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MSTEPLVGVVGVGYVGLTTAVCVAAAGRKTVAVDINPDRVGRLRAGVAVIDEPGLSELLGDGLAGGVLRF SADFAELADRDVVFVCVPTPSAPDGHADLAAVESVIDRLGRVLRRGAVVALKSTVPVGTTSTMAQRLCHK GIRVVSTPEFLREGRAVDDFRNPDRLVIGSHDELAAQLVHQAYGLAGHRVLRMSPESAELAKYASNAFLA VKLSYTNSLAALCARVGADIDDVTCCMGADRRIGAEFLRPGPGWGGSCLPKDTAALLDIAHRHRVSFAEV EAARQTNTAQARRIVTALRHTLGRPLSGRRITALGLTFKAATSDTRESPALAACRELAAAGAQVAGYDPQ LPNIDPAVLQQNRVTAVDDPYRAAKAADAVVVLTEWPQFRSLDWRAVAQDAPLAVVLDARNSLDPATVRE AGLRYLGNGVPQGF
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_4092 | - | - | 100% (434) | UDP-glucose 6-dehydrogenase |
| M. avium 104 | MAV_4823 | - | 6e-65 | 38.55% (441) | UDP-glucose 6-dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0330 | udgA | 3e-66 | 38.32% (441) | UDP-glucose 6-dehydrogenase UdgA |
| M. gilvum PYR-GCK | Mflv_0289 | - | 3e-64 | 37.70% (443) | UDP-glucose 6-dehydrogenase |
| M. tuberculosis H37Rv | Rv0322 | udgA | 3e-66 | 38.32% (441) | UDP-glucose 6-dehydrogenase UdgA |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_4295c | - | 6e-68 | 39.49% (433) | UDP-glucose 6-dehydrogenase (UdgA) |
| M. marinum M | MMAR_0603 | udgA | 3e-65 | 38.11% (433) | UDP-glucose dehydrogenase UdgA |
| M. smegmatis MC2 155 | MSMEG_5982 | - | 6e-65 | 36.96% (441) | UDP-glucose 6-dehydrogenase |
| M. thermoresistible (build 8) | TH_0768 | udgA | 6e-63 | 38.14% (430) | PROBABLE UDP-GLUCOSE 6-DEHYDROGENASE UDGA (UDP-GLC |
| M. ulcerans Agy99 | MUL_1511 | - | 1e-23 | 26.20% (397) | UDP-glucose 6-dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_0598 | - | 1e-63 | 38.13% (438) | UDP-glucose 6-dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_0289|M.gilvum_PYR-GCK ---MRCT----VFGTGYLGATHAAGMAELGHEVVGVDIDPGKVAKLAAGE
Mvan_0598|M.vanbaalenii_PYR-1 ---MRCT----VFGTGYLGATHAAGMAELGHDVLGVDIDAGKVAKLSGGE
TH_0768|M.thermoresistible__bu ---MRCT----VFGAGYLGTTHAAGMAALGHEVIAVDVDAGKVAKLAAGE
Mb0330|M.bovis_AF2122/97 ---MRCS----VFGTGYLGATHAVGMAQLGHEVVGVDIDPGKVAKLAGGD
Rv0322|M.tuberculosis_H37Rv ---MRCS----VFGTGYLGATHAVGMAQLGHEVVGVDIDPGKVAKLAGGD
MMAR_0603|M.marinum_M ---MRCT----VFGTGYLGATHAVGMAQLGHEVVGVDIDPGKVAKLAGGD
MAB_4295c|M.abscessus_ATCC_199 ---MRCT----VFGTGYLGATHAACMAELGHEVLGVDIDPGKVAKLSSGD
MSMEG_5982|M.smegmatis_MC2_155 ---MRMV----VMGTGYLGATHAACMAELGHEVLGVDIDPAKLAKLEAGE
MAV_4092|M.avium_104 ---MSTEPLVGVVGVGYVGLTTAVCVAAAGRKTVAVDINPDRVGRLRAGV
MUL_1511|M.ulcerans_Agy99 MTTQPSERICIVGGAGHVGLPLALVLADEGYNVDILDTNAEALETIMAGR
* *.*::* . * :* * .. :* :. : : .*
Mflv_0289|M.gilvum_PYR-GCK VPFYEPGLREALQRNIEAGRLRFTTDYAEAAEFADVHFLGVGTPQKKGEY
Mvan_0598|M.vanbaalenii_PYR-1 VPFYEPGLREMLRRNIDAGRLRFTTDYAEAAGFADVHFLGVGTPQKKGEY
TH_0768|M.thermoresistible__bu VPFYEPGLRALVTENLATGRLQFTTDYDAAADFADLHFLGVGTPQQRGDY
Mb0330|M.bovis_AF2122/97 IPFYEPGLRKLLTDNLAAGRLRFTTDYDMAADFADVHFLGVGTPQKIGEY
Rv0322|M.tuberculosis_H37Rv IPFYEPGLRKLLTDNLAAGRLRFTTDYDMAADFADVHFLGVGTPQKIGEY
MMAR_0603|M.marinum_M IPFYEPGLRKLLRDNLAAGRLHFTTDYDMAAEFADVHFLGVGTPQKRGEY
MAB_4295c|M.abscessus_ATCC_199 IPFYEPGLRKILQSNIASGRLRFTTSYAEAAEFADVHFLGVGTPQKKGEY
MSMEG_5982|M.smegmatis_MC2_155 VPFFEPGLSEVLRRHTSSGRLRFSSSYQEAAEFADVFFVAVATPQKKGDY
MAV_4092|M.avium_104 AVIDEPGLSELLGDGLAGGVLRFSADFAELAD-RDVVFVCVPTPSAP-DG
MUL_1511|M.ulcerans_Agy99 MPFIETGAEDLLKPLLPTGRISGSTDSQVVRN-SDIVICVVGTPVDEYLT
: *.* : * : ::. *: : * **
Mflv_0289|M.gilvum_PYR-GCK AADLRHVYAVIDTLVPLLRRPAVIVGKSTVPVGTAAELVERAAGLAPDGV
Mvan_0598|M.vanbaalenii_PYR-1 GADLRHVYAVIDTLVPLLTRPAVIVGKSTVPVGTAADLSERAAGLAPEGV
TH_0768|M.thermoresistible__bu SADLTQVHAVVDTLVPRLRRPAVIVGKSTVPVGTARDLLERARRLAPTGV
Mb0330|M.bovis_AF2122/97 GADLRHVHAVIDALVPRLVRASILVGKSTVPVGTAAELGHRAGALAPRGV
Rv0322|M.tuberculosis_H37Rv GADLRHVHAVIDALVPRLVRASILVGKSTVPVGTAAELGHRAGALAPRGV
MMAR_0603|M.marinum_M GADLRHIHAVIDTLVPRLTRTSVLIGKSTVPVGTAAELARRAAGLAVAGV
MAB_4295c|M.abscessus_ATCC_199 GADLRHVHSVIDTLVPLLSRSAVIIGKSTVPVGTARELGQRAAGFAAAGV
MSMEG_5982|M.smegmatis_MC2_155 GADLCFVDAVIDNLAPLLDKPSLIIGKSTVPVGTATRLGRCVRDLAPAGD
MAV_4092|M.avium_104 HADLAAVESVIDRLGRVLRRGAVVALKSTVPVGTTSTMAQRLCHKG----
MUL_1511|M.ulcerans_Agy99 PQAHTFFR-VIDEISPYFHDGQTLILRSTVYPGLSQRVHDMFSERG---I
. *:* : : : :*** * : : .
Mflv_0289|M.gilvum_PYR-GCK TVEVAWNPEFLREGFAVQDTLHPDRIVLGVQK-DSRIAEPVLRELYAALL
Mvan_0598|M.vanbaalenii_PYR-1 TVEVAWNPEFLREGFAVADTLHPDRIVLGVQR-DSQLAEPVLREMYAPLL
TH_0768|M.thermoresistible__bu DVEVAWNPEFLREGFAVRDTLHPDRIVVGAPP-DSVRAEPMLRELYAPLL
Mb0330|M.bovis_AF2122/97 DVEIAWNPEFLREGFAVHDTLNPDRIVLGVQD-DSTRAEVAVRELYAPLL
Rv0322|M.tuberculosis_H37Rv DVEIAWNPEFLREGFAVHDTLNPDRIVLGVQD-DSTRAEVAVRELYAPLL
MMAR_0603|M.marinum_M GVEIAWNPEFLREGFAVRDTLRPDRIVLGVQE-DSILAEQFVRELYGPLL
MAB_4295c|M.abscessus_ATCC_199 DVEVAWNPEFLREGYAVKDTLHPDRIVLGVQR-DSDRAEKLVRELYGPIL
MSMEG_5982|M.smegmatis_MC2_155 AVELVWNPEFLREGFAVQGTLHPDRLVLGVERPGSGRAEGIVREIYADLI
MAV_4092|M.avium_104 -IRVVSTPEFLREGRAVDDFRNPDRLVIGSHD---ELAAQLVHQAYG---
MUL_1511|M.ulcerans_Agy99 GVHVTFCPERIAQGHSIRELRIIPQIISGFDA----EGLRVVRELFS---
:.:. ** : :* :: ::: * . ::: :.
Mflv_0289|M.gilvum_PYR-GCK ADGAPFLVSDLQTAELAKVSANAFLATKISFINAISEVCEAVGADVTLLA
Mvan_0598|M.vanbaalenii_PYR-1 AAGVPFLIADLQTAELVKVSANAFLATKISFINAISEVCEAVDADVTLLA
TH_0768|M.thermoresistible__bu GDGVPWLSTDLQTAELVKVSANAFLATKISFINAISDVCEAVGADVVTLA
Mb0330|M.bovis_AF2122/97 AAGVPFLVTDLQTAELVKVSANAFLATKISFINAISEVCEAAGADVSQLA
Rv0322|M.tuberculosis_H37Rv AAGVPFLVTDLQTAELVKVSANAFLATKISFINAISEVCEAAGADVSQLA
MMAR_0603|M.marinum_M EAGVPFLVTDLQTAELVKVSANAFLATKISFINAISEVCEAAGADVSLLA
MAB_4295c|M.abscessus_ATCC_199 DEEVPFLVTDLETAELVKVSANAFLATKISFINAISEVCEAVGADVTTLA
MSMEG_5982|M.smegmatis_MC2_155 NDGVPFIVTDLATAELVKVSANAFLATKISFINAIAEVCEAVDADVTVLA
MAV_4092|M.avium_104 LAGHRVLRMSPESAELAKYASNAFLAVKLSYTNSLAALCARVGADIDDVT
MUL_1511|M.ulcerans_Agy99 GIASEIIKVEPQEAELAKLFCNSYRYIQFAVANQFYLLSREAGQDFDRVH
: . ***.* .*:: ::: * : :. .. *. :
Mflv_0289|M.gilvum_PYR-GCK DALGHDARIGRRFLNAGLGFGGGCLPKDIRAFMARAGELGANQALTFLRE
Mvan_0598|M.vanbaalenii_PYR-1 DALGHDARIGRRFLNAGLGFGGGCLPKDIRAFMARAGELGANHALTFLRE
TH_0768|M.thermoresistible__bu DALGHDPRIGRRFLNAGLGFGGGCLPKDIRAFMARAGELGANHTLTLLRE
Mb0330|M.bovis_AF2122/97 DALGYDPRIGRQCLNAGLGFGGGCLPKDIRAFMARAGELGADQALTFLRE
Rv0322|M.tuberculosis_H37Rv DALGYDPRIGRQCLNAGLGFGGGCLPKDIRAFMARAGELGADQALTFLRE
MMAR_0603|M.marinum_M DALGYDTRIGRQCLNAGLGFGGGCLPKDIRAFMARAGELGANQALTFLRE
MAB_4295c|M.abscessus_ATCC_199 DALGYDPRIGRRFLNAGLGFGGGCLPKDIRAFMARAGELGASHALTFLRE
MSMEG_5982|M.smegmatis_MC2_155 DAIGYDSRIGRRFLNAGLGFGGGCLPKDIRAFMARAGELGANQALTFLRE
MAV_4092|M.avium_104 CCMGADRRIGAEFLRPGPGWGGSCLPKDTAALLDIAHRH--RVSFAEVEA
MUL_1511|M.ulcerans_Agy99 HATTYKNSRVDSLPRAGLAAG-PCLLKDTMQLAAFS-----NNNFMLGHS
. . ..* . * ** ** : : : .
Mflv_0289|M.gilvum_PYR-GCK VDSINMRRRTRMVELATTACGGSLLGANIAVLGAAFKPESDDVRDSPALN
Mvan_0598|M.vanbaalenii_PYR-1 VDSINMRRRTRMVELATKACGGSLLGANVAVLGAAFKPESDDVRDSPALN
TH_0768|M.thermoresistible__bu VDSINMRRRARMVELATTACGGSLLGANIAVLGAAFKPDSDDVRDSPALN
Mb0330|M.bovis_AF2122/97 VDSINMRRRTKMVELATTACGGSLLGANIAVLGAAFKPESDDVRDSPALN
Rv0322|M.tuberculosis_H37Rv VDSINMRRRTKMVELATTACGGSLLGANIAVLGAAFKPESDDVRDSPALN
MMAR_0603|M.marinum_M VDSINMRRRTRMVELATTACGGSLLGANLAVLGAAFKPESDDVRDSPALN
MAB_4295c|M.abscessus_ATCC_199 VDSINMRRRTRMVELATKACGGSLLGANVAVLGAAFKPESDDVRDSPALN
MSMEG_5982|M.smegmatis_MC2_155 VDSINMRRRTRVVEIAREICGGGFIGSRVAVLGAAFKPDSDDVRDSPALN
MAV_4092|M.avium_104 ARQTNTAQARRIVTALRHTLGRPLSGRRITALGLTFKAATSDTRESPALA
MUL_1511|M.ulcerans_Agy99 AMLINEGQPQFIVNMLKRRVN--LRDKTVGILGMTFKADCDDTRDSLSFK
. * : :* . : . : ** :**. .*.*:* ::
Mflv_0289|M.gilvum_PYR-GCK VAGMLQLHGATVNVYDPKAMDNSRRLFP--TLNYSASALDACERADAVLV
Mvan_0598|M.vanbaalenii_PYR-1 VAGMLQLNGATVNVYDPQAIENSRRLFP--TLNYATTVVEACDRADAVLV
TH_0768|M.thermoresistible__bu VAGMLQLNGATVTVYDPKAMENSRRVFP--TLTYSTSVAEACDRADAVLV
Mb0330|M.bovis_AF2122/97 VAGQLQLNGATVHVYDPKALDNAHRLFP--TLNYAVSVAEACERADAVLV
Rv0322|M.tuberculosis_H37Rv VAGQLQLNGATVHVYDPKALDNAHRLFP--TLNYAVSVAEACERADAVLV
MMAR_0603|M.marinum_M VAGQLQLNGAAVNVYDPKALDNANRLFP--TLNYAVSVAEACERADAVLI
MAB_4295c|M.abscessus_ATCC_199 VAGLLQLNGAAVNVYDPKALENSRRLFP--TLNYATSVLEAADRADAVLL
MSMEG_5982|M.smegmatis_MC2_155 VAGQIQLQGACVNVFDPQAMDNSRTLFP--TLNYATSAFEACDGADVVLV
MAV_4092|M.avium_104 ACRELAAAGAQVAGYDPQLPNIDPAVLQQNRVTAVDDPYRAAKAADAVVV
MUL_1511|M.ulcerans_Agy99 LRHLLMLEAKEVILHDPFLEGKDYHPLQ-----------TVVDRSDVIVV
: . * .** : . . :*.:::
Mflv_0289|M.gilvum_PYR-GCK LTEWSEFVGMHPDELSAAVRTKVIVDGRNCLDIGVWRDAGWQVHALGRTV
Mvan_0598|M.vanbaalenii_PYR-1 LTEWREFVELDPVLLADTVRAKVVVDGRNCLDVGRWQQAGWQVFALGRFG
TH_0768|M.thermoresistible__bu LTEWQEFIDLNPAELADIVRAKVIVDGRNCLDVRRWQRAGWKVFCLGRTP
Mb0330|M.bovis_AF2122/97 LTEWREFIDLEPADLANRVRARVIVDGRNCLDVTRWRRAGWRVFRLG--V
Rv0322|M.tuberculosis_H37Rv LTEWREFIDLEPADLANRVRARVIVDGRNCLDVTRWRRAGWRVFRLG--V
MMAR_0603|M.marinum_M LTEWQEFVDLDPDDLADRVRARVIVDGRNCLDVSRWERAGWRVFRLG--A
MAB_4295c|M.abscessus_ATCC_199 LTEWQEFVDFDPDALAKVVRTKVIVDGRNCLDAAKWVNAGWRVFCLGKRV
MSMEG_5982|M.smegmatis_MC2_155 LTEWEEFRSIDPAELKTTVRSAAVIDGRNCLDAAAWCAAGWYYRALGRPA
MAV_4092|M.avium_104 LTEWPQFRSLDWRAVAQDAPLAVVLDARNSLDPATVREAGLRYLGNGVPQ
MUL_1511|M.ulcerans_Agy99 GVPHSAYRGLR------VPRGKVVEDVWGCLDVTEFDVDPCNGANLAELG
. : : .: * ..** .
Mflv_0289|M.gilvum_PYR-GCK EVGA--------
Mvan_0598|M.vanbaalenii_PYR-1 GEPAAA------
TH_0768|M.thermoresistible__bu ------------
Mb0330|M.bovis_AF2122/97 PRLGH-------
Rv0322|M.tuberculosis_H37Rv PRLGH-------
MMAR_0603|M.marinum_M RIRAAS------
MAB_4295c|M.abscessus_ATCC_199 EELAHT------
MSMEG_5982|M.smegmatis_MC2_155 APRGANASVVTK
MAV_4092|M.avium_104 GF----------
MUL_1511|M.ulcerans_Agy99 TAAAR-------