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STAGDDAVGVPPACGGRSDAVGVPQLARESGAMRDQDCSGELLRSPTHNGHLLVGALKRHQNKPVLFLGD TRLTGGQLADRISQYIQAFEALGAGTGVAVGLLSLNRPEVLMIIGAGQARGYRRTALHPLGSLADHAYVL NDAGISSLIIDPNPMFVERALALLEQVDSLQQILTIGPVPDALKHVAVDLSAEAAKYQPQPLVAADLPPD QVIGLTYTGGTTGKPKGVIGTAQSIATMTSIQLAEWEWPANPRFLMCTPLSHAGAAFFTPTVIKGGEMIV LAKFDPAEVLRIIEEQRITATMLVPSMLYALLDHPDSHTRDLSSLETVYYGASAINPVRLAEAIRRFGPI FAQYYGQSEAPMVITYLAKGDHDEKRLTSCGRPTLFARVALLDEHGKPVKQGEVGEICVSGPLLAGGYWN LPDETSRTFKDGWLHTGDLAREDSDGFYYIVDRVKDMIVTGGFNVFPREVEDVVAEHPAVAQVCVVGAPD EKWGEAVTAVVVLRSNAARDEPAIEAMTAEIQAAVKQRKGSVQAPKRVVVVDSLPLTGLGKPDKKAVRAR FWEGAGRAVG*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv0551c | fadD8 | - | 100% (571) | acyl-CoA synthetase |
| M. tuberculosis H37Rv | Rv0166 | fadD5 | 4e-54 | 32.58% (528) | acyl-CoA synthetase |
| M. tuberculosis H37Rv | Rv2505c | fadD35 | 6e-49 | 28.57% (518) | AMP-binding domain protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0566c | fadD8 | 0.0 | 100.00% (571) | acyl-CoA synthetase |
| M. gilvum PYR-GCK | Mflv_0015 | - | 0.0 | 81.17% (531) | acyl-CoA synthetase |
| M. leprae Br4923 | MLBr_02546 | fadD2 | 7e-40 | 32.17% (345) | acyl-CoA synthetase |
| M. abscessus ATCC 19977 | MAB_4626c | - | 0.0 | 71.10% (519) | acyl-CoA synthetase |
| M. marinum M | MMAR_0897 | fadD8 | 0.0 | 88.35% (532) | fatty-acid-CoA synthase, FadD8 |
| M. avium 104 | MAV_4592 | - | 0.0 | 83.40% (530) | acyl-CoA synthetase |
| M. smegmatis MC2 155 | MSMEG_1098 | - | 0.0 | 81.95% (532) | acyl-CoA synthetase |
| M. thermoresistible (build 8) | TH_2679 | - | 0.0 | 83.08% (532) | PUTATIVE acyl-CoA synthase |
| M. ulcerans Agy99 | MUL_0650 | fadD8 | 0.0 | 87.97% (532) | acyl-CoA synthetase |
| M. vanbaalenii PYR-1 | Mvan_0953 | - | 0.0 | 83.71% (528) | acyl-CoA synthetase |
CLUSTAL 2.0.9 multiple sequence alignment
Rv0551c|M.tuberculosis_H37Rv MSTAGDDAVGVPPACGGRSDAVGVPQLARESGAMRDQDCSGELLRSPTHN
Mb0566c|M.bovis_AF2122/97 MSTAGDDAVGVPPACGGRSDAVGVPQLARESGAMRDQDCSGELLRSPTHN
MMAR_0897|M.marinum_M --------------------------------------MSDDLLRNPTHN
MUL_0650|M.ulcerans_Agy99 --------------------------------------MSDDLLRNPTHN
MSMEG_1098|M.smegmatis_MC2_155 --------------------------------MTQVKSSSPDLLRHPTHS
TH_2679|M.thermoresistible__bu --------------------------------------MSDQLLRHPLHS
MAV_4592|M.avium_104 --------------------------------------MGDELLRHPIHS
Mflv_0015|M.gilvum_PYR-GCK ---------------------------MTAVDVSSRERSSDPQLRPFLHS
Mvan_0953|M.vanbaalenii_PYR-1 --------------------------------------MSD-QLRHFLHS
MAB_4626c|M.abscessus_ATCC_199 ------------------------------------MPDPFDPLHGSINS
MLBr_02546|M.leprae_Br4923 --MTKLRHYLERGAAEVHYLRSIFESGALGFEPPLTYAAMAVAMRKWGDL
:: .
Rv0551c|M.tuberculosis_H37Rv GHLLVGALKRHQNKPVLFLGDTRLTGGQLADRISQYIQAFEALGAGTGVA
Mb0566c|M.bovis_AF2122/97 GHLLVGALKRHQNKPVLFLGDTRLTGGQLADRISQYIQAFEALGAGTGVA
MMAR_0897|M.marinum_M GHLLVGALKRHKNRPVLFLGDTTLTGGQLAERISQYIQAFEALGAGTGVT
MUL_0650|M.ulcerans_Agy99 GHLLVGALERHKNRPVLFLGDTTLTGGQLAERISQYIQAFEALGAGTGVT
MSMEG_1098|M.smegmatis_MC2_155 GHLTVAALKRNRDKPVLFLGDTTLTGGELADRISQYIQAFEALGAGSGEG
TH_2679|M.thermoresistible__bu GHLTVGALKRNKDKPVLFLGDTTLTGGQLADRISQYIQAFEALGAGTGAA
MAV_4592|M.avium_104 GHLTVGALKRNKDKPVLHLGDTTLTGGQLAERISQYIQAFEALGAGTGAT
Mflv_0015|M.gilvum_PYR-GCK GHLTVGALKRHKDRPVLFLGDTTLTGGELADRISQYIQAFEALGAGTGAA
Mvan_0953|M.vanbaalenii_PYR-1 GHLTVGALKRHKDKPVLFLGDTTLTGGELADRISQYIQAFEALGAGTGAA
MAB_4626c|M.abscessus_ATCC_199 GHLLVSALKRNRDAPALVLGDVTLTGAQMADEISKYIQAFIELVPDPTDG
MLBr_02546|M.leprae_Br4923 AMLPAMPARRSPHRAALIDEEGTLTYKELDRAAHALANGLIAKGVRGGDG
. * . . .* . ..* : ** :: :.:
Rv0551c|M.tuberculosis_H37Rv VGLLSLNRPEVLMIIGAGQARGYRRTALHPLGSLADHAYVLNDAGISSLI
Mb0566c|M.bovis_AF2122/97 VGLLSLNRPEVLMIIGAGQARGYRRTALHPLGSLADHAYVLNDAGISSLI
MMAR_0897|M.marinum_M VGLLSLNRPEVLMILGASQARGYRRTALHPLGSLDDHAYVLSDAGASALI
MUL_0650|M.ulcerans_Agy99 VGLLSLNRPEVLMILGASQARGYRRTALHPLGSLDDHAYVLYDAGASALI
MSMEG_1098|M.smegmatis_MC2_155 VGLLSLNRPEVLMIIGAGQTQGYRRTALHPLGSLDDHAYVLSDAEVTTLI
TH_2679|M.thermoresistible__bu VGLLSLNRPEVLMIIGAGQTQGYRRTALHPLGSLDDHAYVLSDAEVTSLI
MAV_4592|M.avium_104 VGLLSLNRPEVLMIIGAGQTQGYRRVALHPLGSLDDHAYVLDDAGVTSLI
Mflv_0015|M.gilvum_PYR-GCK VGLLSLNRPEVLMIIGAGQTQGYRRTALHPLGSLDDHAYVLTDAEVTSLI
Mvan_0953|M.vanbaalenii_PYR-1 VGLLSLNRPEVLMIIGAGQTQGYRRTALHPLGSLDDHAYVLSDAEVTSLI
MAB_4626c|M.abscessus_ATCC_199 QGMLALNRPEVLLVIGAGQLLGTRRTALHPLGSLDDHAYVLADAKITTLV
MLBr_02546|M.leprae_Br4923 IAILARNHRWFVIANYGCARVGARIILLNSEFSGPQIKEVSEREGAKVII
.:*: *: .:: . * * *:. * : * . ::
Rv0551c|M.tuberculosis_H37Rv IDPNPMFVERALALLEQVDSLQQILTIGPVPDALKHV---AVDLSAEAAK
Mb0566c|M.bovis_AF2122/97 IDPNPMFVERALALLEQVDSLQQILTIGPVPDALKHV---AVDLSAEAAK
MMAR_0897|M.marinum_M IDPNPMFVERALGLLEKVDSLEQVLTIGPVPEALEDR---AVDLSAEAAK
MUL_0650|M.ulcerans_Agy99 IDPNPMFVERALGLLEKVDSLEQVLTIGPVPEALEDR---AVDLSAEAAK
MSMEG_1098|M.smegmatis_MC2_155 IDPTPAFVERALGLLEKVPTLRQILTIGPVPEALAGV---ATDLNAEAAK
TH_2679|M.thermoresistible__bu IDPNPAFVERAHALLEKVPSLQRILTIGPVPPALDGV---AVDLTAEAAK
MAV_4592|M.avium_104 IDPTPAFVERALGLLEKVPGLKQILTIGPVPEALSGS---AVDLVAEAAK
Mflv_0015|M.gilvum_PYR-GCK IDPNPMFVERALGLVEKVPTLTQVLTIGPVPEEFAKAGVKAVDLSAEAAK
Mvan_0953|M.vanbaalenii_PYR-1 IDPNPMFVERALGLLEKVPSLKQVLTIGPVPAELSDV---AVDLSAEAAK
MAB_4626c|M.abscessus_ATCC_199 IDPTPQFVERAAALVAKVPTLTRVLTLGPVPAELAEVG---QDLVAAAAG
MLBr_02546|M.leprae_Br4923 YDD-----EYTKVVSKAEPALGKLRALGVNPDEEEPP---GSTDETLAEL
* * : : * :: ::* * : *
Rv0551c|M.tuberculosis_H37Rv YQPQPLVAADLPPDQVIGLTYTGGTTGKPKGVIGTAQSIATMTSIQLAEW
Mb0566c|M.bovis_AF2122/97 YQPQPLVAADLPPDQVIGLTYTGGTTGKPKGVIGTAQSIATMTSIQLAEW
MMAR_0897|M.marinum_M YQPKPLVVADLPPNHIGGLTYTGGTTGKPKGVIGTAGNITAMTSIQLAEW
MUL_0650|M.ulcerans_Agy99 YQPKPLVVADLPPNHIGGLTYTGGTTGKPKGVIGTAGNITAMTSIQLAEW
MSMEG_1098|M.smegmatis_MC2_155 YPAKPLVAAELPPDHIGGLTYTGGTTGKPKGVMGTVRSITTMTTIQLAEW
TH_2679|M.thermoresistible__bu YEPRPLVAADLPPDHIGGLTYTGGTTGKPKGVIGTVQSITTMTTIQLAEW
MAV_4592|M.avium_104 YAPKPLVAADLPPDHIGGMAYTGGTTGKPKGVLGTAQSITTMTTIQLAEW
Mflv_0015|M.gilvum_PYR-GCK YSPRPLTAAALPPDHIGGLTYTGGTTGKPKGVIGTTQSITTMTTVQLAEW
Mvan_0953|M.vanbaalenii_PYR-1 YAPKPLVAADLPPDHIGGLTYTGGTTGKPKGVIGTTQSITTMTTVQLAEW
MAB_4626c|M.abscessus_ATCC_199 FAARPLTPINLSPDHINGLTYTGGTTGKPKGVIGTSQSILTMTQIQLAEW
MLBr_02546|M.leprae_Br4923 IARSSSAPAPKVRKRASIIILTSGTTGTPKGANRNTPASLAPLGGILSKV
. . .: : *.****.***. . : *::
Rv0551c|M.tuberculosis_H37Rv EWPANPRFLMCTPLSHAG-AAFFTPTVIKGGEMIVLAKFDPAEVLRIIEE
Mb0566c|M.bovis_AF2122/97 EWPANPRFLMCTPLSHAG-AAFFTPTVIKGGEMIVLAKFDPAEVLRIIEE
MMAR_0897|M.marinum_M EWPEHPRFLMCTPLSHAG-AAFFTPTLVKGGEMIVLAKFDPGEVLRVIEE
MUL_0650|M.ulcerans_Agy99 EWPEHPRFLMCTPLSHAG-AAFFTPTLVKGGEMIVLAKFDPGEVLRVIEE
MSMEG_1098|M.smegmatis_MC2_155 EWPENPRFLMCTPLSHAG-AAFFVPTIVKGGEMIVLPKFDPGEVLRVIEE
TH_2679|M.thermoresistible__bu EWPENPRFLMCTPLSHAG-AAFFVPTIVKGGEMIVLPKFDPAEVLRVIEE
MAV_4592|M.avium_104 EWPENPRFLMCTPLSHAG-AAFFVPTIIKGGELVVLTKFDPAEVLRVIEE
Mflv_0015|M.gilvum_PYR-GCK EWPENPRFLMCTPLSHAG-AAFFTPVIVKGGELIVLTKFDPAEVLRVIEE
Mvan_0953|M.vanbaalenii_PYR-1 EWPENPRFLMCTPLSHAG-AAFFTPVIVKGGELIVLTKFDPAEVLRVIEE
MAB_4626c|M.abscessus_ATCC_199 EWPERPKFLMCTPLSHAG-AAFFMPTLMKGGSMVVLPKFDAGAVLAAIEE
MLBr_02546|M.leprae_Br4923 PFRAHEVTLLPAPMFHALGYLHATLAMFLGSTLVLRRRFKPATVLEDIEK
: . *: :*: ** . .:. *. ::: :*... ** **:
Rv0551c|M.tuberculosis_H37Rv QRITATMLVPSMLYALLDHPD--SHTRDLSSLETVYYGASAINPVRLAEA
Mb0566c|M.bovis_AF2122/97 QRITATMLVPSMLYALLDHPD--SHTRDLSSLETVYYGASAINPVRLAEA
MMAR_0897|M.marinum_M QRITATMLVPSMLYALMDHPD--SHTRDLSSLETVYYGASAINPVRLAEA
MUL_0650|M.ulcerans_Agy99 QRITATMLVPSMLYALMDHPD--PHTRDLSSLETVYYGASAINPVRLAEA
MSMEG_1098|M.smegmatis_MC2_155 RRITATMLVPSMLYALLDHPD--SHTRDLSSLETVYYGASAMNPVRLAEA
TH_2679|M.thermoresistible__bu RRITATMLVPSMLYALLDHPD--SRTRDLSSLETVYYGASAINPVRLKEA
MAV_4592|M.avium_104 QKITATMLVPSMIYALMDHPD--SHTRDLSSLETVYYGASAMNPVRLAEA
Mflv_0015|M.gilvum_PYR-GCK QKITATMLVPSMIYALMDHPD--SHTRDLSSLETVYYGASAMNPVRLKEA
Mvan_0953|M.vanbaalenii_PYR-1 QKITATMLVPSMIYALMDHPD--SHTRDLSSLETVYYGASAMNPVRLAEA
MAB_4626c|M.abscessus_ATCC_199 HQITATMLVPSMIYALLDHPD--SRTRDLSSLQTVYYGASAINPVRLAEA
MLBr_02546|M.leprae_Br4923 HQATAMVVVPVMLSRILDTLENLETKSDLSSLRVVFVSGSQLGAELATRA
:: ** ::** *: ::* : . *****..*: ..* :.. .*
Rv0551c|M.tuberculosis_H37Rv IRRFGPIFAQYYGQSEAPMVITYLAKGDHDEKRLTSCGRPTLFARVALLD
Mb0566c|M.bovis_AF2122/97 IRRFGPIFAQYYGQSEAPMVITYLAKGDHDEKRLTSCGRPTLFARVALLD
MMAR_0897|M.marinum_M IDRFGPIFAQYYGQSEAPMVITYLPKADHDEKRLTSCGRPTLFARVALLG
MUL_0650|M.ulcerans_Agy99 IDRFGPIFAQYYGQSEAPMVITYLPKADHDEKRLTSCGRPTLFARVALLG
MSMEG_1098|M.smegmatis_MC2_155 LKRFGPIFAQYYGQSEAPMVISYLGKKDHDEKRLTSCGRPTMFARTALLD
TH_2679|M.thermoresistible__bu IDRFGPIFAQYYGQSEAPMVITYLPKGAHDEKRLTSCGRPTLFARTALLD
MAV_4592|M.avium_104 IRRFGPIFAQYYGQSEAPMVISYLAKKDHDEKRLTSCGRPTLFARTALLD
Mflv_0015|M.gilvum_PYR-GCK IRRFGPIFAQYYGQSEAPMVITYLSKKEHDDKRLTSCGRPTLFAKVALLG
Mvan_0953|M.vanbaalenii_PYR-1 IRRFGPIFAQYYGQSEAPMVITYLSKKDHDEKRLTSCGRPTLFARVALLG
MAB_4626c|M.abscessus_ATCC_199 IERFGPIFAQYFGQSEAPMVISYLAKGDHDAKRLSSCGRPSAFLRTALLD
MLBr_02546|M.leprae_Br4923 LEELGPVIYNMYG--STEIAFATIAGPKDLQINSATVGPVVKGVKVKILD
: .:**:: : :* .: :.:: : . . :: * :. :*.
Rv0551c|M.tuberculosis_H37Rv EHGKPVKQGEVGEICVSGPLLAGGYWNLPDETSRTFKDGWLHTGDLARED
Mb0566c|M.bovis_AF2122/97 EHGKPVKQGEVGEICVSGPLLAGGYWNLPDETSRTFKDGWLHTGDLARED
MMAR_0897|M.marinum_M EDGKPVPQGEPGEICVSGPLLAGGYWNKPDDTAQTFRDGWLHTGDMARED
MUL_0650|M.ulcerans_Agy99 EDGKPVPQGEPGEICVSGPLLAGGYWNKPDDTAQTFRDGWLHTGDMARED
MSMEG_1098|M.smegmatis_MC2_155 PEGNPVPQGEVGEICVSGPLLAGGYWKLPDATAETFKDGWLHTGDMARED
TH_2679|M.thermoresistible__bu PDGNPVPQGEVGEICVSGPLLAGGYWKLPEETAKTFKDGWLRTGDMARED
MAV_4592|M.avium_104 ADGNPVPQGEVGEICVSGPLLSGGYWNLPEETAKTFKDGWLHTGDMARED
Mflv_0015|M.gilvum_PYR-GCK EDGQPVPQGEVGEICVSGPLLSGGYWNLPEATAETFRDGWMHTGDLARED
Mvan_0953|M.vanbaalenii_PYR-1 EDGQPVPQGEVGEICVSGPLLSGGYWNLPEATAETFRDGWMHTGDLARED
MAB_4626c|M.abscessus_ATCC_199 ENDRPVKQGEPGEICVAGPLVAGGYWGLPEQTAETFKNGWLRTGDVARED
MLBr_02546|M.leprae_Br4923 DSGKEVPRGQVGRIFVGNAFPFEGYTG---GGGKQIIDGLLSSGDVGYFD
.. * :*: *.* *...: ** .. : :* : :**:. *
Rv0551c|M.tuberculosis_H37Rv SDGFYYIVDRVKDMIVTGGFNVFPREVEDVVAEHPAVAQVCVVGAPDEKW
Mb0566c|M.bovis_AF2122/97 SDGFYYIVDRVKDMIVTGGFNVFPREVEDVVAEHPAVAQVCVVGAPDEKW
MMAR_0897|M.marinum_M EDGFYFIVDRVKDMIVTGGFNVFPREVEDVVAEHSAVAQVCVVGAPDEKW
MUL_0650|M.ulcerans_Agy99 EDGFYFIVDRVKDMIVTGGFNVFPREVEDVVAEHSAVAQVCVVGAPDEKW
MSMEG_1098|M.smegmatis_MC2_155 EDGYWFIVDRVKDMIVTGGFNVFPREVEDVVAEHPSVAQVCVIGTPDEKW
TH_2679|M.thermoresistible__bu EDGYWYIVDRVKDMIITGGFNVFPREVEDIVAEHPAVAQVCVIGTPDEKW
MAV_4592|M.avium_104 EDGFWFIVDRVKDMIVTGGFNVFPREVEDVVAEHPAVAQVCVIGTPDEKW
Mflv_0015|M.gilvum_PYR-GCK EDGFYFIVDRTKDMIVTGGFNVFPREVEDVVAEHPSIAQVCVIGTPDEKW
Mvan_0953|M.vanbaalenii_PYR-1 EDGFYFIVDRTKDMIVTGGFNVFPREVEDVVAEHPSIAQVCVIGTPDEKW
MAB_4626c|M.abscessus_ATCC_199 EDGFWFIVDRTKDMIVTGGFNVFPREVEDVVAEHPSVAQVGVIGVPDEKW
MLBr_02546|M.leprae_Br4923 EHDLLYISGRDDEMIVSGGENVFPAEVEDLISGHPEVVEATAIGVDDKEW
... :* .* .:**::** **** ****::: *. :.:. .:*. *::*
Rv0551c|M.tuberculosis_H37Rv GEAVTAVVVLRSNAARDEPAIEAMTAEIQAAVKQRKGSVQAPKRVVVVDS
Mb0566c|M.bovis_AF2122/97 GEAVTAVVVLRSNAARDEPAIEAMTAEIQAAVKQRKGSVQAPKRVVVVDS
MMAR_0897|M.marinum_M GEAVTAVVVLRADAARDDAAIETMTAEIQAAVKQRKGSVQSPKQVVVVDS
MUL_0650|M.ulcerans_Agy99 GEAVTAVVVLRADAARDDAAIETMTAEIQAAVKQRKGSVQSPKQVVVVDS
MSMEG_1098|M.smegmatis_MC2_155 GEAVTAVVVLRPDADRSEEGIERLTAEIQASVKERKGSVQSPKQVIVVDS
TH_2679|M.thermoresistible__bu GEAVTAVIVLRPEVDRDEANVERIKDEIRASVKERKGSVQAPKQVIVVDS
MAV_4592|M.avium_104 GEAVTAVIVLRPDHPSDEESVAKVTAEIQAAVKERKGSVQSPKQVIVVDS
Mflv_0015|M.gilvum_PYR-GCK GEAVTAVVVLRPDAASDAAAVEVMISEIQASVKERKGSVHVPKQVVVTDS
Mvan_0953|M.vanbaalenii_PYR-1 GEAVTAVVVLRPDADSSEAAVETMTVEIQASVKERKGSVHTPKQVIVVDS
MAB_4626c|M.abscessus_ATCC_199 GEAVTAIVVLRSDASSDEEAVALMTSEIQSAVKERKGSVQSPKHVIIADS
MLBr_02546|M.leprae_Br4923 GARLRAFVVKKQDATIDED-------AIKAYVRDHLARYKVPREVIFLEE
* : *.:* : : . *:: *::: . : *:.*:. :.
Rv0551c|M.tuberculosis_H37Rv LPLTGLGKPDKKAVRARFWEGAGRAVG
Mb0566c|M.bovis_AF2122/97 LPLTGLGKPDKKAVRARFWEGAGRAVG
MMAR_0897|M.marinum_M LPLTGLGKPDKKAVRARFWEGAGRAVG
MUL_0650|M.ulcerans_Agy99 LPLTGLGKPDKKAVRARFWEGAGRAVG
MSMEG_1098|M.smegmatis_MC2_155 VPVTALGKPDKKAVRAQFWEGAARAVG
TH_2679|M.thermoresistible__bu VPTTALGKPDKKAVRARFWKDSERAIG
MAV_4592|M.avium_104 VPVTALGKPDKKAVRARFWEGAGRAVG
Mflv_0015|M.gilvum_PYR-GCK VPITALGKPDKKAVRAQFWESAGRAVG
Mvan_0953|M.vanbaalenii_PYR-1 VPVTALGKPDKKAVRARFWEGAGRSIG
MAB_4626c|M.abscessus_ATCC_199 LPLTALGKLDKKALRQKYATV------
MLBr_02546|M.leprae_Br4923 LPRNPTGKVLKRELRDFEVH-------
:* . ** *: :*