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MDHDAAVRTDGHGRRADVIRVISPHTERPVAEVDAATPSDVDAAVAAARAAFDAGTWSRGGPSHRIAAIR RLADIYDRRRAEMAETITAEIGAPISFARRAQVGLPAFMIRAFCDLAERHPWQETRPGFFGSDVYVRREP VGVVAAIVPWNMPQFLIVTKLIPALLAGCTVVLKPAPESPLDALLLAEMISEADLPPGAVSVLPGDAALG AYLAGHRGVDKVSFTGSTAAGRAVAAACAANLTKVSLELGGKSAALVLDDAPPDKVAAGVRAASLSNSGQ ICNALTRVLVPQARHDDYVDALAAHMGGLRVGDPADPDTDLGPLVSRRQQQRVRDYIRIGQQEGARLVVG GADMPDGLDRGWYVRPTLFAAAGNAMRIAREEIFGPVITVIPYRDDDEAVAIANDSDYGLAGSVWSDDTD RALALATRIHTGTVGVNQGYTMDPFAPFGGVKASGYGRELGPEGLDGYLDTKSIAVAPSG
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_3969 | - | - | 100% (480) | aldehyde dehydrogenase |
| M. avium 104 | MAV_1643 | - | e-150 | 59.03% (454) | aldehyde dehydrogenase |
| M. avium 104 | MAV_2647 | - | e-117 | 49.25% (467) | betaine-aldehyde dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0791 | aldA | 1e-100 | 45.20% (469) | aldehyde dehydrogenase NAD dependant AldA |
| M. gilvum PYR-GCK | Mflv_4389 | - | 1e-125 | 49.89% (471) | aldehyde dehydrogenase |
| M. tuberculosis H37Rv | Rv0223c | - | 1e-110 | 46.19% (459) | aldehyde dehydrogenase |
| M. leprae Br4923 | MLBr_02573 | gabD1 | 1e-54 | 31.68% (464) | succinic semialdehyde dehydrogenase |
| M. abscessus ATCC 19977 | MAB_4484 | - | 1e-115 | 48.58% (457) | aldehyde dehydrogenase |
| M. marinum M | MMAR_3965 | - | 1e-150 | 58.61% (459) | NAD-dependent aldehyde dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_0309 | - | 1e-116 | 46.41% (459) | aldehyde dehydrogenase family protein |
| M. thermoresistible (build 8) | TH_3080 | - | 0.0 | 73.06% (464) | PUTATIVE aldehyde dehydrogenase |
| M. ulcerans Agy99 | MUL_1122 | - | 1e-105 | 44.71% (463) | aldehyde dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_0240 | - | 1e-118 | 49.02% (459) | betaine-aldehyde dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
MAV_3969|M.avium_104 ------------MDHD--AAVRTDGHGRR---ADVIRVISPHTERPVAEV
TH_3080|M.thermoresistible__bu -------------VHP--EELFIGGEWATPSSAQRIEVISPHTEEPVAAV
MMAR_3965|M.marinum_M --------MTADSTHRSFHELFIGGRWCKPTIAEPITVISPHSEEPIGRA
Rv0223c|M.tuberculosis_H37Rv ----------MSDSATEYDKLFIGGKWTKPSTSDVIEVRCPATGEYVGKV
MUL_1122|M.ulcerans_Agy99 -----------MGEKTEYDKLFIGGRWTEPSTSEVIEVHCPATGEYVGKV
MAB_4484|M.abscessus_ATCC_1997 --------------MTNYDKLFIGGVWTEPATDQVIEVISPATGQKVGQC
MSMEG_0309|M.smegmatis_MC2_155 MTAMTQTAPAATAATTNWDKLFIGGQWVEPSSSEIIEVFSPATGEKVGQA
Mvan_0240|M.vanbaalenii_PYR-1 ---MTQS----TTFRTEWDKLFIGGKWVEPATSDVIEVHSPATGELVGKV
Mflv_4389|M.gilvum_PYR-GCK -----------MTQIVDTAGVFVGGEFRR--TDRTVPVFEAATGEILGEG
Mb0791|M.bovis_AF2122/97 ----------MALWGDGISALLIDGKLSD-GRAGTFPTVNPATEEVLGVA
MLBr_02573|M.leprae_Br4923 ---------------------------------MSIATINPATGETVKTF
. . . : . :
MAV_3969|M.avium_104 DAATPSDVDAAVAAARAAFDAGTWSRGGPSHRIAAIRRLADIYDRRRAEM
TH_3080|M.thermoresistible__bu AAACPDDVDRAVAAARAAFDTGPWPRMDPAERVAVIRGLAERYGERRSEL
MMAR_3965|M.marinum_M PAAGPDEVEAAVAAARRAFDYGPWPRLDPDERIRKVEELAAIYASHLDDM
Rv0223c|M.tuberculosis_H37Rv PMAAAADVDAAVAAARAAFDNGPWPSTPPHERAAVIAAAVKMLAERKDLF
MUL_1122|M.ulcerans_Agy99 PLAAAADVDAAVAAARAAFDNGPWPSTPPKERATVIANALKLLEERKDHF
MAB_4484|M.abscessus_ATCC_1997 PLASPADVDAAVSAARRAFDNGPWPRLTPHERQAVLQKAVSLLESRKDEI
MSMEG_0309|M.smegmatis_MC2_155 PLATKADVDAACAAARKAFDEGPWPRMTPQEREAVLAKATALIEESADEF
Mvan_0240|M.vanbaalenii_PYR-1 PLASAADVDAACAAAREAFDNGPWPHMSPAERGEILGRAVKIMEERADEL
Mflv_4389|M.gilvum_PYR-GCK PSAAAADIDDAVAAARGE-GAAKWRAATVDERADGLKRFATALRGRAKHT
Mb0791|M.bovis_AF2122/97 ADADAEDMGRAIEAARRAFDSTDWSR-NTELRVRCVRQLRDAMQQHVEEL
MLBr_02573|M.leprae_Br4923 TPTTQDEVEDAIARAYARFDN--YRHTTFTQRAKWANATADLLEAEANQS
: :: * * . : *
MAV_3969|M.avium_104 AETITAEIGAPISFARRAQVGLPAFMIRAFCD-LAERHPWQETRPGFFGS
TH_3080|M.thermoresistible__bu AELITAQIGAPISFAQRAQVGLPWTMMSAFCT-LAENHPWQQTRAGMYGA
MMAR_3965|M.marinum_M ADLITAEMGSPHSFSRLGQAAGAAGLMQLALA-AGRNFPWVERRQGIRG-
Rv0223c|M.tuberculosis_H37Rv TKLLAAETGQPPTIIETMHWMGSMGAMNYFAG-AADKVTWTETRTGSYG-
MUL_1122|M.ulcerans_Agy99 AKLFADETGQPPMTVETMHWMGSIGALNFFAGPAVDQVRWKEIRNGSYG-
MAB_4484|M.abscessus_ATCC_1997 CKAIADETGAPPMVIETLQWMGGFGAIQYYAN-AADAVKWKELRNGAYG-
MSMEG_0309|M.smegmatis_MC2_155 KTLLKLETGQPQTIVDMMQYGAAMSTLQFYAS-AADKFAWKDIRDGIYG-
Mvan_0240|M.vanbaalenii_PYR-1 KFLLAAETGQPPTIVDMMQYGAAMSSFQFYAG-AADKFTWQDIRDGVYG-
Mflv_4389|M.gilvum_PYR-GCK STLVSRENGMPITLSRAVNGAFPSVLVNYYAK-LIRSWTAEEVRPALIG-
Mb0791|M.bovis_AF2122/97 RELTISEVGAPRMLTASAQLEGPVGDLSFAAD-TAESYPWKQDLGEASPL
MLBr_02573|M.leprae_Br4923 AALMTLEMGKTLQSAKDEAMKCAKG-FRYYAEKAETLLADEPAEAAAVGA
: * . .
MAV_3969|M.avium_104 ----DVYVRREPVGVVAAIVPWNMPQFLIVTKLIPALLAGCTVVLKPAPE
TH_3080|M.thermoresistible__bu ----DVHVRREPVGVVAAIVPWNMPQFLIVTKLIPALLAGCTVVLKPAPE
MMAR_3965|M.marinum_M ----QAHLRRAPVGVVGAIVPWNVPQFLIMPKLIPALIAGCTVIIKPAPE
Rv0223c|M.tuberculosis_H37Rv ----QSIVSREPVGVVGAIVAWNVPLFLAVNKIAPALLAGCTIVLKPAAE
MUL_1122|M.ulcerans_Agy99 ----QTIVHREPIGVVGAIVAWNVPLFLAINKLGPAPLAGCTVVLKPAAE
MAB_4484|M.abscessus_ATCC_1997 ----QTLVTREPAGVVAAIAAWNVPLFLALNKIGPAFLAGCAVVLKPAAE
MSMEG_0309|M.smegmatis_MC2_155 ----QTLVLKEPVGVVGAVVAWNVPFFLAANKLGPALLAGCTIVLKPAAE
Mvan_0240|M.vanbaalenii_PYR-1 ----QTLVVREPVGVVGAVTAWNVPFFLAANKLGPALLAGCTVVLKPAAE
Mflv_4389|M.gilvum_PYR-GCK ----HTVVRREPIGVVGAITPWNYPQALAVMKIAPALAAGCSVVLKASPE
Mb0791|M.bovis_AF2122/97 GIATRRTLAREAVGVVGAITPWNFPHQINLAKLGPALAAGNTVVLKPAPD
MLBr_02573|M.leprae_Br4923 S---KALARYQPLGVVLAVMPWNFPLWQTVRFAAPALMAGNVGLLKHASN
. *** *: .** * ** ** ::* :.:
MAV_3969|M.avium_104 SPLDALLLAEMISEAD-LPPGAVSVLPGD-AALGAYLAGHRGVDKVSFTG
TH_3080|M.thermoresistible__bu SPLDALLLAELIADSG-IPSGVVNVLPGP-AGVGERLVRHPGVDKVSFTG
MMAR_3965|M.marinum_M TPLDALWLAEMIEQIE-LPEGVVSVLPGG-PSVGEALVRHPGVDKIAFTG
Rv0223c|M.tuberculosis_H37Rv TPLTANALAEVFAEVG-LPEGVLSVVPGG-IETGQALTSNPDIDMFTFTG
MUL_1122|M.ulcerans_Agy99 TPLTANALAEVFAEAG-LPEGVLSVVPGG-VETGQALTSNPGVDLFTFTG
MAB_4484|M.abscessus_ATCC_1997 TPLSSFILAEVFAEAG-VPEGVLSVVPGG-AETGRALTNNPDVDVFSFTG
MSMEG_0309|M.smegmatis_MC2_155 TPLTTNLMAQKFLEAG-LPEGVLSVVPGG-PETGRALTDNPALDKFTFTG
Mvan_0240|M.vanbaalenii_PYR-1 TPLSVFAMAEMFVEAG-LPEGVLSIVPGG-PETGQALTANPNLDKYTFTG
Mflv_4389|M.gilvum_PYR-GCK TSLDALVFAEAAAEAG-LPPGVLNVVPGD-AAAGAHLVTHPGVDKVAFTG
Mb0791|M.bovis_AF2122/97 TPWCAAALGEIIVEHTDFPPGVVNIVTSSSHALGALLAKDPRVDMISFTG
MLBr_02573|M.leprae_Br4923 VPQCALYLADVIARGG-FPEDCFQTLLIS-ANGVEAILRDPRVAAATLTG
. :.: .* . .. : : . : ::**
MAV_3969|M.avium_104 STAAGRAVAAACAANLTKVSLELGGKSAALVLDDAPPDKVAAGVRAASLS
TH_3080|M.thermoresistible__bu STAAGRAVAAAAAAGLKRVSLELGGKSAAVVLSDADPAAVATAVRSASLS
MMAR_3965|M.marinum_M SSATGRRIAALCGEGLKRVSLELGGKSAAIILDDADIGKTVAGLKTAGLM
Rv0223c|M.tuberculosis_H37Rv SSAVGREVGRRAAEMLKPCTLELGGKSAAIILEDVDLAAAIPMMVFSGVM
MUL_1122|M.ulcerans_Agy99 SSAVGKEIGRRAAEMLKPCTLELGGKSAAILLEDVDLSTAVPMMVFSGIM
MAB_4484|M.abscessus_ATCC_1997 STAVGKEIAEIAAKNLKKVTLELGGKSAAIVLEDADLAAALPMLVFSGLM
MSMEG_0309|M.smegmatis_MC2_155 SSAVGKEIGKIAAEKLKPCTLELGGKSAAIILEDADLDSTLPMLLFSGLM
Mvan_0240|M.vanbaalenii_PYR-1 SSGVGKEIAKIAADKLKPCTLELGGKSAAIILEDADLDSTLPMLVFSGLM
Mflv_4389|M.gilvum_PYR-GCK STNAGRVIGAECGRLIRPVTLELGGKSAAVILDDADLDTTVNGLRTASFV
Mb0791|M.bovis_AF2122/97 STATGRAVMADAAATIKKVFLELGGKSAFVVLDDADLAAASAVSAFSACM
MLBr_02573|M.leprae_Br4923 SEPAGQAVGAIAGNEIKPTVLELGGSDPFIVMPSADLDAAVATAVTGRVQ
* .*: : .. : *****... ::: .. . .
MAV_3969|M.avium_104 NSGQICNALTRVLVPQARHDDYVDALAAHMGGLRVGDPADPDTDLGPLVS
TH_3080|M.thermoresistible__bu NSGQICNALTRILMPAGRAAEFTDALAAEMESLVIGDPTDAETQIGPLVA
MMAR_3965|M.marinum_M NNGQACVAQTRILVSERRHDEVVDALADMMSALQVGDPADEKTDVGPLVA
Rv0223c|M.tuberculosis_H37Rv NAGQGCVNQTRILAPRSRYDEIVAAVTNFVTALPVGPPSDPAAQIGPLIS
MUL_1122|M.ulcerans_Agy99 NTGQACVGQTRILAPRSRYEEIVEAVSAFVQTLPVGPPSDPAAQIGSLIS
MAB_4484|M.abscessus_ATCC_1997 NAGQGCVNQTRVLAPRSRYDEVVDGIVGMVSLMGVGLPDDPATQVGPLIT
MSMEG_0309|M.smegmatis_MC2_155 NSGQACVGQTRILAPRSRYDEVVEKVAAGVAAMQVGVPDDPAAMVGPLIS
Mvan_0240|M.vanbaalenii_PYR-1 NSGQACVGQTRILAPRSRYDEVVEKLAAAAAGMAPGLPDNPAAMIGPLIS
Mflv_4389|M.gilvum_PYR-GCK NNGQTCHLSSRILVPAKRYAEFVSAIAELADSLTVGDPLDEKTEIGPLVS
Mb0791|M.bovis_AF2122/97 HAGQGCAITTRLVVPRARYEEAVAIAAATMSSIRPGDPNDPGTVCGPLIS
MLBr_02573|M.leprae_Br4923 NNGQSCIAAKRFIAHADIYDEFVEKFVARMETLRVGDPTDPDTDVGPLAT
: ** * .*.: : . : * * : : *.* :
MAV_3969|M.avium_104 RRQQQRVRDYIRIGQQEGARLVVGGADMPDGLDRGWYVRPTLFAAAGNAM
TH_3080|M.thermoresistible__bu RRQQERVRGYIEAGCAEGARLVTGGPGLPAGVDRGWYVQPTLFADADNSM
MMAR_3965|M.marinum_M QRQQRRVRDYIRSGQQEGARIVLGGQDSPQ--DRGWYVRPTLFTDATNDM
Rv0223c|M.tuberculosis_H37Rv EKQRTRVEGYIAKGIEEGARLVCGG-GRPEGLDNGFFIQPTVFADVDNKM
MUL_1122|M.ulcerans_Agy99 EKQRARVEGYIAKGIEEGARLVSGG-GRPESLDNGFFVQPTVFADVDNKM
MAB_4484|M.abscessus_ATCC_1997 EKQRTRVEGYIAKGIAEGARLAYGG-KRPEGLDGGYFVQPTIFADVDNSM
MSMEG_0309|M.smegmatis_MC2_155 EKQRERVEGYIKKGIEEGARLVTGG-GRPEGLDSGWFVQPTVFADVDNSM
Mvan_0240|M.vanbaalenii_PYR-1 EKQRDRVEGYIKKGIEEGARVVTGG-GRPEGLDSGWYVQPTVFADVDNSM
Mflv_4389|M.gilvum_PYR-GCK ERQRERVLDYVQVGRDSGARLVAGG-SVPTGLERGWYVAPTVFADVDNSD
Mb0791|M.bovis_AF2122/97 ARQRDRVQGYLDLAVAEGGRFACGG-ARPADREVGFYIEPTVIAGLTNDA
MLBr_02573|M.leprae_Br4923 ESGRAQVEQQVDAAAAAGAVIRCGG---KRPDRPGWFYPPTVITDITKDM
: :* : . *. . ** *:: **::: :
MAV_3969|M.avium_104 RIAREEIFGPVITVIPYRDDDEAVAIANDSDYGLAGSVWSDDTDRALALA
TH_3080|M.thermoresistible__bu RIAREEIFGPVLTVIPYPDEDAAVAIANDSDYGLAGSVFTADTERGLAIA
MMAR_3965|M.marinum_M CIAREEIFGPVLTVLTYRDEQDAIRIANDSDYGLAGSVWTADTAHGLEIA
Rv0223c|M.tuberculosis_H37Rv TIAQEEIFGPVLAIIPYDTEEDAIAIANDSVYGLAGSVWTTDVPKGIKIS
MUL_1122|M.ulcerans_Agy99 TIAQEEIFGPVLVVIPYDTKEDAIKIANDSVYGLAGSVWTSNVPKGIEIS
MAB_4484|M.abscessus_ATCC_1997 TIAQEEIFGPVLSIIAYDSVDEAVKIANDSNYGLAGSVWTTDVQKGLEVA
MSMEG_0309|M.smegmatis_MC2_155 TIAQEEIFGPVLVVIPFEDEDDAVRIANDSVYGLAGSVYTTDHAKGVEIA
Mvan_0240|M.vanbaalenii_PYR-1 TIAQEEIFGPVLAVIPYEDEDDAVRIANDSVYGLAGSVYTTDNDRALKIA
Mflv_4389|M.gilvum_PYR-GCK RLAQEEIFGPVITITAYADDADAVRLANDTEFGLAGTVWSQDSARATEIA
Mb0791|M.bovis_AF2122/97 RVAREEIFGPVLTVIAHDGDDDAVRIANDSPYGLSGTVYGADPQRAARIA
MLBr_02573|M.leprae_Br4923 ALYTDEVFGPVASVYCATNIDDAIEIANATPFGLGSNAWTQNESEQRHFI
: :*:**** : *: :** : :**....: : . .
MAV_3969|M.avium_104 TRIHTGTVGVNQGYTMDPFAPFGGVKASGYGRELGPEGLDGYLDTKSIAV
TH_3080|M.thermoresistible__bu ARIRTGTFGVNQGYTMDPFAPFGGVKGSGYGRELGPEGIDAYTDVKSISV
MMAR_3965|M.marinum_M AAVRTGTYGINM-YTLDISAPFGGFKQSGIGREFGPEGLAEYVELQTVLC
Rv0223c|M.tuberculosis_H37Rv QQIRTGTYGINW-YAFDPGSPFGGYKNSGIGRENGPEGVEHFTQQKSVLL
MUL_1122|M.ulcerans_Agy99 EKIRTGTYAINW-YAFDPCCPFGGYKNSGIGRENGPEGVEHFTQQKSVLM
MAB_4484|M.abscessus_ATCC_1997 AQIRTGTYGINW-YAFDPSCPFGGYKQSGIGRENGPEGIEEYCELKSVLL
MSMEG_0309|M.smegmatis_MC2_155 SKVRTGTYGINM-YAFDPGAPFGGYKNSGIGRECGPEGIAGYCESKSVLL
Mvan_0240|M.vanbaalenii_PYR-1 RRIRTGTYAVNM-YAFDPCAPFGGFKNSGIGRENGWEGIEAYCEPKSILL
Mflv_4389|M.gilvum_PYR-GCK RAMHTGSVGVNH-YQLDIQSPFGGIKSSGLGRELGPEGLDAYLVTKSIYQ
Mb0791|M.bovis_AF2122/97 SRLRVGTVNVNGGVWYCADAPFGGYKQSGIGREMGLLGFEEYLEAKLIAT
MLBr_02573|M.leprae_Br4923 DNIVAGQVFINGMTVSYPELPFGGIKRSGYGRELSTHGIREFCNIKTVWI
: .* :* **** * ** *** . *. : : :
MAV_3969|M.avium_104 APSG-----------
TH_3080|M.thermoresistible__bu APASTT---------
MMAR_3965|M.marinum_M SGKMPPLRGFEEPAG
Rv0223c|M.tuberculosis_H37Rv PMGYTVA--------
MUL_1122|M.ulcerans_Agy99 PMGYTLES-------
MAB_4484|M.abscessus_ATCC_1997 PMGYTLESI------
MSMEG_0309|M.smegmatis_MC2_155 PFGYTPE--------
Mvan_0240|M.vanbaalenii_PYR-1 PFGYTPAT-------
Mflv_4389|M.gilvum_PYR-GCK ADPFPE---------
Mb0791|M.bovis_AF2122/97 AAN------------
MLBr_02573|M.leprae_Br4923 A--------------
.