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MSLPTVEPVLDPYDYDFHEDPYPYYKRLRDEAPLYRNDERNFWALSRHEDVLKGFRNSTALSNKHGVSLD PVSRNDEAHRVMSFLALDDPAHLRLRTLVSKGFTPRRIRELEARVTEIAVQHLEIALQSDSFDFVDDFAG KLPMDVISELMGVPEEDRVRIRALADGVMHREDGVADVPASAIAASGELLVYYADMVKRRRRNVSDDLTS ALVEAEIDGDKLTDDEIMAFLFLMVVAGNETTTKLLANAAYWGFKNPDQLAPVFDDHSQIPLWVEETLRY DTSSQILARAVVEDLTFYGTTVPAGDVLVLLAGSANRDERAFDDPDEYRIGRDIGSKLVSFGSGAHFCLG AHLARMEARVALAELFKRIRGYDVDESASVRVHSSSVRGFAHLPITVEKR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_5861 | - | - | 100% (400) | cytochrome P450 109 |
| M. smegmatis MC2 155 | MSMEG_3693 | - | 2e-73 | 41.31% (397) | cytochrome P450 monooxygenase |
| M. smegmatis MC2 155 | MSMEG_4818 | - | 2e-72 | 37.66% (401) | putative cytochrome P450 123 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0789c | cyp123 | 1e-175 | 75.63% (394) | cytochrome P450 123 |
| M. gilvum PYR-GCK | Mflv_1598 | - | 1e-175 | 76.59% (393) | cytochrome P450 |
| M. tuberculosis H37Rv | Rv0766c | cyp123 | 1e-175 | 75.63% (394) | cytochrome P450 123 |
| M. leprae Br4923 | MLBr_02088 | - | 8e-51 | 33.50% (391) | putative cytochrome p450 |
| M. abscessus ATCC 19977 | MAB_1216c | - | 1e-171 | 73.67% (395) | cytochrome P450 |
| M. marinum M | MMAR_4930 | cyp123A3 | 1e-174 | 75.76% (396) | cytochrome P450 123A3 Cyp123A3 |
| M. avium 104 | MAV_0366 | - | 1e-73 | 40.86% (394) | cytochrome P450 superfamily protein |
| M. thermoresistible (build 8) | TH_2506 | - | 1e-176 | 74.63% (402) | PUTATIVE cytochrome P450 |
| M. ulcerans Agy99 | MUL_0475 | cyp123A3 | 1e-173 | 75.25% (396) | cytochrome P450 123A3 Cyp123A3 |
| M. vanbaalenii PYR-1 | Mvan_5159 | - | 1e-175 | 75.95% (395) | cytochrome P450 |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_1598|M.gilvum_PYR-GCK --------------------------MTTS-----AVRLDPYNYDFHEDP
Mvan_5159|M.vanbaalenii_PYR-1 --------------------------MTIS-----EVRLDPYNYDFHEDP
TH_2506|M.thermoresistible__bu --------------------------MTVT-----ELILDPYDYDFHEDP
MMAR_4930|M.marinum_M --------------------------MSVHV-GGPELVLDPYDYDFHEDP
MUL_0475|M.ulcerans_Agy99 --------------------------MSVHV-GGPELVLDPYDYDFHEDP
MSMEG_5861|M.smegmatis_MC2_155 --------------------------MSLP---TVEPVLDPYDYDFHEDP
Mb0789c|M.bovis_AF2122/97 --------------------------MTVRVGDPE-LVLDPYDYDFHEDP
Rv0766c|M.tuberculosis_H37Rv --------------------------MTVRVGDPE-LVLDPYDYDFHEDP
MAB_1216c|M.abscessus_ATCC_199 --------------------------MTVAETSAVPLVFDPYDYDFHEDP
MAV_0366|M.avium_104 --------------------------MTVAN--DTAVYYDPYDIGIITDP
MLBr_02088|M.leprae_Br4923 MRTCVPTRTCVYAFIEYLSHNRPMGTNPPSLVEAQMLLLRLIDPGTRADP
. : . **
Mflv_1598|M.gilvum_PYR-GCK YPYYQRLRDEAPLYRNDELGFWALSRHADVLKGFRNSTTLSNKFGVSLDP
Mvan_5159|M.vanbaalenii_PYR-1 YPYYKRLRDEAPLYRNEELGFWALSRHADVLKGFRNSTTLSNKFGVSLDP
TH_2506|M.thermoresistible__bu YPYYKRLRDEAPLYHNEDLGFWALSRHADVLKGFRNSVNLSNKYGVSLDP
MMAR_4930|M.marinum_M YPYYRRLRDEAPLYHNQELGFWALSRHRDVHQGFRNSTTLSNRDGVSLDP
MUL_0475|M.ulcerans_Agy99 YPYYRRLRNEAPLYHNQELGFWALSRRRDVHQGFRNSTTLSNRDGVSLDP
MSMEG_5861|M.smegmatis_MC2_155 YPYYKRLRDEAPLYRNDERNFWALSRHEDVLKGFRNSTALSNKHGVSLDP
Mb0789c|M.bovis_AF2122/97 YPYYRRLRDEAPLYRNEERNFWAVSRHHDVLQGFRDSTALSNAYGVSLDP
Rv0766c|M.tuberculosis_H37Rv YPYYRRLRDEAPLYRNEERNFWAVSRHHDVLQGFRDSTALSNAYGVSLDP
MAB_1216c|M.abscessus_ATCC_199 YPYYRRLRDEAPLYRNDDLKFWALSRHHDVLQGFRNSEALSNANGVSMDK
MAV_0366|M.avium_104 YPTYARLREEAPIYYNERYDFWALSRHSDVERALANWQVFSNRRSDILEL
MLBr_02088|M.leprae_Br4923 FPVYRALIDYGPMQLPG-MPLTVFSSFSDCDEALRHPLSASDRLKATLAQ
:* * * : .*: : ..* * ..: . *: :
Mflv_1598|M.gilvum_PYR-GCK A----SRGPHASKTMSFLAMDDPDHLRLRTLVSKGFTPRRIRELEPRVTE
Mvan_5159|M.vanbaalenii_PYR-1 A----SRGPHASKTMSFLAMDDPAHLRLRTLVSKGFTPRRIRELEPRVTE
TH_2506|M.thermoresistible__bu A----SRGPHASKTMSFLAMDDPEHLRLRTLVSKGFTPRRVRELEPRVTE
MMAR_4930|M.marinum_M V----SRGPHATKTMSFLAMDDPAHLRLRTLVSKGFTPRRIRELEPRVTE
MUL_0475|M.ulcerans_Agy99 V----SRGPHATKTMSFLAIDDPAHLRLRTLVSKGFTPRRIRELEPRVTE
MSMEG_5861|M.smegmatis_MC2_155 V----SRNDEAHRVMSFLALDDPAHLRLRTLVSKGFTPRRIRELEARVTE
Mb0789c|M.bovis_AF2122/97 S----SRTSEAYRVMSMLAMDDPAHLRMRTLVSKGFTPRRIRELEPQVLE
Rv0766c|M.tuberculosis_H37Rv S----SRTSEAYRVMSMLAMDDPAHLRMRTLVSKGFTPRRIRELEPQVLE
MAB_1216c|M.abscessus_ATCC_199 A----SFGPHAKLVMSFLAMDDPEHLRLRALVSKGFTPRRIRELEGQVVA
MAV_0366|M.avium_104 IQ---SKFDMPGGVMMFQ--DPPEHTVLRGLMSRVFTPRRMAALEDQIRQ
MLBr_02088|M.leprae_Br4923 QAIAAGAEPRPFYASSFMFLDPPDHTRLRKLVSKAFAPKVVQALEGDIAA
. . . : * * * :* *:*: *:*: : ** :
Mflv_1598|M.gilvum_PYR-GCK IANQHLDSMLEAAASGATVDYVDEFAGKLPMDVISELMGVPNADR-----
Mvan_5159|M.vanbaalenii_PYR-1 IAVTHLDAMLEQATTGDAVDYVDEFAGKLPMDVISELMGVPDADR-----
TH_2506|M.thermoresistible__bu IATQHLDTMLARAGDNETVDYVDEFAGKLPMDVISELMGVPEPDR-----
MMAR_4930|M.marinum_M LAVAHLDTMLDMAGGSQTVDYVAEFAGKLPMDVISELMGVPVADR-----
MUL_0475|M.ulcerans_Agy99 LAVAHLDTMLDMAGGSQTVDYVAEFAGKLPMDVISELMGVPVADR-----
MSMEG_5861|M.smegmatis_MC2_155 IAVQHLEIALQ----SDSFDFVDDFAGKLPMDVISELMGVPEEDR-----
Mb0789c|M.bovis_AF2122/97 LARIHLDSALQ-TES---FDFVAEFAGKLPMDVISELIGVPDTDR-----
Rv0766c|M.tuberculosis_H37Rv LARIHLDSALQ-TES---FDFVAEFAGKLPMDVISELIGVPDTDR-----
MAB_1216c|M.abscessus_ATCC_199 LARTHLDRALA-NASDRSFDFIAEYAGKLPMDVISELMGVPESDR-----
MAV_0366|M.avium_104 YCIRCLDPLVG----SSSFDIIAELASMMPMRVIGMLLGIPESEQ-----
MLBr_02088|M.leprae_Br4923 LVDSLLDKGAA----AGQFDVIADLAFPLAVAVICRLLGVPYEDAPEFGR
*: .* : : * :.: ** *:*:* :
Mflv_1598|M.gilvum_PYR-GCK --AQVRAWADAVMHREDGVTDVPDSAIEASLNLIVYYQEMVKQRRTALTD
Mvan_5159|M.vanbaalenii_PYR-1 --VQVRAWADAVMHRDDGVTDVPDSAIEASLNLIVYYQEMVAERRKKLTD
TH_2506|M.thermoresistible__bu --AQLRAWADGVMHREEGVTDVPPAAVEASINLIVYYQQMVAERRRKPTD
MMAR_4930|M.marinum_M --DQIRAMADGVMHREDGVTDVPASAIEASINLIVYYQQMIAERRKKPSD
MUL_0475|M.ulcerans_Agy99 --DQIRAMADGVMHREDGVTDVPASAIEASINLIVYYQQMIAERRKKPSD
MSMEG_5861|M.smegmatis_MC2_155 --VRIRALADGVMHREDGVADVPASAIAASGELLVYYADMVKRRRRNVSD
Mb0789c|M.bovis_AF2122/97 --ARIRALADAVLHREDGVADVPPPAMAASIELMRYYADLIAEFRRRPAN
Rv0766c|M.tuberculosis_H37Rv --ARIRALADAVLHREDGVADVPPPAMAASIELMRYYADLIAEFRRRPAN
MAB_1216c|M.abscessus_ATCC_199 --ARIRELADGVMHREDGLADVPPEAIQASFDLMTYYIEMVRERRRRPTE
MAV_0366|M.avium_104 --VSVRDANDANLRTKPGAP--LRVADADSIADGRIYADYVEWRSKNPSD
MLBr_02088|M.leprae_Br4923 VSALLVQSVDPFITITGEPPEATEERLRAGVWLRDYLEQLVKCRRGTPGE
: * : . . : : :
Mflv_1598|M.gilvum_PYR-GCK DLTSALLEAEIDGD-----RLTDDEIIGFMFLMVIAGNETTTKLLANAAF
Mvan_5159|M.vanbaalenii_PYR-1 DLTSALLEAEIDGD-----RLTDDEIIGFMFLMVIAGNETTTKLLANAAF
TH_2506|M.thermoresistible__bu DLTTALLEAEIDGD-----RLTDDEILGFMFLMVIAGNETTTKLLANAMY
MMAR_4930|M.marinum_M DLTSALLAADVDGD-----RLTDEEVLGFMFLMVIAGNETTTKLLANAAF
MUL_0475|M.ulcerans_Agy99 DLTSALLAADVDGD-----RLTDEEVLGFMFLMVIAGNETTTKLLANAAF
MSMEG_5861|M.smegmatis_MC2_155 DLTSALVEAEIDGD-----KLTDDEIMAFLFLMVVAGNETTTKLLANAAY
Mb0789c|M.bovis_AF2122/97 NLTSALLAAELDGD-----RLSDQEIMAFLFLMVIAGNETTTKLLANAVY
Rv0766c|M.tuberculosis_H37Rv NLTSALLAAELDGD-----RLSDQEIMAFLFLMVIAGNETTTKLLANAVY
MAB_1216c|M.abscessus_ATCC_199 DLTSALLQAEIDGD-----RLTDEEVLAFLFLMVIAGNETTTKLLANAVY
MAV_0366|M.avium_104 DLMTTLLNVEFDDEDGVRRKLTRKEVLHYTQVVAGAGNETTGRLIGWLAK
MLBr_02088|M.leprae_Br4923 DLISRLIELDESGD-----QLTEEEIIATCGLLLVAGHETTVNLIANAVL
:* : *: : ..: :*: .*:: :: **:*** .*:.
Mflv_1598|M.gilvum_PYR-GCK WGHRNPDQLGPVFDDHERIPLWVEETLRYDTSSQILARTVIGELELYDTV
Mvan_5159|M.vanbaalenii_PYR-1 WGHRNPDQLTSVYQDLARVPLWVEETLRFDTSSQILARTVSGELTLYDTT
TH_2506|M.thermoresistible__bu WAHRNPDQIAPLYDDLDRIPQWVEETLRYDTSSQILARTVVGDLTLYDTR
MMAR_4930|M.marinum_M WGHKNTDQLTPIYADLSRVPLWVEETLRYDTSSQILARTVVGELTLYDTT
MUL_0475|M.ulcerans_Agy99 WGHKNTDQLTPIYADLSRVPLWVEETLRYDTSSQILARTVVGELTLYDTT
MSMEG_5861|M.smegmatis_MC2_155 WGFKNPDQLAPVFDDHSQIPLWVEETLRYDTSSQILARAVVEDLTFYGTT
Mb0789c|M.bovis_AF2122/97 WAAHHPGQLARVFADHSRIPMWVEETLRYDTSSQILARTVAHDLTLYDTT
Rv0766c|M.tuberculosis_H37Rv WAAHHPGQLARVFADHSRIPMWVEETLRYDTSSQILARTVAHDLTLYDTT
MAB_1216c|M.abscessus_ATCC_199 WGHRNPDQLATVHADHDRIPLWVEESLRYDTSSQILARTVAEDITVYDTK
MAV_0366|M.avium_104 VLAEHPDQRREVYRDRSLLTRTVDETLRFEPTGPHVARWMAADFECYGTT
MLBr_02088|M.leprae_Br4923 AMLRNPSQWKALSSNPQRAPLVVEETLRYDPAIHLIGRVAAKDMTIGQTT
.:..* : : . *:*:**::.: :.* :: *
Mflv_1598|M.gilvum_PYR-GCK LPDGDVVLLLPGSAHRDERVFQNPDDFVIGREIGSKLMSFGSGAHFCLGA
Mvan_5159|M.vanbaalenii_PYR-1 IPDGDVVLLLPGSAHRDERVFENPDDYVIGREIGSKLMSFGSGAHFCLGA
TH_2506|M.thermoresistible__bu IPEGDVVLLLPGSAHRDERVFDDPDRYLIGREIGSKLVSFGSGAHFCLGA
MMAR_4930|M.marinum_M IPEGDVVLLLPGSAHRDERAFRDPDEYLIGREIGSKLLSFGSGAHFCLGA
MUL_0475|M.ulcerans_Agy99 IPEGDVVLLLPGSAHRDERAFRDPDEYLIGREIGSKLLSFGSGAHFCLGA
MSMEG_5861|M.smegmatis_MC2_155 VPAGDVLVLLAGSANRDERAFDDPDEYRIGRDIGSKLVSFGSGAHFCLGA
Mb0789c|M.bovis_AF2122/97 IPEGEVLLLLPGSANRDDRVFDDPDDYRIGREIGCKLVSFGSGAHFCLGA
Rv0766c|M.tuberculosis_H37Rv IPEGEVLLLLPGSANRDDRVFDDPDDYRIGREIGCKLVSFGSGAHFCLGA
MAB_1216c|M.abscessus_ATCC_199 IPAGDILLLLPGSANRDDRVFDDADQYRIGREIGAKLVSFGSGAHFCLGA
MAV_0366|M.avium_104 VPAGSAMLLLFGAANRDPRRYTDPDTFNIHRDN-ISHITFGKGVHYCLGA
MLBr_02088|M.leprae_Br4923 LTEGDTMVLLLAAANRDPAVYSRPDEFDPDRPS-SRHLAFAVGSHFCLGA
:. *. ::** .:*:** : .* : * ::*. * *:****
Mflv_1598|M.gilvum_PYR-GCK HLARMEARVALAELFKRIRGYEVDEDNAVRVHSSNVRGFAHLPISVKVS-
Mvan_5159|M.vanbaalenii_PYR-1 HLARMEARVALAELFKRIRGYEVDEANAVRVHSSNVRGFAHLPIRVEIR-
TH_2506|M.thermoresistible__bu HLARMEARVALTELFKRIRGYEVDEANAVRVHSSNVRGFAHLPITVEVR-
MMAR_4930|M.marinum_M HLARMEARVALTELFKRIRGYQVDEGNAVRVHSSNVRGFAHLPITVEVA-
MUL_0475|M.ulcerans_Agy99 HLARMEARVALTELFKRIRGYQVDEGNAVRVHSSNVRGFAHLPITVEVA-
MSMEG_5861|M.smegmatis_MC2_155 HLARMEARVALAELFKRIRGYDVDESASVRVHSSSVRGFAHLPITVEKR-
Mb0789c|M.bovis_AF2122/97 HLARMEARVALGALLRRIRNYEVDDDNVVRVHSSNVRGFAHLPISVQAR-
Rv0766c|M.tuberculosis_H37Rv HLARMEARVALGALLRRIRNYEVDDDNVVRVHSSNVRGFAHLPISVQAR-
MAB_1216c|M.abscessus_ATCC_199 HLARMEAKVALTELFTRISGYEIDERNSVRVHSSNVRGFAHLPMTVQLRE
MAV_0366|M.avium_104 NLARLEGRVALDELLNRWPEWDIDYDTAQLASTSTVRGWERLRIVVP---
MLBr_02088|M.leprae_Br4923 ALARLEATVTLSAISARFPQVQLAG-ELVYKPNVAMRGMSALPVQV----
***:*. *:* : * :: . :** * : *
Mflv_1598|M.gilvum_PYR-GCK --
Mvan_5159|M.vanbaalenii_PYR-1 --
TH_2506|M.thermoresistible__bu --
MMAR_4930|M.marinum_M --
MUL_0475|M.ulcerans_Agy99 --
MSMEG_5861|M.smegmatis_MC2_155 --
Mb0789c|M.bovis_AF2122/97 --
Rv0766c|M.tuberculosis_H37Rv --
MAB_1216c|M.abscessus_ATCC_199 GR
MAV_0366|M.avium_104 --
MLBr_02088|M.leprae_Br4923 --