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NPVDRFFEITARQSSVATEIRGGVVTFIAMAYIIVLNPIILSSSADVDGNKLDFAQVSAMTSLAAGVMTI LFGVVARLPFALAAGLGINSFLATTVVGSLTWPEAMGLVVINGLIIVLLAVTGLRRLVFDAVPMQLKLAI TAGIGLFILFIGLVDAGFISSTGVPSPPVGLGGGGQGSISTVPTVIFVFTLLLTGVLVAKRVRGGILIGL VIGTVIAVVVEAIWHLGSATEKPGGWSLSVPTLSGSPFSLPDLSLVGAFSLDSFGRIGVLAAVMLVFTLV FANFFDAMGTMTGLSREAGLSDANGTFPRLRSALVVEGAGAVVGGATSSSSNTVFIESGAGIEEGARTGL ANVVTGLLFLAAMFVAPLASIVPTEVAAAALVVVGAMMVSHLRHIDLSEFSVALPVVLTVAVMPFSYSIA NGIGVGFITWVVMRTAAGKVREVSPLLWVVAAGFAVYFARTPLESLIGV*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_0392 | - | - | 100% (470) | xanthine/uracil/vitamin C permease |
| M. vanbaalenii PYR-1 | Mvan_5693 | - | 7e-11 | 24.67% (381) | sulphate transporter |
| M. vanbaalenii PYR-1 | Mvan_3054 | - | 4e-06 | 27.14% (210) | xanthine/uracil/vitamin C permease |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3301 | - | 1e-10 | 23.32% (386) | transmembrane carbonic anhydrase |
| M. gilvum PYR-GCK | Mflv_0346 | - | 0.0 | 88.51% (470) | xanthine/uracil/vitamin C permease |
| M. tuberculosis H37Rv | Rv3273 | - | 1e-10 | 23.32% (386) | transmembrane carbonic anhydrase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_3353c | - | 1e-150 | 58.35% (473) | putative xanthine/uracil/vitamin C permease family protein |
| M. marinum M | MMAR_4750 | - | 5e-10 | 22.61% (429) | integral membrane transporter |
| M. avium 104 | MAV_4578 | - | 5e-10 | 24.77% (432) | carbonate dehydratase |
| M. smegmatis MC2 155 | MSMEG_0564 | - | 0.0 | 85.11% (470) | xanthine/uracil permease |
| M. thermoresistible (build 8) | TH_1201 | - | 0.0 | 80.00% (470) | xanthine/uracil permease |
| M. ulcerans Agy99 | MUL_0321 | - | 4e-10 | 22.58% (434) | integral membrane transporter |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_0392|M.vanbaalenii_PYR-1 --MNPVDRFFEITARQSSVATEIRGGVVTFIAMAYIIVLNPIILSSSA--
Mflv_0346|M.gilvum_PYR-GCK --MNSVDRFFEITARQSTLGTEIRGGVVTFIAMAYIIVLNPIILSGSE--
MSMEG_0564|M.smegmatis_MC2_155 --MNRLDRFFDITARGSTLTAEIRGGVVTFIAMAYIIVLNPVILSSAP--
TH_1201|M.thermoresistible__bu --VNRLDRFFEISARGSTVSTEVRGGLVTFIAMAYIIVLNPIILSGSA--
MAB_3353c|M.abscessus_ATCC_199 -MTALLDRFFRITERQSTLGREIRGGVVTFFAMAYIVVLNPLIIGGEPGR
Mb3301|M.bovis_AF2122/97 -MTIPRSQHMSTAVNSCTEAPASRSQWMLANLRHDVPASLVVFLVALP--
Rv3273|M.tuberculosis_H37Rv -MTIPRSQHMSTAVNSCTEAPASRSQWMLANLRHDVPASLVVFLVALP--
MAV_4578|M.avium_104 ---MQDIQRADDALP-----TASRAERLRGVIRHDLPSSLVVFLVALP--
MMAR_4750|M.marinum_M ---------------------MLAALRSPTRLRTEVLAGLVVALALIP--
MUL_0321|M.ulcerans_Agy99 MSSQQVSAVPTIRKAGDPSTAVLAALRSPTRLRTEVLAGLVVALALIP--
. : : :
Mvan_0392|M.vanbaalenii_PYR-1 ----DVDGNKLDFAQVSAMTSLAAGVMTILFGVVARLPFALAAGLGINSF
Mflv_0346|M.gilvum_PYR-GCK ----DVTGAKLDFAQVSATTSLAAGVMTILFGLIARLPFALAAGLGINSF
MSMEG_0564|M.smegmatis_MC2_155 ----DVDGNNLEFAQVSAVTSLAAGVMTILFGLVARLPFAFAAGLGINSF
TH_1201|M.thermoresistible__bu ----DVDGNRLGFAQVSAATALTAGVMTILFGVVARLPFAFAAGLGINSF
MAB_3353c|M.abscessus_ATCC_199 AHNVDVLGHVLPVGQVAAVTALAAGVMSILFGFVANYPFALAAGLGINSL
Mb3301|M.bovis_AF2122/97 ----LSLGIAIASGAPIIAGVIAAVVGGIVAGAVGGSPVQVSGPAAGLTV
Rv3273|M.tuberculosis_H37Rv ----LSLGIAIASGAPIIAGVIAAVVGGIVAGAVGGSPVQVSGPAAGLTV
MAV_4578|M.avium_104 ----LSLGIAIASNAPVLAGLIAAIVGGIVVGALGGSPLQVSGPAAGLTV
MMAR_4750|M.marinum_M ----EAISFSIIAGVDPRVGLFASFTMAVTIAVVGGRPAMISAATGAIAL
MUL_0321|M.ulcerans_Agy99 ----EAISFSIIAGVDPRVGLFASFTMAVTIAVVGGRLAMISAATGAIAL
. : ::: . : . :. .:. . :.
Mvan_0392|M.vanbaalenii_PYR-1 LATTVVGSLTWPEAMGLVVINGLIIVLLAVTGLRRLVFDAVPMQLKLAIT
Mflv_0346|M.gilvum_PYR-GCK LATTVVGDLTWAEAMGLVVINGLLIVLLAVTGLRRLVFDAVPMELKLGIT
MSMEG_0564|M.smegmatis_MC2_155 LATTVVGSVTWPEAMGLVVINGLIIVLLAATGLRRLVFDAVPMQLKLAIT
TH_1201|M.thermoresistible__bu LATSVVGSVSWAEAMGLVVINGLIIVLLSSTGLRRMIFDAVPMQLKLSIT
MAB_3353c|M.abscessus_ATCC_199 LAVSFAPQMTWPEAMGLVIVDGLIIVALGISGFRTAVFHAIPDELKAAIA
Mb3301|M.bovis_AF2122/97 VVAELIDELGWPMLCLMTIAAGALQIVFGLSRMARAALAIAPVVVHAMLA
Rv3273|M.tuberculosis_H37Rv VVAELIDELGWPMLCLMTIAAGALQIVFGLSRMARAALAIAPVVVHAMLA
MAV_4578|M.avium_104 VVAGLVSDFGWGVTCFITVAAGAVQVLLGLSRVARAALAISPVVVHAMLA
MMAR_4750|M.marinum_M VIAPLAREHGADYFIAAVILAGLVQITLSLLGVARLMRFIPRSVMVGFVN
MUL_0321|M.ulcerans_Agy99 VIAPLAREQGADYFIAAVILAGLVQITLSLLGVARLMRFIPRSVMVGFVN
: . . . .: * : : :. . : :
Mvan_0392|M.vanbaalenii_PYR-1 AGIGLFILFIGLVDAGFIS---STGVPSPPVGLGGGGQGSISTVPTVIFV
Mflv_0346|M.gilvum_PYR-GCK AGIGLFILFIGLVDAGFIG---STGRPSPPVGLGSGGLGSISTVPTLVFI
MSMEG_0564|M.smegmatis_MC2_155 AGIGLFILFIGVVDAGFIG---STGLPSPPVGLGAGGEGSINTVPTVVFV
TH_1201|M.thermoresistible__bu AGIGLFILFIGLVNAGFIG---STGLPSPPTGLGVDGGGSITTVPTVLFV
MAB_3353c|M.abscessus_ATCC_199 AGIGCFIAFIGFVDAGFVRRVPDAANTTVPVGLGIDN--SVATIPTLIFA
Mb3301|M.bovis_AF2122/97 GIGITIALQQIHVLLGGTSHSSAWRNIVALPDGILHHELHEVIVGGTVIA
Rv3273|M.tuberculosis_H37Rv GIGITIALQQIHVLLGGTSHSSAWRNIVALPDGILHHELHEVIVGGTVIA
MAV_4578|M.avium_104 GIGITIALQQTHVLLGGKSKSTAWHNLIGLPGQIIGAHRPGVLLGVLVIV
MMAR_4750|M.marinum_M ALAILIFLSQLPHLLG-----------------------VPPVVYPFVIV
MUL_0321|M.ulcerans_Agy99 ALAILIFLSQVPHLLG-----------------------VPAVVYPFVIV
. : * : ::
Mvan_0392|M.vanbaalenii_PYR-1 FTLLLTGVLVAKRVRGGILIGLVIGTVIAVVVEAIWHLGSATEKPGGWSL
Mflv_0346|M.gilvum_PYR-GCK LTLLLTAALVIRKVRGGILIGLVCGTVVAVIIEAVWHLGSAVDKPGGWSL
MSMEG_0564|M.smegmatis_MC2_155 FTLLVTGILVARRVRGGILIGLVAGTVVAVVIEAIWHLGSAVEKPGGWGL
TH_1201|M.thermoresistible__bu ATLLVTGILIARRVRGAILIGLIGGTVVAAVIEAVWHLGPAAERPGGWGL
MAB_3353c|M.abscessus_ATCC_199 AGVLLMGILVVRKVRGGLLIGIVAMTVVSMIAQALCGRGAQPTDAKGWNL
Mb3301|M.bovis_AF2122/97 ILLMWSKLPAKVRIIPGPLVAIAGATVLALLPVLQTER------------
Rv3273|M.tuberculosis_H37Rv ILLMWSKLPAKVRIIPGPLVAIAGATVLALLPVLQTER------------
MAV_4578|M.avium_104 ILVAWRWVPAKVRRVPGPLVAIVAVTVISVVFPFHVRR------------
MMAR_4750|M.marinum_M GLLLMVFLPKLTTVVPAPLVAIVVLTAAAVAFSVEIPN------------
MUL_0321|M.ulcerans_Agy99 GLLLMVFLPKLTTVVPAPLVAIVVLTAAAVAFSVEILN------------
: . *:.: *. :
Mvan_0392|M.vanbaalenii_PYR-1 SVPTLSGSPFSLPDLSLVGAFS-LDSFGRIGVLAAVMLVFTLVFANFFDA
Mflv_0346|M.gilvum_PYR-GCK SVPTLSGSPFALPDLSLVGEFS-LDSFGRIGVLAAVMLVFTLVFANFFDA
MSMEG_0564|M.smegmatis_MC2_155 SVPSLSGSPFAMPDLSLVGEVS-LGSFSRIGALAAIMLVFTLVFANFFDA
TH_1201|M.thermoresistible__bu SVPALDGSPFALPDLSLIGEFS-FAGFSRIGVLAATVFVFTLVFANFFDA
MAB_3353c|M.abscessus_ATCC_199 TVPDWPSSAGGMPDLSLLGQVDLFGAFTRVGVLSATVLVFALVLSNFFDA
Mb3301|M.bovis_AF2122/97 --IDLQGNFFDAIGLPKLAEMSPGGQPWSHEISAIALGVLTIALIASVES
Rv3273|M.tuberculosis_H37Rv --IDLQGNFFDAIGLPKLAEMSPGGQPWSHEISAIALGVLTIALIASVES
MAV_4578|M.avium_104 --IDLDGSPLDALQLPDLPHGN---------WSGVAVGVITVALIASVES
MMAR_4750|M.marinum_M --VGDEGQLPSSLPTLLVPHVP----FALETLSIIGPYALAMALVGLLES
MUL_0321|M.ulcerans_Agy99 --VGDEGQLPSSLPTLLVPHVP----FALETLSIIGPYALAMALVGLLES
.. : .:::.: .::
Mvan_0392|M.vanbaalenii_PYR-1 MGTMTGLSREAGLSDANGTFPRLRSALVVEGAGAVVGGATS-SSSNTVFI
Mflv_0346|M.gilvum_PYR-GCK MGTMTGLSREAGLSDAKGTFPRLKSALIVEGAGAVVGGATS-SSSNTVFI
MSMEG_0564|M.smegmatis_MC2_155 MGTMTGLSREAGLSDPQGTFPRLKSALIVEGTGAVVGGASS-ASSNTVFI
TH_1201|M.thermoresistible__bu MGTFTGLSREAGLAGPDGTFPRLRSALVVEGVGAVAGGAAS-ASSNTVFV
MAB_3353c|M.abscessus_ATCC_199 MGTMTGLGKEAGLADEHGTLPGIGRALTVEGVGAVIGGVSS-SSSNTVYV
Mb3301|M.bovis_AF2122/97 LLSAVGVD-----KLHHGPRTDFNREMVGQGSANVVSGLLGGLPITGVIV
Rv3273|M.tuberculosis_H37Rv LLSAVGVD-----KLHHGPRTDFNREMVGQGSANVVSGLLGGLPITGVIV
MAV_4578|M.avium_104 LLSAVSVD-----RMHNGPRTDFNRELVGQGAANMISGAVGGLPVTGVIV
MMAR_4750|M.marinum_M LLTAKLVD-----DITD-THSNKTREAWGQGVANVVTGFFGGMGGCAMIG
MUL_0321|M.ulcerans_Agy99 LLTAKLVD-----DITD-THSNKTREAWGQGVANVVTGFFGGMGGCAMIG
: : :. . . . :* . : * . :
Mvan_0392|M.vanbaalenii_PYR-1 ESGAGIEEG-ARTGLANVVTGLLFLAAMFVAP-LASIVPTEVAAAALVVV
Mflv_0346|M.gilvum_PYR-GCK ESGAGIEEG-ARTGLANVVAGVLFLAAMFISP-LASIVPTEVAAAALVVV
MSMEG_0564|M.smegmatis_MC2_155 ESGAGIEEG-ARTGLANLITGVLFLAAMFVAP-LASVVPTEVAAAALVVV
TH_1201|M.thermoresistible__bu ESGAGIGEG-ARTGLANLVTGALFLAAMFVSP-LASVVPTEVAAAALVVV
MAB_3353c|M.abscessus_ATCC_199 ESASGIAEG-ARTGLANVVTGLLFLAAMFFTP-LYSVVPLEAAAPALVVV
Mb3301|M.bovis_AF2122/97 RSSANVAAG-ARTRMSTILHGVWILLFASLFTNLVELIPKAALAGLLIVI
Rv3273|M.tuberculosis_H37Rv RSSANVAAG-ARTRMSTILHGVWILLFASLFTNLVELIPKAALAGLLIVI
MAV_4578|M.avium_104 RSSTNVNAG-ARSRASAIMHGVWILLFTIPFAGLVDEIPTAALAGLLIVI
MMAR_4750|M.marinum_M QTMINVKVSGARTRISTFLAGLFLLGLVVGLGDVVALIPMAALVAVMIMV
MUL_0321|M.ulcerans_Agy99 QTMINVKVPGARTRISTFLAGLFLLGLVVGLGDVVALIPMAALVAVMIMV
.: .: **: : .: * :* : :* . . ::::
Mvan_0392|M.vanbaalenii_PYR-1 GA----MMVSHLRHIDLSEFSVALPVVLTVAVMPFSYSIANGIGVGFITW
Mflv_0346|M.gilvum_PYR-GCK GA----MMVSQLRHIDLTDFSVALPVVLTVAVMPFSYSIANGIGVGFISW
MSMEG_0564|M.smegmatis_MC2_155 GA----MMVSHLRHIDLSEFSVALPVVLTVATMAFSYSIANGIGVGFVAW
TH_1201|M.thermoresistible__bu GA----MMVSHLRHVDITEFSVALPVVLTVVSMPFSYSIANGIGIGFISW
MAB_3353c|M.abscessus_ATCC_199 GA----MMIGQLRSVDLTRFDYALPCFLTVVTMPFTYSIANGIGVGFISW
Mb3301|M.bovis_AF2122/97 GA-----QLVKLAHIKLAWRTGNFVIYAITIVCVVFLNLLEGVAIGLVVA
Rv3273|M.tuberculosis_H37Rv GA-----QLVKLAHIKLAWRTGNFVIYAITIVCVVFLNLLEGVAIGLVVA
MAV_4578|M.avium_104 GI-----QLLKPAHIETAMKHGDLAVYVVTAVSVIFLNLLHGVMIGLALA
MMAR_4750|M.marinum_M SVGTMDWHSIAPATLRRMPRSETLVMLATVVVTVATHNLAYGVVAGVLTA
MUL_0321|M.ulcerans_Agy99 SVGTMDWHSIAPATLRRMPRSETLVMLATVVVTVATHNLAYGVVAGVLTA
. : : . .: *: *.
Mvan_0392|M.vanbaalenii_PYR-1 VVMRTAAGKVREVSP---------------------LLWVVAAGFAVYFA
Mflv_0346|M.gilvum_PYR-GCK AVLRTAAGKGREISP---------------------LLWVVAAGFAVYFA
MSMEG_0564|M.smegmatis_MC2_155 VVLRSAAGKFREISP---------------------LLWVVALGFVLYFA
TH_1201|M.thermoresistible__bu VVMRSAVGRAREVSP---------------------LLWVVAAGFLLYFA
MAB_3353c|M.abscessus_ATCC_199 VVLALARGRFRSVHP---------------------LLYVVAMLFVIYFA
Mb3301|M.bovis_AF2122/97 IVFLLVRVVRAPVEVKPVGGEQSKRWRVDIDG-TLSFLLLPR--LTTVLS
Rv3273|M.tuberculosis_H37Rv IVFLLVRVVRAPVEVKPVGGEQSKRWRVDIDG-TLSFLLLPR--LTTVLS
MAV_4578|M.avium_104 IALTGWRVIRAKIEAAQLDG----EWRVTIEGAACTFLALPR--LTRVLA
MMAR_4750|M.marinum_M MVLFARRVAHFMTVERIVESDTGSAAETVVYRVSGELFFASSNDLVYQFN
MUL_0321|M.ulcerans_Agy99 MVLFARRVAHFMTVERIVESDTGSAAETVVYRVSCELFFASSNDLVYQFN
.: :: : :
Mvan_0392|M.vanbaalenii_PYR-1 RTPLESLIGV----------------------------------------
Mflv_0346|M.gilvum_PYR-GCK RTPLESLLGV----------------------------------------
MSMEG_0564|M.smegmatis_MC2_155 RGWIESFIGM----------------------------------------
TH_1201|M.thermoresistible__bu RGWIEALAGV----------------------------------------
MAB_3353c|M.abscessus_ATCC_199 KGPIEDLLAHGA--------------------------------------
Mb3301|M.bovis_AF2122/97 KLPEGSEVTLNLNADYIDDS-VSEAISDWRRAHETRGGVVAIVETSPAKL
Rv3273|M.tuberculosis_H37Rv KLPEGSEVTLNLNADYIDDS-VSEAISDWRRAHETRGGVVAIVETSPAKL
MAV_4578|M.avium_104 SVPRGATVTVAIAVHYLDHA-AHQAITDWQRQQEATGGTVRIEG------
MMAR_4750|M.marinum_M YVDDPDNVVIDMSQSHIWDASTVAALDAIITKYHAKGRCVEIIG------
MUL_0321|M.ulcerans_Agy99 YVDDPDNVVIDMSQSHIWDASTVAALDAIITKYHAKGRCVEIIG------
Mvan_0392|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_0346|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_0564|M.smegmatis_MC2_155 --------------------------------------------------
TH_1201|M.thermoresistible__bu --------------------------------------------------
MAB_3353c|M.abscessus_ATCC_199 --------------------------------------------------
Mb3301|M.bovis_AF2122/97 HHAHARPPKRHFASDPIGLVPWRSARGKDRGSASVLDRIDEYHRNGAAVL
Rv3273|M.tuberculosis_H37Rv HHAHARPPKRHFASDPIGLVPWRSARGKDRGSASVLDRIDEYHRNGAAVL
MAV_4578|M.avium_104 --------------------------------------------------
MMAR_4750|M.marinum_M --------------------------------------------------
MUL_0321|M.ulcerans_Agy99 --------------------------------------------------
Mvan_0392|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_0346|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_0564|M.smegmatis_MC2_155 --------------------------------------------------
TH_1201|M.thermoresistible__bu --------------------------------------------------
MAB_3353c|M.abscessus_ATCC_199 --------------------------------------------------
Mb3301|M.bovis_AF2122/97 HPHIAGLTDSQDPYELFLTCADSRILPNVITASGPGDLYTVRNLGNLVPT
Rv3273|M.tuberculosis_H37Rv HPHIAGLTDSQDPYELFLTCADSRILPNVITASGPGDLYTVRNLGNLVPT
MAV_4578|M.avium_104 ----------------------------AVVATGRR--------------
MMAR_4750|M.marinum_M -------------------------------------------------L
MUL_0321|M.ulcerans_Agy99 -------------------------------------------------L
Mvan_0392|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_0346|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_0564|M.smegmatis_MC2_155 --------------------------------------------------
TH_1201|M.thermoresistible__bu --------------------------------------------------
MAB_3353c|M.abscessus_ATCC_199 --------------------------------------------------
Mb3301|M.bovis_AF2122/97 DPDDRSVDAALDFAVNQLGVSSVVVCGHSSCAAMTALLEDDPANTTTPMM
Rv3273|M.tuberculosis_H37Rv DPDDRSVDAALDFAVNQLGVSSVVVCGHSSCAAMTALLEDDPANTTTPMM
MAV_4578|M.avium_104 --DEPQVEAEMPGAAA----------------------------------
MMAR_4750|M.marinum_M NQDSAERHGRLSGQFGAEH-------------------------------
MUL_0321|M.ulcerans_Agy99 NQDSAERHGRLSGQFGAEH-------------------------------
Mvan_0392|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_0346|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_0564|M.smegmatis_MC2_155 --------------------------------------------------
TH_1201|M.thermoresistible__bu --------------------------------------------------
MAB_3353c|M.abscessus_ATCC_199 --------------------------------------------------
Mb3301|M.bovis_AF2122/97 RWLENAHDSLVVFRNHHPARRSAESAGYPEADQLSIVNVAVQVERLTRHP
Rv3273|M.tuberculosis_H37Rv RWLENAHDSLVVFRNHHPARRSAESAGYPEADQLSIVNVAVQVERLTRHP
MAV_4578|M.avium_104 --------------------------------------------------
MMAR_4750|M.marinum_M --------------------------------------------------
MUL_0321|M.ulcerans_Agy99 --------------------------------------------------
Mvan_0392|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_0346|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_0564|M.smegmatis_MC2_155 --------------------------------------------------
TH_1201|M.thermoresistible__bu --------------------------------------------------
MAB_3353c|M.abscessus_ATCC_199 --------------------------------------------------
Mb3301|M.bovis_AF2122/97 ILATAVAAADLQVIGIFFDISTARVYEVGPNGIICPDEPADRPVDHESAQ
Rv3273|M.tuberculosis_H37Rv ILATAVAAADLQVIGIFFDISTARVYEVGPNGIICPDEPADRPVDHESAQ
MAV_4578|M.avium_104 --------------------------------------------------
MMAR_4750|M.marinum_M --------------------------------------------------
MUL_0321|M.ulcerans_Agy99 --------------------------------------------------