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MRCTVFGTGYLGATHAAGMAELGHDVLGVDIDAGKVAKLSGGEVPFYEPGLREMLRRNIDAGRLRFTTDY AEAAGFADVHFLGVGTPQKKGEYGADLRHVYAVIDTLVPLLTRPAVIVGKSTVPVGTAADLSERAAGLAP EGVTVEVAWNPEFLREGFAVADTLHPDRIVLGVQRDSQLAEPVLREMYAPLLAAGVPFLIADLQTAELVK VSANAFLATKISFINAISEVCEAVDADVTLLADALGHDARIGRRFLNAGLGFGGGCLPKDIRAFMARAGE LGANHALTFLREVDSINMRRRTRMVELATKACGGSLLGANVAVLGAAFKPESDDVRDSPALNVAGMLQLN GATVNVYDPQAIENSRRLFPTLNYATTVVEACDRADAVLVLTEWREFVELDPVLLADTVRAKVVVDGRNC LDVGRWQQAGWQVFALGRFGGEPAAA
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_0598 | - | - | 100% (446) | UDP-glucose 6-dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_1699 | - | 2e-34 | 29.35% (368) | GDP-mannose 6-dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_0586 | - | 1e-11 | 28.77% (292) | UDP-glucose/GDP-mannose dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0330 | udgA | 0.0 | 80.55% (437) | UDP-glucose 6-dehydrogenase UdgA |
| M. gilvum PYR-GCK | Mflv_0289 | - | 0.0 | 87.21% (438) | UDP-glucose 6-dehydrogenase |
| M. tuberculosis H37Rv | Rv0322 | udgA | 0.0 | 80.55% (437) | UDP-glucose 6-dehydrogenase UdgA |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_4295c | - | 0.0 | 83.33% (438) | UDP-glucose 6-dehydrogenase (UdgA) |
| M. marinum M | MMAR_0603 | udgA | 0.0 | 82.15% (437) | UDP-glucose dehydrogenase UdgA |
| M. avium 104 | MAV_4823 | - | 0.0 | 83.14% (433) | UDP-glucose 6-dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_0680 | - | 0.0 | 85.02% (434) | UDP-glucose 6-dehydrogenase |
| M. thermoresistible (build 8) | TH_0768 | udgA | 0.0 | 81.05% (438) | PROBABLE UDP-GLUCOSE 6-DEHYDROGENASE UDGA (UDP-GLC |
| M. ulcerans Agy99 | MUL_1511 | - | 1e-20 | 26.57% (429) | UDP-glucose 6-dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_0598|M.vanbaalenii_PYR-1 -------MRCTVFGTGYLGATHAAGMAELGHDVLGVDIDAGKVAKLSGGE
Mflv_0289|M.gilvum_PYR-GCK -------MRCTVFGTGYLGATHAAGMAELGHEVVGVDIDPGKVAKLAAGE
Mb0330|M.bovis_AF2122/97 -------MRCSVFGTGYLGATHAVGMAQLGHEVVGVDIDPGKVAKLAGGD
Rv0322|M.tuberculosis_H37Rv -------MRCSVFGTGYLGATHAVGMAQLGHEVVGVDIDPGKVAKLAGGD
MMAR_0603|M.marinum_M -------MRCTVFGTGYLGATHAVGMAQLGHEVVGVDIDPGKVAKLAGGD
MAV_4823|M.avium_104 -----------MFGTGYLGATHAVGMAELGHDVLGVDIDPGKVAKLAGGD
MSMEG_0680|M.smegmatis_MC2_155 -----------MFGTGYLGATHAAGMAELGHEVIGVDIDPGKVAKLASGD
MAB_4295c|M.abscessus_ATCC_199 -------MRCTVFGTGYLGATHAACMAELGHEVLGVDIDPGKVAKLSSGD
TH_0768|M.thermoresistible__bu -------MRCTVFGAGYLGTTHAAGMAALGHEVIAVDVDAGKVAKLAAGE
MUL_1511|M.ulcerans_Agy99 MTTQPSERICIVGGAGHVGLPLALVLADEGYNVDILDTNAEALETIMAGR
: *:*::* . * :* *::* :* :. : .: .*
Mvan_0598|M.vanbaalenii_PYR-1 VPFYEPGLREMLRRNIDAGRLRFTTDYAEAAGFADVHFLGVGTPQKKGEY
Mflv_0289|M.gilvum_PYR-GCK VPFYEPGLREALQRNIEAGRLRFTTDYAEAAEFADVHFLGVGTPQKKGEY
Mb0330|M.bovis_AF2122/97 IPFYEPGLRKLLTDNLAAGRLRFTTDYDMAADFADVHFLGVGTPQKIGEY
Rv0322|M.tuberculosis_H37Rv IPFYEPGLRKLLTDNLAAGRLRFTTDYDMAADFADVHFLGVGTPQKIGEY
MMAR_0603|M.marinum_M IPFYEPGLRKLLRDNLAAGRLHFTTDYDMAAEFADVHFLGVGTPQKRGEY
MAV_4823|M.avium_104 IPFYEPGLRKLLNENLAAGRLRFTTDYDMAAGFADVHFLGVGTPQKKGEY
MSMEG_0680|M.smegmatis_MC2_155 IPFYEPGLRKVLNDNLSAGRLRFTTDYDEAADFADVHFLGVGTPQKKGEY
MAB_4295c|M.abscessus_ATCC_199 IPFYEPGLRKILQSNIASGRLRFTTSYAEAAEFADVHFLGVGTPQKKGEY
TH_0768|M.thermoresistible__bu VPFYEPGLRALVTENLATGRLQFTTDYDAAADFADLHFLGVGTPQQRGDY
MUL_1511|M.ulcerans_Agy99 MPFIETGAEDLLKPLLPTGRISGSTDSQVVRN-SDIVICVVGTP-VDEYL
:** *.* . : : :**: :*. . :*: : ****
Mvan_0598|M.vanbaalenii_PYR-1 GADLRHVYAVIDTLVPLLTRPAVIVGKSTVPVGTAADLSERAAGLAPEGV
Mflv_0289|M.gilvum_PYR-GCK AADLRHVYAVIDTLVPLLRRPAVIVGKSTVPVGTAAELVERAAGLAPDGV
Mb0330|M.bovis_AF2122/97 GADLRHVHAVIDALVPRLVRASILVGKSTVPVGTAAELGHRAGALAPRGV
Rv0322|M.tuberculosis_H37Rv GADLRHVHAVIDALVPRLVRASILVGKSTVPVGTAAELGHRAGALAPRGV
MMAR_0603|M.marinum_M GADLRHIHAVIDTLVPRLTRTSVLIGKSTVPVGTAAELARRAAGLAVAGV
MAV_4823|M.avium_104 GADLRHVYAVIDELVPRLTTSAVLVGKSTVPVGTAAELNQRAAALAPRGV
MSMEG_0680|M.smegmatis_MC2_155 GADLRHVHAVIDTLVPRLRRNAVIVGKSTVPVGTAADLAQRAALLAPPGV
MAB_4295c|M.abscessus_ATCC_199 GADLRHVHSVIDTLVPLLSRSAVIIGKSTVPVGTARELGQRAAGFAAAGV
TH_0768|M.thermoresistible__bu SADLTQVHAVVDTLVPRLRRPAVIVGKSTVPVGTARDLLERARRLAPTGV
MUL_1511|M.ulcerans_Agy99 TPQAHTFFRVIDEISPYFHDGQTLILRSTVYPGLSQRVHD---MFSERGI
.: .. *:* : * : :: :*** * : : :: *:
Mvan_0598|M.vanbaalenii_PYR-1 TVEVAWNPEFLREGFAVADTLHPDRIVLGVQRDSQLAEPVLREMYAPLLA
Mflv_0289|M.gilvum_PYR-GCK TVEVAWNPEFLREGFAVQDTLHPDRIVLGVQKDSRIAEPVLRELYAALLA
Mb0330|M.bovis_AF2122/97 DVEIAWNPEFLREGFAVHDTLNPDRIVLGVQDDSTRAEVAVRELYAPLLA
Rv0322|M.tuberculosis_H37Rv DVEIAWNPEFLREGFAVHDTLNPDRIVLGVQDDSTRAEVAVRELYAPLLA
MMAR_0603|M.marinum_M GVEIAWNPEFLREGFAVRDTLRPDRIVLGVQEDSILAEQFVRELYGPLLE
MAV_4823|M.avium_104 NVEIAWNPEFLREGYAVQDTLRPDRIVLGIKQDSPRAEAAVRELYGPLLD
MSMEG_0680|M.smegmatis_MC2_155 DVEIAWNPEFLREGFAVHDTLHPDRVVLGVQPGSTRAEAAVRDLYGPLIA
MAB_4295c|M.abscessus_ATCC_199 DVEVAWNPEFLREGYAVKDTLHPDRIVLGVQRDSDRAEKLVRELYGPILD
TH_0768|M.thermoresistible__bu DVEVAWNPEFLREGFAVRDTLHPDRIVVGAPPDSVRAEPMLRELYAPLLG
MUL_1511|M.ulcerans_Agy99 GVHVTFCPERIAQGHSIRELRIIPQIISGFDAEG---LRVVRELFS---G
*.::: ** : :*.:: : ::: * . :*:::.
Mvan_0598|M.vanbaalenii_PYR-1 AGVPFLIADLQTAELVKVSANAFLATKISFINAISEVCEAVDADVTLLAD
Mflv_0289|M.gilvum_PYR-GCK DGAPFLVSDLQTAELAKVSANAFLATKISFINAISEVCEAVGADVTLLAD
Mb0330|M.bovis_AF2122/97 AGVPFLVTDLQTAELVKVSANAFLATKISFINAISEVCEAAGADVSQLAD
Rv0322|M.tuberculosis_H37Rv AGVPFLVTDLQTAELVKVSANAFLATKISFINAISEVCEAAGADVSQLAD
MMAR_0603|M.marinum_M AGVPFLVTDLQTAELVKVSANAFLATKISFINAISEVCEAAGADVSLLAD
MAV_4823|M.avium_104 AGVPFLVTDLQTAELVKVSANAFLATKISFINAISEVCEAAGADVSLLAD
MSMEG_0680|M.smegmatis_MC2_155 DGVPFLVTDLQTAELVKVAANAFLATKISFINAISEVCEAADADVTVLAD
MAB_4295c|M.abscessus_ATCC_199 EEVPFLVTDLETAELVKVSANAFLATKISFINAISEVCEAVGADVTTLAD
TH_0768|M.thermoresistible__bu DGVPWLSTDLQTAELVKVSANAFLATKISFINAISDVCEAVGADVVTLAD
MUL_1511|M.ulcerans_Agy99 IASEIIKVEPQEAELAKLFCNSYRYIQFAVANQFYLLSREAGQDFDRVHH
: : : ***.*: .*:: :::. * : :.. .. *. : .
Mvan_0598|M.vanbaalenii_PYR-1 ALGHDARIGRRFLNAGLGFGGGCLPKDIRAFMARAGELGANHALTFLREV
Mflv_0289|M.gilvum_PYR-GCK ALGHDARIGRRFLNAGLGFGGGCLPKDIRAFMARAGELGANQALTFLREV
Mb0330|M.bovis_AF2122/97 ALGYDPRIGRQCLNAGLGFGGGCLPKDIRAFMARAGELGADQALTFLREV
Rv0322|M.tuberculosis_H37Rv ALGYDPRIGRQCLNAGLGFGGGCLPKDIRAFMARAGELGADQALTFLREV
MMAR_0603|M.marinum_M ALGYDTRIGRQCLNAGLGFGGGCLPKDIRAFMARAGELGANQALTFLREV
MAV_4823|M.avium_104 ALGYDPRIGRQFLNAGLGFGGGCLPKDIRAFMARAGELGADQALTFLREV
MSMEG_0680|M.smegmatis_MC2_155 ALGHDPRIGRRFLNAGLGFGGGCLPKDIRAFMARAGELGANHALTFLREV
MAB_4295c|M.abscessus_ATCC_199 ALGYDPRIGRRFLNAGLGFGGGCLPKDIRAFMARAGELGASHALTFLREV
TH_0768|M.thermoresistible__bu ALGHDPRIGRRFLNAGLGFGGGCLPKDIRAFMARAGELGANHTLTLLREV
MUL_1511|M.ulcerans_Agy99 ATTYKNSRVDSLPRAGLAAG-PCLLKDTMQLAAFS-----NNNFMLGHSA
* :. .***. * ** ** : * : .: : : :..
Mvan_0598|M.vanbaalenii_PYR-1 DSINMRRRTRMVELATKACGGSLLGANVAVLGAAFKPESDDVRDSPALNV
Mflv_0289|M.gilvum_PYR-GCK DSINMRRRTRMVELATTACGGSLLGANIAVLGAAFKPESDDVRDSPALNV
Mb0330|M.bovis_AF2122/97 DSINMRRRTKMVELATTACGGSLLGANIAVLGAAFKPESDDVRDSPALNV
Rv0322|M.tuberculosis_H37Rv DSINMRRRTKMVELATTACGGSLLGANIAVLGAAFKPESDDVRDSPALNV
MMAR_0603|M.marinum_M DSINMRRRTRMVELATTACGGSLLGANLAVLGAAFKPESDDVRDSPALNV
MAV_4823|M.avium_104 DSINMRRRTRMVELASAACGGSLLGANVAVLGAAFKPESDDVRDSPALNV
MSMEG_0680|M.smegmatis_MC2_155 DSINMRRRTAMVELATRACGGSLLGANIAVLGAAFKPESDDVRDSPALNV
MAB_4295c|M.abscessus_ATCC_199 DSINMRRRTRMVELATKACGGSLLGANVAVLGAAFKPESDDVRDSPALNV
TH_0768|M.thermoresistible__bu DSINMRRRARMVELATTACGGSLLGANIAVLGAAFKPDSDDVRDSPALNV
MUL_1511|M.ulcerans_Agy99 MLINEGQPQFIVNMLKRRVN--LRDKTVGILGMTFKADCDDTRDSLSFKL
** : :*:: . . * . .:.:** :**.:.**.*** ::::
Mvan_0598|M.vanbaalenii_PYR-1 AGMLQLNGATVNVYDPQAIENSRRLFPTLNYATTVVEACDRADAVLVLTE
Mflv_0289|M.gilvum_PYR-GCK AGMLQLHGATVNVYDPKAMDNSRRLFPTLNYSASALDACERADAVLVLTE
Mb0330|M.bovis_AF2122/97 AGQLQLNGATVHVYDPKALDNAHRLFPTLNYAVSVAEACERADAVLVLTE
Rv0322|M.tuberculosis_H37Rv AGQLQLNGATVHVYDPKALDNAHRLFPTLNYAVSVAEACERADAVLVLTE
MMAR_0603|M.marinum_M AGQLQLNGAAVNVYDPKALDNANRLFPTLNYAVSVAEACERADAVLILTE
MAV_4823|M.avium_104 AGQLQLNGAAVNVYDPKALDNAQRLFPTLNYAVSVEEACERADAVLVLTE
MSMEG_0680|M.smegmatis_MC2_155 AGMLQLNGATVNVYDPKAVENSRRLFPTLTYATTVAEACERADAVLVLTE
MAB_4295c|M.abscessus_ATCC_199 AGLLQLNGAAVNVYDPKALENSRRLFPTLNYATSVLEAADRADAVLLLTE
TH_0768|M.thermoresistible__bu AGMLQLNGATVTVYDPKAMENSRRVFPTLTYSTSVAEACDRADAVLVLTE
MUL_1511|M.ulcerans_Agy99 RHLLMLEAKEVILHDP---------FLEGKDYHPLQTVVDRSDVIVVGVP
* *.. * ::** * . . . :*:*.::: .
Mvan_0598|M.vanbaalenii_PYR-1 WREFVELDPVLLADTVRAKVVVDGRNCLDVGRWQQAGWQVFALGRFGGEP
Mflv_0289|M.gilvum_PYR-GCK WSEFVGMHPDELSAAVRTKVIVDGRNCLDIGVWRDAGWQVHALGRTVEVG
Mb0330|M.bovis_AF2122/97 WREFIDLEPADLANRVRARVIVDGRNCLDVTRWRRAGWRVFRLGVPRLGH
Rv0322|M.tuberculosis_H37Rv WREFIDLEPADLANRVRARVIVDGRNCLDVTRWRRAGWRVFRLGVPRLGH
MMAR_0603|M.marinum_M WQEFVDLDPDDLADRVRARVIVDGRNCLDVSRWERAGWRVFRLGARIRAA
MAV_4823|M.avium_104 WRQFVEMDPDDLADRVRARVVVDGRNCLDVTRWQRAGWRVYRLGAPRP--
MSMEG_0680|M.smegmatis_MC2_155 WSEFVDLDPAALDGTVRAKVVVDGRNCLDIDRWSRAGWRVYALGRRLERQ
MAB_4295c|M.abscessus_ATCC_199 WQEFVDFDPDALAKVVRTKVIVDGRNCLDAAKWVNAGWRVFCLGKRVEEL
TH_0768|M.thermoresistible__bu WQEFIDLNPAELADIVRAKVIVDGRNCLDVRRWQRAGWKVFCLGRTP---
MUL_1511|M.ulcerans_Agy99 HSAYRGLR------VPRGKVVEDVWGCLDVTEFDVDPCNGANLAELGTAA
: : * :*: * .*** : . *.
Mvan_0598|M.vanbaalenii_PYR-1 AAA--
Mflv_0289|M.gilvum_PYR-GCK A----
Mb0330|M.bovis_AF2122/97 -----
Rv0322|M.tuberculosis_H37Rv -----
MMAR_0603|M.marinum_M S----
MAV_4823|M.avium_104 -----
MSMEG_0680|M.smegmatis_MC2_155 NVREL
MAB_4295c|M.abscessus_ATCC_199 AHT--
TH_0768|M.thermoresistible__bu -----
MUL_1511|M.ulcerans_Agy99 AR---