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QPRPGGPRIHNAWWTAILLVMVAVFLVVTAGVYNGRFRAYVPVSLTSDRSGLVMETGAKVKLRGVEVGRV KNISGGDGPARLELAIYPDQIQFIPANVQAQIQATTAFGAKFVDLVYPADPSPDRLAAGAVLRSTNVSTE VNTIFENLSELLQMIDPAKLNAVLTAVADGVRGKGERMGQAATDLNVVLTALNERNETIRQDWRSFKDFN DTYATVASDIITILDGASTTSATVVDHADELDALLLNTIGLTRSGTELLGSSKDSLVGLVSTLEPTTGLL HKYSPVYTCWLQGTTWFLDNGGFDVWGGRNGRSIELDVGLLFGNDPYKYPENLPVIAAKGGPGGRPGCGS LPDATKNFPVRQLITNTGWGRGVDIRPNPGIGHPCWANYFPVTRANPEPPSIRQCLPGPAPGPIPYPGAP PYGAPLYGPGGVPLFPGVAPAPPAPPAALAPPAPPAP*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_3982 | - | - | 100% (458) | virulence factor Mce family protein |
| M. vanbaalenii PYR-1 | Mvan_0363 | - | 0.0 | 72.12% (452) | virulence factor Mce family protein |
| M. vanbaalenii PYR-1 | Mvan_4604 | - | e-160 | 60.99% (446) | virulence factor Mce family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3529c | mce4A | 2e-54 | 35.21% (338) | MCE-family protein MCE4A |
| M. gilvum PYR-GCK | Mflv_2101 | - | 1e-154 | 60.90% (445) | virulence factor Mce family protein |
| M. tuberculosis H37Rv | Rv1966 | mce3A | 1e-170 | 68.17% (421) | MCE-family protein MCE3A |
| M. leprae Br4923 | MLBr_02589 | mce1A | 2e-56 | 33.92% (395) | putative cell invasion protein |
| M. abscessus ATCC 19977 | MAB_4153c | - | 7e-59 | 38.12% (341) | MCE-family protein |
| M. marinum M | MMAR_2882 | mce3A | 1e-180 | 67.41% (451) | MCE-family protein Mce3A |
| M. avium 104 | MAV_2532 | - | 1e-147 | 61.23% (423) | virulence factor Mce family protein |
| M. smegmatis MC2 155 | MSMEG_0346 | - | 1e-167 | 61.54% (468) | virulence factor |
| M. thermoresistible (build 8) | TH_2548 | - | 1e-167 | 64.12% (432) | PUTATIVE virulence factor Mce family protein |
| M. ulcerans Agy99 | MUL_3918 | mce3A_1 | 1e-156 | 59.24% (449) | MCE-family protein Mce3A_1 |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3529c|M.bovis_AF2122/97 ----MSGGGSRRTSVRVAAALLAGLMVGSAVLTYLSYTAAFTSTDTVTVS
MAB_4153c|M.abscessus_ATCC_199 ----MSDTSTRR-AVRLAGTVLASVLVLLTVLTYLAYNDAFADTKPITVV
Rv1966|M.tuberculosis_H37Rv ---MRRGPGRHRLHDAWWTLILFAVIGVAVLVTAVSFTGSLRSTVPVTLA
MMAR_2882|M.marinum_M ---MGRGPGKHRLHDAWWTVILFAAIVAAILVTTVSFTGTLRPHVAVTLT
Mvan_3982|M.vanbaalenii_PYR-1 ---MQPRPGGPRIHNAWWTAILLVMVAVFLVVTAGVYNGRFRAYVPVSLT
TH_2548|M.thermoresistible__bu -------------------VILVAAVTVFIVVTSAFFRGAFTATVPVTLS
Mflv_2101|M.gilvum_PYR-GCK -----MDD--DGLKPGWWTLILVAVFAVAIFVTYALFTGSLKSTVPVTLT
MUL_3918|M.ulcerans_Agy99 -----MDDRKEGLHPAWHTLILVLLFVAAMWVTYALFMGSLRSVVPVTLT
MAV_2532|M.avium_104 ----------------------------------------------MTLT
MSMEG_0346|M.smegmatis_MC2_155 ---MQPRFRDARIKPAWWTWILIAALGVFFFTTGSLFAGTFRSFVPVTLV
MLBr_02589|M.leprae_Br4923 MTSSTKINASRKPPYKLAGVGLLVVAVVIFGLVYGQFRGNFTPKSKLTML
:::
Mb3529c|M.bovis_AF2122/97 SPRAGLVMEKGAKVKYRGIQVGKVTDISYSG----NQARLKLAIDSGEMG
MAB_4153c|M.abscessus_ATCC_199 SPRAGLVMEEGGKVKFHGLQIGKVTSISYAN----DQAKLELAVNAKDLR
Rv1966|M.tuberculosis_H37Rv ADRSGLVMDSGAKVMMRGVQVGRVAQIGRIEW-AQNGASLRLEIDPDQIR
MMAR_2882|M.marinum_M SERSGLVMDAGAKVMLRGVQVGRVRQID-----SNHGASLELEIDPDQIR
Mvan_3982|M.vanbaalenii_PYR-1 SDRSGLVMETGAKVKLRGVEVGRVKNISG----GDGPARLELAIYPDQIQ
TH_2548|M.thermoresistible__bu AERSGIILEPNAKVKMRGVEVGKVAHVEA----TGGAAQVRLELFPEQLA
Mflv_2101|M.gilvum_PYR-GCK SDRAGLVMETNAKVKLRGVQVGRVSDISVTGR-QDPTVALQLEIDPDQVQ
MUL_3918|M.ulcerans_Agy99 SERSGLVMETNAKVKLRGVQVGRVASIVGGGK-GATPVALTLEIDSDQIR
MAV_2532|M.avium_104 ADRSGLIMEPGAKVKLRGVQVGRVTSIHSGD-----PVTLRLELYPEQLQ
MSMEG_0346|M.smegmatis_MC2_155 SDRSGLVMETGAKVKLNGVEVGRVSEIRGGAS-G---VSLQLEIEPDQIR
MLBr_02589|M.leprae_Br4923 ADRAGLVMDRGSKITYNGVKIGRVADISETVRNGRPVAEFTLDVYPRYLS
: *:*:::: ..*: .*:::*:* : . . * : . :
Mb3529c|M.bovis_AF2122/97 FIPSNATVRIAGNTIFGAKSVEFIPPKTPSPKPLSPNAHVAASQVQLEVN
MAB_4153c|M.abscessus_ATCC_199 LIPSNATVRIAGTTVFGAKSVEFLAPQKPSDSSLRPGATVTAEAVALEVN
Rv1966|M.tuberculosis_H37Rv YIPANVEAQISATTAFGAKFVDLVMPQNPSRARLSAGAVLHSKNVSTEIN
MMAR_2882|M.marinum_M YIPANVEAQISATTAFGAKFVDLVIPPTPSRARLAAGAVLHSKNVSTEIN
Mvan_3982|M.vanbaalenii_PYR-1 FIPANVQAQIQATTAFGAKFVDLVYPADPSPDRLAAGAVLRSTNVSTEVN
TH_2548|M.thermoresistible__bu RIPANVMAEIDSTTAFGAKFVNLVYPDNPSEERLTAGAVLHADRVATEVN
Mflv_2101|M.gilvum_PYR-GCK YIPANVEAQIRATTIFGAKFVDLVFPDDPSNQRLEAGQVLQSRNVTTEVN
MUL_3918|M.ulcerans_Agy99 YIPANVQAEIRATTVFGAKFVDLIYPEDPSPQRLKAGQVLMSRNVTSEAN
MAV_2532|M.avium_104 YIPANVTAQITATTAFGGKYVDLQIPESPSPRRLAAGAVVRSRNVTTEVN
MSMEG_0346|M.smegmatis_MC2_155 FIPANVEARITATTAFGAKYVDLSYPDNPTGQHLAAGAVLRSRNVSTEVN
MLBr_02589|M.leprae_Br4923 LIPANVNADIKATTVFGGKYVSLTTPEHPSQKRLTPQTVIDARSVTTEIN
**:*. . * ..* **.* *.: * *: * . : : * * *
Mb3529c|M.bovis_AF2122/97 TLFQSLIDLLHKIDPLETNATLSALSEGLRGHGDDLGALLSGLNTLTRQA
MAB_4153c|M.abscessus_ATCC_199 TVFENLTRLLGKIDPVNLNATLTAVGEGLRGNGDNFGQGLVELDQYLDQL
Rv1966|M.tuberculosis_H37Rv TVFENVVDLLNMIDPLKLNAVLTAVADAVRGQGERIGQATTDLNEVLEAL
MMAR_2882|M.marinum_M TVFENVVDLLNMIDPLKLNAVLSAVAEGVRGQGERIGQATTDLNQVLQAL
Mvan_3982|M.vanbaalenii_PYR-1 TIFENLSELLQMIDPAKLNAVLTAVADGVRGKGERMGQAATDLNVVLTAL
TH_2548|M.thermoresistible__bu TVFENVVELIGMIDPAKLNAVLSATAEAVRGQGERIGEATTALSEVLQAV
Mflv_2101|M.gilvum_PYR-GCK TVFQNLVAVLDQVDAAKLNSTLSALADGVRGQGERIGRATTDANQVLLAL
MUL_3918|M.ulcerans_Agy99 TVFQNLVAVLDQIDPAKLNAALSALAEGLRGQGPLIGQATTDANQVLLEL
MAV_2532|M.avium_104 TVFQNLVAVLNQVDTPKLNAVLTALGDGLRGKGEALGEATTDLNEVLGAI
MSMEG_0346|M.smegmatis_MC2_155 TVFENLTDVLKMVDPAKLNAVLSALAEGFRGQGERMGQAITDANEVLMAI
MLBr_02589|M.leprae_Br4923 TLFQTITLIAEKVDPIKLNLTLSAAAQSLAGLGERFGQSIVNGNSVLDDV
*:*:.: : :*. : * .*:* .:.. * * :* .
Mb3529c|M.bovis_AF2122/97 NPKLPALQEDFRKAAVVANVYADAAGDLNTVFDNLPTINKTIVDQKDNLN
MAB_4153c|M.abscessus_ATCC_199 NPKLPALQQDFRQAGQVGQIYGDAAPDIVRILDNLPALSRTVVDQQQDLK
Rv1966|M.tuberculosis_H37Rv NARGDTIGGNWRSLKNFTDTYDAAAQDILTILNAASTTSATVVNHSTQLD
MMAR_2882|M.marinum_M NARRDTLRQNWRSLRDFSNTYDAAARDILTILDAASTTSTTVVDHARSLD
Mvan_3982|M.vanbaalenii_PYR-1 NERNETIRQDWRSFKDFNDTYATVASDIITILDGASTTSATVVDHADELD
TH_2548|M.thermoresistible__bu NDRSGLIREDWRAFKAFNDTYAAVAEDLLTVLDAASVTSETLVDHSAALD
Mflv_2101|M.gilvum_PYR-GCK NPRNETITEDLRALDQFNQTYSAAAQNILATLDAASTTSTTVVNQAKELD
MUL_3918|M.ulcerans_Agy99 NPRYETVTADLRAVKDFNDTFSAAAQDILDTLNALSTTSTTITGHSTQLD
MAV_2532|M.avium_104 NPRSETIRADSRALEGFSDTYSAAAHDIVTVLDAGSTTSATVSNNAQALD
MSMEG_0346|M.smegmatis_MC2_155 NPRQDTIREDWRAMGEVSAAYDHAADDIVKILDAGTTTAETVTSHRSELD
MLBr_02589|M.leprae_Br4923 NSQLPQARHDIQQLASLGDTYANSASDFFDFLNNSIVTSRTINQQQKDLD
* : : : . : * :: :: . *: : *.
Mb3529c|M.bovis_AF2122/97 DTLLATIGLSNNAYETLAPAEQNFIDAINRLRAPLKVTSDYSPVFGCLFK
MAB_4153c|M.abscessus_ATCC_199 ATLLAAIGLGNNGYETLAPAEKDLTAALQRLRAPATLLGRYSPEIPCTLQ
Rv1966|M.tuberculosis_H37Rv ALLLNAIGLSNAGTNLLGSSRDNLVGAADILAPTTSLLFKYNPEYTCFLQ
MMAR_2882|M.marinum_M SLLLNVIGLADTGTNLLANNRESLTTSINILEPTTNLLFKYNPEYTCLLQ
Mvan_3982|M.vanbaalenii_PYR-1 ALLLNTIGLTRSGTELLGSSKDSLVGLVSTLEPTTGLLHKYSPVYTCWLQ
TH_2548|M.thermoresistible__bu ALLLSVTGFGRAGSGLLEESRDDLVTAARVLEPTTALLHRYSPSYTCLLQ
Mflv_2101|M.gilvum_PYR-GCK ALLLAAIGLSNSGIDLLAPNQANLIKAVNTLAPTTNLLHKYSPSYTCLLL
MUL_3918|M.ulcerans_Agy99 ALLLATIGLSNTGISLLAPNQANLIKAINALEPTTNLLYKYSPEYTCLLE
MAV_2532|M.avium_104 SLLLNVIGLSHSGIGLIGPNKDNLVHGVNLLESTTRLLMKYNPELTCTLL
MSMEG_0346|M.smegmatis_MC2_155 TLLLNVIGFGRAGVDLLAPSFTNLVNAVNGFAPTSDLLMKYQPEYTCLLD
MLBr_02589|M.leprae_Br4923 QVLLAAVGFGNTGADIFSRSGPYLARGAADLVPTAQLLDTYSPAIFCTLR
** . *: . : : : .. : *.* * :
Mb3529c|M.bovis_AF2122/97 GIARGVKE--FAPLIGVRKAGLFTSSSFVLGAPSYTYP-ESLPIVNASGG
MAB_4153c|M.abscessus_ATCC_199 AISKALVT--FTPLIGGVRPGLFLTNSFPLGAPVYTYP-DSLPIVNASGG
Rv1966|M.tuberculosis_H37Rv GAKWYLDNGGYAAWGGADGRTLQLDVALLFGNDPYVYP-DNLPVVAAKGG
MMAR_2882|M.marinum_M GTKWYLDNGGYAAWGGADGRTLQLDVALLLGNDPYVFP-DNLPLVAARGG
Mvan_3982|M.vanbaalenii_PYR-1 GTTWFLDNGGFDVWGGRNGRSIELDVGLLFGNDPYKYP-ENLPVIAAKGG
TH_2548|M.thermoresistible__bu GAQLLLENGAYDVYGGADGRSLIFDVGLLPGNDLYEYP-RHLPVVAAKGG
Mflv_2101|M.gilvum_PYR-GCK GAKHLLDEGGYEAPGG-NGRTLVLDTSLSFGDDPYQYP-RHLPIIGAKGG
MUL_3918|M.ulcerans_Agy99 GAKYLLDHGGYEAPGG-NGRSLVLDAALALGDDPYRFP-DNLPIIGAKGG
MAV_2532|M.avium_104 GSKYDAEFFGDVAGGH-NGYSVTLDVALLLGDEAYRYP-DNLPINGAKGG
MSMEG_0346|M.smegmatis_MC2_155 GSVSLLQNGHVDAFGG-NGRSAIFDIGLLLGNDPYHYP-DDLPIVGAKGG
MLBr_02589|M.leprae_Br4923 --NYHDIEPKVTSFLGGNGYSINDHVELLSGLGFLLNPTSAISIIGAGVL
: * * :.: *
Mb3529c|M.bovis_AF2122/97 PN----CRGLPDIPTKQTG-----------GSFYRAPFLVTDNALIPYQP
MAB_4153c|M.abscessus_ATCC_199 PN----CRGLPNIPTKMQN-----------GSWFRSPFLVTDNAYIPYKP
Rv1966|M.tuberculosis_H37Rv PGGRPGCGPLPDATHNFPVRQLVTNTGWGTGLDIRPNPGIGHPCWANYFP
MMAR_2882|M.marinum_M PGGAPGCGSLPDATKNFPVRQLVTDTGWGTGLDIRPNPGIGHPCWADYLP
Mvan_3982|M.vanbaalenii_PYR-1 PGGRPGCGSLPDATKNFPVRQLITNTGWGRGVDIRPNPGIGHPCWANYFP
TH_2548|M.thermoresistible__bu PGGRPGCGSLPDVAENFPVRKLITDTGWGTGLDIRPNPGIGSPCFANWFP
Mflv_2101|M.gilvum_PYR-GCK PGGKPGCGSLPKVAENWPVRNLVTNTGFGSGLDWRPNPGIAFPTYANYLP
MUL_3918|M.ulcerans_Agy99 PGGKPGCGSLPIVDNNWPVRNLVTNTGFGTGMDWRPNPGIGFPGWANYFP
MAV_2532|M.avium_104 PGGQPGCGSLPDVSKNFPLRYLVTNTGWGRGLDMRPNPGIGFPGYVDYLP
MSMEG_0346|M.smegmatis_MC2_155 PGGKPGCGSLPDVAKNFPVRQLVTNTGWGTGLDIRPNPGIGFPGWANYFP
MLBr_02589|M.leprae_Br4923 SQGLLAPLGLAGVVNGAANPYIYPEN------LPRVNARGGPGGAPGCWQ
. *. *
Mb3529c|M.bovis_AF2122/97 FTELQVDAPSTLQFLFNGAFAERDDF------------------------
MAB_4153c|M.abscessus_ATCC_199 LEELQVNAPDTLQYLYNGAFAKRSEF------------------------
Rv1966|M.tuberculosis_H37Rv VTRAVPEPPSIRQCIPGPAIG--PNP----------------------AA
MMAR_2882|M.marinum_M VTRAVPQPPSVRPCLPGPAIG--PNPGGPPYGAALYGPGGVPLWPGVPPA
Mvan_3982|M.vanbaalenii_PYR-1 VTRANPEPPSIRQCLPGPAPGPIPYPGAPPYGAPLYGPGGVPLFPGVAPA
TH_2548|M.thermoresistible__bu VTRAVPEPPSIRTCLPGPAIGPVPYPGAPPYGAPMYGPGGVPLWPGVPPA
Mflv_2101|M.gilvum_PYR-GCK VTRAVPEPPSVRNLFGGPAIGPIPYPGAPAYGAQLYAPDGTPLWPGLPPA
MUL_3918|M.ulcerans_Agy99 VTRGTPEPPSIRNLFGGPAPGPIPYPGAPPYGAELYAPDGTPLWPGLPPA
MAV_2532|M.avium_104 VTRGTPQPPSLR-HPGGTAPGPMPYPGAPPYGAPQYAPDGTPLYPGLPPA
MSMEG_0346|M.smegmatis_MC2_155 VTRGIPQPPIIRNLGGGPAPGPIPYPGAPPYGADLYADDGTPLWPGLPPA
MLBr_02589|M.leprae_Br4923 HITRDLWPTPELVMDTGNSIAPYNHLDSGSPYAIEYVWGRQVGDNTINP-
.. . : .
Mb3529c|M.bovis_AF2122/97 --------------------------------------------------
MAB_4153c|M.abscessus_ATCC_199 --------------------------------------------------
Rv1966|M.tuberculosis_H37Rv GEQP----------------------------------------------
MMAR_2882|M.marinum_M PTEP-------APIPEPLAPQQETETPSP---------------------
Mvan_3982|M.vanbaalenii_PYR-1 PPAP-------PAALAPPAPPAP---------------------------
TH_2548|M.thermoresistible__bu GPEP-------GPAQPDSNGQTPP--------------------------
Mflv_2101|M.gilvum_PYR-GCK PPPG--APRDPGPRP-GSEPFVVPHPSQMQPTAVPYPFVPPPVPAQPGPP
MUL_3918|M.ulcerans_Agy99 PPPG--APRESGPTP-GSEPFVVPASAQAQPTPLP----PAPLPQEVAPS
MAV_2532|M.avium_104 PPPG--RPRDAGPPPAGSEPFTPPVPGAIQPTCGVLNQVCEPLPPPPNVP
MSMEG_0346|M.smegmatis_MC2_155 PPPSDQPPPDPNNPPPGAEPFVPPAPAAMTPTQ-----------------
MLBr_02589|M.leprae_Br4923 --------------------------------------------------
Mb3529c|M.bovis_AF2122/97 --
MAB_4153c|M.abscessus_ATCC_199 --
Rv1966|M.tuberculosis_H37Rv --
MMAR_2882|M.marinum_M --
Mvan_3982|M.vanbaalenii_PYR-1 --
TH_2548|M.thermoresistible__bu --
Mflv_2101|M.gilvum_PYR-GCK R-
MUL_3918|M.ulcerans_Agy99 P-
MAV_2532|M.avium_104 GP
MSMEG_0346|M.smegmatis_MC2_155 --
MLBr_02589|M.leprae_Br4923 --