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M. abscessus ATCC 19977 MAB_4295c (-)

annotation: UDP-glucose 6-dehydrogenase (UdgA)
coordinates: 4371594 - 4372934
length: 446

RCTVFGTGYLGATHAACMAELGHEVLGVDIDPGKVAKLSSGDIPFYEPGLRKILQSNIASGRLRFTTSYA
EAAEFADVHFLGVGTPQKKGEYGADLRHVHSVIDTLVPLLSRSAVIIGKSTVPVGTARELGQRAAGFAAA
GVDVEVAWNPEFLREGYAVKDTLHPDRIVLGVQRDSDRAEKLVRELYGPILDEEVPFLVTDLETAELVKV
SANAFLATKISFINAISEVCEAVGADVTTLADALGYDPRIGRRFLNAGLGFGGGCLPKDIRAFMARAGEL
GASHALTFLREVDSINMRRRTRMVELATKACGGSLLGANVAVLGAAFKPESDDVRDSPALNVAGLLQLNG
AAVNVYDPKALENSRRLFPTLNYATSVLEAADRADAVLLLTEWQEFVDFDPDALAKVVRTKVIVDGRNCL
DAAKWVNAGWRVFCLGKRVEELAHT*
Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. abscessus ATCC 19977MAB_4295c--100% (446)UDP-glucose 6-dehydrogenase (UdgA)

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb0330udgA0.079.78% (445) UDP-glucose 6-dehydrogenase UdgA
M. gilvum PYR-GCKMflv_0289-0.081.86% (441) UDP-glucose 6-dehydrogenase
M. tuberculosis H37RvRv0322udgA0.079.78% (445) UDP-glucose 6-dehydrogenase UdgA
M. leprae Br4923-----
M. marinum MMMAR_0603udgA0.082.73% (440) UDP-glucose dehydrogenase UdgA
M. avium 104MAV_4823-0.082.45% (433) UDP-glucose 6-dehydrogenase
M. smegmatis MC2 155MSMEG_0680-0.082.84% (437) UDP-glucose 6-dehydrogenase
M. thermoresistible (build 8)TH_0768udgA0.077.63% (438) PROBABLE UDP-GLUCOSE 6-DEHYDROGENASE UDGA (UDP-GLC
M. ulcerans Agy99MUL_1511-5e-2325.52% (431) UDP-glucose 6-dehydrogenase
M. vanbaalenii PYR-1Mvan_0598-0.083.33% (438) UDP-glucose 6-dehydrogenase

CLUSTAL 2.0.9 multiple sequence alignment


Mb0330|M.bovis_AF2122/97            -------MRCSVFGTGYLGATHAVGMAQLGHEVVGVDIDPGKVAKLAGGD
Rv0322|M.tuberculosis_H37Rv         -------MRCSVFGTGYLGATHAVGMAQLGHEVVGVDIDPGKVAKLAGGD
MMAR_0603|M.marinum_M               -------MRCTVFGTGYLGATHAVGMAQLGHEVVGVDIDPGKVAKLAGGD
MAV_4823|M.avium_104                -----------MFGTGYLGATHAVGMAELGHDVLGVDIDPGKVAKLAGGD
MSMEG_0680|M.smegmatis_MC2_155      -----------MFGTGYLGATHAAGMAELGHEVIGVDIDPGKVAKLASGD
MAB_4295c|M.abscessus_ATCC_199      -------MRCTVFGTGYLGATHAACMAELGHEVLGVDIDPGKVAKLSSGD
Mflv_0289|M.gilvum_PYR-GCK          -------MRCTVFGTGYLGATHAAGMAELGHEVVGVDIDPGKVAKLAAGE
Mvan_0598|M.vanbaalenii_PYR-1       -------MRCTVFGTGYLGATHAAGMAELGHDVLGVDIDAGKVAKLSGGE
TH_0768|M.thermoresistible__bu      -------MRCTVFGAGYLGTTHAAGMAALGHEVIAVDVDAGKVAKLAAGE
MUL_1511|M.ulcerans_Agy99           MTTQPSERICIVGGAGHVGLPLALVLADEGYNVDILDTNAEALETIMAGR
                                               : *:*::* . *  :*  *::*  :* :.  : .: .* 

Mb0330|M.bovis_AF2122/97            IPFYEPGLRKLLTDNLAAGRLRFTTDYDMAADFADVHFLGVGTPQKIGEY
Rv0322|M.tuberculosis_H37Rv         IPFYEPGLRKLLTDNLAAGRLRFTTDYDMAADFADVHFLGVGTPQKIGEY
MMAR_0603|M.marinum_M               IPFYEPGLRKLLRDNLAAGRLHFTTDYDMAAEFADVHFLGVGTPQKRGEY
MAV_4823|M.avium_104                IPFYEPGLRKLLNENLAAGRLRFTTDYDMAAGFADVHFLGVGTPQKKGEY
MSMEG_0680|M.smegmatis_MC2_155      IPFYEPGLRKVLNDNLSAGRLRFTTDYDEAADFADVHFLGVGTPQKKGEY
MAB_4295c|M.abscessus_ATCC_199      IPFYEPGLRKILQSNIASGRLRFTTSYAEAAEFADVHFLGVGTPQKKGEY
Mflv_0289|M.gilvum_PYR-GCK          VPFYEPGLREALQRNIEAGRLRFTTDYAEAAEFADVHFLGVGTPQKKGEY
Mvan_0598|M.vanbaalenii_PYR-1       VPFYEPGLREMLRRNIDAGRLRFTTDYAEAAGFADVHFLGVGTPQKKGEY
TH_0768|M.thermoresistible__bu      VPFYEPGLRALVTENLATGRLQFTTDYDAAADFADLHFLGVGTPQQRGDY
MUL_1511|M.ulcerans_Agy99           MPFIETGAEDLLKPLLPTGRISGSTDSQVVRN-SDIVICVVGTP-VDEYL
                                    :** *.* .  :   : :**:  :*.   .   :*: :  ****      

Mb0330|M.bovis_AF2122/97            GADLRHVHAVIDALVPRLVRASILVGKSTVPVGTAAELGHRAGALAPRGV
Rv0322|M.tuberculosis_H37Rv         GADLRHVHAVIDALVPRLVRASILVGKSTVPVGTAAELGHRAGALAPRGV
MMAR_0603|M.marinum_M               GADLRHIHAVIDTLVPRLTRTSVLIGKSTVPVGTAAELARRAAGLAVAGV
MAV_4823|M.avium_104                GADLRHVYAVIDELVPRLTTSAVLVGKSTVPVGTAAELNQRAAALAPRGV
MSMEG_0680|M.smegmatis_MC2_155      GADLRHVHAVIDTLVPRLRRNAVIVGKSTVPVGTAADLAQRAALLAPPGV
MAB_4295c|M.abscessus_ATCC_199      GADLRHVHSVIDTLVPLLSRSAVIIGKSTVPVGTARELGQRAAGFAAAGV
Mflv_0289|M.gilvum_PYR-GCK          AADLRHVYAVIDTLVPLLRRPAVIVGKSTVPVGTAAELVERAAGLAPDGV
Mvan_0598|M.vanbaalenii_PYR-1       GADLRHVYAVIDTLVPLLTRPAVIVGKSTVPVGTAADLSERAAGLAPEGV
TH_0768|M.thermoresistible__bu      SADLTQVHAVVDTLVPRLRRPAVIVGKSTVPVGTARDLLERARRLAPTGV
MUL_1511|M.ulcerans_Agy99           TPQAHTFFRVIDEISPYFHDGQTLILRSTVYPGLSQRVHD---MFSERGI
                                     .:   .. *:* : * :     :: :***  * :  :      ::  *:

Mb0330|M.bovis_AF2122/97            DVEIAWNPEFLREGFAVHDTLNPDRIVLGVQDDSTRAEVAVRELYAPLLA
Rv0322|M.tuberculosis_H37Rv         DVEIAWNPEFLREGFAVHDTLNPDRIVLGVQDDSTRAEVAVRELYAPLLA
MMAR_0603|M.marinum_M               GVEIAWNPEFLREGFAVRDTLRPDRIVLGVQEDSILAEQFVRELYGPLLE
MAV_4823|M.avium_104                NVEIAWNPEFLREGYAVQDTLRPDRIVLGIKQDSPRAEAAVRELYGPLLD
MSMEG_0680|M.smegmatis_MC2_155      DVEIAWNPEFLREGFAVHDTLHPDRVVLGVQPGSTRAEAAVRDLYGPLIA
MAB_4295c|M.abscessus_ATCC_199      DVEVAWNPEFLREGYAVKDTLHPDRIVLGVQRDSDRAEKLVRELYGPILD
Mflv_0289|M.gilvum_PYR-GCK          TVEVAWNPEFLREGFAVQDTLHPDRIVLGVQKDSRIAEPVLRELYAALLA
Mvan_0598|M.vanbaalenii_PYR-1       TVEVAWNPEFLREGFAVADTLHPDRIVLGVQRDSQLAEPVLREMYAPLLA
TH_0768|M.thermoresistible__bu      DVEVAWNPEFLREGFAVRDTLHPDRIVVGAPPDSVRAEPMLRELYAPLLG
MUL_1511|M.ulcerans_Agy99           GVHVTFCPERIAQGHSIRELRIIPQIISGFDAEG---LRVVRELFS---G
                                     *.::: ** : :*.:: :     ::: *    .      :*:::.    

Mb0330|M.bovis_AF2122/97            AGVPFLVTDLQTAELVKVSANAFLATKISFINAISEVCEAAGADVSQLAD
Rv0322|M.tuberculosis_H37Rv         AGVPFLVTDLQTAELVKVSANAFLATKISFINAISEVCEAAGADVSQLAD
MMAR_0603|M.marinum_M               AGVPFLVTDLQTAELVKVSANAFLATKISFINAISEVCEAAGADVSLLAD
MAV_4823|M.avium_104                AGVPFLVTDLQTAELVKVSANAFLATKISFINAISEVCEAAGADVSLLAD
MSMEG_0680|M.smegmatis_MC2_155      DGVPFLVTDLQTAELVKVAANAFLATKISFINAISEVCEAADADVTVLAD
MAB_4295c|M.abscessus_ATCC_199      EEVPFLVTDLETAELVKVSANAFLATKISFINAISEVCEAVGADVTTLAD
Mflv_0289|M.gilvum_PYR-GCK          DGAPFLVSDLQTAELAKVSANAFLATKISFINAISEVCEAVGADVTLLAD
Mvan_0598|M.vanbaalenii_PYR-1       AGVPFLIADLQTAELVKVSANAFLATKISFINAISEVCEAVDADVTLLAD
TH_0768|M.thermoresistible__bu      DGVPWLSTDLQTAELVKVSANAFLATKISFINAISDVCEAVGADVVTLAD
MUL_1511|M.ulcerans_Agy99           IASEIIKVEPQEAELAKLFCNSYRYIQFAVANQFYLLSREAGQDFDRVHH
                                         :  : : ***.*: .*::   :::. * :  :.. .. *.  : .

Mb0330|M.bovis_AF2122/97            ALGYDPRIGRQCLNAGLGFGGGCLPKDIRAFMARAGELGADQALTFLREV
Rv0322|M.tuberculosis_H37Rv         ALGYDPRIGRQCLNAGLGFGGGCLPKDIRAFMARAGELGADQALTFLREV
MMAR_0603|M.marinum_M               ALGYDTRIGRQCLNAGLGFGGGCLPKDIRAFMARAGELGANQALTFLREV
MAV_4823|M.avium_104                ALGYDPRIGRQFLNAGLGFGGGCLPKDIRAFMARAGELGADQALTFLREV
MSMEG_0680|M.smegmatis_MC2_155      ALGHDPRIGRRFLNAGLGFGGGCLPKDIRAFMARAGELGANHALTFLREV
MAB_4295c|M.abscessus_ATCC_199      ALGYDPRIGRRFLNAGLGFGGGCLPKDIRAFMARAGELGASHALTFLREV
Mflv_0289|M.gilvum_PYR-GCK          ALGHDARIGRRFLNAGLGFGGGCLPKDIRAFMARAGELGANQALTFLREV
Mvan_0598|M.vanbaalenii_PYR-1       ALGHDARIGRRFLNAGLGFGGGCLPKDIRAFMARAGELGANHALTFLREV
TH_0768|M.thermoresistible__bu      ALGHDPRIGRRFLNAGLGFGGGCLPKDIRAFMARAGELGANHTLTLLREV
MUL_1511|M.ulcerans_Agy99           ATTYKNSRVDSLPRAGLAAG-PCLLKDTMQLAAFS-----NNNFMLGHSA
                                    *  :.        .***. *  ** **   : * :     .: : : :..

Mb0330|M.bovis_AF2122/97            DSINMRRRTKMVELATTACGGSLLGANIAVLGAAFKPESDDVRDSPALNV
Rv0322|M.tuberculosis_H37Rv         DSINMRRRTKMVELATTACGGSLLGANIAVLGAAFKPESDDVRDSPALNV
MMAR_0603|M.marinum_M               DSINMRRRTRMVELATTACGGSLLGANLAVLGAAFKPESDDVRDSPALNV
MAV_4823|M.avium_104                DSINMRRRTRMVELASAACGGSLLGANVAVLGAAFKPESDDVRDSPALNV
MSMEG_0680|M.smegmatis_MC2_155      DSINMRRRTAMVELATRACGGSLLGANIAVLGAAFKPESDDVRDSPALNV
MAB_4295c|M.abscessus_ATCC_199      DSINMRRRTRMVELATKACGGSLLGANVAVLGAAFKPESDDVRDSPALNV
Mflv_0289|M.gilvum_PYR-GCK          DSINMRRRTRMVELATTACGGSLLGANIAVLGAAFKPESDDVRDSPALNV
Mvan_0598|M.vanbaalenii_PYR-1       DSINMRRRTRMVELATKACGGSLLGANVAVLGAAFKPESDDVRDSPALNV
TH_0768|M.thermoresistible__bu      DSINMRRRARMVELATTACGGSLLGANIAVLGAAFKPDSDDVRDSPALNV
MUL_1511|M.ulcerans_Agy99           MLINEGQPQFIVNMLKRRVN--LRDKTVGILGMTFKADCDDTRDSLSFKL
                                      **  :   :*:: .   .  * . .:.:** :**.:.**.*** ::::

Mb0330|M.bovis_AF2122/97            AGQLQLNGATVHVYDPKALDNAHRLFPTLNYAVSVAEACERADAVLVLTE
Rv0322|M.tuberculosis_H37Rv         AGQLQLNGATVHVYDPKALDNAHRLFPTLNYAVSVAEACERADAVLVLTE
MMAR_0603|M.marinum_M               AGQLQLNGAAVNVYDPKALDNANRLFPTLNYAVSVAEACERADAVLILTE
MAV_4823|M.avium_104                AGQLQLNGAAVNVYDPKALDNAQRLFPTLNYAVSVEEACERADAVLVLTE
MSMEG_0680|M.smegmatis_MC2_155      AGMLQLNGATVNVYDPKAVENSRRLFPTLTYATTVAEACERADAVLVLTE
MAB_4295c|M.abscessus_ATCC_199      AGLLQLNGAAVNVYDPKALENSRRLFPTLNYATSVLEAADRADAVLLLTE
Mflv_0289|M.gilvum_PYR-GCK          AGMLQLHGATVNVYDPKAMDNSRRLFPTLNYSASALDACERADAVLVLTE
Mvan_0598|M.vanbaalenii_PYR-1       AGMLQLNGATVNVYDPQAIENSRRLFPTLNYATTVVEACDRADAVLVLTE
TH_0768|M.thermoresistible__bu      AGMLQLNGATVTVYDPKAMENSRRVFPTLTYSTSVAEACDRADAVLVLTE
MUL_1511|M.ulcerans_Agy99           RHLLMLEAKEVILHDP---------FLEGKDYHPLQTVVDRSDVIVVGVP
                                       * *..  * ::**         *   .   .   . :*:*.::: . 

Mb0330|M.bovis_AF2122/97            WREFIDLEPADLANRVRARVIVDGRNCLDVTRWRRAGWRVFRLGVPRLGH
Rv0322|M.tuberculosis_H37Rv         WREFIDLEPADLANRVRARVIVDGRNCLDVTRWRRAGWRVFRLGVPRLGH
MMAR_0603|M.marinum_M               WQEFVDLDPDDLADRVRARVIVDGRNCLDVSRWERAGWRVFRLGARIRAA
MAV_4823|M.avium_104                WRQFVEMDPDDLADRVRARVVVDGRNCLDVTRWQRAGWRVYRLGAPRP--
MSMEG_0680|M.smegmatis_MC2_155      WSEFVDLDPAALDGTVRAKVVVDGRNCLDIDRWSRAGWRVYALGRRLERQ
MAB_4295c|M.abscessus_ATCC_199      WQEFVDFDPDALAKVVRTKVIVDGRNCLDAAKWVNAGWRVFCLGKRVEEL
Mflv_0289|M.gilvum_PYR-GCK          WSEFVGMHPDELSAAVRTKVIVDGRNCLDIGVWRDAGWQVHALGRTVEVG
Mvan_0598|M.vanbaalenii_PYR-1       WREFVELDPVLLADTVRAKVVVDGRNCLDVGRWQQAGWQVFALGRFGGEP
TH_0768|M.thermoresistible__bu      WQEFIDLNPAELADIVRAKVIVDGRNCLDVRRWQRAGWKVFCLGRTP---
MUL_1511|M.ulcerans_Agy99           HSAYRGLR------VPRGKVVEDVWGCLDVTEFDVDPCNGANLAELGTAA
                                       :  :         * :*: *  .***   :     .   *.      

Mb0330|M.bovis_AF2122/97            -----
Rv0322|M.tuberculosis_H37Rv         -----
MMAR_0603|M.marinum_M               S----
MAV_4823|M.avium_104                -----
MSMEG_0680|M.smegmatis_MC2_155      NVREL
MAB_4295c|M.abscessus_ATCC_199      AHT--
Mflv_0289|M.gilvum_PYR-GCK          A----
Mvan_0598|M.vanbaalenii_PYR-1       AAA--
TH_0768|M.thermoresistible__bu      -----
MUL_1511|M.ulcerans_Agy99           AR---