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VRTGRASREHATALTPLHGTSPLPQRSSLYSGPRPTNPKSHSDWTTKRVPLTGLTRSGYEFDIPNLQVLS DPVEADVFVLCVDSPVGTTTRKADLSNLKAASESVGRYLRSTNLVIVRSTVPVGTTRGVVARLLSESSGL VEGDFSLAFAPERTSTGMTLRESSQIPHLVGGRDSLSAERAAEFLQSAGMRSLVMESAEAAELGKLASNA ARDTALALAAQICAVAELHNLDVERLVNDVNHDYPRDHIKMPRPGVGGSCLTKDSYILAESLASTPLGDT LFGLVRRINDETQAPTIRSLARHFTDHFRREFAPRILVCGAAFKGDPPTRDTRNAVSLVVARELMAQEYS VAVFDPFISGEEISELGFEPASIAEMNAPWNGLLLYSNHKFFSDENVVRKLVQNVCGNGFIYDPYRWCKP TMDAIRPGTLYRTLSTEKILP
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_0586 | - | - | 100% (441) | UDP-glucose/GDP-mannose dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_0598 | - | 1e-11 | 29.01% (293) | UDP-glucose 6-dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_1699 | - | 1e-08 | 23.38% (325) | GDP-mannose 6-dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0330 | udgA | 7e-14 | 29.25% (294) | UDP-glucose 6-dehydrogenase UdgA |
| M. gilvum PYR-GCK | Mflv_0289 | - | 3e-14 | 28.42% (292) | UDP-glucose 6-dehydrogenase |
| M. tuberculosis H37Rv | Rv0322 | udgA | 7e-14 | 29.25% (294) | UDP-glucose 6-dehydrogenase UdgA |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_4295c | - | 4e-13 | 27.93% (290) | UDP-glucose 6-dehydrogenase (UdgA) |
| M. marinum M | MMAR_0603 | udgA | 2e-14 | 29.35% (293) | UDP-glucose dehydrogenase UdgA |
| M. avium 104 | MAV_4092 | - | 2e-19 | 31.23% (285) | UDP-glucose 6-dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_0475 | - | 8e-22 | 28.07% (285) | nucleotide-sugar dehydrogenase |
| M. thermoresistible (build 8) | TH_0768 | udgA | 3e-15 | 28.72% (289) | PROBABLE UDP-GLUCOSE 6-DEHYDROGENASE UDGA (UDP-GLC |
| M. ulcerans Agy99 | MUL_1511 | - | 6e-13 | 25.26% (293) | UDP-glucose 6-dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_0289|M.gilvum_PYR-GCK ----MRCT----VFGTGYLGATHAAGMAELGHEVVGVDIDPGKVAKLAAG
MAB_4295c|M.abscessus_ATCC_199 ----MRCT----VFGTGYLGATHAACMAELGHEVLGVDIDPGKVAKLSSG
Mb0330|M.bovis_AF2122/97 ----MRCS----VFGTGYLGATHAVGMAQLGHEVVGVDIDPGKVAKLAGG
Rv0322|M.tuberculosis_H37Rv ----MRCS----VFGTGYLGATHAVGMAQLGHEVVGVDIDPGKVAKLAGG
MMAR_0603|M.marinum_M ----MRCT----VFGTGYLGATHAVGMAQLGHEVVGVDIDPGKVAKLAGG
TH_0768|M.thermoresistible__bu ----MRCT----VFGAGYLGTTHAAGMAALGHEVIAVDVDAGKVAKLAAG
MAV_4092|M.avium_104 ----MSTEPLVGVVGVGYVGLTTAVCVAAAGRKTVAVDINPDRVGRLRAG
MSMEG_0475|M.smegmatis_MC2_155 MITLQRTT--IAVVGLGYVGLPTALAFAEMGAEIIGCDLSEDRLTNIKTG
MUL_1511|M.ulcerans_Agy99 -MTTQPSERICIVGGAGHVGLPLALVLADEGYNVDILDTNAEALETIMAG
Mvan_0586|M.vanbaalenii_PYR-1 ----MRTG----RASREHATALTPLHGTSPLPQRSSLYSGPRPTNPKSHS
. : . : : . .
Mflv_0289|M.gilvum_PYR-GCK EVPFYEPGLREALQRNIEAGRLRFTTDYAEAAEFADVHFLGVGTPQKKGE
MAB_4295c|M.abscessus_ATCC_199 DIPFYEPGLRKILQSNIASGRLRFTTSYAEAAEFADVHFLGVGTPQKKGE
Mb0330|M.bovis_AF2122/97 DIPFYEPGLRKLLTDNLAAGRLRFTTDYDMAADFADVHFLGVGTPQKIGE
Rv0322|M.tuberculosis_H37Rv DIPFYEPGLRKLLTDNLAAGRLRFTTDYDMAADFADVHFLGVGTPQKIGE
MMAR_0603|M.marinum_M DIPFYEPGLRKLLRDNLAAGRLHFTTDYDMAAEFADVHFLGVGTPQKRGE
TH_0768|M.thermoresistible__bu EVPFYEPGLRALVTENLATGRLQFTTDYDAAADFADLHFLGVGTPQQRGD
MAV_4092|M.avium_104 VAVIDEPGLSELLGDGLAGGVLRFSADFAELAD-RDVVFVCVPTPSAP-D
MSMEG_0475|M.smegmatis_MC2_155 DVDMLPRDRTRLLRQ---LDSFKLTTEPSAIGA-ADAVVVCVPTPVDP-H
MUL_1511|M.ulcerans_Agy99 RMPFIETGAEDLLKPLLPTGRISGSTDSQVVRN-SDIVICVVGTPVDE-Y
Mvan_0586|M.vanbaalenii_PYR-1 DWTTKRVPLTGLTRSGYEFDIPNLQVLSDPVEA--DVFVLCVDSPVGTTT
. . * . * :*
Mflv_0289|M.gilvum_PYR-GCK YAADLRHVYAVIDTLVPLLRRPAVIVGKSTVPVGTAAELVER--AAGLAP
MAB_4295c|M.abscessus_ATCC_199 YGADLRHVHSVIDTLVPLLSRSAVIIGKSTVPVGTARELGQR--AAGFAA
Mb0330|M.bovis_AF2122/97 YGADLRHVHAVIDALVPRLVRASILVGKSTVPVGTAAELGHR--AGALAP
Rv0322|M.tuberculosis_H37Rv YGADLRHVHAVIDALVPRLVRASILVGKSTVPVGTAAELGHR--AGALAP
MMAR_0603|M.marinum_M YGADLRHIHAVIDTLVPRLTRTSVLIGKSTVPVGTAAELARR--AAGLAV
TH_0768|M.thermoresistible__bu YSADLTQVHAVVDTLVPRLRRPAVIVGKSTVPVGTARDLLER--ARRLAP
MAV_4092|M.avium_104 GHADLAAVESVIDRLGRVLRRGAVVALKSTVPVGTTSTMAQR--LCHKG-
MSMEG_0475|M.smegmatis_MC2_155 QSPDLRALTAACANVVRYATKGQLLVLTSTTYVGCTHEMLVDPLQAAGFT
MUL_1511|M.ulcerans_Agy99 LTPQAHTFFRVIDEISPYFHDGQTLILRSTVYPGLSQRVHDM-----FSE
Mvan_0586|M.vanbaalenii_PYR-1 RKADLSNLKAASESVGRYLRSTNLVIVRSTVPVGTTRGVVARLLSESSGL
.: . . : : **. * : :
Mflv_0289|M.gilvum_PYR-GCK DGVTVEVAWNPEFLREGFAVQDTLHPDRIVLGVQKDSRIAEPVLRELYAA
MAB_4295c|M.abscessus_ATCC_199 AGVDVEVAWNPEFLREGYAVKDTLHPDRIVLGVQRDSDRAEKLVRELYGP
Mb0330|M.bovis_AF2122/97 RGVDVEIAWNPEFLREGFAVHDTLNPDRIVLGVQDDSTRAEVAVRELYAP
Rv0322|M.tuberculosis_H37Rv RGVDVEIAWNPEFLREGFAVHDTLNPDRIVLGVQDDSTRAEVAVRELYAP
MMAR_0603|M.marinum_M AGVGVEIAWNPEFLREGFAVRDTLRPDRIVLGVQEDSILAEQFVRELYGP
TH_0768|M.thermoresistible__bu TGVDVEVAWNPEFLREGFAVRDTLHPDRIVVGAPPDSVRAEPMLRELYAP
MAV_4092|M.avium_104 ----IRVVSTPEFLREGRAVDDFRNPDRLVIGSHD--ELAAQLVHQAYG-
MSMEG_0475|M.smegmatis_MC2_155 VGKDIFVAFSPERIDPGVKDHAPERTPRVVGGVTPACTARAAALLRHTAS
MUL_1511|M.ulcerans_Agy99 RGIGVHVTFCPERIAQGHSIRELRIIPQIISGFDAEGLRVVRELFSGIAS
Mvan_0586|M.vanbaalenii_PYR-1 VEGDFSLAFAPERTSTGMTLRESSQIPHLVGGRDSLSAERAAEFLQSAGM
. :. ** * ::: * . .
Mflv_0289|M.gilvum_PYR-GCK LLADGAPFLVSDLQTAELAKVSANAFLATKISFINAISEVCEAVGADVTL
MAB_4295c|M.abscessus_ATCC_199 ILDEEVPFLVTDLETAELVKVSANAFLATKISFINAISEVCEAVGADVTT
Mb0330|M.bovis_AF2122/97 LLAAGVPFLVTDLQTAELVKVSANAFLATKISFINAISEVCEAAGADVSQ
Rv0322|M.tuberculosis_H37Rv LLAAGVPFLVTDLQTAELVKVSANAFLATKISFINAISEVCEAAGADVSQ
MMAR_0603|M.marinum_M LLEAGVPFLVTDLQTAELVKVSANAFLATKISFINAISEVCEAAGADVSL
TH_0768|M.thermoresistible__bu LLGDGVPWLSTDLQTAELVKVSANAFLATKISFINAISDVCEAVGADVVT
MAV_4092|M.avium_104 --LAGHRVLRMSPESAELAKYASNAFLAVKLSYTNSLAALCARVGADIDD
MSMEG_0475|M.smegmatis_MC2_155 -----SVHTVSSPESAEMTKLVENSFRAVNIALANEFSEVARELSVDVME
MUL_1511|M.ulcerans_Agy99 ------EIIKVEPQEAELAKLFCNSYRYIQFAVANQFYLLSREAGQDFDR
Mvan_0586|M.vanbaalenii_PYR-1 R-----SLVMESAEAAELGKLASNAARDTALALAAQICAVAELHNLDVER
. : **: * *: :: : :. . *.
Mflv_0289|M.gilvum_PYR-GCK LADALGHDARIGRRFLNAGLGFGGGCLPKDIRAFMARAGELGANQALTFL
MAB_4295c|M.abscessus_ATCC_199 LADALGYDPRIGRRFLNAGLGFGGGCLPKDIRAFMARAGELGASHALTFL
Mb0330|M.bovis_AF2122/97 LADALGYDPRIGRQCLNAGLGFGGGCLPKDIRAFMARAGELGADQALTFL
Rv0322|M.tuberculosis_H37Rv LADALGYDPRIGRQCLNAGLGFGGGCLPKDIRAFMARAGELGADQALTFL
MMAR_0603|M.marinum_M LADALGYDTRIGRQCLNAGLGFGGGCLPKDIRAFMARAGELGANQALTFL
TH_0768|M.thermoresistible__bu LADALGHDPRIGRRFLNAGLGFGGGCLPKDIRAFMARAGELGANHTLTLL
MAV_4092|M.avium_104 VTCCMGADRRIGAEFLRPGPGWGGSCLPKDTAALLDIAHRHRVS--FAEV
MSMEG_0475|M.smegmatis_MC2_155 VIDAAATKP-YGFMPFYPGPGVGGHCIPCDPHYLLWQLRARRFDS--PLM
MUL_1511|M.ulcerans_Agy99 VHHATTYKNSRVDSLPRAGLAAG-PCLLKDTMQLAAFS-----NNNFMLG
Mvan_0586|M.vanbaalenii_PYR-1 LVNDVNHDYPRDHIKMPR-PGVGGSCLTKDSYILAESLASTPLGD--TLF
: . . * *: * : .
Mflv_0289|M.gilvum_PYR-GCK REVDSINMRRRTRMVELATTACG---GSLLGANIAVLGAAFK--PESDDV
MAB_4295c|M.abscessus_ATCC_199 REVDSINMRRRTRMVELATKACG---GSLLGANVAVLGAAFK--PESDDV
Mb0330|M.bovis_AF2122/97 REVDSINMRRRTKMVELATTACG---GSLLGANIAVLGAAFK--PESDDV
Rv0322|M.tuberculosis_H37Rv REVDSINMRRRTKMVELATTACG---GSLLGANIAVLGAAFK--PESDDV
MMAR_0603|M.marinum_M REVDSINMRRRTRMVELATTACG---GSLLGANLAVLGAAFK--PESDDV
TH_0768|M.thermoresistible__bu REVDSINMRRRARMVELATTACG---GSLLGANIAVLGAAFK--PDSDDV
MAV_4092|M.avium_104 EAARQTNTAQARRIVTALRHTLG---RPLSGRRITALGLTFK--AATSDT
MSMEG_0475|M.smegmatis_MC2_155 RTAMTCIAARPRDVVSRAREMLAERGKPTQGARVLVVGVTYK--PGVADL
MUL_1511|M.ulcerans_Agy99 HSAMLINEGQPQFIVNMLKRRVN-----LRDKTVGILGMTFK--ADCDDT
Mvan_0586|M.vanbaalenii_PYR-1 GLVRRINDETQAPTIRSLARHFTDHFRREFAPRILVCGAAFKGDPPTRDT
. : : * ::* . *
Mflv_0289|M.gilvum_PYR-GCK RDSPALNVAGMLQLHGATVNVYDPKAMDNSRRLFP--TLNYSASALDACE
MAB_4295c|M.abscessus_ATCC_199 RDSPALNVAGLLQLNGAAVNVYDPKALENSRRLFP--TLNYATSVLEAAD
Mb0330|M.bovis_AF2122/97 RDSPALNVAGQLQLNGATVHVYDPKALDNAHRLFP--TLNYAVSVAEACE
Rv0322|M.tuberculosis_H37Rv RDSPALNVAGQLQLNGATVHVYDPKALDNAHRLFP--TLNYAVSVAEACE
MMAR_0603|M.marinum_M RDSPALNVAGQLQLNGAAVNVYDPKALDNANRLFP--TLNYAVSVAEACE
TH_0768|M.thermoresistible__bu RDSPALNVAGMLQLNGATVTVYDPKAMENSRRVFP--TLTYSTSVAEACD
MAV_4092|M.avium_104 RESPALAACRELAAAGAQVAGYDPQLPNIDPAVLQQNRVTAVDDPYRAAK
MSMEG_0475|M.smegmatis_MC2_155 RESPALAIIDDLTAAGAVVSFTDPLVPMLRTPQAG----TLTNHRSPEHD
MUL_1511|M.ulcerans_Agy99 RDSLSFKLRHLLMLEAKEVILHDPFLEGKDYHPLQ-----------TVVD
Mvan_0586|M.vanbaalenii_PYR-1 RNAVSLVVARELMAQEYSVAVFDPFISGEEISELG----FEPASIAEMNA
*:: :: * * **
Mflv_0289|M.gilvum_PYR-GCK RADAVLVLTEWSEFVG--MHPDELSAAVRTKVIVDGRNCLDIGVWRDAGW
MAB_4295c|M.abscessus_ATCC_199 RADAVLLLTEWQEFVD--FDPDALAKVVRTKVIVDGRNCLDAAKWVNAGW
Mb0330|M.bovis_AF2122/97 RADAVLVLTEWREFID--LEPADLANRVRARVIVDGRNCLDVTRWRRAGW
Rv0322|M.tuberculosis_H37Rv RADAVLVLTEWREFID--LEPADLANRVRARVIVDGRNCLDVTRWRRAGW
MMAR_0603|M.marinum_M RADAVLILTEWQEFVD--LDPDDLADRVRARVIVDGRNCLDVSRWERAGW
TH_0768|M.thermoresistible__bu RADAVLVLTEWQEFID--LNPAELADIVRAKVIVDGRNCLDVRRWQRAGW
MAV_4092|M.avium_104 AADAVVVLTEWPQFRS--LDWRAVAQDAPLAVVLDARNSLDPATVREAGL
MSMEG_0475|M.smegmatis_MC2_155 EWDLVLVHHWAEELRD--WVS---AQPVVLDTTFGRRG------------
MUL_1511|M.ulcerans_Agy99 RSDVIVVGVPHSAYRG--LRVP------RGKVVEDVWGCLDVTEFDVDPC
Mvan_0586|M.vanbaalenii_PYR-1 PWNGLLLYSNHKFFSDENVVRKLVQNVCGNGFIYDPYRWCKPTMDAIRPG
: ::: . .
Mflv_0289|M.gilvum_PYR-GCK QVHALGRTVEVGA--
MAB_4295c|M.abscessus_ATCC_199 RVFCLGKRVEELAHT
Mb0330|M.bovis_AF2122/97 RVFRLGVPRLGH---
Rv0322|M.tuberculosis_H37Rv RVFRLGVPRLGH---
MMAR_0603|M.marinum_M RVFRLGARIRAAS--
TH_0768|M.thermoresistible__bu KVFCLGRTP------
MAV_4092|M.avium_104 RYLGNGVPQGF----
MSMEG_0475|M.smegmatis_MC2_155 ---------------
MUL_1511|M.ulcerans_Agy99 NGANLAELGTAAAR-
Mvan_0586|M.vanbaalenii_PYR-1 TLYRTLSTEKILP--