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M. thermoresistible (build 8) TH_2679 (-)

annotation: acyl-CoA synthase
coordinates: 323706 - 325307
length: 534

aa seq not available

Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. thermoresistible (build 8)TH_2679--100% (534)acyl-CoA synthase
M. thermoresistible (build 8)TH_2854-4e-7534.04% (520) PUTATIVE putative AMP-dependent synthetase and ligase
M. thermoresistible (build 8)TH_3645-9e-6734.58% (480) PUTATIVE AMP-dependent synthetase and ligase

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb0566cfadD80.083.08% (532) acyl-CoA synthetase
M. gilvum PYR-GCKMflv_0015-0.083.74% (535) acyl-CoA synthetase
M. tuberculosis H37RvRv0551cfadD80.083.08% (532) acyl-CoA synthetase
M. leprae Br4923MLBr_02546fadD25e-3929.60% (429) acyl-CoA synthetase
M. abscessus ATCC 19977MAB_4626c-0.072.50% (520) acyl-CoA synthetase
M. marinum MMMAR_0897fadD80.081.99% (533) fatty-acid-CoA synthase, FadD8
M. avium 104MAV_4592-0.087.05% (533) acyl-CoA synthetase
M. smegmatis MC2 155MSMEG_1098-0.087.78% (532) acyl-CoA synthetase
M. ulcerans Agy99MUL_0650fadD80.081.43% (533) acyl-CoA synthetase
M. vanbaalenii PYR-1Mvan_0953-0.086.30% (533) acyl-CoA synthetase

CLUSTAL 2.0.9 multiple sequence alignment


Mb0566c|M.bovis_AF2122/97           MSTAGDDAVGVPPACGGRSDAVGVPQLARESGAMRDQDCSGELLRSPTHN
Rv0551c|M.tuberculosis_H37Rv        MSTAGDDAVGVPPACGGRSDAVGVPQLARESGAMRDQDCSGELLRSPTHN
MMAR_0897|M.marinum_M               --------------------------------------MSDDLLRNPTHN
MUL_0650|M.ulcerans_Agy99           --------------------------------------MSDDLLRNPTHN
TH_2679|M.thermoresistible__bu      --------------------------------------MSDQLLRHPLHS
MSMEG_1098|M.smegmatis_MC2_155      --------------------------------MTQVKSSSPDLLRHPTHS
MAV_4592|M.avium_104                --------------------------------------MGDELLRHPIHS
Mflv_0015|M.gilvum_PYR-GCK          ---------------------------MTAVDVSSRERSSDPQLRPFLHS
Mvan_0953|M.vanbaalenii_PYR-1       --------------------------------------MSD-QLRHFLHS
MAB_4626c|M.abscessus_ATCC_199      ------------------------------------MPDPFDPLHGSINS
MLBr_02546|M.leprae_Br4923          --MTKLRHYLERGAAEVHYLRSIFESGALGFEPPLTYAAMAVAMRKWGDL
                                                                               ::   . 

Mb0566c|M.bovis_AF2122/97           GHLLVGALKRHQNKPVLFLGDTRLTGGQLADRISQYIQAFEALGAGTGVA
Rv0551c|M.tuberculosis_H37Rv        GHLLVGALKRHQNKPVLFLGDTRLTGGQLADRISQYIQAFEALGAGTGVA
MMAR_0897|M.marinum_M               GHLLVGALKRHKNRPVLFLGDTTLTGGQLAERISQYIQAFEALGAGTGVT
MUL_0650|M.ulcerans_Agy99           GHLLVGALERHKNRPVLFLGDTTLTGGQLAERISQYIQAFEALGAGTGVT
TH_2679|M.thermoresistible__bu      GHLTVGALKRNKDKPVLFLGDTTLTGGQLADRISQYIQAFEALGAGTGAA
MSMEG_1098|M.smegmatis_MC2_155      GHLTVAALKRNRDKPVLFLGDTTLTGGELADRISQYIQAFEALGAGSGEG
MAV_4592|M.avium_104                GHLTVGALKRNKDKPVLHLGDTTLTGGQLAERISQYIQAFEALGAGTGAT
Mflv_0015|M.gilvum_PYR-GCK          GHLTVGALKRHKDRPVLFLGDTTLTGGELADRISQYIQAFEALGAGTGAA
Mvan_0953|M.vanbaalenii_PYR-1       GHLTVGALKRHKDKPVLFLGDTTLTGGELADRISQYIQAFEALGAGTGAA
MAB_4626c|M.abscessus_ATCC_199      GHLLVSALKRNRDAPALVLGDVTLTGAQMADEISKYIQAFIELVPDPTDG
MLBr_02546|M.leprae_Br4923          AMLPAMPARRSPHRAALIDEEGTLTYKELDRAAHALANGLIAKGVRGGDG
                                    . * . . .*  . ..*   :  **  ::        :.:          

Mb0566c|M.bovis_AF2122/97           VGLLSLNRPEVLMIIGAGQARGYRRTALHPLGSLADHAYVLNDAGISSLI
Rv0551c|M.tuberculosis_H37Rv        VGLLSLNRPEVLMIIGAGQARGYRRTALHPLGSLADHAYVLNDAGISSLI
MMAR_0897|M.marinum_M               VGLLSLNRPEVLMILGASQARGYRRTALHPLGSLDDHAYVLSDAGASALI
MUL_0650|M.ulcerans_Agy99           VGLLSLNRPEVLMILGASQARGYRRTALHPLGSLDDHAYVLYDAGASALI
TH_2679|M.thermoresistible__bu      VGLLSLNRPEVLMIIGAGQTQGYRRTALHPLGSLDDHAYVLSDAEVTSLI
MSMEG_1098|M.smegmatis_MC2_155      VGLLSLNRPEVLMIIGAGQTQGYRRTALHPLGSLDDHAYVLSDAEVTTLI
MAV_4592|M.avium_104                VGLLSLNRPEVLMIIGAGQTQGYRRVALHPLGSLDDHAYVLDDAGVTSLI
Mflv_0015|M.gilvum_PYR-GCK          VGLLSLNRPEVLMIIGAGQTQGYRRTALHPLGSLDDHAYVLTDAEVTSLI
Mvan_0953|M.vanbaalenii_PYR-1       VGLLSLNRPEVLMIIGAGQTQGYRRTALHPLGSLDDHAYVLSDAEVTSLI
MAB_4626c|M.abscessus_ATCC_199      QGMLALNRPEVLLVIGAGQLLGTRRTALHPLGSLDDHAYVLADAKITTLV
MLBr_02546|M.leprae_Br4923          IAILARNHRWFVIANYGCARVGARIILLNSEFSGPQIKEVSEREGAKVII
                                     .:*: *:  .::   .    * *   *:.  *  :   *      . ::

Mb0566c|M.bovis_AF2122/97           IDPNPMFVERALALLEQVDSLQQILTIGPVPDALKHV---AVDLSAEAAK
Rv0551c|M.tuberculosis_H37Rv        IDPNPMFVERALALLEQVDSLQQILTIGPVPDALKHV---AVDLSAEAAK
MMAR_0897|M.marinum_M               IDPNPMFVERALGLLEKVDSLEQVLTIGPVPEALEDR---AVDLSAEAAK
MUL_0650|M.ulcerans_Agy99           IDPNPMFVERALGLLEKVDSLEQVLTIGPVPEALEDR---AVDLSAEAAK
TH_2679|M.thermoresistible__bu      IDPNPAFVERAHALLEKVPSLQRILTIGPVPPALDGV---AVDLTAEAAK
MSMEG_1098|M.smegmatis_MC2_155      IDPTPAFVERALGLLEKVPTLRQILTIGPVPEALAGV---ATDLNAEAAK
MAV_4592|M.avium_104                IDPTPAFVERALGLLEKVPGLKQILTIGPVPEALSGS---AVDLVAEAAK
Mflv_0015|M.gilvum_PYR-GCK          IDPNPMFVERALGLVEKVPTLTQVLTIGPVPEEFAKAGVKAVDLSAEAAK
Mvan_0953|M.vanbaalenii_PYR-1       IDPNPMFVERALGLLEKVPSLKQVLTIGPVPAELSDV---AVDLSAEAAK
MAB_4626c|M.abscessus_ATCC_199      IDPTPQFVERAAALVAKVPTLTRVLTLGPVPAELAEVG---QDLVAAAAG
MLBr_02546|M.leprae_Br4923          YDD-----EYTKVVSKAEPALGKLRALGVNPDEEEPP---GSTDETLAEL
                                     *      * :  :      * :: ::*  *              : *  

Mb0566c|M.bovis_AF2122/97           YQPQPLVAADLPPDQVIGLTYTGGTTGKPKGVIGTAQSIATMTSIQLAEW
Rv0551c|M.tuberculosis_H37Rv        YQPQPLVAADLPPDQVIGLTYTGGTTGKPKGVIGTAQSIATMTSIQLAEW
MMAR_0897|M.marinum_M               YQPKPLVVADLPPNHIGGLTYTGGTTGKPKGVIGTAGNITAMTSIQLAEW
MUL_0650|M.ulcerans_Agy99           YQPKPLVVADLPPNHIGGLTYTGGTTGKPKGVIGTAGNITAMTSIQLAEW
TH_2679|M.thermoresistible__bu      YEPRPLVAADLPPDHIGGLTYTGGTTGKPKGVIGTVQSITTMTTIQLAEW
MSMEG_1098|M.smegmatis_MC2_155      YPAKPLVAAELPPDHIGGLTYTGGTTGKPKGVMGTVRSITTMTTIQLAEW
MAV_4592|M.avium_104                YAPKPLVAADLPPDHIGGMAYTGGTTGKPKGVLGTAQSITTMTTIQLAEW
Mflv_0015|M.gilvum_PYR-GCK          YSPRPLTAAALPPDHIGGLTYTGGTTGKPKGVIGTTQSITTMTTVQLAEW
Mvan_0953|M.vanbaalenii_PYR-1       YAPKPLVAADLPPDHIGGLTYTGGTTGKPKGVIGTTQSITTMTTVQLAEW
MAB_4626c|M.abscessus_ATCC_199      FAARPLTPINLSPDHINGLTYTGGTTGKPKGVIGTSQSILTMTQIQLAEW
MLBr_02546|M.leprae_Br4923          IARSSSAPAPKVRKRASIIILTSGTTGTPKGANRNTPASLAPLGGILSKV
                                        . .      .:   :  *.****.***.  .     :     *:: 

Mb0566c|M.bovis_AF2122/97           EWPANPRFLMCTPLSHAG-AAFFTPTVIKGGEMIVLAKFDPAEVLRIIEE
Rv0551c|M.tuberculosis_H37Rv        EWPANPRFLMCTPLSHAG-AAFFTPTVIKGGEMIVLAKFDPAEVLRIIEE
MMAR_0897|M.marinum_M               EWPEHPRFLMCTPLSHAG-AAFFTPTLVKGGEMIVLAKFDPGEVLRVIEE
MUL_0650|M.ulcerans_Agy99           EWPEHPRFLMCTPLSHAG-AAFFTPTLVKGGEMIVLAKFDPGEVLRVIEE
TH_2679|M.thermoresistible__bu      EWPENPRFLMCTPLSHAG-AAFFVPTIVKGGEMIVLPKFDPAEVLRVIEE
MSMEG_1098|M.smegmatis_MC2_155      EWPENPRFLMCTPLSHAG-AAFFVPTIVKGGEMIVLPKFDPGEVLRVIEE
MAV_4592|M.avium_104                EWPENPRFLMCTPLSHAG-AAFFVPTIIKGGELVVLTKFDPAEVLRVIEE
Mflv_0015|M.gilvum_PYR-GCK          EWPENPRFLMCTPLSHAG-AAFFTPVIVKGGELIVLTKFDPAEVLRVIEE
Mvan_0953|M.vanbaalenii_PYR-1       EWPENPRFLMCTPLSHAG-AAFFTPVIVKGGELIVLTKFDPAEVLRVIEE
MAB_4626c|M.abscessus_ATCC_199      EWPERPKFLMCTPLSHAG-AAFFMPTLMKGGSMVVLPKFDAGAVLAAIEE
MLBr_02546|M.leprae_Br4923          PFRAHEVTLLPAPMFHALGYLHATLAMFLGSTLVLRRRFKPATVLEDIEK
                                     :  .   *: :*: **    .   .:. *. :::  :*... **  **:

Mb0566c|M.bovis_AF2122/97           QRITATMLVPSMLYALLDHPD--SHTRDLSSLETVYYGASAINPVRLAEA
Rv0551c|M.tuberculosis_H37Rv        QRITATMLVPSMLYALLDHPD--SHTRDLSSLETVYYGASAINPVRLAEA
MMAR_0897|M.marinum_M               QRITATMLVPSMLYALMDHPD--SHTRDLSSLETVYYGASAINPVRLAEA
MUL_0650|M.ulcerans_Agy99           QRITATMLVPSMLYALMDHPD--PHTRDLSSLETVYYGASAINPVRLAEA
TH_2679|M.thermoresistible__bu      RRITATMLVPSMLYALLDHPD--SRTRDLSSLETVYYGASAINPVRLKEA
MSMEG_1098|M.smegmatis_MC2_155      RRITATMLVPSMLYALLDHPD--SHTRDLSSLETVYYGASAMNPVRLAEA
MAV_4592|M.avium_104                QKITATMLVPSMIYALMDHPD--SHTRDLSSLETVYYGASAMNPVRLAEA
Mflv_0015|M.gilvum_PYR-GCK          QKITATMLVPSMIYALMDHPD--SHTRDLSSLETVYYGASAMNPVRLKEA
Mvan_0953|M.vanbaalenii_PYR-1       QKITATMLVPSMIYALMDHPD--SHTRDLSSLETVYYGASAMNPVRLAEA
MAB_4626c|M.abscessus_ATCC_199      HQITATMLVPSMIYALLDHPD--SRTRDLSSLQTVYYGASAINPVRLAEA
MLBr_02546|M.leprae_Br4923          HQATAMVVVPVMLSRILDTLENLETKSDLSSLRVVFVSGSQLGAELATRA
                                    :: ** ::** *:  ::*  :    . *****..*: ..* :..    .*

Mb0566c|M.bovis_AF2122/97           IRRFGPIFAQYYGQSEAPMVITYLAKGDHDEKRLTSCGRPTLFARVALLD
Rv0551c|M.tuberculosis_H37Rv        IRRFGPIFAQYYGQSEAPMVITYLAKGDHDEKRLTSCGRPTLFARVALLD
MMAR_0897|M.marinum_M               IDRFGPIFAQYYGQSEAPMVITYLPKADHDEKRLTSCGRPTLFARVALLG
MUL_0650|M.ulcerans_Agy99           IDRFGPIFAQYYGQSEAPMVITYLPKADHDEKRLTSCGRPTLFARVALLG
TH_2679|M.thermoresistible__bu      IDRFGPIFAQYYGQSEAPMVITYLPKGAHDEKRLTSCGRPTLFARTALLD
MSMEG_1098|M.smegmatis_MC2_155      LKRFGPIFAQYYGQSEAPMVISYLGKKDHDEKRLTSCGRPTMFARTALLD
MAV_4592|M.avium_104                IRRFGPIFAQYYGQSEAPMVISYLAKKDHDEKRLTSCGRPTLFARTALLD
Mflv_0015|M.gilvum_PYR-GCK          IRRFGPIFAQYYGQSEAPMVITYLSKKEHDDKRLTSCGRPTLFAKVALLG
Mvan_0953|M.vanbaalenii_PYR-1       IRRFGPIFAQYYGQSEAPMVITYLSKKDHDEKRLTSCGRPTLFARVALLG
MAB_4626c|M.abscessus_ATCC_199      IERFGPIFAQYFGQSEAPMVISYLAKGDHDAKRLSSCGRPSAFLRTALLD
MLBr_02546|M.leprae_Br4923          LEELGPVIYNMYG--STEIAFATIAGPKDLQINSATVGPVVKGVKVKILD
                                    : .:**:: : :*  .: :.:: :    .   . :: *      :. :*.

Mb0566c|M.bovis_AF2122/97           EHGKPVKQGEVGEICVSGPLLAGGYWNLPDETSRTFKDGWLHTGDLARED
Rv0551c|M.tuberculosis_H37Rv        EHGKPVKQGEVGEICVSGPLLAGGYWNLPDETSRTFKDGWLHTGDLARED
MMAR_0897|M.marinum_M               EDGKPVPQGEPGEICVSGPLLAGGYWNKPDDTAQTFRDGWLHTGDMARED
MUL_0650|M.ulcerans_Agy99           EDGKPVPQGEPGEICVSGPLLAGGYWNKPDDTAQTFRDGWLHTGDMARED
TH_2679|M.thermoresistible__bu      PDGNPVPQGEVGEICVSGPLLAGGYWKLPEETAKTFKDGWLRTGDMARED
MSMEG_1098|M.smegmatis_MC2_155      PEGNPVPQGEVGEICVSGPLLAGGYWKLPDATAETFKDGWLHTGDMARED
MAV_4592|M.avium_104                ADGNPVPQGEVGEICVSGPLLSGGYWNLPEETAKTFKDGWLHTGDMARED
Mflv_0015|M.gilvum_PYR-GCK          EDGQPVPQGEVGEICVSGPLLSGGYWNLPEATAETFRDGWMHTGDLARED
Mvan_0953|M.vanbaalenii_PYR-1       EDGQPVPQGEVGEICVSGPLLSGGYWNLPEATAETFRDGWMHTGDLARED
MAB_4626c|M.abscessus_ATCC_199      ENDRPVKQGEPGEICVAGPLVAGGYWGLPEQTAETFKNGWLRTGDVARED
MLBr_02546|M.leprae_Br4923          DSGKEVPRGQVGRIFVGNAFPFEGYTG---GGGKQIIDGLLSSGDVGYFD
                                      .. * :*: *.* *...:   **       .. : :* : :**:.  *

Mb0566c|M.bovis_AF2122/97           SDGFYYIVDRVKDMIVTGGFNVFPREVEDVVAEHPAVAQVCVVGAPDEKW
Rv0551c|M.tuberculosis_H37Rv        SDGFYYIVDRVKDMIVTGGFNVFPREVEDVVAEHPAVAQVCVVGAPDEKW
MMAR_0897|M.marinum_M               EDGFYFIVDRVKDMIVTGGFNVFPREVEDVVAEHSAVAQVCVVGAPDEKW
MUL_0650|M.ulcerans_Agy99           EDGFYFIVDRVKDMIVTGGFNVFPREVEDVVAEHSAVAQVCVVGAPDEKW
TH_2679|M.thermoresistible__bu      EDGYWYIVDRVKDMIITGGFNVFPREVEDIVAEHPAVAQVCVIGTPDEKW
MSMEG_1098|M.smegmatis_MC2_155      EDGYWFIVDRVKDMIVTGGFNVFPREVEDVVAEHPSVAQVCVIGTPDEKW
MAV_4592|M.avium_104                EDGFWFIVDRVKDMIVTGGFNVFPREVEDVVAEHPAVAQVCVIGTPDEKW
Mflv_0015|M.gilvum_PYR-GCK          EDGFYFIVDRTKDMIVTGGFNVFPREVEDVVAEHPSIAQVCVIGTPDEKW
Mvan_0953|M.vanbaalenii_PYR-1       EDGFYFIVDRTKDMIVTGGFNVFPREVEDVVAEHPSIAQVCVIGTPDEKW
MAB_4626c|M.abscessus_ATCC_199      EDGFWFIVDRTKDMIVTGGFNVFPREVEDVVAEHPSVAQVGVIGVPDEKW
MLBr_02546|M.leprae_Br4923          EHDLLYISGRDDEMIVSGGENVFPAEVEDLISGHPEVVEATAIGVDDKEW
                                    ...  :* .* .:**::** **** ****::: *. :.:. .:*. *::*

Mb0566c|M.bovis_AF2122/97           GEAVTAVVVLRSNAARDEPAIEAMTAEIQAAVKQRKGSVQAPKRVVVVDS
Rv0551c|M.tuberculosis_H37Rv        GEAVTAVVVLRSNAARDEPAIEAMTAEIQAAVKQRKGSVQAPKRVVVVDS
MMAR_0897|M.marinum_M               GEAVTAVVVLRADAARDDAAIETMTAEIQAAVKQRKGSVQSPKQVVVVDS
MUL_0650|M.ulcerans_Agy99           GEAVTAVVVLRADAARDDAAIETMTAEIQAAVKQRKGSVQSPKQVVVVDS
TH_2679|M.thermoresistible__bu      GEAVTAVIVLRPEVDRDEANVERIKDEIRASVKERKGSVQAPKQVIVVDS
MSMEG_1098|M.smegmatis_MC2_155      GEAVTAVVVLRPDADRSEEGIERLTAEIQASVKERKGSVQSPKQVIVVDS
MAV_4592|M.avium_104                GEAVTAVIVLRPDHPSDEESVAKVTAEIQAAVKERKGSVQSPKQVIVVDS
Mflv_0015|M.gilvum_PYR-GCK          GEAVTAVVVLRPDAASDAAAVEVMISEIQASVKERKGSVHVPKQVVVTDS
Mvan_0953|M.vanbaalenii_PYR-1       GEAVTAVVVLRPDADSSEAAVETMTVEIQASVKERKGSVHTPKQVIVVDS
MAB_4626c|M.abscessus_ATCC_199      GEAVTAIVVLRSDASSDEEAVALMTSEIQSAVKERKGSVQSPKHVIIADS
MLBr_02546|M.leprae_Br4923          GARLRAFVVKKQDATIDED-------AIKAYVRDHLARYKVPREVIFLEE
                                    *  : *.:* : :   .          *:: *::: .  : *:.*:. :.

Mb0566c|M.bovis_AF2122/97           LPLTGLGKPDKKAVRARFWEGAGRAVG
Rv0551c|M.tuberculosis_H37Rv        LPLTGLGKPDKKAVRARFWEGAGRAVG
MMAR_0897|M.marinum_M               LPLTGLGKPDKKAVRARFWEGAGRAVG
MUL_0650|M.ulcerans_Agy99           LPLTGLGKPDKKAVRARFWEGAGRAVG
TH_2679|M.thermoresistible__bu      VPTTALGKPDKKAVRARFWKDSERAIG
MSMEG_1098|M.smegmatis_MC2_155      VPVTALGKPDKKAVRAQFWEGAARAVG
MAV_4592|M.avium_104                VPVTALGKPDKKAVRARFWEGAGRAVG
Mflv_0015|M.gilvum_PYR-GCK          VPITALGKPDKKAVRAQFWESAGRAVG
Mvan_0953|M.vanbaalenii_PYR-1       VPVTALGKPDKKAVRARFWEGAGRSIG
MAB_4626c|M.abscessus_ATCC_199      LPLTALGKLDKKALRQKYATV------
MLBr_02546|M.leprae_Br4923          LPRNPTGKVLKRELRDFEVH-------
                                    :* .  **  *: :*