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MSNDGMWGVLPDVLDRACAYYGERTAILDAATGASVTYRELGQWRNQIAHALIDNGVQKGERVGLLMPNC LEFIPIQQAIWAAGAVLVQMPTRAAAEGFKSNLAQTDATTLLYHAKFEDAIASIRDGLPKLQTLIRVGTA ENEKSVDALDFATLVAGQPTHRPQVDIDEHDEAYVLFTSGSTGEPKGVVNSHYTWSYYSISAGLEIGDIR FGEVFAHGAPLTHFTQIFVLPTFVRGGTNVMLPGLEPESLLTFIERHGVTAVALVPTIIYLLLDHPRRSE FDLSTLQTVVYAGSPIAPERLRQALEVFGPIFIQTYAGTEPGYVACLRKPEHVQREGESVEEWTARLAAA GRPMFPVRVSVQDENDRILPVGEVGEICSQQLGQMLSYLDPARNAETLRDGWVHTGDVGYLDHDGYLYIV DRKKDMVVSGGFNVFPRQVEDALATHPAVAQSAVIGVPHEKWGEAVMAVVVPQSGEITGPELESELIKHV KAALGSVAAPKTVLFADSLPLNPAGKVDKKAIRKPYWRNQTRQVG
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_0326 | - | - | 100% (535) | AMP-dependent synthetase and ligase |
| M. smegmatis MC2 155 | MSMEG_1098 | - | 1e-78 | 36.89% (515) | acyl-CoA synthetase |
| M. smegmatis MC2 155 | MSMEG_2883 | - | 3e-67 | 33.64% (538) | acyl-CoA synthetase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0566c | fadD8 | 1e-76 | 37.18% (511) | acyl-CoA synthetase |
| M. gilvum PYR-GCK | Mflv_0015 | - | 6e-76 | 35.53% (546) | acyl-CoA synthetase |
| M. tuberculosis H37Rv | Rv0551c | fadD8 | 1e-76 | 37.18% (511) | acyl-CoA synthetase |
| M. leprae Br4923 | MLBr_02546 | fadD2 | 1e-48 | 27.97% (522) | acyl-CoA synthetase |
| M. abscessus ATCC 19977 | MAB_4626c | - | 4e-77 | 40.60% (436) | acyl-CoA synthetase |
| M. marinum M | MMAR_0897 | fadD8 | 3e-76 | 35.60% (514) | fatty-acid-CoA synthase, FadD8 |
| M. avium 104 | MAV_4592 | - | 4e-77 | 36.17% (517) | acyl-CoA synthetase |
| M. thermoresistible (build 8) | TH_2679 | - | 8e-79 | 36.31% (515) | PUTATIVE acyl-CoA synthase |
| M. ulcerans Agy99 | MUL_0650 | fadD8 | 6e-76 | 35.60% (514) | acyl-CoA synthetase |
| M. vanbaalenii PYR-1 | Mvan_0353 | - | 0.0 | 74.58% (531) | AMP-dependent synthetase and ligase |
CLUSTAL 2.0.9 multiple sequence alignment
MSMEG_0326|M.smegmatis_MC2_155 --------------------------------------MSN--DGMWGVL
Mvan_0353|M.vanbaalenii_PYR-1 ------------------------------------MEHLD--TGMWGVL
MAV_4592|M.avium_104 --------------------------------------MGD--ELLRHPI
TH_2679|M.thermoresistible__bu --------------------------------------MSD--QLLRHPL
Mflv_0015|M.gilvum_PYR-GCK ---------------------------MTAVDVSSRERSSD--PQLRPFL
Mb0566c|M.bovis_AF2122/97 MSTAGDDAVGVPPACGGRSDAVGVPQLARESGAMRDQDCSG--ELLRSPT
Rv0551c|M.tuberculosis_H37Rv MSTAGDDAVGVPPACGGRSDAVGVPQLARESGAMRDQDCSG--ELLRSPT
MMAR_0897|M.marinum_M --------------------------------------MSD--DLLRNPT
MUL_0650|M.ulcerans_Agy99 --------------------------------------MSD--DLLRNPT
MAB_4626c|M.abscessus_ATCC_199 --------------------------------------MPDPFDPLHGSI
MLBr_02546|M.leprae_Br4923 ----MTKLRHYLERGAAEVHYLRSIFESGALGFEPPLTYAAMAVAMRKWG
:
MSMEG_0326|M.smegmatis_MC2_155 PDVLDRACAYYGERTAILDAATGASVTYRELGQWRNQIAHALIDNGVQKG
Mvan_0353|M.vanbaalenii_PYR-1 PEVLDRACTYYSDRVAIVDGDR--SLTYRELWLWRNRIANALIAAGVQKG
MAV_4592|M.avium_104 HSGHLTVGALKRNKDKPVLHLGDTTLTGGQLAERISQYIQAFEALGAGTG
TH_2679|M.thermoresistible__bu HSGHLTVGALKRNKDKPVLFLGDTTLTGGQLADRISQYIQAFEALGAGTG
Mflv_0015|M.gilvum_PYR-GCK HSGHLTVGALKRHKDRPVLFLGDTTLTGGELADRISQYIQAFEALGAGTG
Mb0566c|M.bovis_AF2122/97 HNGHLLVGALKRHQNKPVLFLGDTRLTGGQLADRISQYIQAFEALGAGTG
Rv0551c|M.tuberculosis_H37Rv HNGHLLVGALKRHQNKPVLFLGDTRLTGGQLADRISQYIQAFEALGAGTG
MMAR_0897|M.marinum_M HNGHLLVGALKRHKNRPVLFLGDTTLTGGQLAERISQYIQAFEALGAGTG
MUL_0650|M.ulcerans_Agy99 HNGHLLVGALERHKNRPVLFLGDTTLTGGQLAERISQYIQAFEALGAGTG
MAB_4626c|M.abscessus_ATCC_199 NSGHLLVSALKRNRDAPALVLGDVTLTGAQMADEISKYIQAFIELVPDPT
MLBr_02546|M.leprae_Br4923 DLAMLPAMPARRSPHRAALIDEEGTLTYKELDRAAHALANGLIAKGVRGG
. . :* :: :.:
MSMEG_0326|M.smegmatis_MC2_155 ERVGLLMPNCLEFIPIQQAIWAAGAVLVQMPTRAAAEGFKSNLAQTDATT
Mvan_0353|M.vanbaalenii_PYR-1 DRVGLLMPNCLEFIPVQQAVWAAGAVLVQMPTRAAADGFRSNLAQTDATT
MAV_4592|M.avium_104 ATVGLLSLNRPEVLMIIGAGQTQGYRRVALHPLGSLDDHAYVLDDAGVTS
TH_2679|M.thermoresistible__bu AAVGLLSLNRPEVLMIIGAGQTQGYRRTALHPLGSLDDHAYVLSDAEVTS
Mflv_0015|M.gilvum_PYR-GCK AAVGLLSLNRPEVLMIIGAGQTQGYRRTALHPLGSLDDHAYVLTDAEVTS
Mb0566c|M.bovis_AF2122/97 VAVGLLSLNRPEVLMIIGAGQARGYRRTALHPLGSLADHAYVLNDAGISS
Rv0551c|M.tuberculosis_H37Rv VAVGLLSLNRPEVLMIIGAGQARGYRRTALHPLGSLADHAYVLNDAGISS
MMAR_0897|M.marinum_M VTVGLLSLNRPEVLMILGASQARGYRRTALHPLGSLDDHAYVLSDAGASA
MUL_0650|M.ulcerans_Agy99 VTVGLLSLNRPEVLMILGASQARGYRRTALHPLGSLDDHAYVLYDAGASA
MAB_4626c|M.abscessus_ATCC_199 DGQGMLALNRPEVLLVIGAGQLLGTRRTALHPLGSLDDHAYVLADAKITT
MLBr_02546|M.leprae_Br4923 DGIAILARNHRWFVIANYGCARVGARIILLNSEFSGPQIKEVSEREGAKV
.:* * .: . * : . : .
MSMEG_0326|M.smegmatis_MC2_155 LLYHAK--FEDAIASIRDGLPKLQTLIRVGTAENEKSVDALDFATLVAGQ
Mvan_0353|M.vanbaalenii_PYR-1 LLYHAK--FEESVAAIRDELPKLQTVIRVGEP-IAALTEAADFAAVVSAA
MAV_4592|M.avium_104 LIIDPTPAFVERALGLLEKVPGLKQILTIGPVPEALSGS---AVDLVAEA
TH_2679|M.thermoresistible__bu LIIDPNPAFVERAHALLEKVPSLQRILTIGPVPPALDGV---AVDLTAEA
Mflv_0015|M.gilvum_PYR-GCK LIIDPNPMFVERALGLVEKVPTLTQVLTIGPVPEEFAKAGVKAVDLSAEA
Mb0566c|M.bovis_AF2122/97 LIIDPNPMFVERALALLEQVDSLQQILTIGPVPDALKHV---AVDLSAEA
Rv0551c|M.tuberculosis_H37Rv LIIDPNPMFVERALALLEQVDSLQQILTIGPVPDALKHV---AVDLSAEA
MMAR_0897|M.marinum_M LIIDPNPMFVERALGLLEKVDSLEQVLTIGPVPEALEDR---AVDLSAEA
MUL_0650|M.ulcerans_Agy99 LIIDPNPMFVERALGLLEKVDSLEQVLTIGPVPEALEDR---AVDLSAEA
MAB_4626c|M.abscessus_ATCC_199 LVIDPTPQFVERAAALVAKVPTLTRVLTLGPVPAELAEVG---QDLVAAA
MLBr_02546|M.leprae_Br4923 IIYDDEY-----TKVVSKAEPALGKLRALGVNPDEEEPPGSTDETLAELI
:: . : * : :* :
MSMEG_0326|M.smegmatis_MC2_155 PTHRP----QVDIDEHDEAYVLFTSGSTGEPKGVVN-SHYTWSYYSISAG
Mvan_0353|M.vanbaalenii_PYR-1 ADTRP----DVAVDEHDEAYVLFTSGSTGEPKGVVN-SHYTWSYYAISAG
MAV_4592|M.avium_104 AKYAPKPLVAADLPPDHIGGMAYTGGTTGKPKGVLG-TAQSITTMTT-IQ
TH_2679|M.thermoresistible__bu AKYEPRPLVAADLPPDHIGGLTYTGGTTGKPKGVIG-TVQSITTMTT-IQ
Mflv_0015|M.gilvum_PYR-GCK AKYSPRPLTAAALPPDHIGGLTYTGGTTGKPKGVIG-TTQSITTMTT-VQ
Mb0566c|M.bovis_AF2122/97 AKYQPQPLVAADLPPDQVIGLTYTGGTTGKPKGVIG-TAQSIATMTS-IQ
Rv0551c|M.tuberculosis_H37Rv AKYQPQPLVAADLPPDQVIGLTYTGGTTGKPKGVIG-TAQSIATMTS-IQ
MMAR_0897|M.marinum_M AKYQPKPLVVADLPPNHIGGLTYTGGTTGKPKGVIG-TAGNITAMTS-IQ
MUL_0650|M.ulcerans_Agy99 AKYQPKPLVVADLPPNHIGGLTYTGGTTGKPKGVIG-TAGNITAMTS-IQ
MAB_4626c|M.abscessus_ATCC_199 AGFAARPLTPINLSPDHINGLTYTGGTTGKPKGVIG-TSQSILTMTQ-IQ
MLBr_02546|M.leprae_Br4923 ARSSS---APAPKVRKRASIIILTSGTTGTPKGANRNTPASLAPLGG--I
. . . : *.*:** ***. : .
MSMEG_0326|M.smegmatis_MC2_155 LEIGDIRFGEVFAHGAPLTHFT-QIFVLPTFVRGGTNVMLPGLEPESLLT
Mvan_0353|M.vanbaalenii_PYR-1 LEIGDIRFGEVFAHGAPLTHFT-QIFVIPTFIRGGTNVMLPGLDVESLLS
MAV_4592|M.avium_104 LAEWEWPENPRFLMCTPLSHAG-AAFFVPTIIKGGELVVLTKFDPAEVLR
TH_2679|M.thermoresistible__bu LAEWEWPENPRFLMCTPLSHAG-AAFFVPTIVKGGEMIVLPKFDPAEVLR
Mflv_0015|M.gilvum_PYR-GCK LAEWEWPENPRFLMCTPLSHAG-AAFFTPVIVKGGELIVLTKFDPAEVLR
Mb0566c|M.bovis_AF2122/97 LAEWEWPANPRFLMCTPLSHAG-AAFFTPTVIKGGEMIVLAKFDPAEVLR
Rv0551c|M.tuberculosis_H37Rv LAEWEWPANPRFLMCTPLSHAG-AAFFTPTVIKGGEMIVLAKFDPAEVLR
MMAR_0897|M.marinum_M LAEWEWPEHPRFLMCTPLSHAG-AAFFTPTLVKGGEMIVLAKFDPGEVLR
MUL_0650|M.ulcerans_Agy99 LAEWEWPEHPRFLMCTPLSHAG-AAFFTPTLVKGGEMIVLAKFDPGEVLR
MAB_4626c|M.abscessus_ATCC_199 LAEWEWPERPKFLMCTPLSHAG-AAFFMPTLMKGGSMVVLPKFDAGAVLA
MLBr_02546|M.leprae_Br4923 LSKVPFRAHEVTLLPAPMFHALGYLHATLAMFLGSTLVLRRRFKPATVLE
* :*: * . ... *. :: :. :*
MSMEG_0326|M.smegmatis_MC2_155 FIERHGVTAVALVPTIIYLLLDHPR--RSEFDLSTLQTVVYAGSPIAPER
Mvan_0353|M.vanbaalenii_PYR-1 NIERHRVTATAVVPTIIYLLLDHAG--RDRFDIASLNTMIYAGAPMAPER
MAV_4592|M.avium_104 VIEEQKITATMLVPSMIYALMDHPD--SHTRDLSSLETVYYGASAMNPVR
TH_2679|M.thermoresistible__bu VIEERRITATMLVPSMLYALLDHPD--SRTRDLSSLETVYYGASAINPVR
Mflv_0015|M.gilvum_PYR-GCK VIEEQKITATMLVPSMIYALMDHPD--SHTRDLSSLETVYYGASAMNPVR
Mb0566c|M.bovis_AF2122/97 IIEEQRITATMLVPSMLYALLDHPD--SHTRDLSSLETVYYGASAINPVR
Rv0551c|M.tuberculosis_H37Rv IIEEQRITATMLVPSMLYALLDHPD--SHTRDLSSLETVYYGASAINPVR
MMAR_0897|M.marinum_M VIEEQRITATMLVPSMLYALMDHPD--SHTRDLSSLETVYYGASAINPVR
MUL_0650|M.ulcerans_Agy99 VIEEQRITATMLVPSMLYALMDHPD--PHTRDLSSLETVYYGASAINPVR
MAB_4626c|M.abscessus_ATCC_199 AIEEHQITATMLVPSMIYALLDHPD--SRTRDLSSLQTVYYGASAINPVR
MLBr_02546|M.leprae_Br4923 DIEKHQATAMVVVPVMLSRILDTLENLETKSDLSSLRVVFVSGSQLGAEL
**.: ** :** :: ::* *:::*..: ..: : .
MSMEG_0326|M.smegmatis_MC2_155 LRQALEVFGPIFIQTYAGTEPGYVACLRKPEHVQREGESVEEWTARLAAA
Mvan_0353|M.vanbaalenii_PYR-1 LRQALDTFGPIFIQTYAGTEQGYVSCLRKHEHLAGEGESDEDWVARLASA
MAV_4592|M.avium_104 LAEAIRRFGPIFAQYYGQSEAPMVISYLAKKDHDEK---------RLTSC
TH_2679|M.thermoresistible__bu LKEAIDRFGPIFAQYYGQSEAPMVITYLPKGAHDEK---------RLTSC
Mflv_0015|M.gilvum_PYR-GCK LKEAIRRFGPIFAQYYGQSEAPMVITYLSKKEHDDK---------RLTSC
Mb0566c|M.bovis_AF2122/97 LAEAIRRFGPIFAQYYGQSEAPMVITYLAKGDHDEK---------RLTSC
Rv0551c|M.tuberculosis_H37Rv LAEAIRRFGPIFAQYYGQSEAPMVITYLAKGDHDEK---------RLTSC
MMAR_0897|M.marinum_M LAEAIDRFGPIFAQYYGQSEAPMVITYLPKADHDEK---------RLTSC
MUL_0650|M.ulcerans_Agy99 LAEAIDRFGPIFAQYYGQSEAPMVITYLPKADHDEK---------RLTSC
MAB_4626c|M.abscessus_ATCC_199 LAEAIERFGPIFAQYFGQSEAPMVISYLAKGDHDAK---------RLSSC
MLBr_02546|M.leprae_Br4923 ATRALEELGPVIYNMYGSTEIAFATIAGPKDLQINS-----------ATV
.*: :**:: : :. :* . . ::
MSMEG_0326|M.smegmatis_MC2_155 GRPMFPVRVSVQDENDRILPVGEVGEICSQQLGQMLSYLD-PARNAETLR
Mvan_0353|M.vanbaalenii_PYR-1 GRPMFAVQVTIRDDRDNVLPTGEAGEICTRQLGQMLGYLD-AQRNAETVR
MAV_4592|M.avium_104 GRPTLFARTALLDADGNPVPQGEVGEICVSGPLLSGGYWNLPEETAKTFK
TH_2679|M.thermoresistible__bu GRPTLFARTALLDPDGNPVPQGEVGEICVSGPLLAGGYWKLPEETAKTFK
Mflv_0015|M.gilvum_PYR-GCK GRPTLFAKVALLGEDGQPVPQGEVGEICVSGPLLSGGYWNLPEATAETFR
Mb0566c|M.bovis_AF2122/97 GRPTLFARVALLDEHGKPVKQGEVGEICVSGPLLAGGYWNLPDETSRTFK
Rv0551c|M.tuberculosis_H37Rv GRPTLFARVALLDEHGKPVKQGEVGEICVSGPLLAGGYWNLPDETSRTFK
MMAR_0897|M.marinum_M GRPTLFARVALLGEDGKPVPQGEPGEICVSGPLLAGGYWNKPDDTAQTFR
MUL_0650|M.ulcerans_Agy99 GRPTLFARVALLGEDGKPVPQGEPGEICVSGPLLAGGYWNKPDDTAQTFR
MAB_4626c|M.abscessus_ATCC_199 GRPSAFLRTALLDENDRPVKQGEPGEICVAGPLVAGGYWGLPEQTAETFK
MLBr_02546|M.leprae_Br4923 GPVVKGVKVKILDDSGKEVPRGQVGRIFVGNAFPFEGYTG---GGGKQII
* :. : . .. : *: *.* .* .. .
MSMEG_0326|M.smegmatis_MC2_155 DGWVHTGDVGYLDHDGYLYIVDRKKDMVVSGGFNVFPRQVEDALATHPAV
Mvan_0353|M.vanbaalenii_PYR-1 DGWVHTGDIGRLDERGYLYLVDRKKDMVVSGGFNVFPRQVEDVLCTHPTV
MAV_4592|M.avium_104 DGWLHTGDMAREDEDGFWFIVDRVKDMIVTGGFNVFPREVEDVVAEHPAV
TH_2679|M.thermoresistible__bu DGWLRTGDMAREDEDGYWYIVDRVKDMIITGGFNVFPREVEDIVAEHPAV
Mflv_0015|M.gilvum_PYR-GCK DGWMHTGDLAREDEDGFYFIVDRTKDMIVTGGFNVFPREVEDVVAEHPSI
Mb0566c|M.bovis_AF2122/97 DGWLHTGDLAREDSDGFYYIVDRVKDMIVTGGFNVFPREVEDVVAEHPAV
Rv0551c|M.tuberculosis_H37Rv DGWLHTGDLAREDSDGFYYIVDRVKDMIVTGGFNVFPREVEDVVAEHPAV
MMAR_0897|M.marinum_M DGWLHTGDMAREDEDGFYFIVDRVKDMIVTGGFNVFPREVEDVVAEHSAV
MUL_0650|M.ulcerans_Agy99 DGWLHTGDMAREDEDGFYFIVDRVKDMIVTGGFNVFPREVEDVVAEHSAV
MAB_4626c|M.abscessus_ATCC_199 NGWLRTGDVAREDEDGFWFIVDRTKDMIVTGGFNVFPREVEDVVAEHPSV
MLBr_02546|M.leprae_Br4923 DGLLSSGDVGYFDEHDLLYISGRDDEMIVSGGENVFPAEVEDLISGHPEV
:* : :**:. * . :: .* .:*:::** **** :*** :. *. :
MSMEG_0326|M.smegmatis_MC2_155 AQSAVIGVPHEKWGEAVMAVVVPQSGEITG----PELESELIKHVKAALG
Mvan_0353|M.vanbaalenii_PYR-1 AQAAVIGVPDPKWGESVLAMVVARPGEITG----TELQLELVDHVKQALG
MAV_4592|M.avium_104 AQVCVIGTPDEKWGEAVTAVIVLRPDHPSDEESVAKVTAEIQAAVKERKG
TH_2679|M.thermoresistible__bu AQVCVIGTPDEKWGEAVTAVIVLRPEVDRDEANVERIKDEIRASVKERKG
Mflv_0015|M.gilvum_PYR-GCK AQVCVIGTPDEKWGEAVTAVVVLRPDAASDAAAVEVMISEIQASVKERKG
Mb0566c|M.bovis_AF2122/97 AQVCVVGAPDEKWGEAVTAVVVLRSNAARDEPAIEAMTAEIQAAVKQRKG
Rv0551c|M.tuberculosis_H37Rv AQVCVVGAPDEKWGEAVTAVVVLRSNAARDEPAIEAMTAEIQAAVKQRKG
MMAR_0897|M.marinum_M AQVCVVGAPDEKWGEAVTAVVVLRADAARDDAAIETMTAEIQAAVKQRKG
MUL_0650|M.ulcerans_Agy99 AQVCVVGAPDEKWGEAVTAVVVLRADAARDDAAIETMTAEIQAAVKQRKG
MAB_4626c|M.abscessus_ATCC_199 AQVGVIGVPDEKWGEAVTAIVVLRSDASSDEEAVALMTSEIQSAVKERKG
MLBr_02546|M.leprae_Br4923 VEATAIGVDDKEWGARLRAFVVKKQDATID-------EDAIKAYVRDHLA
.: .:*. . :** : *.:* : . : *: .
MSMEG_0326|M.smegmatis_MC2_155 SVAAPKTVLFADSLPLNPAGKVDKKAIRKPYWRNQTRQVG
Mvan_0353|M.vanbaalenii_PYR-1 SIPAPKKILFTDELPLNPAGKVDKKAIRKPYWQSNSRQIG
MAV_4592|M.avium_104 SVQSPKQVIVVDSVPVTALGKPDKKAVRARFWEGAGRAVG
TH_2679|M.thermoresistible__bu SVQAPKQVIVVDSVPTTALGKPDKKAVRARFWKDSERAIG
Mflv_0015|M.gilvum_PYR-GCK SVHVPKQVVVTDSVPITALGKPDKKAVRAQFWESAGRAVG
Mb0566c|M.bovis_AF2122/97 SVQAPKRVVVVDSLPLTGLGKPDKKAVRARFWEGAGRAVG
Rv0551c|M.tuberculosis_H37Rv SVQAPKRVVVVDSLPLTGLGKPDKKAVRARFWEGAGRAVG
MMAR_0897|M.marinum_M SVQSPKQVVVVDSLPLTGLGKPDKKAVRARFWEGAGRAVG
MUL_0650|M.ulcerans_Agy99 SVQSPKQVVVVDSLPLTGLGKPDKKAVRARFWEGAGRAVG
MAB_4626c|M.abscessus_ATCC_199 SVQSPKHVIIADSLPLTALGKLDKKALRQKYATV------
MLBr_02546|M.leprae_Br4923 RYKVPREVIFLEELPRNPTGKVLKRELRDFEVH-------
*: ::. :.:* . ** *: :*