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SDQLRHFLHSGHLTVGALKRHKDKPVLFLGDTTLTGGELADRISQYIQAFEALGAGTGAAVGLLSLNRPE VLMIIGAGQTQGYRRTALHPLGSLDDHAYVLSDAEVTSLIIDPNPMFVERALGLLEKVPSLKQVLTIGPV PAELSDVAVDLSAEAAKYAPKPLVAADLPPDHIGGLTYTGGTTGKPKGVIGTTQSITTMTTVQLAEWEWP ENPRFLMCTPLSHAGAAFFTPVIVKGGELIVLTKFDPAEVLRVIEEQKITATMLVPSMIYALMDHPDSHT RDLSSLETVYYGASAMNPVRLAEAIRRFGPIFAQYYGQSEAPMVITYLSKKDHDEKRLTSCGRPTLFARV ALLGEDGQPVPQGEVGEICVSGPLLSGGYWNLPEATAETFRDGWMHTGDLAREDEDGFYFIVDRTKDMIV TGGFNVFPREVEDVVAEHPSIAQVCVIGTPDEKWGEAVTAVVVLRPDADSSEAAVETMTVEIQASVKERK GSVHTPKQVIVVDSVPVTALGKPDKKAVRARFWEGAGRSIG*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_0953 | - | - | 100% (532) | acyl-CoA synthetase |
| M. vanbaalenii PYR-1 | Mvan_0353 | - | 1e-79 | 35.55% (526) | AMP-dependent synthetase and ligase |
| M. vanbaalenii PYR-1 | Mvan_3993 | - | 2e-77 | 35.40% (531) | AMP-dependent synthetase and ligase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0566c | fadD8 | 0.0 | 83.71% (528) | acyl-CoA synthetase |
| M. gilvum PYR-GCK | Mflv_0015 | - | 0.0 | 93.23% (532) | acyl-CoA synthetase |
| M. tuberculosis H37Rv | Rv0551c | fadD8 | 0.0 | 83.71% (528) | acyl-CoA synthetase |
| M. leprae Br4923 | MLBr_02546 | fadD2 | 6e-39 | 29.11% (426) | acyl-CoA synthetase |
| M. abscessus ATCC 19977 | MAB_4626c | - | 0.0 | 72.17% (521) | acyl-CoA synthetase |
| M. marinum M | MMAR_0897 | fadD8 | 0.0 | 85.09% (530) | fatty-acid-CoA synthase, FadD8 |
| M. avium 104 | MAV_4592 | - | 0.0 | 88.56% (533) | acyl-CoA synthetase |
| M. smegmatis MC2 155 | MSMEG_1098 | - | 0.0 | 86.79% (530) | acyl-CoA synthetase |
| M. thermoresistible (build 8) | TH_2679 | - | 0.0 | 86.30% (533) | PUTATIVE acyl-CoA synthase |
| M. ulcerans Agy99 | MUL_0650 | fadD8 | 0.0 | 84.53% (530) | acyl-CoA synthetase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0566c|M.bovis_AF2122/97 MSTAGDDAVGVPPACGGRSDAVGVPQLARESGAMRDQDCSGELLRSPTHN
Rv0551c|M.tuberculosis_H37Rv MSTAGDDAVGVPPACGGRSDAVGVPQLARESGAMRDQDCSGELLRSPTHN
MMAR_0897|M.marinum_M --------------------------------------MSDDLLRNPTHN
MUL_0650|M.ulcerans_Agy99 --------------------------------------MSDDLLRNPTHN
Mvan_0953|M.vanbaalenii_PYR-1 --------------------------------------MSD-QLRHFLHS
Mflv_0015|M.gilvum_PYR-GCK ---------------------------MTAVDVSSRERSSDPQLRPFLHS
MSMEG_1098|M.smegmatis_MC2_155 --------------------------------MTQVKSSSPDLLRHPTHS
TH_2679|M.thermoresistible__bu --------------------------------------MSDQLLRHPLHS
MAV_4592|M.avium_104 --------------------------------------MGDELLRHPIHS
MAB_4626c|M.abscessus_ATCC_199 ------------------------------------MPDPFDPLHGSINS
MLBr_02546|M.leprae_Br4923 --MTKLRHYLERGAAEVHYLRSIFESGALGFEPPLTYAAMAVAMRKWGDL
:: .
Mb0566c|M.bovis_AF2122/97 GHLLVGALKRHQNKPVLFLGDTRLTGGQLADRISQYIQAFEALGAGTGVA
Rv0551c|M.tuberculosis_H37Rv GHLLVGALKRHQNKPVLFLGDTRLTGGQLADRISQYIQAFEALGAGTGVA
MMAR_0897|M.marinum_M GHLLVGALKRHKNRPVLFLGDTTLTGGQLAERISQYIQAFEALGAGTGVT
MUL_0650|M.ulcerans_Agy99 GHLLVGALERHKNRPVLFLGDTTLTGGQLAERISQYIQAFEALGAGTGVT
Mvan_0953|M.vanbaalenii_PYR-1 GHLTVGALKRHKDKPVLFLGDTTLTGGELADRISQYIQAFEALGAGTGAA
Mflv_0015|M.gilvum_PYR-GCK GHLTVGALKRHKDRPVLFLGDTTLTGGELADRISQYIQAFEALGAGTGAA
MSMEG_1098|M.smegmatis_MC2_155 GHLTVAALKRNRDKPVLFLGDTTLTGGELADRISQYIQAFEALGAGSGEG
TH_2679|M.thermoresistible__bu GHLTVGALKRNKDKPVLFLGDTTLTGGQLADRISQYIQAFEALGAGTGAA
MAV_4592|M.avium_104 GHLTVGALKRNKDKPVLHLGDTTLTGGQLAERISQYIQAFEALGAGTGAT
MAB_4626c|M.abscessus_ATCC_199 GHLLVSALKRNRDAPALVLGDVTLTGAQMADEISKYIQAFIELVPDPTDG
MLBr_02546|M.leprae_Br4923 AMLPAMPARRSPHRAALIDEEGTLTYKELDRAAHALANGLIAKGVRGGDG
. * . . .* . ..* : ** :: :.:
Mb0566c|M.bovis_AF2122/97 VGLLSLNRPEVLMIIGAGQARGYRRTALHPLGSLADHAYVLNDAGISSLI
Rv0551c|M.tuberculosis_H37Rv VGLLSLNRPEVLMIIGAGQARGYRRTALHPLGSLADHAYVLNDAGISSLI
MMAR_0897|M.marinum_M VGLLSLNRPEVLMILGASQARGYRRTALHPLGSLDDHAYVLSDAGASALI
MUL_0650|M.ulcerans_Agy99 VGLLSLNRPEVLMILGASQARGYRRTALHPLGSLDDHAYVLYDAGASALI
Mvan_0953|M.vanbaalenii_PYR-1 VGLLSLNRPEVLMIIGAGQTQGYRRTALHPLGSLDDHAYVLSDAEVTSLI
Mflv_0015|M.gilvum_PYR-GCK VGLLSLNRPEVLMIIGAGQTQGYRRTALHPLGSLDDHAYVLTDAEVTSLI
MSMEG_1098|M.smegmatis_MC2_155 VGLLSLNRPEVLMIIGAGQTQGYRRTALHPLGSLDDHAYVLSDAEVTTLI
TH_2679|M.thermoresistible__bu VGLLSLNRPEVLMIIGAGQTQGYRRTALHPLGSLDDHAYVLSDAEVTSLI
MAV_4592|M.avium_104 VGLLSLNRPEVLMIIGAGQTQGYRRVALHPLGSLDDHAYVLDDAGVTSLI
MAB_4626c|M.abscessus_ATCC_199 QGMLALNRPEVLLVIGAGQLLGTRRTALHPLGSLDDHAYVLADAKITTLV
MLBr_02546|M.leprae_Br4923 IAILARNHRWFVIANYGCARVGARIILLNSEFSGPQIKEVSEREGAKVII
.:*: *: .:: . * * *:. * : * . ::
Mb0566c|M.bovis_AF2122/97 IDPNPMFVERALALLEQVDSLQQILTIGPVPDALKHV---AVDLSAEAAK
Rv0551c|M.tuberculosis_H37Rv IDPNPMFVERALALLEQVDSLQQILTIGPVPDALKHV---AVDLSAEAAK
MMAR_0897|M.marinum_M IDPNPMFVERALGLLEKVDSLEQVLTIGPVPEALEDR---AVDLSAEAAK
MUL_0650|M.ulcerans_Agy99 IDPNPMFVERALGLLEKVDSLEQVLTIGPVPEALEDR---AVDLSAEAAK
Mvan_0953|M.vanbaalenii_PYR-1 IDPNPMFVERALGLLEKVPSLKQVLTIGPVPAELSDV---AVDLSAEAAK
Mflv_0015|M.gilvum_PYR-GCK IDPNPMFVERALGLVEKVPTLTQVLTIGPVPEEFAKAGVKAVDLSAEAAK
MSMEG_1098|M.smegmatis_MC2_155 IDPTPAFVERALGLLEKVPTLRQILTIGPVPEALAGV---ATDLNAEAAK
TH_2679|M.thermoresistible__bu IDPNPAFVERAHALLEKVPSLQRILTIGPVPPALDGV---AVDLTAEAAK
MAV_4592|M.avium_104 IDPTPAFVERALGLLEKVPGLKQILTIGPVPEALSGS---AVDLVAEAAK
MAB_4626c|M.abscessus_ATCC_199 IDPTPQFVERAAALVAKVPTLTRVLTLGPVPAELAEVG---QDLVAAAAG
MLBr_02546|M.leprae_Br4923 YDD-----EYTKVVSKAEPALGKLRALGVNPDEEEPP---GSTDETLAEL
* * : : * :: ::* * : *
Mb0566c|M.bovis_AF2122/97 YQPQPLVAADLPPDQVIGLTYTGGTTGKPKGVIGTAQSIATMTSIQLAEW
Rv0551c|M.tuberculosis_H37Rv YQPQPLVAADLPPDQVIGLTYTGGTTGKPKGVIGTAQSIATMTSIQLAEW
MMAR_0897|M.marinum_M YQPKPLVVADLPPNHIGGLTYTGGTTGKPKGVIGTAGNITAMTSIQLAEW
MUL_0650|M.ulcerans_Agy99 YQPKPLVVADLPPNHIGGLTYTGGTTGKPKGVIGTAGNITAMTSIQLAEW
Mvan_0953|M.vanbaalenii_PYR-1 YAPKPLVAADLPPDHIGGLTYTGGTTGKPKGVIGTTQSITTMTTVQLAEW
Mflv_0015|M.gilvum_PYR-GCK YSPRPLTAAALPPDHIGGLTYTGGTTGKPKGVIGTTQSITTMTTVQLAEW
MSMEG_1098|M.smegmatis_MC2_155 YPAKPLVAAELPPDHIGGLTYTGGTTGKPKGVMGTVRSITTMTTIQLAEW
TH_2679|M.thermoresistible__bu YEPRPLVAADLPPDHIGGLTYTGGTTGKPKGVIGTVQSITTMTTIQLAEW
MAV_4592|M.avium_104 YAPKPLVAADLPPDHIGGMAYTGGTTGKPKGVLGTAQSITTMTTIQLAEW
MAB_4626c|M.abscessus_ATCC_199 FAARPLTPINLSPDHINGLTYTGGTTGKPKGVIGTSQSILTMTQIQLAEW
MLBr_02546|M.leprae_Br4923 IARSSSAPAPKVRKRASIIILTSGTTGTPKGANRNTPASLAPLGGILSKV
. . .: : *.****.***. . : *::
Mb0566c|M.bovis_AF2122/97 EWPANPRFLMCTPLSHAG-AAFFTPTVIKGGEMIVLAKFDPAEVLRIIEE
Rv0551c|M.tuberculosis_H37Rv EWPANPRFLMCTPLSHAG-AAFFTPTVIKGGEMIVLAKFDPAEVLRIIEE
MMAR_0897|M.marinum_M EWPEHPRFLMCTPLSHAG-AAFFTPTLVKGGEMIVLAKFDPGEVLRVIEE
MUL_0650|M.ulcerans_Agy99 EWPEHPRFLMCTPLSHAG-AAFFTPTLVKGGEMIVLAKFDPGEVLRVIEE
Mvan_0953|M.vanbaalenii_PYR-1 EWPENPRFLMCTPLSHAG-AAFFTPVIVKGGELIVLTKFDPAEVLRVIEE
Mflv_0015|M.gilvum_PYR-GCK EWPENPRFLMCTPLSHAG-AAFFTPVIVKGGELIVLTKFDPAEVLRVIEE
MSMEG_1098|M.smegmatis_MC2_155 EWPENPRFLMCTPLSHAG-AAFFVPTIVKGGEMIVLPKFDPGEVLRVIEE
TH_2679|M.thermoresistible__bu EWPENPRFLMCTPLSHAG-AAFFVPTIVKGGEMIVLPKFDPAEVLRVIEE
MAV_4592|M.avium_104 EWPENPRFLMCTPLSHAG-AAFFVPTIIKGGELVVLTKFDPAEVLRVIEE
MAB_4626c|M.abscessus_ATCC_199 EWPERPKFLMCTPLSHAG-AAFFMPTLMKGGSMVVLPKFDAGAVLAAIEE
MLBr_02546|M.leprae_Br4923 PFRAHEVTLLPAPMFHALGYLHATLAMFLGSTLVLRRRFKPATVLEDIEK
: . *: :*: ** . .:. *. ::: :*... ** **:
Mb0566c|M.bovis_AF2122/97 QRITATMLVPSMLYALLDHPD--SHTRDLSSLETVYYGASAINPVRLAEA
Rv0551c|M.tuberculosis_H37Rv QRITATMLVPSMLYALLDHPD--SHTRDLSSLETVYYGASAINPVRLAEA
MMAR_0897|M.marinum_M QRITATMLVPSMLYALMDHPD--SHTRDLSSLETVYYGASAINPVRLAEA
MUL_0650|M.ulcerans_Agy99 QRITATMLVPSMLYALMDHPD--PHTRDLSSLETVYYGASAINPVRLAEA
Mvan_0953|M.vanbaalenii_PYR-1 QKITATMLVPSMIYALMDHPD--SHTRDLSSLETVYYGASAMNPVRLAEA
Mflv_0015|M.gilvum_PYR-GCK QKITATMLVPSMIYALMDHPD--SHTRDLSSLETVYYGASAMNPVRLKEA
MSMEG_1098|M.smegmatis_MC2_155 RRITATMLVPSMLYALLDHPD--SHTRDLSSLETVYYGASAMNPVRLAEA
TH_2679|M.thermoresistible__bu RRITATMLVPSMLYALLDHPD--SRTRDLSSLETVYYGASAINPVRLKEA
MAV_4592|M.avium_104 QKITATMLVPSMIYALMDHPD--SHTRDLSSLETVYYGASAMNPVRLAEA
MAB_4626c|M.abscessus_ATCC_199 HQITATMLVPSMIYALLDHPD--SRTRDLSSLQTVYYGASAINPVRLAEA
MLBr_02546|M.leprae_Br4923 HQATAMVVVPVMLSRILDTLENLETKSDLSSLRVVFVSGSQLGAELATRA
:: ** ::** *: ::* : . *****..*: ..* :.. .*
Mb0566c|M.bovis_AF2122/97 IRRFGPIFAQYYGQSEAPMVITYLAKGDHDEKRLTSCGRPTLFARVALLD
Rv0551c|M.tuberculosis_H37Rv IRRFGPIFAQYYGQSEAPMVITYLAKGDHDEKRLTSCGRPTLFARVALLD
MMAR_0897|M.marinum_M IDRFGPIFAQYYGQSEAPMVITYLPKADHDEKRLTSCGRPTLFARVALLG
MUL_0650|M.ulcerans_Agy99 IDRFGPIFAQYYGQSEAPMVITYLPKADHDEKRLTSCGRPTLFARVALLG
Mvan_0953|M.vanbaalenii_PYR-1 IRRFGPIFAQYYGQSEAPMVITYLSKKDHDEKRLTSCGRPTLFARVALLG
Mflv_0015|M.gilvum_PYR-GCK IRRFGPIFAQYYGQSEAPMVITYLSKKEHDDKRLTSCGRPTLFAKVALLG
MSMEG_1098|M.smegmatis_MC2_155 LKRFGPIFAQYYGQSEAPMVISYLGKKDHDEKRLTSCGRPTMFARTALLD
TH_2679|M.thermoresistible__bu IDRFGPIFAQYYGQSEAPMVITYLPKGAHDEKRLTSCGRPTLFARTALLD
MAV_4592|M.avium_104 IRRFGPIFAQYYGQSEAPMVISYLAKKDHDEKRLTSCGRPTLFARTALLD
MAB_4626c|M.abscessus_ATCC_199 IERFGPIFAQYFGQSEAPMVISYLAKGDHDAKRLSSCGRPSAFLRTALLD
MLBr_02546|M.leprae_Br4923 LEELGPVIYNMYG--STEIAFATIAGPKDLQINSATVGPVVKGVKVKILD
: .:**:: : :* .: :.:: : . . :: * :. :*.
Mb0566c|M.bovis_AF2122/97 EHGKPVKQGEVGEICVSGPLLAGGYWNLPDETSRTFKDGWLHTGDLARED
Rv0551c|M.tuberculosis_H37Rv EHGKPVKQGEVGEICVSGPLLAGGYWNLPDETSRTFKDGWLHTGDLARED
MMAR_0897|M.marinum_M EDGKPVPQGEPGEICVSGPLLAGGYWNKPDDTAQTFRDGWLHTGDMARED
MUL_0650|M.ulcerans_Agy99 EDGKPVPQGEPGEICVSGPLLAGGYWNKPDDTAQTFRDGWLHTGDMARED
Mvan_0953|M.vanbaalenii_PYR-1 EDGQPVPQGEVGEICVSGPLLSGGYWNLPEATAETFRDGWMHTGDLARED
Mflv_0015|M.gilvum_PYR-GCK EDGQPVPQGEVGEICVSGPLLSGGYWNLPEATAETFRDGWMHTGDLARED
MSMEG_1098|M.smegmatis_MC2_155 PEGNPVPQGEVGEICVSGPLLAGGYWKLPDATAETFKDGWLHTGDMARED
TH_2679|M.thermoresistible__bu PDGNPVPQGEVGEICVSGPLLAGGYWKLPEETAKTFKDGWLRTGDMARED
MAV_4592|M.avium_104 ADGNPVPQGEVGEICVSGPLLSGGYWNLPEETAKTFKDGWLHTGDMARED
MAB_4626c|M.abscessus_ATCC_199 ENDRPVKQGEPGEICVAGPLVAGGYWGLPEQTAETFKNGWLRTGDVARED
MLBr_02546|M.leprae_Br4923 DSGKEVPRGQVGRIFVGNAFPFEGYTG---GGGKQIIDGLLSSGDVGYFD
.. * :*: *.* *...: ** .. : :* : :**:. *
Mb0566c|M.bovis_AF2122/97 SDGFYYIVDRVKDMIVTGGFNVFPREVEDVVAEHPAVAQVCVVGAPDEKW
Rv0551c|M.tuberculosis_H37Rv SDGFYYIVDRVKDMIVTGGFNVFPREVEDVVAEHPAVAQVCVVGAPDEKW
MMAR_0897|M.marinum_M EDGFYFIVDRVKDMIVTGGFNVFPREVEDVVAEHSAVAQVCVVGAPDEKW
MUL_0650|M.ulcerans_Agy99 EDGFYFIVDRVKDMIVTGGFNVFPREVEDVVAEHSAVAQVCVVGAPDEKW
Mvan_0953|M.vanbaalenii_PYR-1 EDGFYFIVDRTKDMIVTGGFNVFPREVEDVVAEHPSIAQVCVIGTPDEKW
Mflv_0015|M.gilvum_PYR-GCK EDGFYFIVDRTKDMIVTGGFNVFPREVEDVVAEHPSIAQVCVIGTPDEKW
MSMEG_1098|M.smegmatis_MC2_155 EDGYWFIVDRVKDMIVTGGFNVFPREVEDVVAEHPSVAQVCVIGTPDEKW
TH_2679|M.thermoresistible__bu EDGYWYIVDRVKDMIITGGFNVFPREVEDIVAEHPAVAQVCVIGTPDEKW
MAV_4592|M.avium_104 EDGFWFIVDRVKDMIVTGGFNVFPREVEDVVAEHPAVAQVCVIGTPDEKW
MAB_4626c|M.abscessus_ATCC_199 EDGFWFIVDRTKDMIVTGGFNVFPREVEDVVAEHPSVAQVGVIGVPDEKW
MLBr_02546|M.leprae_Br4923 EHDLLYISGRDDEMIVSGGENVFPAEVEDLISGHPEVVEATAIGVDDKEW
... :* .* .:**::** **** ****::: *. :.:. .:*. *::*
Mb0566c|M.bovis_AF2122/97 GEAVTAVVVLRSNAARDEPAIEAMTAEIQAAVKQRKGSVQAPKRVVVVDS
Rv0551c|M.tuberculosis_H37Rv GEAVTAVVVLRSNAARDEPAIEAMTAEIQAAVKQRKGSVQAPKRVVVVDS
MMAR_0897|M.marinum_M GEAVTAVVVLRADAARDDAAIETMTAEIQAAVKQRKGSVQSPKQVVVVDS
MUL_0650|M.ulcerans_Agy99 GEAVTAVVVLRADAARDDAAIETMTAEIQAAVKQRKGSVQSPKQVVVVDS
Mvan_0953|M.vanbaalenii_PYR-1 GEAVTAVVVLRPDADSSEAAVETMTVEIQASVKERKGSVHTPKQVIVVDS
Mflv_0015|M.gilvum_PYR-GCK GEAVTAVVVLRPDAASDAAAVEVMISEIQASVKERKGSVHVPKQVVVTDS
MSMEG_1098|M.smegmatis_MC2_155 GEAVTAVVVLRPDADRSEEGIERLTAEIQASVKERKGSVQSPKQVIVVDS
TH_2679|M.thermoresistible__bu GEAVTAVIVLRPEVDRDEANVERIKDEIRASVKERKGSVQAPKQVIVVDS
MAV_4592|M.avium_104 GEAVTAVIVLRPDHPSDEESVAKVTAEIQAAVKERKGSVQSPKQVIVVDS
MAB_4626c|M.abscessus_ATCC_199 GEAVTAIVVLRSDASSDEEAVALMTSEIQSAVKERKGSVQSPKHVIIADS
MLBr_02546|M.leprae_Br4923 GARLRAFVVKKQDATIDED-------AIKAYVRDHLARYKVPREVIFLEE
* : *.:* : : . *:: *::: . : *:.*:. :.
Mb0566c|M.bovis_AF2122/97 LPLTGLGKPDKKAVRARFWEGAGRAVG
Rv0551c|M.tuberculosis_H37Rv LPLTGLGKPDKKAVRARFWEGAGRAVG
MMAR_0897|M.marinum_M LPLTGLGKPDKKAVRARFWEGAGRAVG
MUL_0650|M.ulcerans_Agy99 LPLTGLGKPDKKAVRARFWEGAGRAVG
Mvan_0953|M.vanbaalenii_PYR-1 VPVTALGKPDKKAVRARFWEGAGRSIG
Mflv_0015|M.gilvum_PYR-GCK VPITALGKPDKKAVRAQFWESAGRAVG
MSMEG_1098|M.smegmatis_MC2_155 VPVTALGKPDKKAVRAQFWEGAARAVG
TH_2679|M.thermoresistible__bu VPTTALGKPDKKAVRARFWKDSERAIG
MAV_4592|M.avium_104 VPVTALGKPDKKAVRARFWEGAGRAVG
MAB_4626c|M.abscessus_ATCC_199 LPLTALGKLDKKALRQKYATV------
MLBr_02546|M.leprae_Br4923 LPRNPTGKVLKRELRDFEVH-------
:* . ** *: :*