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DFLESPEHRDLRQAVGAVTDKYGPGYFAECATAGEPTTDLWQDLAAHGFIGISLPEEFGGGGAGMAELAI VCEETAAHGCPLLLLLVSSAISGELIARYGSAEQRQEWLPRMASGETKVVFAITEPDAGSNTHKISTTAQ RDGDDYVITGTKYYISGVDEAGALIVVARTAPEKLSLFLVPTDAPGLVAHRLPVGISLPEKQFTLHFDNV RLPATSLVGTEHEGFRQVFDGLNPERITGAAVCLGVGRHAIAKAADYARVRSVWGPAIGSYQAISHPLAQ ARIEVDLAAMMTAKAAWLYDNGHPAGEASNMAKYAAAEAAVAAADQAIQTHGGNGLSAEYGLLPQWGLAR LLRIAPVSREMILNYVAQHTLALPRSY*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_0341 | - | - | 100% (378) | acyl-CoA dehydrogenase domain-containing protein |
| M. vanbaalenii PYR-1 | Mvan_4850 | - | e-116 | 55.06% (385) | acyl-CoA dehydrogenase domain-containing protein |
| M. vanbaalenii PYR-1 | Mvan_4210 | - | 2e-65 | 35.46% (392) | acyl-CoA dehydrogenase domain-containing protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0997c | fadE12 | 1e-112 | 53.00% (383) | acyl-CoA dehydrogenase FADE12 |
| M. gilvum PYR-GCK | Mflv_4615 | - | 1e-122 | 57.03% (384) | acyl-CoA dehydrogenase domain-containing protein |
| M. tuberculosis H37Rv | Rv0972c | fadE12 | 1e-113 | 53.26% (383) | acyl-CoA dehydrogenase FADE12 |
| M. leprae Br4923 | MLBr_00737 | fadE25 | 2e-33 | 27.94% (340) | putative acyl-CoA dehydrogenase |
| M. abscessus ATCC 19977 | MAB_2065c | - | 1e-131 | 60.42% (384) | acyl-CoA dehydrogenase FadE |
| M. marinum M | MMAR_4535 | fadE12 | 1e-113 | 53.26% (383) | acyl-CoA dehydrogenase FadE12 |
| M. avium 104 | MAV_1088 | - | 1e-115 | 54.05% (383) | acyl-CoA dehydrogenase fadE12 |
| M. smegmatis MC2 155 | MSMEG_0338 | - | 0.0 | 81.75% (378) | acyl-CoA dehydrogenase fadE12 |
| M. thermoresistible (build 8) | TH_3057 | - | 1e-120 | 54.74% (380) | PUTATIVE acyl-CoA dehydrogenase domain protein |
| M. ulcerans Agy99 | MUL_4707 | fadE12 | 1e-113 | 53.00% (383) | acyl-CoA dehydrogenase FadE12 |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_0341|M.vanbaalenii_PYR-1 ----------MDFLESPEHRDLRQAVGAVTDKYGPGYFAECATAGEPTTD
MSMEG_0338|M.smegmatis_MC2_155 ----------MDFREPSEHSDLRAAVAAITDRYGPAYFAERATAHEPTDE
Mb0997c|M.bovis_AF2122/97 -------MTDTSFIESEERQALRKAVASWVANYGHEYYLDKARKHEHTSE
Rv0972c|M.tuberculosis_H37Rv -------MTDTSFIESEERQALRKAVASWVANYGHEYYLDKARKHEHTSE
MMAR_4535|M.marinum_M -------MTDTSFIENEDRRALRKAVSEWASNYGHEYYLKKARAHEHTTE
MUL_4707|M.ulcerans_Agy99 ------MMTGTSFIENEDRRALRKAVSEWASNYGHEYYLKKARAHEHTTE
MAV_1088|M.avium_104 -------MTDSSFIENEERQALRKAVAEWASNYGSEYYLRKARAHEHTNE
Mflv_4615|M.gilvum_PYR-GCK ----------MELHETEERRALRKAVSEIAKDFGHDYYVAKSLGGEKSSE
MAB_2065c|M.abscessus_ATCC_199 ----------MELHETEERQDLRKAVAEIAKDFGHEYYLEKSLAGAKSTE
TH_3057|M.thermoresistible__bu --------MSGLLHETDEHRAIRETVAGIAQRYGVHYYLERGRAGGNIDE
MLBr_00737|M.leprae_Br4923 MVGWSGNPLFDLFKLPEEHNELRATIRALAEKEIAPHAADVDQRARFPEE
: :: :* :: . : :
Mvan_0341|M.vanbaalenii_PYR-1 LWQDLAAHGFIGISLPEEFGGGGAGMAELAIVCEETAAHGCPLLLLLVSS
MSMEG_0338|M.smegmatis_MC2_155 LWKDLAQHGFIGINFPEEFGGGGAGMAELAIVCEETAAGGCPLLLMLVSS
Mb0997c|M.bovis_AF2122/97 LWAEAGKLGFLGVNLPEEYGGGGAGMYELSLVMEEMAAAGSALLLMVVSP
Rv0972c|M.tuberculosis_H37Rv LWAEAGKLGFLGVNLPEEYGGGGAGMYELSLVMEEMAAAGSALLLMVVSP
MMAR_4535|M.marinum_M LWSEAGKLGFIGVNLPEEYGGGGAGMYELSMVMEEMAAAGSALLLMVVSP
MUL_4707|M.ulcerans_Agy99 LWSEAGKLGFIGVNLPEEYGGGGAGMYELSMVMEEMAAAGSALLLMVVSP
MAV_1088|M.avium_104 LWSEAGKLGFLGVNLPEEYGGGGAGMYELSLVMEEMAAAGSALLLMVVSP
Mflv_4615|M.gilvum_PYR-GCK LWHAVGEQGFLGINIAEEYGGGGGGIYDMQIVGEELAAAGCPLLMTVVSP
MAB_2065c|M.abscessus_ATCC_199 LWQAVGKQGFLGVNLSEQYGGGGGGIYDMQIVGEELAAAGCPLLMTVVSP
TH_3057|M.thermoresistible__bu LWKDLGAAGLLGVHLPEEYGGGGGGMAEAVIVVEELAAHGMPLLIWVISP
MLBr_00737|M.leprae_Br4923 ALAALNASGFNAIHVPEEYGGQGADSVAACIVIEEVARVDASASLIPAVN
*: .: ..*::** *.. :* ** * . . :
Mvan_0341|M.vanbaalenii_PYR-1 AISGELIARYGSAEQRQEWLPRMASGETKVVFAITEPDAGSNTHKISTTA
MSMEG_0338|M.smegmatis_MC2_155 AISGELISRYGSSEQQKDWLPRMASGETKVVFAITEPDAGSNTRQIATTA
Mb0997c|M.bovis_AF2122/97 AINGTIIAKFGTDDQKKRWLPGIADGSLTMAFAITEPDAGSNSHKITTTA
Rv0972c|M.tuberculosis_H37Rv AINGTIIAKFGTDDQKKRWLPGIADGSLTMAFAITEPDAGSNSHKITTTA
MMAR_4535|M.marinum_M AINGTIISKFGTDEQKQRWLPGIADGTLTMAFAITEPDAGSNSHKITTTA
MUL_4707|M.ulcerans_Agy99 AINGTIISKFGTDEQKQRWLPGIADGTLTMAFAITEPEAGSNSHKITTTA
MAV_1088|M.avium_104 AINGTIISKFGTEEQKKRWLPGIADGTLTMAFAITEPDAGSNSHKITTTA
Mflv_4615|M.gilvum_PYR-GCK TICGTIIQAFGSDELKARWLPGIASGEVIMAFAITEPDAGSNSHNISTYA
MAB_2065c|M.abscessus_ATCC_199 TICGTIIQAFGSEELKQQWLPGIASGETIMAFAITEPDAGSNSHNISTTA
TH_3057|M.thermoresistible__bu AICGSILAHHGSDAMRKDWLPTIADGSRRMAFGLTEPDAGSNSHNVKTTA
MLBr_00737|M.leprae_Br4923 KLGTMGLILRGSEELKKQVLPSLAAEGAMASYALSEREAGSDAASMRTRA
: : *: : ** :* :.::* :***:: .: * *
Mvan_0341|M.vanbaalenii_PYR-1 QRDGDDYVITGTKYYISGVDEAGALIVVARTA------PEKLSLFLVPTD
MSMEG_0338|M.smegmatis_MC2_155 VRDGGDYVINGTKYYISGVDEAECLIVVTRTA------PERLSLFLVPTD
Mb0997c|M.bovis_AF2122/97 RRDGSDWIIKGQKVFISGIDQAQAVLVVGRSEEAKT-GKLRPALFVVPTD
Rv0972c|M.tuberculosis_H37Rv RRDGSDWIIKGQKVFISGIDQAQAVLVVGRSEEAKT-GKLRPALFVVPTD
MMAR_4535|M.marinum_M RRDGSDWIIKGQKVYISGIDQAQAVLVVGRTEEAKT-GKLRPALFVVPTD
MUL_4707|M.ulcerans_Agy99 RRDGSDWIIKGQKVYISGIDQAQAVLVVGRTEEAKT-GKLRPALFVVPTD
MAV_1088|M.avium_104 RRDGSDWILKGQKVFISGIDQAQAVLVVARTEEAKT-GKLRPALFVVPTD
Mflv_4615|M.gilvum_PYR-GCK KRVGGDWILNGTKYYISGVDEAEAILVVTRTATDDR-GRGRLSLLVVPTD
MAB_2065c|M.abscessus_ATCC_199 KRDGDDWVINGTKYYISGVDEAEAILVVTRTSTNDS-GRGLLSLLVVPTD
TH_3057|M.thermoresistible__bu RRTDSGWVISGSKYYISAVDESDAILLVTRDADLSTPEKSRLSLFVVPTD
MLBr_00737|M.leprae_Br4923 KADGDDWILNGFKCWITNGGKSTWYTVMAVTDPDKG--ANGISAFIVHKD
...:::.* * :*: .:: :: : ::* .*
Mvan_0341|M.vanbaalenii_PYR-1 APGLVAHRLPVGISLP-EKQFTLHFDNVRLPATSLVGTEHEGFRQVFDGL
MSMEG_0338|M.smegmatis_MC2_155 APGLVKHRLPVGINLP-EKQYTLHFDNVRVPASNLVGVEHEGFKQVFDGL
Mb0997c|M.bovis_AF2122/97 APGFSYTPIEMELVSP-ERQFQVFLDDVRLPADALVGAEDAAIAHLFAGL
Rv0972c|M.tuberculosis_H37Rv APGFSYTPIEMELVSP-ERQFQVFLDDVRLPADALVGAEDAAIAQLFAGL
MMAR_4535|M.marinum_M TPGFTYTAIDMELVSP-ERQFQVFLDDVRLPADALVGAQDAAIAQLFAGL
MUL_4707|M.ulcerans_Agy99 TPGFTYTAIDMELVSP-ERQFQVFLDDVRLPADALVGAQDAAIAQLFAGL
MAV_1088|M.avium_104 APGFSATPIEMELISP-ERQFQVFLDDVRLPSDALVGAEDAAIAQLFAGL
Mflv_4615|M.gilvum_PYR-GCK APGLTKTLIPVQAVTP-EKQFTLFFDDVRVPAENLIGAENDGLRQVFMGL
MAB_2065c|M.abscessus_ATCC_199 VPGLTKSLIPVQAVTP-EKQFTLFFDDVRVPAANLIGTENEGLRQVFMGL
TH_3057|M.thermoresistible__bu APGLTYQQIPTSIVSP-DKQFTVFLDNVEVGEEALIGEAGNGLRQVFDGL
MLBr_00737|M.leprae_Br4923 DEGFSIGPKEKKLGIKGSPTTELYFDKCRIPGDRIIGEPGTGFKTALATL
*: . :.:*. .: ::* .: : *
Mvan_0341|M.vanbaalenii_PYR-1 NPERITGAAVCLGVGRHAIAKAADYARVRSVWGPAIGSYQAISHPLAQAR
MSMEG_0338|M.smegmatis_MC2_155 NPERITGAAVCVGIGRHVVEKAADYARQRSVWGPPIGTYQAIAHPLAKAK
Mb0997c|M.bovis_AF2122/97 NPERIMGAASAVGMGRFALGRAVDYVKTRKVWSTPIGAHQGLAHPLAQCH
Rv0972c|M.tuberculosis_H37Rv NPERIMGAASAVGMGRFALGRAVDYVKTRKVWSTPIGAHQGLAHPLAQCH
MMAR_4535|M.marinum_M NPERIMGAASAVGMGRFALNRAVDYVKTRQVWSTPIGAHQGLAHPLAQCH
MUL_4707|M.ulcerans_Agy99 NPERIMGAASAVGMGRFALNRAVDYVKTRQVWSTPIGAHQGLAHPLAQCH
MAV_1088|M.avium_104 NPERIMGAASSVGMGRFALARAAEYVKTRQVWGTPVGAHQGLSHPLAQCH
Mflv_4615|M.gilvum_PYR-GCK NPERIMGAALGNGIGRYALDKASAYARERKVWDVPIGAHQGLSHPLAHAK
MAB_2065c|M.abscessus_ATCC_199 NPERIMGAALGNGIGRYALDKAADYARNRHVWGAPIGSHQGVSHPLAHAK
TH_3057|M.thermoresistible__bu NPERIMVGALCGGIGRYAIGKAAEYAKERTVWSTPIGAHQGVAHPLAECH
MLBr_00737|M.leprae_Br4923 DHTRPTIGAQAVGIAQGALDAAIVYTKDRKQFGESISTFQSIQFMLADMA
: * .* *:.: .: * *.: * :. .:.:.*.: . **.
Mvan_0341|M.vanbaalenii_PYR-1 IEVDLAAMMTAKAAWLYDNGHP--AGEASNMAKYAAAEAAVAAADQAIQT
MSMEG_0338|M.smegmatis_MC2_155 IEVDMAALATSRAAWLFDNQLP--AGEASNIAKYLAAEAAVAAADHAIQL
Mb0997c|M.bovis_AF2122/97 IEVELAKLMTQKAATLYDHGDDFGAAEAANMAKYAAAEASSRAVDQAVQS
Rv0972c|M.tuberculosis_H37Rv IEVELAKLMTQKAATLYDHGDDFGAAEAANMAKYAAAEASSRAVDQAVQS
MMAR_4535|M.marinum_M IEVELAKLMMQKAATLYDHGDDGGAAEAANMAKYAAAEASARSVDQAVQS
MUL_4707|M.ulcerans_Agy99 IEVELAKLMMQKAATLYDHGDDGGAAEAANMAKYAAAEASARSVDQAVQS
MAV_1088|M.avium_104 IEVELAKLMMQKAATLYDAGNDMGAAEAANMAKYAAAEAATRSVDQAVQS
Mflv_4615|M.gilvum_PYR-GCK IQLELARLMTQRAASLHDADDPG-SAEASNMAKYAAAEAGILALDQAIQT
MAB_2065c|M.abscessus_ATCC_199 IQVELARLMTQRAAALHDAGDPG-SGEASNMAKYAAAEAGILALDQAIQT
TH_3057|M.thermoresistible__bu IAVELSRLVTARSAELFDAGEP--AGEAANIAKFAASEAALKALDQAIQT
MLBr_00737|M.leprae_Br4923 MKVEAARLIVYAAAARAERGEPD-LGFISAASKCFASDIAMEVTTDAVQL
: :: : : :* : . : :* *:: . .*:*
Mvan_0341|M.vanbaalenii_PYR-1 HGGNGLSAEYGLLPQWGLARLLRIAPVSREMILNYVAQHTLALPRSY
MSMEG_0338|M.smegmatis_MC2_155 HGGNGISAEYGLLPQWGLARLLQIAPVSREMILNYVAQHSLNLPRSY
Mb0997c|M.bovis_AF2122/97 MGGNGLTKEYGVAAMMTSARLARIAPISREMVLNFVAQTSLGLPRSY
Rv0972c|M.tuberculosis_H37Rv MGGNGLTKEYGVAAMMTSARLARIAPISREMVLNFVAQTSLGLPRSY
MMAR_4535|M.marinum_M MGGNGLTQEYGVAAMLTSSRLARIAPISREMVLNFVAQTSLGLPRSY
MUL_4707|M.ulcerans_Agy99 MGGNGLTQEYGVAAMLTSSRLARIAPISREMVLNFVAQTSLGLPRSY
MAV_1088|M.avium_104 MGGNGLTKEYGVAAMLASARLGRIAPVSREMVLNFVAQTSLGLPRSY
Mflv_4615|M.gilvum_PYR-GCK HGGNGLATEYGLATLWGPARLMRTAPISREMILNYVAQHSLNLPRSY
MAB_2065c|M.abscessus_ATCC_199 HGGNGMATEYGLATLWGPARLMRTAPISREMILNFVAQHSLKLPASY
TH_3057|M.thermoresistible__bu HGGNGLSYEYGLSELWFVTRLMRTAPVSREMVLNFVAQTSLGLPRSY
MLBr_00737|M.leprae_Br4923 FGGAGYTSDFPVERFMRDAKITQIYEGTNQIQRVVMSRALLR-----
** * : :: : ::: : :.:: ::: *