4538|M.ulcerans_Agy99 DKVDRIVTIGAFEAFKMERYAAFFERSYDILPDDGRMLLHTILTYTQKQF
MAV_4680|M.avium_104 DKVDRIVTIGAFEAFKMERYSAFFDRAYDILPDDGRMLLHTILTYTQKQQ
MLBr_01900|M.leprae_Br4923 EKVDRIVSFEALDAFKKERYPAFFERSYNILPDDGRMLLHSLFTYDRRWL
TH_3763|M.thermoresistible__bu EPVDRIVSIGAFEAFKKPRYAAFFEMAHKALPADGRMLLHTILAHPQTYF
Mflv_1800|M.gilvum_PYR-GCK EPVDRIISIEAIEAFPQERYAPFFKMCSSVLPEGGRFVLQAILGHPLKKW
: ****::: *::** **. **. . . ** .**::*:::: :
Mvan_0803|M.vanbaalenii_PYR-1 RDNGIKLTISDLKFMRFIGTEIFPGGQLPAVEDIEKLAADSGFTLERAHL
MSMEG_0913|M.smegmatis_MC2_155 RENGIKLTISDLKFMKFIGEEIFPGGQLPAVEDIEKLAADSGFKLERIHL
MAB_4088c|M.abscessus_ATCC_199 RENGIAITISDLKFMKFIGEEIFPGGQLPAVEDIEKLAADSGFNLERVHL
Mb0478|M.bovis_AF2122/97 HEMGVKVTMSDVRFMKFIGEEIFPGGQLPAQEDIFKFAQAADFSVEKVQL
Rv0469|M.tuberculosis_H37Rv HEMGVKVTMSDVRFMKFIGEEIFPGGQLPAQEDIFKFAQAADFSVEKVQL
MMAR_0794|M.marinum_M HEMGVKVTMSDVRFMRFIGQEIFPGGQLPAQEDIFNFAQAAGFSVERAQL
MUL_4538|M.ulcerans_Agy99 HEMGVKVTMSDVRFMRFIGQEIFPGGQLPAQEDIFNFAQAAGFSVERAQL
MAV_4680|M.avium_104 HERGVSITMSDLRFMRFIGQEIFPGGQLPAQEDIFKFGEAAGFSVERVQL
MLBr_01900|M.leprae_Br4923 HEQGIPLTMGDLRFLKFLRESIFPGGELPSQPDIVDNAEAAGFSVEQIQL
TH_3763|M.thermoresistible__bu REAGIKITISDLKFMQFIGREIFPGGELPAEGDVVEFATGAGFSVERIQL
Mflv_1800|M.gilvum_PYR-GCK PELGIPIVMSDLKFMRFIAKEIFPGGSVPGEENIVELSAEAGFTLEQTQF
: *: :.:.*::*::*: .*****.:*. :: . . :.*.:*: ::
Mvan_0803|M.vanbaalenii_PYR-1 LRPHYARTLDMWAANLEANRQEATRITSPEVYERYMHYLTGCADFFRRGI
MSMEG_0913|M.smegmatis_MC2_155 LQPHYARTLDMWAANLEAKKDEAIAMQGQEVYDRYMKYLTGCADFFRRGI
MAB_4088c|M.abscessus_ATCC_199 LQPHYAKTLDIWAQNLEQRREEAIAIQSQEVYDRFMKYLTGCADFFRRGV
Mb0478|M.bovis_AF2122/97 LQQHYARTLNIWAANLEANKDRAIALQSEEIYNKYMHYLTGCEHFFRKGI
Rv0469|M.tuberculosis_H37Rv LQQHYARTLNIWAANLEANKDRAIALQSEEIYNKYMHYLTGCEHFFRKGI
MMAR_0794|M.marinum_M LQQHYARTLNIWAANLEARKEEAIAMQSQEIYDKYMHYLTGCENFFRKGI
MUL_4538|M.ulcerans_Agy99 LQQHYARTLNIWAANLEARKEEAIAMQSQEIYDKYMHYLTGCENFFRKGI
MAV_4680|M.avium_104 LREHYARTLNIWAANLEANKDKAIAIQSQAVYDRYMHYLTGCENFFRKGI
MLBr_01900|M.leprae_Br4923 MQPHYARTLDMWATNLAAARDHALAIQPEEIYDNFMHYLTGCADRFRRGL
TH_3763|M.thermoresistible__bu LRPHYARTLDIWAENLAANREPAIAMQSEEVYDRYYRYLTGCADFFRRGI
Mflv_1800|M.gilvum_PYR-GCK LNKDYARTLDTWAEALEAHHDEAVAATSEEVYQRYMKYLTGCSDFFTRGI
:. .**:**: ** * :: * :*:.: :***** . * :*:
Mvan_0803|M.vanbaalenii_PYR-1 TNVGQFTLVKG
MSMEG_0913|M.smegmatis_MC2_155 TNVGQFTLVK-
MAB_4088c|M.abscessus_ATCC_199 TNVGQFTLVK-
Mb0478|M.bovis_AF2122/97 SNVGQFTLTK-
Rv0469|M.tuberculosis_H37Rv SNVGQFTLTK-
MMAR_0794|M.marinum_M SNVGQFTLVK-
MUL_4538|M.ulcerans_Agy99 SNVGQFTLVK-
MAV_4680|M.avium_104 SNVGQFTLVK-
MLBr_01900|M.leprae_Br4923 INVAQFTLTK-
TH_3763|M.thermoresistible__bu TNVGQFTLTKG
Mflv_1800|M.gilvum_PYR-GCK SELGQFTLVKA
::.****.*