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LITLQRTTIAVVGLGYVGLPTALAFAEMGAEIIGCDLSEDRLTNIKTGDVDMLPRDRTRLLRQLDSFKLT TEPSAIGAADAVVVCVPTPVDPHQSPDLRALTAACANVVRYATKGQLLVLTSTTYVGCTHEMLVDPLQAA GFTVGKDIFVAFSPERIDPGVKDHAPERTPRVVGGVTPACTARAAALLRHTASSVHTVSSPESAEMTKLV ENSFRAVNIALANEFSEVARELSVDVMEVIDAAATKPYGFMPFYPGPGVGGHCIPCDPHYLLWQLRARRF DSPLMRTAMTCIAARPRDVVSRAREMLAERGKPTQGARVLVVGVTYKPGVADLRESPALAIIDDLTAAGA VVSFTDPLVPMLRTPQAGTLTNHRSPEHDEWDLVLVHHWAEELRDWVSAQPVVLDTTFGRRG
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_0475 | - | - | 100% (412) | nucleotide-sugar dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_5957 | algD | 4e-27 | 29.78% (366) | GDP-mannose 6-dehydrogenase AlgD |
| M. smegmatis MC2 155 | MSMEG_0680 | - | 4e-25 | 29.41% (425) | UDP-glucose 6-dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0330 | udgA | 7e-24 | 27.90% (362) | UDP-glucose 6-dehydrogenase UdgA |
| M. gilvum PYR-GCK | Mflv_0289 | - | 1e-22 | 29.16% (367) | UDP-glucose 6-dehydrogenase |
| M. tuberculosis H37Rv | Rv0322 | udgA | 7e-24 | 27.90% (362) | UDP-glucose 6-dehydrogenase UdgA |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_4295c | - | 1e-24 | 29.23% (366) | UDP-glucose 6-dehydrogenase (UdgA) |
| M. marinum M | MMAR_0603 | udgA | 8e-22 | 28.14% (366) | UDP-glucose dehydrogenase UdgA |
| M. avium 104 | MAV_4092 | - | 6e-35 | 31.67% (360) | UDP-glucose 6-dehydrogenase |
| M. thermoresistible (build 8) | TH_0768 | udgA | 8e-23 | 28.27% (421) | PROBABLE UDP-GLUCOSE 6-DEHYDROGENASE UDGA (UDP-GLC |
| M. ulcerans Agy99 | MUL_1511 | - | 7e-21 | 26.33% (357) | UDP-glucose 6-dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_1699 | - | 9e-25 | 29.85% (412) | GDP-mannose 6-dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0330|M.bovis_AF2122/97 ---MRCS----VFGTGYLGATHAVGMAQLGHEVVGVDIDPGKVAKLAGGD
Rv0322|M.tuberculosis_H37Rv ---MRCS----VFGTGYLGATHAVGMAQLGHEVVGVDIDPGKVAKLAGGD
MMAR_0603|M.marinum_M ---MRCT----VFGTGYLGATHAVGMAQLGHEVVGVDIDPGKVAKLAGGD
MAB_4295c|M.abscessus_ATCC_199 ---MRCT----VFGTGYLGATHAACMAELGHEVLGVDIDPGKVAKLSSGD
Mflv_0289|M.gilvum_PYR-GCK ---MRCT----VFGTGYLGATHAAGMAELGHEVVGVDIDPGKVAKLAAGE
TH_0768|M.thermoresistible__bu ---MRCT----VFGAGYLGTTHAAGMAALGHEVIAVDVDAGKVAKLAAGE
MAV_4092|M.avium_104 ---MSTEPLVGVVGVGYVGLTTAVCVAAAGRKTVAVDINPDRVGRLRAGV
Mvan_1699|M.vanbaalenii_PYR-1 ---MNIA----ILGLGYVGVTAAACLASQGHYVIGIDPNATKVNAVLEGR
MSMEG_0475|M.smegmatis_MC2_155 -MITLQRTTIAVVGLGYVGLPTALAFAEMGAEIIGCDLSEDRLTNIKTGD
MUL_1511|M.ulcerans_Agy99 MTTQPSERICIVGGAGHVGLPLALVLADEGYNVDILDTNAEALETIMAGR
: * *::* . * .* * * . : : *
Mb0330|M.bovis_AF2122/97 IPFYEPGLRKLLTDNLAAGRLRFTTDYDMAADFADVHFLGVGTPQKIG--
Rv0322|M.tuberculosis_H37Rv IPFYEPGLRKLLTDNLAAGRLRFTTDYDMAADFADVHFLGVGTPQKIG--
MMAR_0603|M.marinum_M IPFYEPGLRKLLRDNLAAGRLHFTTDYDMAAEFADVHFLGVGTPQKRG--
MAB_4295c|M.abscessus_ATCC_199 IPFYEPGLRKILQSNIASGRLRFTTSYAEAAEFADVHFLGVGTPQKKG--
Mflv_0289|M.gilvum_PYR-GCK VPFYEPGLREALQRNIEAGRLRFTTDYAEAAEFADVHFLGVGTPQKKG--
TH_0768|M.thermoresistible__bu VPFYEPGLRALVTENLATGRLQFTTDYDAAADFADLHFLGVGTPQQRG--
MAV_4092|M.avium_104 AVIDEPGLSELLGDGLAGGVLRFSADFAELAD-RDVVFVCVPTPSAP---
Mvan_1699|M.vanbaalenii_PYR-1 SPITEPRIGELIAEAREQGLITANVALGSEVAMCDVAIVCVGTPSAVDGS
MSMEG_0475|M.smegmatis_MC2_155 VDMLPRDRTRLLRQLDS---FKLTTEP-SAIGAADAVVVCVPTPVDPH--
MUL_1511|M.ulcerans_Agy99 MPFIETGAEDLLKPLLPTGRISGSTDS-QVVRNSDIVICVVGTPVDEY--
: : : .. * . * **
Mb0330|M.bovis_AF2122/97 EYGADLRHVHAVIDALVPRLVRASILVG-KSTVPVGTAAELGHRAG--AL
Rv0322|M.tuberculosis_H37Rv EYGADLRHVHAVIDALVPRLVRASILVG-KSTVPVGTAAELGHRAG--AL
MMAR_0603|M.marinum_M EYGADLRHIHAVIDTLVPRLTRTSVLIG-KSTVPVGTAAELARRAA--GL
MAB_4295c|M.abscessus_ATCC_199 EYGADLRHVHSVIDTLVPLLSRSAVIIG-KSTVPVGTARELGQRAA--GF
Mflv_0289|M.gilvum_PYR-GCK EYAADLRHVYAVIDTLVPLLRRPAVIVG-KSTVPVGTAAELVERAA--GL
TH_0768|M.thermoresistible__bu DYSADLTQVHAVVDTLVPRLRRPAVIVG-KSTVPVGTARDLLERAR--RL
MAV_4092|M.avium_104 DGHADLAAVESVIDRLGRVLRRGAVVAL-KSTVPVGTTSTMAQRLC--HK
Mvan_1699|M.vanbaalenii_PYR-1 HNMSYIAEVSRQLAELVKAHPDASLTVAYRSTVRPGTMENLIQPIFDGVL
MSMEG_0475|M.smegmatis_MC2_155 -QSPDLRALTAACANVVRYATKGQLLVL-TSTTYVGCTHEMLVDPLQAAG
MUL_1511|M.ulcerans_Agy99 -LTPQAHTFFRVIDEISPYFHDGQTLIL-RSTVYPGLSQRVHDMFS----
. . : **. * :
Mb0330|M.bovis_AF2122/97 APRGVDVEIAWNPEFLREGFAVHDTLNPDRIVLGVQDDSTRAEVAVRELY
Rv0322|M.tuberculosis_H37Rv APRGVDVEIAWNPEFLREGFAVHDTLNPDRIVLGVQDDSTRAEVAVRELY
MMAR_0603|M.marinum_M AVAGVGVEIAWNPEFLREGFAVRDTLRPDRIVLGVQEDSILAEQFVRELY
MAB_4295c|M.abscessus_ATCC_199 AAAGVDVEVAWNPEFLREGYAVKDTLHPDRIVLGVQRDSDRAEKLVRELY
Mflv_0289|M.gilvum_PYR-GCK APDGVTVEVAWNPEFLREGFAVQDTLHPDRIVLGVQKDSRIAEPVLRELY
TH_0768|M.thermoresistible__bu APTGVDVEVAWNPEFLREGFAVRDTLHPDRIVVGAPPDSVRAEPMLRELY
MAV_4092|M.avium_104 G-----IRVVSTPEFLREGRAVDDFRNPDRLVIGSHD--ELAAQLVHQAY
Mvan_1699|M.vanbaalenii_PYR-1 GGDSARIELVYYPEFLRESSAVDDYFSPPKIVIGTKD-----GDRCAKID
MSMEG_0475|M.smegmatis_MC2_155 FTVGKDIFVAFSPERIDPGVKDHAPERTPRVVGGVTP-----ACTARAAA
MUL_1511|M.ulcerans_Agy99 -ERGIGVHVTFCPERIAQGHSIRELRIIPQIISGFDAEG------LRVVR
: :. ** : . ::: *
Mb0330|M.bovis_AF2122/97 APLLAAGVPFLVTDLQTAELVKVSANAFLATKISFINAISEVCEAAGADV
Rv0322|M.tuberculosis_H37Rv APLLAAGVPFLVTDLQTAELVKVSANAFLATKISFINAISEVCEAAGADV
MMAR_0603|M.marinum_M GPLLEAGVPFLVTDLQTAELVKVSANAFLATKISFINAISEVCEAAGADV
MAB_4295c|M.abscessus_ATCC_199 GPILDEEVPFLVTDLETAELVKVSANAFLATKISFINAISEVCEAVGADV
Mflv_0289|M.gilvum_PYR-GCK AALLADGAPFLVSDLQTAELAKVSANAFLATKISFINAISEVCEAVGADV
TH_0768|M.thermoresistible__bu APLLGDGVPWLSTDLQTAELVKVSANAFLATKISFINAISDVCEAVGADV
MAV_4092|M.avium_104 G---LAGHRVLRMSPESAELAKYASNAFLAVKLSYTNSLAALCARVGADI
Mvan_1699|M.vanbaalenii_PYR-1 KINEGITAPVFYVRYPESEITKFVDNSFHAVKIAFANEIGRVCTQLGISA
MSMEG_0475|M.smegmatis_MC2_155 LLRHTASSVHTVSSPESAEMTKLVENSFRAVNIALANEFSEVARELSVDV
MUL_1511|M.ulcerans_Agy99 ELFSGIASEIIKVEPQEAELAKLFCNSYRYIQFAVANQFYLLSREAGQDF
:*:.* *:: ::: * : :. . .
Mb0330|M.bovis_AF2122/97 SQLADALGYDPRIGR--QCLNAGLGFGGGCLPKDIRAFMARAGELGADQA
Rv0322|M.tuberculosis_H37Rv SQLADALGYDPRIGR--QCLNAGLGFGGGCLPKDIRAFMARAGELGADQA
MMAR_0603|M.marinum_M SLLADALGYDTRIGR--QCLNAGLGFGGGCLPKDIRAFMARAGELGANQA
MAB_4295c|M.abscessus_ATCC_199 TTLADALGYDPRIGR--RFLNAGLGFGGGCLPKDIRAFMARAGELGASHA
Mflv_0289|M.gilvum_PYR-GCK TLLADALGHDARIGR--RFLNAGLGFGGGCLPKDIRAFMARAGELGANQA
TH_0768|M.thermoresistible__bu VTLADALGHDPRIGR--RFLNAGLGFGGGCLPKDIRAFMARAGELGANHT
MAV_4092|M.avium_104 DDVTCCMGADRRIGA--EFLRPGPGWGGSCLPKDTAALLDIAHRHRVS--
Mvan_1699|M.vanbaalenii_PYR-1 AEVHKIFVSDTKLNVSPYYLRPGGAFGGSCLPKDVRALQHIARVSGSS--
MSMEG_0475|M.smegmatis_MC2_155 MEVIDAAATKPYGFMP---FYPGPGVGGHCIPCDPHYLLWQLRARRFDSP
MUL_1511|M.ulcerans_Agy99 DRVHHATTYKNSRVDS--LPRAGLAAG-PCLLKDTMQLAAFS-----NNN
: . .* . * *: * : .
Mb0330|M.bovis_AF2122/97 LTFLREVDSIN-MRRRTKMVELATTACGGSLLGANIAVLGAAFKPESDDV
Rv0322|M.tuberculosis_H37Rv LTFLREVDSIN-MRRRTKMVELATTACGGSLLGANIAVLGAAFKPESDDV
MMAR_0603|M.marinum_M LTFLREVDSIN-MRRRTRMVELATTACGGSLLGANLAVLGAAFKPESDDV
MAB_4295c|M.abscessus_ATCC_199 LTFLREVDSIN-MRRRTRMVELATKACGGSLLGANVAVLGAAFKPESDDV
Mflv_0289|M.gilvum_PYR-GCK LTFLREVDSIN-MRRRTRMVELATTACGGSLLGANIAVLGAAFKPESDDV
TH_0768|M.thermoresistible__bu LTLLREVDSIN-MRRRARMVELATTACGGSLLGANIAVLGAAFKPDSDDV
MAV_4092|M.avium_104 FAEVEAARQTN-TAQARRIVTALRHTLGRPLSGRRITALGLTFKAATSDT
Mvan_1699|M.vanbaalenii_PYR-1 ---THLIDSLI-TSNEAHKSFLFDHATRGLEHGAKVLLLGIAFKNASDDL
MSMEG_0475|M.smegmatis_MC2_155 LMRTAMTCIAARPRDVVSRAREMLAERGKPTQGARVLVVGVTYKPGVADL
MUL_1511|M.ulcerans_Agy99 FMLGHSAMLIN-EGQPQFIVNMLKRRVN--LRDKTVGILGMTFKADCDDT
. : :* ::* *
Mb0330|M.bovis_AF2122/97 RDSPALNVAGQLQLNGATVHVYDPKALDNAHRLFP--TLNYAVSVAEACE
Rv0322|M.tuberculosis_H37Rv RDSPALNVAGQLQLNGATVHVYDPKALDNAHRLFP--TLNYAVSVAEACE
MMAR_0603|M.marinum_M RDSPALNVAGQLQLNGAAVNVYDPKALDNANRLFP--TLNYAVSVAEACE
MAB_4295c|M.abscessus_ATCC_199 RDSPALNVAGLLQLNGAAVNVYDPKALENSRRLFP--TLNYATSVLEAAD
Mflv_0289|M.gilvum_PYR-GCK RDSPALNVAGMLQLHGATVNVYDPKAMDNSRRLFP--TLNYSASALDACE
TH_0768|M.thermoresistible__bu RDSPALNVAGMLQLNGATVTVYDPKAMENSRRVFP--TLTYSTSVAEACD
MAV_4092|M.avium_104 RESPALAACRELAAAGAQVAGYDPQLPNIDPAVLQQNRVTAVDDPYRAAK
Mvan_1699|M.vanbaalenii_PYR-1 RESPNIDLARMLITAGYQLSIFDQYVTPQN-------LIGQNLGALSNSP
MSMEG_0475|M.smegmatis_MC2_155 RESPALAIIDDLTAAGAVVSFTDPLVPMLRTPQAG----TLTNHRSPEHD
MUL_1511|M.ulcerans_Agy99 RDSLSFKLRHLLMLEAKEVILHDPFLEGKDYHPLQT-VVDRSDVIVVGVP
*:* : * . : *
Mb0330|M.bovis_AF2122/97 RADAVLVLTEWREFIDLEPADLANRVRARVIVDGRNCLDVTRWRRAGWRV
Rv0322|M.tuberculosis_H37Rv RADAVLVLTEWREFIDLEPADLANRVRARVIVDGRNCLDVTRWRRAGWRV
MMAR_0603|M.marinum_M RADAVLILTEWQEFVDLDPDDLADRVRARVIVDGRNCLDVSRWERAGWRV
MAB_4295c|M.abscessus_ATCC_199 RADAVLLLTEWQEFVDFDPDALAKVVRTKVIVDGRNCLDAAKWVNAGWRV
Mflv_0289|M.gilvum_PYR-GCK RADAVLVLTEWSEFVGMHPDELSAAVRTKVIVDGRNCLDIGVWRDAGWQV
TH_0768|M.thermoresistible__bu RADAVLVLTEWQEFIDLNPAELADIVRAKVIVDGRNCLDVRRWQRAGWKV
MAV_4092|M.avium_104 AADAVVVLTEWPQFRSLDWRAVAQDAPLAVVLDARNSLDPATVREAGLRY
Mvan_1699|M.vanbaalenii_PYR-1 FIRELLVDQSVVESTHWDLVIDSRGSADKYALTTSRTINISRLA------
MSMEG_0475|M.smegmatis_MC2_155 EWDLVLVHHWAEELRDWVS---AQPVVLDTTFGRRG--------------
MUL_1511|M.ulcerans_Agy99 HSAYRGLRVPRGKVVEDVWGCLDVTEFDVDPCNGANLAELGTAAAR----
: :
Mb0330|M.bovis_AF2122/97 FRLG--VPRLGH-
Rv0322|M.tuberculosis_H37Rv FRLG--VPRLGH-
MMAR_0603|M.marinum_M FRLG--ARIRAAS
MAB_4295c|M.abscessus_ATCC_199 FCLGKRVEELAHT
Mflv_0289|M.gilvum_PYR-GCK HALGRTVEVGA--
TH_0768|M.thermoresistible__bu FCLG----RTP--
MAV_4092|M.avium_104 LGNG--VPQGF--
Mvan_1699|M.vanbaalenii_PYR-1 -------------
MSMEG_0475|M.smegmatis_MC2_155 -------------
MUL_1511|M.ulcerans_Agy99 -------------