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LGNKVIVTGGAGVIGQAICRRLLQGGYVPVAADLKQAVDAVDFGQAGLQGTLSVAMDVTDRASVDEAVAS TVDDGETLFGLVNCAGILRDSFLGELDEAKLDLMFQVNIAGMARVTDAVAPLLTEGSAIVNVGSLTGHFG RFRGASVYGATKAGIAAYTRYVAEELASRSVRVNNVAPGVIRAPMSPSMARVSGGEEVSASYAMLKRIGE PEEVAEAVEFLLSPRASFITAQTLLVDGGVVAW
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_0607 | - | - | 100% (243) | short-chain dehydrogenase/reductase SDR |
| M. vanbaalenii PYR-1 | Mvan_1975 | fabG | 2e-29 | 36.10% (241) | 3-ketoacyl-(acyl-carrier-protein) reductase |
| M. vanbaalenii PYR-1 | Mvan_2242 | - | 4e-29 | 39.18% (245) | short-chain dehydrogenase/reductase SDR |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1385 | fabG | 2e-26 | 34.18% (237) | 3-ketoacyl-(acyl-carrier-protein) reductase |
| M. gilvum PYR-GCK | Mflv_4369 | fabG | 2e-28 | 35.27% (241) | 3-ketoacyl-(acyl-carrier-protein) reductase |
| M. tuberculosis H37Rv | Rv1350 | fabG | 2e-26 | 34.18% (237) | 3-ketoacyl-(acyl-carrier-protein) reductase |
| M. leprae Br4923 | MLBr_02565 | fabG | 3e-24 | 31.82% (242) | 3-ketoacyl-(acyl-carrier-protein) reductase |
| M. abscessus ATCC 19977 | MAB_0827 | - | 1e-27 | 33.06% (245) | putative short-chain dehydrogenase/reductase |
| M. marinum M | MMAR_0402 | - | 4e-29 | 38.27% (243) | short chain dehydrogenase |
| M. avium 104 | MAV_5088 | fabG | 7e-30 | 39.02% (246) | 3-ketoacyl-(acyl-carrier-protein) reductase |
| M. smegmatis MC2 155 | MSMEG_3823 | - | 1e-113 | 86.19% (239) | 3-oxoacyl- |
| M. thermoresistible (build 8) | TH_3954 | - | 7e-28 | 40.08% (242) | PUTATIVE 3-oxoacyl-[acyl-carrier-protein] reductase |
| M. ulcerans Agy99 | MUL_1052 | - | 9e-28 | 37.86% (243) | short chain dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1385|M.bovis_AF2122/97 --------------------------------------------------
Rv1350|M.tuberculosis_H37Rv --------------------------------------------------
Mflv_4369|M.gilvum_PYR-GCK --------------------------------------------------
MAV_5088|M.avium_104 --------------------------------------------------
TH_3954|M.thermoresistible__bu --------------------------------------------------
Mvan_0607|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_3823|M.smegmatis_MC2_155 --------------------------------------------------
MAB_0827|M.abscessus_ATCC_1997 --------------------------------------------------
MMAR_0402|M.marinum_M --------------------------------------------------
MUL_1052|M.ulcerans_Agy99 --------------------------------------------------
MLBr_02565|M.leprae_Br4923 MAPKCSSDLFSQIVSSGPGSFVAKQLGVPRPETLRRYRPSDAPLCGSLLI
Mb1385|M.bovis_AF2122/97 --------------------------------------------------
Rv1350|M.tuberculosis_H37Rv --------------------------------------------------
Mflv_4369|M.gilvum_PYR-GCK --------------------------------------------------
MAV_5088|M.avium_104 --------------------------------------------------
TH_3954|M.thermoresistible__bu --------------------------------------------------
Mvan_0607|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_3823|M.smegmatis_MC2_155 --------------------------------------------------
MAB_0827|M.abscessus_ATCC_1997 --------------------------------------------------
MMAR_0402|M.marinum_M --------------------------------------------------
MUL_1052|M.ulcerans_Agy99 --------------------------------------------------
MLBr_02565|M.leprae_Br4923 GGDGRLVEPLRATLEKDYDLVSNNLGGRWTDSFGGLVFDATGITAPAELK
Mb1385|M.bovis_AF2122/97 --------------------------------------------------
Rv1350|M.tuberculosis_H37Rv --------------------------------------------------
Mflv_4369|M.gilvum_PYR-GCK --------------------------------------------------
MAV_5088|M.avium_104 --------------------------------------------------
TH_3954|M.thermoresistible__bu --------------------------------------------------
Mvan_0607|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_3823|M.smegmatis_MC2_155 --------------------------------------------------
MAB_0827|M.abscessus_ATCC_1997 --------------------------------------------------
MMAR_0402|M.marinum_M --------------------------------------------------
MUL_1052|M.ulcerans_Agy99 --------------------------------------------------
MLBr_02565|M.leprae_Br4923 GLHNFFTPLLRNLGRCARVVVIGTTPDATTSTDERIAQRALEGFSRSLGK
Mb1385|M.bovis_AF2122/97 --------------------------------------------------
Rv1350|M.tuberculosis_H37Rv --------------------------------------------------
Mflv_4369|M.gilvum_PYR-GCK --------------------------------------------------
MAV_5088|M.avium_104 --------------------------------------------------
TH_3954|M.thermoresistible__bu --------------------------------------------------
Mvan_0607|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_3823|M.smegmatis_MC2_155 --------------------------------------------------
MAB_0827|M.abscessus_ATCC_1997 --------------------------------------------------
MMAR_0402|M.marinum_M --------------------------------------------------
MUL_1052|M.ulcerans_Agy99 --------------------------------------------------
MLBr_02565|M.leprae_Br4923 ELRRGATVALVYLSPDAKPAATGLESTMRFILSAKSAYVNGQVFYVGAAD
Mb1385|M.bovis_AF2122/97 ------MASLLNARTAVITGGAQGLGLAIGQRFVAEG-ARVVLGDVNLEA
Rv1350|M.tuberculosis_H37Rv ------MASLLNARTAVITGGAQGLGLAIGQRFVAEG-ARVVLGDVNLEA
Mflv_4369|M.gilvum_PYR-GCK -------MSLLTGQTAVITGGAQGLGFAIAQRFVDEG-ARVVLGDVNLEA
MAV_5088|M.avium_104 -----MAESLLLGKVAVVTGAGQGIGREIARALHRHG-ARVVLADLDGSA
TH_3954|M.thermoresistible__bu -----MPSALLAEKVAVVTGAGRGIGREIARVLHAHG-AEVVLADLDADA
Mvan_0607|M.vanbaalenii_PYR-1 -----------MGNKVIVTGGAGVIGQAICRRLLQG---GYVPVAADLKQ
MSMEG_3823|M.smegmatis_MC2_155 ---------------MIVTGGAGVIGQAICRRLLQS---DYVPVAADLKP
MAB_0827|M.abscessus_ATCC_1997 ------MTSPLKSRRAFVTGGSRGIGAGIVRRLAEDGARVVFTYSSSVQQ
MMAR_0402|M.marinum_M --------MTGGGRVALVTGAAGGQGWAIVQRLRAEG---HSVAACDLRA
MUL_1052|M.ulcerans_Agy99 --------MTGGGRVALVTGAAGGQGWAIVQRLRAEG---HSVAACDLRA
MLBr_02565|M.leprae_Br4923 STPPTNWDRPLENKVAIVTGAARGIGAAIAEVVARDG---ARVVAIDVES
.:**.. * * . . .
Mb1385|M.bovis_AF2122/97 TEVAAKRLGGDD-VALAVRCDVTQADDVDILIRTAVERFG-GLDVMVNNA
Rv1350|M.tuberculosis_H37Rv TEVAAKRLGGDD-VALAVRCDVTQADDVDILIRTAVERFG-GLDVMVNNA
Mflv_4369|M.gilvum_PYR-GCK TQEAAEKLGGAD-VAHAVRCDVTSSAEVDALVAAAVDTFG-ALDIMVNNA
MAV_5088|M.avium_104 ARSAAAQIDDSGANCTGLACDVTSEEQVGALVAGTVREHG-GLDVFVNNA
TH_3954|M.thermoresistible__bu AAQAAAEVDG-----TGVGCDVTAEDQMKRLVADTVAKHG-RLDLFVNNA
Mvan_0607|M.vanbaalenii_PYR-1 AVDAVDFGQAGLQGTLSVAMDVTDRASVDEAVASTVDDGE-TLFGLVNCA
MSMEG_3823|M.smegmatis_MC2_155 AVDQLDLTQENMTGALKVAMDVSDRESVQSAVDSVVEDGD-TLYGLVNCA
MAB_0827|M.abscessus_ATCC_1997 AADVVDDINEDGGWARAVKADVADPDQLGAAIGQAAEELG-GLDILVNNA
MMAR_0402|M.marinum_M DRLDALVAESGDDAVISLALDVTDEAQWQEAVERAVTRFG-ALTALINNA
MUL_1052|M.ulcerans_Agy99 DRLDALVAESGDDAVISLALDVTDEAQWQEAVERAVTRFG-ALTALINNA
MLBr_02565|M.leprae_Br4923 AAEALDETANRVGG-TTLSLDVTADDAVDKITEHLHDYQGGHADILVNNA
: **: ::* *
Mb1385|M.bovis_AF2122/97 GITRDATMRTMTEEQFDQVIAVHLKGTWNGTRLAAAIMRERKRGAIVNMS
Rv1350|M.tuberculosis_H37Rv GITRDATMRTMTEEQFDQVIAVHLKGTWNGTRLAAAIMRERKRGAIVNMS
Mflv_4369|M.gilvum_PYR-GCK GITRDATMRKMTEDDFDKVIAVHLKGTWNGLRAAAAIMRENKRGVIVNMS
MAV_5088|M.avium_104 GITRDASLKRMTVADFDAVIAVHLRGTWLGVREAAAVMRERKTGSIVNMS
TH_3954|M.thermoresistible__bu GITRDASLKRMTVADFDAVVTVHLRGTWLGVREATAVMREQKSGSIVNIS
Mvan_0607|M.vanbaalenii_PYR-1 GILRDSFLGELDEAKLDLMFQVNIAGMARVTDAVAPLLT--EGSAIVNVG
MSMEG_3823|M.smegmatis_MC2_155 GILRDSFLGELDEAKLELMFQVNIAGMARVTDAVAPHLR--EGSAIVNIG
MAB_0827|M.abscessus_ATCC_1997 GILSIGDVDTATLADFDEIVAVNVRAVFAGIKAASPHLT--EGGRIVTIG
MMAR_0402|M.marinum_M GVLHRAALVDETAAGFESAWRVNCLGAFLGMRAALGALSAAEGPVIVNIC
MUL_1052|M.ulcerans_Agy99 GVLHRAALVDETAAGFESAWRVNCLGAFLGMRAALGALSAAEGPVIVNIC
MLBr_02565|M.leprae_Br4923 GITRDKLLANMDDCRWDAVLEVNLLAPQRLTEGLVGNGSISKGGRVIVLS
*: : : *: . : :: :
Mb1385|M.bovis_AF2122/97 SVSGKVG-MVGQTNYSAAKAGIVGMTKAAAKELAHLGIRVNAIAPGLIRS
Rv1350|M.tuberculosis_H37Rv SVSGKVG-MVGQTNYSAAKAGIVGMTKAAAKELAHLGIRVNAIAPGLIRS
Mflv_4369|M.gilvum_PYR-GCK SISGKVG-MIGQTNYSAAKAGIVGMTKAASKELAYLGVRVNAIQPGLIRS
MAV_5088|M.avium_104 SLSGKAG-NPGQTNYSAAKAGIVGLTKAAAKELAHHNVRVNAIQPGLIRT
TH_3954|M.thermoresistible__bu SLSGKSG-NPGQTNYSAAKAGIIGLTKAAAKEVAHHNVRVNAIQPGLIRT
Mvan_0607|M.vanbaalenii_PYR-1 SLTGHFGRFRGASVYGATKAGIAAYTRYVAEELASRSVRVNNVAPGVIRA
MSMEG_3823|M.smegmatis_MC2_155 SLTGHFGRFRGASVYGATKAGIAAYTRYLAEELAPRGIRVNNIAPGVIRA
MAB_0827|M.abscessus_ATCC_1997 SINGDSSPTANLSLYSMTKAAVAGLTRGLAREFGPRGITINNVQPGPIGT
MMAR_0402|M.marinum_M ST-GAIRPFPHHCAYGAAKWALRGLTQTAAAELAPAGIRVNAVFPGPIAT
MUL_1052|M.ulcerans_Agy99 ST-GAIRPFPHHCAYGAAKWALRGLTQTAAAELAPAGFRVNAVFPGPIAT
MLBr_02565|M.leprae_Br4923 SMAGIAG-NRGQTNYATAKAGVIGLTQALAPGLAEKGITINAVAPGFIET
* * *. :* .: . *: : .. .. :* : ** * :
Mb1385|M.bovis_AF2122/97 AMTEAMPQRIW--DQKLAEVPMGRAGEPSEVASVAVFLASDLSSYMTGTV
Rv1350|M.tuberculosis_H37Rv AMTEAMPQRIW--DQKLAEVPMGRAGEPSEVASVAVFLASDLSSYMTGTV
Mflv_4369|M.gilvum_PYR-GCK AMTEAMPQRIW--DSKVAEVPLGRAGEPDEVAKVALFLASDLSSYMTGTV
MAV_5088|M.avium_104 PMTAAMPPDVF--AEREAAVPMKRAGEPEEVAGAVVFLASELSSYITGTV
TH_3954|M.thermoresistible__bu PMTETMPAEVF--AEREAAVPMKRAGEPAEVAGAVVFLGSDLSSYITGSV
Mvan_0607|M.vanbaalenii_PYR-1 PMSPSMARVSGGEEVSASYAMLKRIGEPEEVAEAVEFLLSPRASFITAQT
MSMEG_3823|M.smegmatis_MC2_155 PMSPSMARVSGGEEISASYAMLKRIGEPEEVAEAVEFMLSPRASFITAQT
MAB_0827|M.abscessus_ATCC_1997 DMNPEDGQLA---DILRPNIAVGRYGQPRDIASLVSYLVSDEAWYITGTA
MMAR_0402|M.marinum_M SMLDEPTQAR-----LAAVSMFGRLGRPAEVADAVAFLVSENSSFITGSE
MUL_1052|M.ulcerans_Agy99 SMLDEPTQAR-----LAAVSMFGRLGRHAEVADAVAFLVSENSSFITGSE
MLBr_02565|M.leprae_Br4923 QMTAAIPLATR--EVGRRLNSLLQGGLPVDVAETIAYFAIPASNAVTGNV
* . : * ::* :: : :*.
Mb1385|M.bovis_AF2122/97 LDVTGGRFI---
Rv1350|M.tuberculosis_H37Rv LDVTGGRFI---
Mflv_4369|M.gilvum_PYR-GCK LEVTGGRHL---
MAV_5088|M.avium_104 LGVGGGRYM---
TH_3954|M.thermoresistible__bu IEVGGGRYM---
Mvan_0607|M.vanbaalenii_PYR-1 LLVDGGVVAW--
MSMEG_3823|M.smegmatis_MC2_155 LLVDGGVVAW--
MAB_0827|M.abscessus_ATCC_1997 INIDGGFTA---
MMAR_0402|M.marinum_M LVVDGGQCLQVP
MUL_1052|M.ulcerans_Agy99 LVVDGGQCLQVP
MLBr_02565|M.leprae_Br4923 IRVCGQAMLGA-
: : *