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M. vanbaalenii PYR-1 Mvan_0353 (-)

annotation: AMP-dependent synthetase and ligase
coordinates: 385249 - 386853
length: 534

EHLDTGMWGVLPEVLDRACTYYSDRVAIVDGDRSLTYRELWLWRNRIANALIAAGVQKGDRVGLLMPNCL
EFIPVQQAVWAAGAVLVQMPTRAAADGFRSNLAQTDATTLLYHAKFEESVAAIRDELPKLQTVIRVGEPI
AALTEAADFAAVVSAAADTRPDVAVDEHDEAYVLFTSGSTGEPKGVVNSHYTWSYYAISAGLEIGDIRFG
EVFAHGAPLTHFTQIFVIPTFIRGGTNVMLPGLDVESLLSNIERHRVTATAVVPTIIYLLLDHAGRDRFD
IASLNTMIYAGAPMAPERLRQALDTFGPIFIQTYAGTEQGYVSCLRKHEHLAGEGESDEDWVARLASAGR
PMFAVQVTIRDDRDNVLPTGEAGEICTRQLGQMLGYLDAQRNAETVRDGWVHTGDIGRLDERGYLYLVDR
KKDMVVSGGFNVFPRQVEDVLCTHPTVAQAAVIGVPDPKWGESVLAMVVARPGEITGTELQLELVDHVKQ
ALGSIPAPKKILFTDELPLNPAGKVDKKAIRKPYWQSNSRQIG*
Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. vanbaalenii PYR-1Mvan_0353--100% (534)AMP-dependent synthetase and ligase
M. vanbaalenii PYR-1Mvan_0953-1e-7935.55% (526) acyl-CoA synthetase
M. vanbaalenii PYR-1Mvan_0943-2e-7537.09% (515) AMP-dependent synthetase and ligase

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb0566cfadD83e-7636.24% (516) acyl-CoA synthetase
M. gilvum PYR-GCKMflv_0015-2e-7835.73% (529) acyl-CoA synthetase
M. tuberculosis H37RvRv0551cfadD83e-7636.24% (516) acyl-CoA synthetase
M. leprae Br4923MLBr_02546fadD29e-5127.66% (517) acyl-CoA synthetase
M. abscessus ATCC 19977MAB_4626c-1e-7735.67% (513) acyl-CoA synthetase
M. marinum MMMAR_0897fadD87e-7634.79% (526) fatty-acid-CoA synthase, FadD8
M. avium 104MAV_4592-3e-7835.85% (530) acyl-CoA synthetase
M. smegmatis MC2 155MSMEG_0326-0.074.58% (531) AMP-dependent synthetase and ligase
M. thermoresistible (build 8)TH_2679-1e-8135.88% (524) PUTATIVE acyl-CoA synthase
M. ulcerans Agy99MUL_0650fadD81e-7534.79% (526) acyl-CoA synthetase

CLUSTAL 2.0.9 multiple sequence alignment


Mvan_0353|M.vanbaalenii_PYR-1       ------------------------------------MEHLD--TGMWGVL
MSMEG_0326|M.smegmatis_MC2_155      --------------------------------------MSN--DGMWGVL
MAV_4592|M.avium_104                --------------------------------------MGD--ELLRHPI
TH_2679|M.thermoresistible__bu      --------------------------------------MSD--QLLRHPL
Mflv_0015|M.gilvum_PYR-GCK          ---------------------------MTAVDVSSRERSSD--PQLRPFL
Mb0566c|M.bovis_AF2122/97           MSTAGDDAVGVPPACGGRSDAVGVPQLARESGAMRDQDCSG--ELLRSPT
Rv0551c|M.tuberculosis_H37Rv        MSTAGDDAVGVPPACGGRSDAVGVPQLARESGAMRDQDCSG--ELLRSPT
MMAR_0897|M.marinum_M               --------------------------------------MSD--DLLRNPT
MUL_0650|M.ulcerans_Agy99           --------------------------------------MSD--DLLRNPT
MAB_4626c|M.abscessus_ATCC_199      --------------------------------------MPDPFDPLHGSI
MLBr_02546|M.leprae_Br4923          ----MTKLRHYLERGAAEVHYLRSIFESGALGFEPPLTYAAMAVAMRKWG
                                                                                 :    

Mvan_0353|M.vanbaalenii_PYR-1       PEVLDRACTYYSDRVAIVDGDR--SLTYRELWLWRNRIANALIAAGVQKG
MSMEG_0326|M.smegmatis_MC2_155      PDVLDRACAYYGERTAILDAATGASVTYRELGQWRNQIAHALIDNGVQKG
MAV_4592|M.avium_104                HSGHLTVGALKRNKDKPVLHLGDTTLTGGQLAERISQYIQAFEALGAGTG
TH_2679|M.thermoresistible__bu      HSGHLTVGALKRNKDKPVLFLGDTTLTGGQLADRISQYIQAFEALGAGTG
Mflv_0015|M.gilvum_PYR-GCK          HSGHLTVGALKRHKDRPVLFLGDTTLTGGELADRISQYIQAFEALGAGTG
Mb0566c|M.bovis_AF2122/97           HNGHLLVGALKRHQNKPVLFLGDTRLTGGQLADRISQYIQAFEALGAGTG
Rv0551c|M.tuberculosis_H37Rv        HNGHLLVGALKRHQNKPVLFLGDTRLTGGQLADRISQYIQAFEALGAGTG
MMAR_0897|M.marinum_M               HNGHLLVGALKRHKNRPVLFLGDTTLTGGQLAERISQYIQAFEALGAGTG
MUL_0650|M.ulcerans_Agy99           HNGHLLVGALERHKNRPVLFLGDTTLTGGQLAERISQYIQAFEALGAGTG
MAB_4626c|M.abscessus_ATCC_199      NSGHLLVSALKRNRDAPALVLGDVTLTGAQMADEISKYIQAFIELVPDPT
MLBr_02546|M.leprae_Br4923          DLAMLPAMPARRSPHRAALIDEEGTLTYKELDRAAHALANGLIAKGVRGG
                                          . .                :*  ::        :.:        

Mvan_0353|M.vanbaalenii_PYR-1       DRVGLLMPNCLEFIPVQQAVWAAGAVLVQMPTRAAADGFRSNLAQTDATT
MSMEG_0326|M.smegmatis_MC2_155      ERVGLLMPNCLEFIPIQQAIWAAGAVLVQMPTRAAAEGFKSNLAQTDATT
MAV_4592|M.avium_104                ATVGLLSLNRPEVLMIIGAGQTQGYRRVALHPLGSLDDHAYVLDDAGVTS
TH_2679|M.thermoresistible__bu      AAVGLLSLNRPEVLMIIGAGQTQGYRRTALHPLGSLDDHAYVLSDAEVTS
Mflv_0015|M.gilvum_PYR-GCK          AAVGLLSLNRPEVLMIIGAGQTQGYRRTALHPLGSLDDHAYVLTDAEVTS
Mb0566c|M.bovis_AF2122/97           VAVGLLSLNRPEVLMIIGAGQARGYRRTALHPLGSLADHAYVLNDAGISS
Rv0551c|M.tuberculosis_H37Rv        VAVGLLSLNRPEVLMIIGAGQARGYRRTALHPLGSLADHAYVLNDAGISS
MMAR_0897|M.marinum_M               VTVGLLSLNRPEVLMILGASQARGYRRTALHPLGSLDDHAYVLSDAGASA
MUL_0650|M.ulcerans_Agy99           VTVGLLSLNRPEVLMILGASQARGYRRTALHPLGSLDDHAYVLYDAGASA
MAB_4626c|M.abscessus_ATCC_199      DGQGMLALNRPEVLLVIGAGQLLGTRRTALHPLGSLDDHAYVLADAKITT
MLBr_02546|M.leprae_Br4923          DGIAILARNHRWFVIANYGCARVGARIILLNSEFSGPQIKEVSEREGAKV
                                       .:*  *   .:    .    *     : .  :             . 

Mvan_0353|M.vanbaalenii_PYR-1       LLYHAK--FEESVAAIRDELPKLQTVIRVGEP-IAALTEAADFAAVVSAA
MSMEG_0326|M.smegmatis_MC2_155      LLYHAK--FEDAIASIRDGLPKLQTLIRVGTAENEKSVDALDFATLVAGQ
MAV_4592|M.avium_104                LIIDPTPAFVERALGLLEKVPGLKQILTIGPVPEALSGS---AVDLVAEA
TH_2679|M.thermoresistible__bu      LIIDPNPAFVERAHALLEKVPSLQRILTIGPVPPALDGV---AVDLTAEA
Mflv_0015|M.gilvum_PYR-GCK          LIIDPNPMFVERALGLVEKVPTLTQVLTIGPVPEEFAKAGVKAVDLSAEA
Mb0566c|M.bovis_AF2122/97           LIIDPNPMFVERALALLEQVDSLQQILTIGPVPDALKHV---AVDLSAEA
Rv0551c|M.tuberculosis_H37Rv        LIIDPNPMFVERALALLEQVDSLQQILTIGPVPDALKHV---AVDLSAEA
MMAR_0897|M.marinum_M               LIIDPNPMFVERALGLLEKVDSLEQVLTIGPVPEALEDR---AVDLSAEA
MUL_0650|M.ulcerans_Agy99           LIIDPNPMFVERALGLLEKVDSLEQVLTIGPVPEALEDR---AVDLSAEA
MAB_4626c|M.abscessus_ATCC_199      LVIDPTPQFVERAAALVAKVPTLTRVLTLGPVPAELAEVG---QDLVAAA
MLBr_02546|M.leprae_Br4923          IIYDDEY-----TKVVSKAEPALGKLRALGVNPDEEEPPGSTDETLAELI
                                    :: .           :      *  :  :*               :    

Mvan_0353|M.vanbaalenii_PYR-1       ADTRP----DVAVDEHDEAYVLFTSGSTGEPKGVVN-SHYTWSYYAISAG
MSMEG_0326|M.smegmatis_MC2_155      PTHRP----QVDIDEHDEAYVLFTSGSTGEPKGVVN-SHYTWSYYSISAG
MAV_4592|M.avium_104                AKYAPKPLVAADLPPDHIGGMAYTGGTTGKPKGVLG-TAQSITTMTT-IQ
TH_2679|M.thermoresistible__bu      AKYEPRPLVAADLPPDHIGGLTYTGGTTGKPKGVIG-TVQSITTMTT-IQ
Mflv_0015|M.gilvum_PYR-GCK          AKYSPRPLTAAALPPDHIGGLTYTGGTTGKPKGVIG-TTQSITTMTT-VQ
Mb0566c|M.bovis_AF2122/97           AKYQPQPLVAADLPPDQVIGLTYTGGTTGKPKGVIG-TAQSIATMTS-IQ
Rv0551c|M.tuberculosis_H37Rv        AKYQPQPLVAADLPPDQVIGLTYTGGTTGKPKGVIG-TAQSIATMTS-IQ
MMAR_0897|M.marinum_M               AKYQPKPLVVADLPPNHIGGLTYTGGTTGKPKGVIG-TAGNITAMTS-IQ
MUL_0650|M.ulcerans_Agy99           AKYQPKPLVVADLPPNHIGGLTYTGGTTGKPKGVIG-TAGNITAMTS-IQ
MAB_4626c|M.abscessus_ATCC_199      AGFAARPLTPINLSPDHINGLTYTGGTTGKPKGVIG-TSQSILTMTQ-IQ
MLBr_02546|M.leprae_Br4923          ARSSS---APAPKVRKRASIIILTSGTTGTPKGANRNTPASLAPLGG--I
                                    .   .          .    :  *.*:** ***.   :  .         

Mvan_0353|M.vanbaalenii_PYR-1       LEIGDIRFGEVFAHGAPLTHFT-QIFVIPTFIRGGTNVMLPGLDVESLLS
MSMEG_0326|M.smegmatis_MC2_155      LEIGDIRFGEVFAHGAPLTHFT-QIFVLPTFVRGGTNVMLPGLEPESLLT
MAV_4592|M.avium_104                LAEWEWPENPRFLMCTPLSHAG-AAFFVPTIIKGGELVVLTKFDPAEVLR
TH_2679|M.thermoresistible__bu      LAEWEWPENPRFLMCTPLSHAG-AAFFVPTIVKGGEMIVLPKFDPAEVLR
Mflv_0015|M.gilvum_PYR-GCK          LAEWEWPENPRFLMCTPLSHAG-AAFFTPVIVKGGELIVLTKFDPAEVLR
Mb0566c|M.bovis_AF2122/97           LAEWEWPANPRFLMCTPLSHAG-AAFFTPTVIKGGEMIVLAKFDPAEVLR
Rv0551c|M.tuberculosis_H37Rv        LAEWEWPANPRFLMCTPLSHAG-AAFFTPTVIKGGEMIVLAKFDPAEVLR
MMAR_0897|M.marinum_M               LAEWEWPEHPRFLMCTPLSHAG-AAFFTPTLVKGGEMIVLAKFDPGEVLR
MUL_0650|M.ulcerans_Agy99           LAEWEWPEHPRFLMCTPLSHAG-AAFFTPTLVKGGEMIVLAKFDPGEVLR
MAB_4626c|M.abscessus_ATCC_199      LAEWEWPERPKFLMCTPLSHAG-AAFFMPTLMKGGSMVVLPKFDAGAVLA
MLBr_02546|M.leprae_Br4923          LSKVPFRAHEVTLLPAPMFHALGYLHATLAMFLGSTLVLRRRFKPATVLE
                                    *              :*: *     .   ... *.  ::   :.   :* 

Mvan_0353|M.vanbaalenii_PYR-1       NIERHRVTATAVVPTIIYLLLDHAG--RDRFDIASLNTMIYAGAPMAPER
MSMEG_0326|M.smegmatis_MC2_155      FIERHGVTAVALVPTIIYLLLDHPR--RSEFDLSTLQTVVYAGSPIAPER
MAV_4592|M.avium_104                VIEEQKITATMLVPSMIYALMDHPD--SHTRDLSSLETVYYGASAMNPVR
TH_2679|M.thermoresistible__bu      VIEERRITATMLVPSMLYALLDHPD--SRTRDLSSLETVYYGASAINPVR
Mflv_0015|M.gilvum_PYR-GCK          VIEEQKITATMLVPSMIYALMDHPD--SHTRDLSSLETVYYGASAMNPVR
Mb0566c|M.bovis_AF2122/97           IIEEQRITATMLVPSMLYALLDHPD--SHTRDLSSLETVYYGASAINPVR
Rv0551c|M.tuberculosis_H37Rv        IIEEQRITATMLVPSMLYALLDHPD--SHTRDLSSLETVYYGASAINPVR
MMAR_0897|M.marinum_M               VIEEQRITATMLVPSMLYALMDHPD--SHTRDLSSLETVYYGASAINPVR
MUL_0650|M.ulcerans_Agy99           VIEEQRITATMLVPSMLYALMDHPD--PHTRDLSSLETVYYGASAINPVR
MAB_4626c|M.abscessus_ATCC_199      AIEEHQITATMLVPSMIYALLDHPD--SRTRDLSSLQTVYYGASAINPVR
MLBr_02546|M.leprae_Br4923          DIEKHQATAMVVVPVMLSRILDTLENLETKSDLSSLRVVFVSGSQLGAEL
                                     **.:  **  :** ::  ::*         *:::*..:  ..: : .  

Mvan_0353|M.vanbaalenii_PYR-1       LRQALDTFGPIFIQTYAGTEQGYVSCLRKHEHLAGEGESDEDWVARLASA
MSMEG_0326|M.smegmatis_MC2_155      LRQALEVFGPIFIQTYAGTEPGYVACLRKPEHVQREGESVEEWTARLAAA
MAV_4592|M.avium_104                LAEAIRRFGPIFAQYYGQSEAPMVISYLAKKDHDEK---------RLTSC
TH_2679|M.thermoresistible__bu      LKEAIDRFGPIFAQYYGQSEAPMVITYLPKGAHDEK---------RLTSC
Mflv_0015|M.gilvum_PYR-GCK          LKEAIRRFGPIFAQYYGQSEAPMVITYLSKKEHDDK---------RLTSC
Mb0566c|M.bovis_AF2122/97           LAEAIRRFGPIFAQYYGQSEAPMVITYLAKGDHDEK---------RLTSC
Rv0551c|M.tuberculosis_H37Rv        LAEAIRRFGPIFAQYYGQSEAPMVITYLAKGDHDEK---------RLTSC
MMAR_0897|M.marinum_M               LAEAIDRFGPIFAQYYGQSEAPMVITYLPKADHDEK---------RLTSC
MUL_0650|M.ulcerans_Agy99           LAEAIDRFGPIFAQYYGQSEAPMVITYLPKADHDEK---------RLTSC
MAB_4626c|M.abscessus_ATCC_199      LAEAIERFGPIFAQYFGQSEAPMVISYLAKGDHDAK---------RLSSC
MLBr_02546|M.leprae_Br4923          ATRALEELGPVIYNMYGSTEIAFATIAGPKDLQINS-----------ATV
                                      .*:  :**:: : :. :*   .           .           :: 

Mvan_0353|M.vanbaalenii_PYR-1       GRPMFAVQVTIRDDRDNVLPTGEAGEICTRQLGQMLGYLD-AQRNAETVR
MSMEG_0326|M.smegmatis_MC2_155      GRPMFPVRVSVQDENDRILPVGEVGEICSQQLGQMLSYLD-PARNAETLR
MAV_4592|M.avium_104                GRPTLFARTALLDADGNPVPQGEVGEICVSGPLLSGGYWNLPEETAKTFK
TH_2679|M.thermoresistible__bu      GRPTLFARTALLDPDGNPVPQGEVGEICVSGPLLAGGYWKLPEETAKTFK
Mflv_0015|M.gilvum_PYR-GCK          GRPTLFAKVALLGEDGQPVPQGEVGEICVSGPLLSGGYWNLPEATAETFR
Mb0566c|M.bovis_AF2122/97           GRPTLFARVALLDEHGKPVKQGEVGEICVSGPLLAGGYWNLPDETSRTFK
Rv0551c|M.tuberculosis_H37Rv        GRPTLFARVALLDEHGKPVKQGEVGEICVSGPLLAGGYWNLPDETSRTFK
MMAR_0897|M.marinum_M               GRPTLFARVALLGEDGKPVPQGEPGEICVSGPLLAGGYWNKPDDTAQTFR
MUL_0650|M.ulcerans_Agy99           GRPTLFARVALLGEDGKPVPQGEPGEICVSGPLLAGGYWNKPDDTAQTFR
MAB_4626c|M.abscessus_ATCC_199      GRPSAFLRTALLDENDRPVKQGEPGEICVAGPLVAGGYWGLPEQTAETFK
MLBr_02546|M.leprae_Br4923          GPVVKGVKVKILDDSGKEVPRGQVGRIFVGNAFPFEGYTG---GGGKQII
                                    *      :. : .  .. :  *: *.*         .*       .. . 

Mvan_0353|M.vanbaalenii_PYR-1       DGWVHTGDIGRLDERGYLYLVDRKKDMVVSGGFNVFPRQVEDVLCTHPTV
MSMEG_0326|M.smegmatis_MC2_155      DGWVHTGDVGYLDHDGYLYIVDRKKDMVVSGGFNVFPRQVEDALATHPAV
MAV_4592|M.avium_104                DGWLHTGDMAREDEDGFWFIVDRVKDMIVTGGFNVFPREVEDVVAEHPAV
TH_2679|M.thermoresistible__bu      DGWLRTGDMAREDEDGYWYIVDRVKDMIITGGFNVFPREVEDIVAEHPAV
Mflv_0015|M.gilvum_PYR-GCK          DGWMHTGDLAREDEDGFYFIVDRTKDMIVTGGFNVFPREVEDVVAEHPSI
Mb0566c|M.bovis_AF2122/97           DGWLHTGDLAREDSDGFYYIVDRVKDMIVTGGFNVFPREVEDVVAEHPAV
Rv0551c|M.tuberculosis_H37Rv        DGWLHTGDLAREDSDGFYYIVDRVKDMIVTGGFNVFPREVEDVVAEHPAV
MMAR_0897|M.marinum_M               DGWLHTGDMAREDEDGFYFIVDRVKDMIVTGGFNVFPREVEDVVAEHSAV
MUL_0650|M.ulcerans_Agy99           DGWLHTGDMAREDEDGFYFIVDRVKDMIVTGGFNVFPREVEDVVAEHSAV
MAB_4626c|M.abscessus_ATCC_199      NGWLRTGDVAREDEDGFWFIVDRTKDMIVTGGFNVFPREVEDVVAEHPSV
MLBr_02546|M.leprae_Br4923          DGLLSSGDVGYFDEHDLLYISGRDDEMIVSGGENVFPAEVEDLISGHPEV
                                    :* : :**:.  *  .  :: .* .:*:::** **** :*** :. *. :

Mvan_0353|M.vanbaalenii_PYR-1       AQAAVIGVPDPKWGESVLAMVVARPGEITG----TELQLELVDHVKQALG
MSMEG_0326|M.smegmatis_MC2_155      AQSAVIGVPHEKWGEAVMAVVVPQSGEITG----PELESELIKHVKAALG
MAV_4592|M.avium_104                AQVCVIGTPDEKWGEAVTAVIVLRPDHPSDEESVAKVTAEIQAAVKERKG
TH_2679|M.thermoresistible__bu      AQVCVIGTPDEKWGEAVTAVIVLRPEVDRDEANVERIKDEIRASVKERKG
Mflv_0015|M.gilvum_PYR-GCK          AQVCVIGTPDEKWGEAVTAVVVLRPDAASDAAAVEVMISEIQASVKERKG
Mb0566c|M.bovis_AF2122/97           AQVCVVGAPDEKWGEAVTAVVVLRSNAARDEPAIEAMTAEIQAAVKQRKG
Rv0551c|M.tuberculosis_H37Rv        AQVCVVGAPDEKWGEAVTAVVVLRSNAARDEPAIEAMTAEIQAAVKQRKG
MMAR_0897|M.marinum_M               AQVCVVGAPDEKWGEAVTAVVVLRADAARDDAAIETMTAEIQAAVKQRKG
MUL_0650|M.ulcerans_Agy99           AQVCVVGAPDEKWGEAVTAVVVLRADAARDDAAIETMTAEIQAAVKQRKG
MAB_4626c|M.abscessus_ATCC_199      AQVGVIGVPDEKWGEAVTAIVVLRSDASSDEEAVALMTSEIQSAVKERKG
MLBr_02546|M.leprae_Br4923          VEATAIGVDDKEWGARLRAFVVKKQDATID-------EDAIKAYVRDHLA
                                    .:  .:*. . :**  : *.:* :     .          :   *:   .

Mvan_0353|M.vanbaalenii_PYR-1       SIPAPKKILFTDELPLNPAGKVDKKAIRKPYWQSNSRQIG
MSMEG_0326|M.smegmatis_MC2_155      SVAAPKTVLFADSLPLNPAGKVDKKAIRKPYWRNQTRQVG
MAV_4592|M.avium_104                SVQSPKQVIVVDSVPVTALGKPDKKAVRARFWEGAGRAVG
TH_2679|M.thermoresistible__bu      SVQAPKQVIVVDSVPTTALGKPDKKAVRARFWKDSERAIG
Mflv_0015|M.gilvum_PYR-GCK          SVHVPKQVVVTDSVPITALGKPDKKAVRAQFWESAGRAVG
Mb0566c|M.bovis_AF2122/97           SVQAPKRVVVVDSLPLTGLGKPDKKAVRARFWEGAGRAVG
Rv0551c|M.tuberculosis_H37Rv        SVQAPKRVVVVDSLPLTGLGKPDKKAVRARFWEGAGRAVG
MMAR_0897|M.marinum_M               SVQSPKQVVVVDSLPLTGLGKPDKKAVRARFWEGAGRAVG
MUL_0650|M.ulcerans_Agy99           SVQSPKQVVVVDSLPLTGLGKPDKKAVRARFWEGAGRAVG
MAB_4626c|M.abscessus_ATCC_199      SVQSPKHVIIADSLPLTALGKLDKKALRQKYATV------
MLBr_02546|M.leprae_Br4923          RYKVPREVIFLEELPRNPTGKVLKRELRDFEVH-------
                                        *: ::. :.:* .  **  *: :*