For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
VTTQPSERICIVGGAGHVGLPLALVLADEGYNVDILDTNAEALETIMAGRMPFIETGAEDLLKPLLPTGR ISGSTDSQVVRNSDIVICVVGTPVDEYLTPQAHTFFRVIDEISPYFHDGQTLILRSTVYPGLSQRVHDMF SERGIGVHVTFCPERIAQGHSIRELRIIPQIISGFDAEGLRVVRELFSGIASEIIKVEPQEAELAKLFCN SYRYIQFAVANQFYLLSREAGQDFDRVHHATTYKNSRVDSLPRAGLAAGPCLLKDTMQLAAFSNNNFMLG HSAMLINEGQPQFIVNMLKRRVNLRDKTVGILGMTFKADCDDTRDSLSFKLRHLLMLEAKEVILHDPFLE GKDYHPLQTVVDRSDVIVVGVPHSAYRGLRVPRGKVVEDVWGCLDVTEFDVDPCNGANLAELGTAAAR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. ulcerans Agy99 | MUL_1511 | - | - | 100% (418) | UDP-glucose 6-dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0330 | udgA | 4e-22 | 25.41% (429) | UDP-glucose 6-dehydrogenase UdgA |
| M. gilvum PYR-GCK | Mflv_0289 | - | 7e-22 | 24.65% (426) | UDP-glucose 6-dehydrogenase |
| M. tuberculosis H37Rv | Rv0322 | udgA | 4e-22 | 25.41% (429) | UDP-glucose 6-dehydrogenase UdgA |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_4295c | - | 5e-23 | 25.52% (431) | UDP-glucose 6-dehydrogenase (UdgA) |
| M. marinum M | MMAR_2309 | udgL | 0.0 | 98.80% (418) | UDP-glucose 6-dehydrogenase, UdgL |
| M. avium 104 | MAV_4092 | - | 1e-23 | 26.20% (397) | UDP-glucose 6-dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_5957 | algD | 7e-24 | 28.05% (353) | GDP-mannose 6-dehydrogenase AlgD |
| M. thermoresistible (build 8) | TH_0768 | udgA | 7e-24 | 25.81% (430) | PROBABLE UDP-GLUCOSE 6-DEHYDROGENASE UDGA (UDP-GLC |
| M. vanbaalenii PYR-1 | Mvan_0598 | - | 2e-20 | 26.57% (429) | UDP-glucose 6-dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0330|M.bovis_AF2122/97 --------------------------------------------------
Rv0322|M.tuberculosis_H37Rv --------------------------------------------------
Mflv_0289|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_0598|M.vanbaalenii_PYR-1 --------------------------------------------------
MAB_4295c|M.abscessus_ATCC_199 --------------------------------------------------
TH_0768|M.thermoresistible__bu --------------------------------------------------
MAV_4092|M.avium_104 --------------------------------------------------
MUL_1511|M.ulcerans_Agy99 --------------------------------------------------
MMAR_2309|M.marinum_M --------------------------------------------------
MSMEG_5957|M.smegmatis_MC2_155 MAKGVSIAISTGRMLAQGLAAREGQSMPRIDNSQGGDSLAAREFKGVAES
Mb0330|M.bovis_AF2122/97 ----MRCS----VFGTGYLGATHAVGMAQLGHEVVGVDIDPGKVAKLAGG
Rv0322|M.tuberculosis_H37Rv ----MRCS----VFGTGYLGATHAVGMAQLGHEVVGVDIDPGKVAKLAGG
Mflv_0289|M.gilvum_PYR-GCK ----MRCT----VFGTGYLGATHAAGMAELGHEVVGVDIDPGKVAKLAAG
Mvan_0598|M.vanbaalenii_PYR-1 ----MRCT----VFGTGYLGATHAAGMAELGHDVLGVDIDAGKVAKLSGG
MAB_4295c|M.abscessus_ATCC_199 ----MRCT----VFGTGYLGATHAACMAELGHEVLGVDIDPGKVAKLSSG
TH_0768|M.thermoresistible__bu ----MRCT----VFGAGYLGTTHAAGMAALGHEVIAVDVDAGKVAKLAAG
MAV_4092|M.avium_104 ----MSTEPLVGVVGVGYVGLTTAVCVAAAGRKTVAVDINPDRVGRLRAG
MUL_1511|M.ulcerans_Agy99 -MTTQPSERICIVGGAGHVGLPLALVLADEGYNVDILDTNAEALETIMAG
MMAR_2309|M.marinum_M -MTTQPSERICIVGGAGHVGLPLALVLADEGYNVDILDTNAEALETIMAG
MSMEG_5957|M.smegmatis_MC2_155 FAPSGRAVRRVAVFGLGYVGSVTAACLASRGHSVIGVDVRREKVDMINRG
* * *::* * :* * .. :* : : *
Mb0330|M.bovis_AF2122/97 DIPFYEPGLRKLLTDNLAAGRLRFTTDYDMAADFADVHFLGVGTPQKIG-
Rv0322|M.tuberculosis_H37Rv DIPFYEPGLRKLLTDNLAAGRLRFTTDYDMAADFADVHFLGVGTPQKIG-
Mflv_0289|M.gilvum_PYR-GCK EVPFYEPGLREALQRNIEAGRLRFTTDYAEAAEFADVHFLGVGTPQKKG-
Mvan_0598|M.vanbaalenii_PYR-1 EVPFYEPGLREMLRRNIDAGRLRFTTDYAEAAGFADVHFLGVGTPQKKG-
MAB_4295c|M.abscessus_ATCC_199 DIPFYEPGLRKILQSNIASGRLRFTTSYAEAAEFADVHFLGVGTPQKKG-
TH_0768|M.thermoresistible__bu EVPFYEPGLRALVTENLATGRLQFTTDYDAAADFADLHFLGVGTPQQRG-
MAV_4092|M.avium_104 VAVIDEPGLSELLGDGLAGGVLRFSADFAELAD-RDVVFVCVPTPSAP--
MUL_1511|M.ulcerans_Agy99 RMPFIETGAEDLLKPLLPTGRISGSTDSQVVRN-SDIVICVVGTPVDE--
MMAR_2309|M.marinum_M RMPFIETGAEDLLKRLLPTGRISGSTDSQVVRN-SDIVICVVGTPVDE--
MSMEG_5957|M.smegmatis_MC2_155 QSPVVEGGLGELIFGEVAAGRLSATTNPADAVANTDIALVCVGTPSAANG
. * * : : * : ::. *: : * **
Mb0330|M.bovis_AF2122/97 -EYGADLRHVHAVIDALVPRLVRASILVGKSTVPVGTAAELGHRAGALAP
Rv0322|M.tuberculosis_H37Rv -EYGADLRHVHAVIDALVPRLVRASILVGKSTVPVGTAAELGHRAGALAP
Mflv_0289|M.gilvum_PYR-GCK -EYAADLRHVYAVIDTLVPLLRRPAVIVGKSTVPVGTAAELVERAAGLAP
Mvan_0598|M.vanbaalenii_PYR-1 -EYGADLRHVYAVIDTLVPLLTRPAVIVGKSTVPVGTAADLSERAAGLAP
MAB_4295c|M.abscessus_ATCC_199 -EYGADLRHVHSVIDTLVPLLSRSAVIIGKSTVPVGTARELGQRAAGFAA
TH_0768|M.thermoresistible__bu -DYSADLTQVHAVVDTLVPRLRRPAVIVGKSTVPVGTARDLLERARRLAP
MAV_4092|M.avium_104 -DGHADLAAVESVIDRLGRVLRRGAVVALKSTVPVGTTSTMAQRLCHKG-
MUL_1511|M.ulcerans_Agy99 -YLTPQAHTFFRVIDEISPYFHDGQTLILRSTVYPGLSQRVHDMFSERG-
MMAR_2309|M.marinum_M -YLTPQAHTFFRVIDEISPYFHDGQTLILRSTVYPGLSQRVHDMFSERG-
MSMEG_5957|M.smegmatis_MC2_155 SLLTTYLERVSEDIGAALAGRAGRYTVVIRSTVLPWTCEQIVLPRLQAAS
. . :. : :*** : .
Mb0330|M.bovis_AF2122/97 ---RGVDVEIAWNPEFLREGFAVHDTLNPDRIVLGVQDDSTRAEVAVREL
Rv0322|M.tuberculosis_H37Rv ---RGVDVEIAWNPEFLREGFAVHDTLNPDRIVLGVQDDSTRAEVAVREL
Mflv_0289|M.gilvum_PYR-GCK ---DGVTVEVAWNPEFLREGFAVQDTLHPDRIVLGVQKDSRIAEPVLREL
Mvan_0598|M.vanbaalenii_PYR-1 ---EGVTVEVAWNPEFLREGFAVADTLHPDRIVLGVQRDSQLAEPVLREM
MAB_4295c|M.abscessus_ATCC_199 ---AGVDVEVAWNPEFLREGYAVKDTLHPDRIVLGVQRDSDRAEKLVREL
TH_0768|M.thermoresistible__bu ---TGVDVEVAWNPEFLREGFAVRDTLHPDRIVVGAPPDSVRAEPMLREL
MAV_4092|M.avium_104 -------IRVVSTPEFLREGRAVDDFRNPDRLVIGS--HDELAAQLVHQA
MUL_1511|M.ulcerans_Agy99 -----IGVHVTFCPERIAQGHSIRELRIIPQIISGFDAEGLR---VVREL
MMAR_2309|M.marinum_M -----IGVHVTFCPERIAQGHSIRELRIIPQIISGFDAEGLR---VVREL
MSMEG_5957|M.smegmatis_MC2_155 GLRAGEDFGVAVNPEFLREGSSIRDFFEPPKIVIGQFDAVSG--DVVAQL
. :. ** : :* :: : ::: * : :
Mb0330|M.bovis_AF2122/97 YAPLLAAGVPFLVTDLQTAELVKVSANAFLATKISFINAISEVCEAAGAD
Rv0322|M.tuberculosis_H37Rv YAPLLAAGVPFLVTDLQTAELVKVSANAFLATKISFINAISEVCEAAGAD
Mflv_0289|M.gilvum_PYR-GCK YAALLADGAPFLVSDLQTAELAKVSANAFLATKISFINAISEVCEAVGAD
Mvan_0598|M.vanbaalenii_PYR-1 YAPLLAAGVPFLIADLQTAELVKVSANAFLATKISFINAISEVCEAVDAD
MAB_4295c|M.abscessus_ATCC_199 YGPILDEEVPFLVTDLETAELVKVSANAFLATKISFINAISEVCEAVGAD
TH_0768|M.thermoresistible__bu YAPLLGDGVPWLSTDLQTAELVKVSANAFLATKISFINAISDVCEAVGAD
MAV_4092|M.avium_104 YG---LAGHRVLRMSPESAELAKYASNAFLAVKLSYTNSLAALCARVGAD
MUL_1511|M.ulcerans_Agy99 FS---GIASEIIKVEPQEAELAKLFCNSYRYIQFAVANQFYLLSREAGQD
MMAR_2309|M.marinum_M FS---GIASEIIEVEPQEAELAKLFCNSYRYIQFAVANQFYLLSREAGLD
MSMEG_5957|M.smegmatis_MC2_155 YEG---MSAPVFRVPLAVAEMVKYADNGFHALKTGFANEIGAVCKAMGLD
: : **:.* *.: : . * : :. . *
Mb0330|M.bovis_AF2122/97 VSQLADALGYDPRI--GRQCLNAGLGFGGGCLPKDIRAFMARAGELGADQ
Rv0322|M.tuberculosis_H37Rv VSQLADALGYDPRI--GRQCLNAGLGFGGGCLPKDIRAFMARAGELGADQ
Mflv_0289|M.gilvum_PYR-GCK VTLLADALGHDARI--GRRFLNAGLGFGGGCLPKDIRAFMARAGELGANQ
Mvan_0598|M.vanbaalenii_PYR-1 VTLLADALGHDARI--GRRFLNAGLGFGGGCLPKDIRAFMARAGELGANH
MAB_4295c|M.abscessus_ATCC_199 VTTLADALGYDPRI--GRRFLNAGLGFGGGCLPKDIRAFMARAGELGASH
TH_0768|M.thermoresistible__bu VVTLADALGHDPRI--GRRFLNAGLGFGGGCLPKDIRAFMARAGELGANH
MAV_4092|M.avium_104 IDDVTCCMGADRRI--GAEFLRPGPGWGGSCLPKDTAALLDIAHRHRVS-
MUL_1511|M.ulcerans_Agy99 FDRVHHATTYKNSR--VDSLPRAGLAAG-PCLLKDTMQLAAFS-----NN
MMAR_2309|M.marinum_M FDRVHHAATYKNSR--VDSLPRAGLAAG-PCLLKDTMQLAAFS-----NN
MSMEG_5957|M.smegmatis_MC2_155 SHAVMDIFVADTKLNISRAYLRPGFAFGGSCLPKDLRALIHRAR--TSDV
: . ..* . * ** ** : : .
Mb0330|M.bovis_AF2122/97 ALTFLREVDSINMRRRTKMVELATTACGGSLLGANIAVLGAAFKPESDDV
Rv0322|M.tuberculosis_H37Rv ALTFLREVDSINMRRRTKMVELATTACGGSLLGANIAVLGAAFKPESDDV
Mflv_0289|M.gilvum_PYR-GCK ALTFLREVDSINMRRRTRMVELATTACGGSLLGANIAVLGAAFKPESDDV
Mvan_0598|M.vanbaalenii_PYR-1 ALTFLREVDSINMRRRTRMVELATKACGGSLLGANVAVLGAAFKPESDDV
MAB_4295c|M.abscessus_ATCC_199 ALTFLREVDSINMRRRTRMVELATKACGGSLLGANVAVLGAAFKPESDDV
TH_0768|M.thermoresistible__bu TLTLLREVDSINMRRRARMVELATTACGGSLLGANIAVLGAAFKPDSDDV
MAV_4092|M.avium_104 -FAEVEAARQTNTAQARRIVTALRHTLGRPLSGRRITALGLTFKAATSDT
MUL_1511|M.ulcerans_Agy99 NFMLGHSAMLINEGQPQFIVNMLKRRVN--LRDKTVGILGMTFKADCDDT
MMAR_2309|M.marinum_M NFMLGHSAMLINEGQPQFIVNMLKRRVN--LRDKTVGILGMTFKADCDDT
MSMEG_5957|M.smegmatis_MC2_155 PLPILESVCISNNGQIDRAFNVIEATGK-----RRVGLLGLAFKSGTDDL
: . . * : . : ** :**. .*
Mb0330|M.bovis_AF2122/97 RDSPALNVAGQLQLNGATVHVYDPKALDNAHRLFP--TLNYAVSVAEACE
Rv0322|M.tuberculosis_H37Rv RDSPALNVAGQLQLNGATVHVYDPKALDNAHRLFP--TLNYAVSVAEACE
Mflv_0289|M.gilvum_PYR-GCK RDSPALNVAGMLQLHGATVNVYDPKAMDNSRRLFP--TLNYSASALDACE
Mvan_0598|M.vanbaalenii_PYR-1 RDSPALNVAGMLQLNGATVNVYDPQAIENSRRLFP--TLNYATTVVEACD
MAB_4295c|M.abscessus_ATCC_199 RDSPALNVAGLLQLNGAAVNVYDPKALENSRRLFP--TLNYATSVLEAAD
TH_0768|M.thermoresistible__bu RDSPALNVAGMLQLNGATVTVYDPKAMENSRRVFP--TLTYSTSVAEACD
MAV_4092|M.avium_104 RESPALAACRELAAAGAQVAGYDPQLPNIDPAVLQQNRVTAVDDPYRAAK
MUL_1511|M.ulcerans_Agy99 RDSLSFKLRHLLMLEAKEVILHDPFLEGKDYHPLQ-----------TVVD
MMAR_2309|M.marinum_M RDSLSFKLRHLLMLEAKEVILHDPFLEGKDYHPLQ-----------TVVD
MSMEG_5957|M.smegmatis_MC2_155 RESPLVALAERLVGRGFDLQIYDPQVSASRLLGAN--RAFAEARIPCLSQ
*:* . * . : :** .
Mb0330|M.bovis_AF2122/97 RADAVLVLTEWREFIDLEPADLANRVRARVIVDGRNCLDVTRWRRAGWRV
Rv0322|M.tuberculosis_H37Rv RADAVLVLTEWREFIDLEPADLANRVRARVIVDGRNCLDVTRWRRAGWRV
Mflv_0289|M.gilvum_PYR-GCK RADAVLVLTEWSEFVGMHPDELSAAVRTKVIVDGRNCLDIGVWRDAGWQV
Mvan_0598|M.vanbaalenii_PYR-1 RADAVLVLTEWREFVELDPVLLADTVRAKVVVDGRNCLDVGRWQQAGWQV
MAB_4295c|M.abscessus_ATCC_199 RADAVLLLTEWQEFVDFDPDALAKVVRTKVIVDGRNCLDAAKWVNAGWRV
TH_0768|M.thermoresistible__bu RADAVLVLTEWQEFIDLNPAELADIVRAKVIVDGRNCLDVRRWQRAGWKV
MAV_4092|M.avium_104 AADAVVVLTEWPQFRSLDWRAVAQDAPLAVVLDARNSLDPATVREAGLRY
MUL_1511|M.ulcerans_Agy99 RSDVIVVGVPHSAYRGLR------VPRGKVVEDVWGCLDVTEFDVDPCNG
MMAR_2309|M.marinum_M RSDVIVVGVPHSAYRGLR------VPRGKVVEDVWGCLDVTELDVDPCNG
MSMEG_5957|M.smegmatis_MC2_155 CVSDSPDEVVNHAEVCVVGAADPESIAALRRVDGRIVVDLVRFPGSVDYQ
. . . * :*
Mb0330|M.bovis_AF2122/97 FRLG--VPRLGH-
Rv0322|M.tuberculosis_H37Rv FRLG--VPRLGH-
Mflv_0289|M.gilvum_PYR-GCK HALGRTVEVGA--
Mvan_0598|M.vanbaalenii_PYR-1 FALGRFGGEPAAA
MAB_4295c|M.abscessus_ATCC_199 FCLGKRVEELAHT
TH_0768|M.thermoresistible__bu FCLGRTP------
MAV_4092|M.avium_104 LGNGVPQGF----
MUL_1511|M.ulcerans_Agy99 ANLAELGTAAAR-
MMAR_2309|M.marinum_M ANLAELGTAAAR-
MSMEG_5957|M.smegmatis_MC2_155 DDPRYIGISW---