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MSEIGVAVLGVGLMGADHVARIASRISGARVAVVNDQVTEKAERLAATITGCRAIADPLDAIADRDVDAV VLATPGPTHEKQLLACLEHRKPVLCEKPLTTDVETSLEVVRREAELGVRLIQVGFMRRFDDEYRALKALI DGGELGNPLVLHCVHRNPVVPGHFDSAMTVRDSLVHEVDVTRFLFDEEIVSIQIVKPTPNSLAREGLFDP QIAILRTASGRHVDVELFVTTGVAYEVRTELVAEKGSVIIGLDVGLVRKSAPGTWGGTITPSFKERFGQA YDTEIQRWVDAVRSGGTTGIYTDGPTAWDGYAATAVCEAGVQALQSGQPVAVSMVDRVSIPGA
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_0387 | - | - | 100% (343) | inositol 2-dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_4020 | - | e-149 | 76.85% (337) | inositol 2-dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_3968 | - | 2e-24 | 28.45% (348) | inositol 2-dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | - | - | - | - | - |
| M. gilvum PYR-GCK | Mflv_2598 | - | 1e-147 | 74.19% (341) | inositol 2-dehydrogenase |
| M. tuberculosis H37Rv | - | - | - | - | - |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_2306c | - | 7e-10 | 31.65% (139) | putative oxidoreductase |
| M. marinum M | MMAR_2628 | - | 2e-06 | 26.90% (145) | hypothetical protein MMAR_2628 |
| M. avium 104 | MAV_2643 | - | 2e-10 | 24.11% (365) | oxidoreductase family protein, NAD-binding Rossmann fold |
| M. smegmatis MC2 155 | MSMEG_4666 | - | 1e-146 | 73.04% (345) | myo-inositol 2-dehydrogenase |
| M. thermoresistible (build 8) | TH_3104 | - | 2e-05 | 23.05% (269) | PUTATIVE oxidoreductase domain protein |
| M. ulcerans Agy99 | - | - | - | - | - |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_0387|M.vanbaalenii_PYR-1 ----MSEIGVAVLGVGLMGADHVARIASRISGARVAVVNDQVTEKAERLA
MSMEG_4666|M.smegmatis_MC2_155 ----MSDLRVAVLGVGVMGADHVERLSTRIAGVKVAVVNDFIETRAEEIA
Mflv_2598|M.gilvum_PYR-GCK ----MTDLRIAVLGVGVMGADHVARITSRISGARVAVVNDHLVEKAEQLA
MAV_2643|M.avium_104 -----MTLRVGIIGVGWGARVQVPGFR-AAKGFEPVALCARTPDRLERAA
TH_3104|M.thermoresistible__bu -------MRVLVIGTGFGRQAMAPVYR--GLGFDVEVVSPRDESALHRAL
MAB_2306c|M.abscessus_ATCC_199 ---MPESIRWGIVGPGRIAGNVARDFP-LTPRAELAAVASRSLPRAQDFA
MMAR_2628|M.marinum_M MTGHGSPLRIGILGAARIAPQALVKPAQGNVEAVVAAVAARDGARAQAFA
: ::* . .: .
Mvan_0387|M.vanbaalenii_PYR-1 ATITGCRAIADPLDAIADRDVDAVVLATPGPTHEKQLLACLEHRKPVLCE
MSMEG_4666|M.smegmatis_MC2_155 AGVPGCRVVSDPLEAIADPDVDAVVLATPGPTHDKQLLACLEQRKPVLCE
Mflv_2598|M.gilvum_PYR-GCK ASIPGCSAVADPLDAIADADVDAVVLATPGGTHEEQLLACLDQRKPVMCE
MAV_2643|M.avium_104 AKLGIEQTSTDWQSFVTRDDLDVISVATPTVLHHEMTIAALAAGKPVLCE
TH_3104|M.thermoresistible__bu N-----------------AGVDLVSVHSPPFLHRQHVTAAVDRGYPVLCD
MAB_2306c|M.abscessus_ATCC_199 GAHQIPRAYGSYRELLADPDIDAVYIATPHPQHRQTAIAALTAGKAILVE
MMAR_2628|M.marinum_M AKHGISRVHSSYEALIADPTLDAVYIPLPNGLHGRWTQAALTAGKHVLCE
:* : : * * . *.: :: :
Mvan_0387|M.vanbaalenii_PYR-1 KPLTTDVETSLEVVRREAELGVRLIQVGFMRRFDDEYRALKALIDGGELG
MSMEG_4666|M.smegmatis_MC2_155 KPLTTDVDSALDVVRREAELGVRLIQVGFMRRFDPEYAELKTLIDAGEFG
Mflv_2598|M.gilvum_PYR-GCK KPLTTDVSTSLEIARREADLGRPLIQVGFMRRFDDEYVRLKALLDGGELG
MAV_2643|M.avium_104 KPLAGDLEAARHMVRAATDS-KLPTACCFENRWNPDWLAVADKVRSGFLG
TH_3104|M.thermoresistible__bu KPFGRNADEARAMRDHAARR-AVPTFLNFELRHQPARAEFKKLADSGVIG
MAB_2306c|M.abscessus_ATCC_199 KTFTATVSGAQEVIDIARARGVFAMEAMWT-RFQPAIVAAKDLVDDGAIG
MMAR_2628|M.marinum_M KPFTANAAEADEIAQLAATT-DRVVMEAFHYRYHPLTLRIEQILASGELG
*.: : : : * . * :*
Mvan_0387|M.vanbaalenii_PYR-1 -----------------NPLVLHCVHRNPVVPGHFDSAMTVRDSLVHEVD
MSMEG_4666|M.smegmatis_MC2_155 -----------------QPLVLHCVHRNAAVPPSFDSTMIVKDSLVHEVD
Mflv_2598|M.gilvum_PYR-GCK -----------------NPLMMHCVHRNPGVPAYFDSSLIVKDSLVHEVD
MAV_2643|M.avium_104 SQYLARVSRSASYWHPSHPLQAHWMYDREQGGGYLAGMLVHDLDFLTSLL
TH_3104|M.thermoresistible__bu ---TPRHLSWTFFGAGLRGRPHGWINERDTGGGWIGANGAHLIDYTRYLF
MAB_2306c|M.abscessus_ATCC_199 -----------------EVRQVQADLGVDRPFDREDRLFNPALGGGALLD
MMAR_2628|M.marinum_M ------------------TLQRVETSMCFPLPKFSDIRYNYALAGGATMD
:
Mvan_0387|M.vanbaalenii_PYR-1 VTRFLFDEEIV--SIQIVKPTPNSL-AREGLFDPQIAILRTASGRHVDVE
MSMEG_4666|M.smegmatis_MC2_155 VTRFLFDEEIA--SVHILRPTPNPG-APEGIQDPQIAIMKTPSGKHVDVE
Mflv_2598|M.gilvum_PYR-GCK ITRYLFGEEIA--SVQIIKPTSNPG-APNGVVDPQIAILRTVSGRHVDVE
MAV_2643|M.avium_104 GRPVSVCAEVR--TSDPVRELPDGGTLPVTADDTAALLMRMESGVTVILS
TH_3104|M.thermoresistible__bu GSEITGCGGVAR-IEDPHRPDPQGRPRRATAEDAYSAWFVTENGCTATHD
MAB_2306c|M.abscessus_ATCC_199 LGVYVVSLAQYF-LGDPAAVVAHGSLFPTGVDAEAGLLLRYDDGRTATLL
MMAR_2628|M.marinum_M AGCYAVHMARTFGGGTPEVVSAQAKRRDSEVDRAMTAELRFPAGHSGRIQ
.. : *
Mvan_0387|M.vanbaalenii_PYR-1 LFVTTGVAYEVRTELVAEKGSVIIGLDVGLVRKSAPGTWGGTITPSFKER
MSMEG_4666|M.smegmatis_MC2_155 LFVTTGVGYEVRTELVAEKGTAMIGLDVGLIRKGVPGTWGGAIAPDFRVR
Mflv_2598|M.gilvum_PYR-GCK LFVTTGVAYEVRTEVVGEHGSAIIGLDVGLIRKKGPGSWGGTLTPGFRER
MAV_2643|M.avium_104 LSVMGAHADHYRLELFGSDGTIIGDGDLRSAAYSLGAATDAGLSPLTVDE
TH_3104|M.thermoresistible__bu TAFAAAVALPPRMVLTGSAGALELIGDSRLIVHRADADPMTHEFPPAPPR
MAB_2306c|M.abscessus_ATCC_199 CSLLHHTPGQAR--IFGTEGWIDILPRFHHPREIVLHRKGAAPEPMVRPP
MMAR_2628|M.marinum_M CSMWSSHLLNMSARVVGDRGELRVLNPVVPQLFHRLTVQSAIGRRVERFP
. : . *
Mvan_0387|M.vanbaalenii_PYR-1 FGQAYDTEIQRWVDAVRSGGTTG--IYTDGPTAWDGYAATAVCEAGVQAL
MSMEG_4666|M.smegmatis_MC2_155 FGTAYDIEFQRWVAAVRHGIATGSDDYTDGPTAWDGYAAAAVCAAGVESL
Mflv_2598|M.gilvum_PYR-GCK FGPAYDTEIQRWVDAVHSG------TNVCGPTAWDGYAAAAVCAAGVESL
MAV_2643|M.avium_104 REPAHPERLPGGLAGHASR--------AMALMLQDWLPAFDGGPSGAATF
TH_3104|M.thermoresistible__bu --SFYEPALTPWLEQVADA-------------LRTGRPATPSFDDGVAVA
MAB_2306c|M.abscessus_ATCC_199 VGGGYSHELAEVTECLLNG-----------RAQSSVMPLADTLAVQRVLN
MMAR_2628|M.marinum_M RRASYAYQLDAFTGAILRG-------------EAVKTTPQDAVQNMTVID
: : .
Mvan_0387|M.vanbaalenii_PYR-1 QSGQPVAVSMVDRVSIPGA----------
MSMEG_4666|M.smegmatis_MC2_155 AGGQPVEVKMVERASINGA----------
Mflv_2598|M.gilvum_PYR-GCK ETGLPVDVQLADEVTSPSPQGVRESDGCR
MAV_2643|M.avium_104 EDG-LLSLAVIDAAHRSAEGGGWEQVQV-
TH_3104|M.thermoresistible__bu EVMDRLRANVIEQVMQ-------------
MAB_2306c|M.abscessus_ATCC_199 TACEQLGVDHTEDPADLD-----------
MMAR_2628|M.marinum_M AIYRAAGLPLRNPS---------------
: