For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
TALLDRFFRITERQSTLGREIRGGVVTFFAMAYIVVLNPLIIGGEPGRAHNVDVLGHVLPVGQVAAVTAL AAGVMSILFGFVANYPFALAAGLGINSLLAVSFAPQMTWPEAMGLVIVDGLIIVALGISGFRTAVFHAIP DELKAAIAAGIGCFIAFIGFVDAGFVRRVPDAANTTVPVGLGIDNSVATIPTLIFAAGVLLMGILVVRKV RGGLLIGIVAMTVVSMIAQALCGRGAQPTDAKGWNLTVPDWPSSAGGMPDLSLLGQVDLFGAFTRVGVLS ATVLVFALVLSNFFDAMGTMTGLGKEAGLADEHGTLPGIGRALTVEGVGAVIGGVSSSSSNTVYVESASG IAEGARTGLANVVTGLLFLAAMFFTPLYSVVPLEAAAPALVVVGAMMIGQLRSVDLTRFDYALPCFLTVV TMPFTYSIANGIGVGFISWVVLALARGRFRSVHPLLYVVAMLFVIYFAKGPIEDLLAHGA*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. abscessus ATCC 19977 | MAB_3353c | - | - | 100% (481) | putative xanthine/uracil/vitamin C permease family protein |
| M. abscessus ATCC 19977 | MAB_3098 | - | 3e-09 | 22.06% (408) | transmembrane carbonic anhydrase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3301 | - | 2e-12 | 23.57% (403) | transmembrane carbonic anhydrase |
| M. gilvum PYR-GCK | Mflv_0346 | - | 1e-151 | 59.58% (475) | xanthine/uracil/vitamin C permease |
| M. tuberculosis H37Rv | Rv3273 | - | 2e-12 | 23.57% (403) | transmembrane carbonic anhydrase |
| M. leprae Br4923 | - | - | - | - | - |
| M. marinum M | MMAR_1266 | sulP_2 | 7e-09 | 23.88% (402) | transmembrane carbonic anhydrase, SulP_2 |
| M. avium 104 | MAV_0121 | - | 1e-07 | 23.96% (384) | carbonate dehydratase |
| M. smegmatis MC2 155 | MSMEG_0564 | - | 1e-151 | 59.79% (475) | xanthine/uracil permease |
| M. thermoresistible (build 8) | TH_1201 | - | 1e-146 | 58.02% (474) | xanthine/uracil permease |
| M. ulcerans Agy99 | - | - | - | - | - |
| M. vanbaalenii PYR-1 | Mvan_0392 | - | 1e-150 | 58.35% (473) | xanthine/uracil/vitamin C permease |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_0346|M.gilvum_PYR-GCK ------MNSVDRFFEITARQSTLGTEIRGGVVTFIAMAYIIVLNPIILSG
Mvan_0392|M.vanbaalenii_PYR-1 ------MNPVDRFFEITARQSSVATEIRGGVVTFIAMAYIIVLNPIILSS
MSMEG_0564|M.smegmatis_MC2_155 ------MNRLDRFFDITARGSTLTAEIRGGVVTFIAMAYIIVLNPVILSS
TH_1201|M.thermoresistible__bu ------VNRLDRFFEISARGSTVSTEVRGGLVTFIAMAYIIVLNPIILSG
MAB_3353c|M.abscessus_ATCC_199 -----MTALLDRFFRITERQSTLGREIRGGVVTFFAMAYIVVLNPLIIGG
Mb3301|M.bovis_AF2122/97 MTIPRSQHMSTAVNSCTEAPASRSQWMLANLRHDVPASLVVFLVALPL--
Rv3273|M.tuberculosis_H37Rv MTIPRSQHMSTAVNSCTEAPASRSQWMLANLRHDVPASLVVFLVALPL--
MMAR_1266|M.marinum_M --------MSTAVKNSAEAPESRSQWMRANLRHDFPASLVVFLVALPL--
MAV_0121|M.avium_104 --------MST----------SRSERLREVLRYDLPASLVVFLVALPL--
: : : .. : ::.* .: :
Mflv_0346|M.gilvum_PYR-GCK SE------DVTGAKLDFAQVSATTSLAAGVMTILFGLIARLPFALAAGLG
Mvan_0392|M.vanbaalenii_PYR-1 SA------DVDGNKLDFAQVSAMTSLAAGVMTILFGVVARLPFALAAGLG
MSMEG_0564|M.smegmatis_MC2_155 AP------DVDGNNLEFAQVSAVTSLAAGVMTILFGLVARLPFAFAAGLG
TH_1201|M.thermoresistible__bu SA------DVDGNRLGFAQVSAATALTAGVMTILFGVVARLPFAFAAGLG
MAB_3353c|M.abscessus_ATCC_199 EPGRAHNVDVLGHVLPVGQVAAVTALAAGVMSILFGFVANYPFALAAGLG
Mb3301|M.bovis_AF2122/97 ---------SLGIAIASGAPIIAGVIAAVVGGIVAGAVGGSPVQVSGPAA
Rv3273|M.tuberculosis_H37Rv ---------SLGIAIASGAPIIAGVIAAVVGGIVAGAVGGSPVQVSGPAA
MMAR_1266|M.marinum_M ---------SLGIAIASGAPLMAGLIAAVVGGIVAGLLGGSSVQVSGPAA
MAV_0121|M.avium_104 ---------SLGIAIASDAPVLAGLIAAIVGGIVGGWLGGSPLQVSGPAA
* : ::* * *: * :. .. .:. .
Mflv_0346|M.gilvum_PYR-GCK INSFLATTVVGDLTWAEAMGLVVINGLLIVLLAVTGLRRLVFDAVPMELK
Mvan_0392|M.vanbaalenii_PYR-1 INSFLATTVVGSLTWPEAMGLVVINGLIIVLLAVTGLRRLVFDAVPMQLK
MSMEG_0564|M.smegmatis_MC2_155 INSFLATTVVGSVTWPEAMGLVVINGLIIVLLAATGLRRLVFDAVPMQLK
TH_1201|M.thermoresistible__bu INSFLATSVVGSVSWAEAMGLVVINGLIIVLLSSTGLRRMIFDAVPMQLK
MAB_3353c|M.abscessus_ATCC_199 INSLLAVSFAPQMTWPEAMGLVIVDGLIIVALGISGFRTAVFHAIPDELK
Mb3301|M.bovis_AF2122/97 GLTVVVAELIDELGWPMLCLMTIAAGALQIVFGLSRMARAALAIAPVVVH
Rv3273|M.tuberculosis_H37Rv GLTVVVAELIDELGWPMLCLMTIAAGALQIVFGLSRMARAALAIAPVVVH
MMAR_1266|M.marinum_M GLTVVVAGLIEQVGWQMLCLMTLGAGVLQIIFGLSRMARAALAIAPVVVH
MAV_0121|M.avium_104 GLTVVVADVVAEFGWGVTCFITVVAGVLQVLLGFSRIARAALAISPVVVH
:.:.. . .. * :.: * : : :. : : : * ::
Mflv_0346|M.gilvum_PYR-GCK LGIT-AGIGLFILFIGLVDAGFIG---STGRPSPPVGLGSGGLGSISTVP
Mvan_0392|M.vanbaalenii_PYR-1 LAIT-AGIGLFILFIGLVDAGFIS---STGVPSPPVGLGGGGQGSISTVP
MSMEG_0564|M.smegmatis_MC2_155 LAIT-AGIGLFILFIGVVDAGFIG---STGLPSPPVGLGAGGEGSINTVP
TH_1201|M.thermoresistible__bu LSIT-AGIGLFILFIGLVNAGFIG---STGLPSPPTGLGVDGGGSITTVP
MAB_3353c|M.abscessus_ATCC_199 AAIA-AGIGCFIAFIGFVDAGFVRRVPDAANTTVPVGLGIDN--SVATIP
Mb3301|M.bovis_AF2122/97 AMLAGIGITIALQQIHVLLGGTSHSSAWRNIVALPDGILHHELHEVIVGG
Rv3273|M.tuberculosis_H37Rv AMLAGIGITIALQQIHVLLGGTSHSSAWRNIVALPDGILHHELHEVIVGG
MMAR_1266|M.marinum_M AMLAGIGVTIVLQQIHVLMGGSAHSSAWRNIAALPNGILHHELHEVIVGG
MAV_0121|M.avium_104 AMLAGIGITIALQQVHVLLGGSSKSSAWSNVTGLPAQILGAHRPGLVLGL
:: *: : : .: .* * : :
Mflv_0346|M.gilvum_PYR-GCK TLVFILTLLLTAALVIRKVRG---GILIGLVCGTVVAVIIEAVWHLGSAV
Mvan_0392|M.vanbaalenii_PYR-1 TVIFVFTLLLTGVLVAKRVRG---GILIGLVIGTVIAVVVEAIWHLGSAT
MSMEG_0564|M.smegmatis_MC2_155 TVVFVFTLLVTGILVARRVRG---GILIGLVAGTVVAVVIEAIWHLGSAV
TH_1201|M.thermoresistible__bu TVLFVATLLVTGILIARRVRG---AILIGLIGGTVVAAVIEAVWHLGPAA
MAB_3353c|M.abscessus_ATCC_199 TLIFAAGVLLMGILVVRKVRG---GLLIGIVAMTVVSMIAQALCGRGAQP
Mb3301|M.bovis_AF2122/97 TVIAILLMWSKLPAKVRIIPGPLVAIAGATVLALLPVLQTERIDLQGNFF
Rv3273|M.tuberculosis_H37Rv TVIAILLMWSKLPAKVRIIPGPLVAIAGATVLALLPVLQTERIDLQGNFF
MMAR_1266|M.marinum_M TVIAILLVWSRLPAMVRMVPGPLVAIAGATALSLMVNLDVERINLSGNFF
MAV_0121|M.avium_104 LVIAILVAWRWVPARLAIVPGPLVAIVVVTIISMVLPFKVSRIELDGSVL
:: : * .: : . : *
Mflv_0346|M.gilvum_PYR-GCK DKPGGWSLSVPTLSGSPFALPDLSLVGEFS-LDSFGRIGVLAAVMLVFTL
Mvan_0392|M.vanbaalenii_PYR-1 EKPGGWSLSVPTLSGSPFSLPDLSLVGAFS-LDSFGRIGVLAAVMLVFTL
MSMEG_0564|M.smegmatis_MC2_155 EKPGGWGLSVPSLSGSPFAMPDLSLVGEVS-LGSFSRIGALAAIMLVFTL
TH_1201|M.thermoresistible__bu ERPGGWGLSVPALDGSPFALPDLSLIGEFS-FAGFSRIGVLAATVFVFTL
MAB_3353c|M.abscessus_ATCC_199 TDAKGWNLTVPDWPSSAGGMPDLSLLGQVDLFGAFTRVGVLSATVLVFAL
Mb3301|M.bovis_AF2122/97 DAIGLPKLAEMSPGGQPWSHEISAIALGVLTIALIASVESLLSAVGVDKL
Rv3273|M.tuberculosis_H37Rv DAIGLPKLAEMSPGGQPWSHEISAIALGVLTIALIASVESLLSAVGVDKL
MMAR_1266|M.marinum_M EAISLPRLPELTPDGQPWSNDISIIAVGVLTIALIASVESLLCAVGVDKL
MAV_0121|M.avium_104 DAVRLPSLPHGN-----WG----AVAIAVITVTLITSVQSLLTAVSIDRM
*. . : . . : : * : : :
Mflv_0346|M.gilvum_PYR-GCK VFANFFDAMGTMTGLSREAGLSDAKGTFPRLKSALIVEGAGAVVGGATSS
Mvan_0392|M.vanbaalenii_PYR-1 VFANFFDAMGTMTGLSREAGLSDANGTFPRLRSALVVEGAGAVVGGATSS
MSMEG_0564|M.smegmatis_MC2_155 VFANFFDAMGTMTGLSREAGLSDPQGTFPRLKSALIVEGTGAVVGGASSA
TH_1201|M.thermoresistible__bu VFANFFDAMGTFTGLSREAGLAGPDGTFPRLRSALVVEGVGAVAGGAASA
MAB_3353c|M.abscessus_ATCC_199 VLSNFFDAMGTMTGLGKEAGLADEHGTLPGIGRALTVEGVGAVIGGVSSS
Mb3301|M.bovis_AF2122/97 HHGPRTDFNREMVGQGSANVVSGLLGGLP--ITGVIVRSSANVAAGARTR
Rv3273|M.tuberculosis_H37Rv HHGPRTDFNREMVGQGSANVVSGLLGGLP--ITGVIVRSSANVAAGARTR
MMAR_1266|M.marinum_M HHGPRTNFNREMLGQGSANVLSGLLGGLP--VTGVIVRSSANVAAGARTR
MAV_0121|M.avium_104 HTGPRTDFNRELIGQGAANIASGALGGLP--IAGVIVRSSANVNAGAKTR
. : : * . :. * :* .: *.. . * .*. :
Mflv_0346|M.gilvum_PYR-GCK SS---NTVFIESGAGIEEGARTGLANVVAG--VLFLAAMFISPLASIVPT
Mvan_0392|M.vanbaalenii_PYR-1 SS---NTVFIESGAGIEEGARTGLANVVTG--LLFLAAMFVAPLASIVPT
MSMEG_0564|M.smegmatis_MC2_155 SS---NTVFIESGAGIEEGARTGLANLITG--VLFLAAMFVAPLASVVPT
TH_1201|M.thermoresistible__bu SS---NTVFVESGAGIGEGARTGLANLVTG--ALFLAAMFVSPLASVVPT
MAB_3353c|M.abscessus_ATCC_199 SS---NTVYVESASGIAEGARTGLANVVTG--LLFLAAMFFTPLYSVVPL
Mb3301|M.bovis_AF2122/97 MSTILHGVWILLFASLFTNLVELIPKAALAGLLIVIGAQLVKLAHIKLAW
Rv3273|M.tuberculosis_H37Rv MSTILHGVWILLFASLFTNLVELIPKAALAGLLIVIGAQLVKLAHIKLAW
MMAR_1266|M.marinum_M TSAVLHGVWILLFASLFTGLVELIPKAALAGLLIVVGAQLIQLAHIQIAW
MAV_0121|M.avium_104 ASTIMHGFWVLVFAVPFAGLVEKIPTAALAGLLIVIGIELLKPAHIETAL
* : .:: : . :.. . :.:. :. .
Mflv_0346|M.gilvum_PYR-GCK EVAAAALVVVGAMMVSQLRHIDLTDFSVALPVVLTVAVMPFSYSIANGIG
Mvan_0392|M.vanbaalenii_PYR-1 EVAAAALVVVGAMMVSHLRHIDLSEFSVALPVVLTVAVMPFSYSIANGIG
MSMEG_0564|M.smegmatis_MC2_155 EVAAAALVVVGAMMVSHLRHIDLSEFSVALPVVLTVATMAFSYSIANGIG
TH_1201|M.thermoresistible__bu EVAAAALVVVGAMMVSHLRHVDITEFSVALPVVLTVVSMPFSYSIANGIG
MAB_3353c|M.abscessus_ATCC_199 EAAAPALVVVGAMMIGQLRSVDLTRFDYALPCFLTVVTMPFTYSIANGIG
Mb3301|M.bovis_AF2122/97 RTGNFVIYAITIVCVVFLNLLEGVAIGLVVAIVFLLVRVVRAPVEVKPVG
Rv3273|M.tuberculosis_H37Rv RTGNFVIYAITIVCVVFLNLLEGVAIGLVVAIVFLLVRVVRAPVEVKPVG
MMAR_1266|M.marinum_M RTGNFAIYVITILGVIFLNLLEGVVIGLGVAIAFLLIRVIRAPIEARLVS
MAV_0121|M.avium_104 RNGDLAIYLVTVTSVIFLNLLHGVLIGLLLAVVVTGWRVVRARIEAEPVG
. . .: : : *. :. :. :. . : : .. :.
Mflv_0346|M.gilvum_PYR-GCK -----------VGFISWAVLRTAAGKGREISPLLWVVAAGFAVYFARTPL
Mvan_0392|M.vanbaalenii_PYR-1 -----------VGFITWVVMRTAAGKVREVSPLLWVVAAGFAVYFARTPL
MSMEG_0564|M.smegmatis_MC2_155 -----------VGFVAWVVLRSAAGKFREISPLLWVVALGFVLYFARGWI
TH_1201|M.thermoresistible__bu -----------IGFISWVVMRSAVGRAREVSPLLWVVAAGFLLYFARGWI
MAB_3353c|M.abscessus_ATCC_199 -----------VGFISWVVLALARGRFRSVHPLLYVVAMLFVIYFAKGPI
Mb3301|M.bovis_AF2122/97 GEQSKRWRVDIDGTLSFLLLPRLTTVLSKLPEGSEVTLNLNADYIDDSVS
Rv3273|M.tuberculosis_H37Rv GEQSKRWRVDIDGTLSFLLLPRLTTVLSKLPEGSEVTLNLNADYIDDSVS
MMAR_1266|M.marinum_M -EEAKRWRVDIDGTLSFLLLPRLTNVLSELPEGSDITLNLNADYIDHSVS
MAV_0121|M.avium_104 ----DGWHVVIEGACTFLALPRLTGVLASIPERTSVTVHLLTNYLDHAAH
* :: : .: :. *:
Mflv_0346|M.gilvum_PYR-GCK ESLLGV--------------------------------------------
Mvan_0392|M.vanbaalenii_PYR-1 ESLIGV--------------------------------------------
MSMEG_0564|M.smegmatis_MC2_155 ESFIGM--------------------------------------------
TH_1201|M.thermoresistible__bu EALAGV--------------------------------------------
MAB_3353c|M.abscessus_ATCC_199 EDLLAHGA------------------------------------------
Mb3301|M.bovis_AF2122/97 EAISDWRRAHETRGGVVAIVETSPAKLHHAHARPPKRHFASDPIGLVPWR
Rv3273|M.tuberculosis_H37Rv EAISDWRRAHETRGGVVAIVETSPAKLHHAHARPPKRHFASDPIGLVPWR
MMAR_1266|M.marinum_M EAISDWKTAHEATGGEVTIIETSPANLVSAHTSPPKRHFMSRAL-REPWT
MAV_0121|M.avium_104 QAIGDWQRRHCATGGTVEVRDTTEP-------------------------
: :
Mflv_0346|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_0392|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_0564|M.smegmatis_MC2_155 --------------------------------------------------
TH_1201|M.thermoresistible__bu --------------------------------------------------
MAB_3353c|M.abscessus_ATCC_199 --------------------------------------------------
Mb3301|M.bovis_AF2122/97 SAR-GKDRGSASVLDRIDEYHRNGAAVLHPHIAGLTDSQDPYELFLTCAD
Rv3273|M.tuberculosis_H37Rv SAR-GKDRGSASVLDRIDEYHRNGAAVLHPHIAGLTDSQDPYELFLTCAD
MMAR_1266|M.marinum_M SRRDSHPDAEPSIRHGVEEYHRNGIGTLHHHVRELMDPANPDTVFLTCAD
MAV_0121|M.avium_104 AAR-----------------RRN---------------------------
Mflv_0346|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_0392|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_0564|M.smegmatis_MC2_155 --------------------------------------------------
TH_1201|M.thermoresistible__bu --------------------------------------------------
MAB_3353c|M.abscessus_ATCC_199 --------------------------------------------------
Mb3301|M.bovis_AF2122/97 SRILPNVITASGPGDLYTVRNLGNLVPTDPDDRSVDAALDFAVNQLGVSS
Rv3273|M.tuberculosis_H37Rv SRILPNVITASGPGDLYTVRNLGNLVPTDPDDRSVDAALDFAVNQLGVSS
MMAR_1266|M.marinum_M SRILPDVITASKPGDLYIVRNVGNLVPIDPTERSVDAALDFAVNQLGVSS
MAV_0121|M.avium_104 -SHLSLVEQVSSPGGA----------------------------------
Mflv_0346|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_0392|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_0564|M.smegmatis_MC2_155 --------------------------------------------------
TH_1201|M.thermoresistible__bu --------------------------------------------------
MAB_3353c|M.abscessus_ATCC_199 --------------------------------------------------
Mb3301|M.bovis_AF2122/97 VVVCGHSSCAAMTALLEDDPANTTTPMMRWLENAHDSLVVFRNHHPARRS
Rv3273|M.tuberculosis_H37Rv VVVCGHSSCAAMTALLEDDPANTTTPMMRWLENAHDSLVVFRNHHPARRS
MMAR_1266|M.marinum_M VVVCGHSSCRSMQALLDNGASDVDRPMNHWLEHAHDSLAAFRDGHPARAS
MAV_0121|M.avium_104 --------------------------------------------------
Mflv_0346|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_0392|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_0564|M.smegmatis_MC2_155 --------------------------------------------------
TH_1201|M.thermoresistible__bu --------------------------------------------------
MAB_3353c|M.abscessus_ATCC_199 --------------------------------------------------
Mb3301|M.bovis_AF2122/97 AESAGYPEADQLSIVNVAVQVERLTRHPILATAVAAADLQVIGIFFDIST
Rv3273|M.tuberculosis_H37Rv AESAGYPEADQLSIVNVAVQVERLTRHPILATAVAAADLQVIGIFFDIST
MMAR_1266|M.marinum_M AASVGFGELDQLAVVNVAVQLERLAHNQVLAPAIASGAIQIVGMFFDFST
MAV_0121|M.avium_104 --------------------------------------------------
Mflv_0346|M.gilvum_PYR-GCK ----------------------------
Mvan_0392|M.vanbaalenii_PYR-1 ----------------------------
MSMEG_0564|M.smegmatis_MC2_155 ----------------------------
TH_1201|M.thermoresistible__bu ----------------------------
MAB_3353c|M.abscessus_ATCC_199 ----------------------------
Mb3301|M.bovis_AF2122/97 ARVYEVGPNGIICPDEPADRPVDHESAQ
Rv3273|M.tuberculosis_H37Rv ARVYEVGPNGIICPDEPADRPVDHESAQ
MMAR_1266|M.marinum_M VHVHEVDQLGIVASNQPVGKP-------
MAV_0121|M.avium_104 ----------------------------