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SVHVGGPELVLDPYDYDFHEDPYPYYRRLRNEAPLYHNQELGFWALSRRRDVHQGFRNSTTLSNRDGVSL DPVSRGPHATKTMSFLAIDDPAHLRLRTLVSKGFTPRRIRELEPRVTELAVAHLDTMLDMAGGSQTVDYV AEFAGKLPMDVISELMGVPVADRDQIRAMADGVMHREDGVTDVPASAIEASINLIVYYQQMIAERRKKPS DDLTSALLAADVDGDRLTDEEVLGFMFLMVIAGNETTTKLLANAAFWGHKNTDQLTPIYADLSRVPLWVE ETLRYDTSSQILARTVVGELTLYDTTIPEGDVVLLLPGSAHRDERAFRDPDEYLIGREIGSKLLSFGSGA HFCLGAHLARMEARVALTELFKRIRGYQVDEGNAVRVHSSNVRGFAHLPITVEVA*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. ulcerans Agy99 | MUL_0475 | cyp123A3 | - | 100% (406) | cytochrome P450 123A3 Cyp123A3 |
| M. ulcerans Agy99 | MUL_0324 | cyp189A7 | 6e-63 | 36.66% (401) | cytochrome P450 189A7 Cyp189A7 |
| M. ulcerans Agy99 | MUL_1282 | cyp124A1 | 1e-43 | 30.65% (398) | cytochrome P450 124A1, Cyp124A1 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0789c | cyp123 | 1e-168 | 71.78% (404) | cytochrome P450 123 |
| M. gilvum PYR-GCK | Mflv_1598 | - | 0.0 | 81.27% (395) | cytochrome P450 |
| M. tuberculosis H37Rv | Rv0766c | cyp123 | 1e-168 | 71.78% (404) | cytochrome P450 123 |
| M. leprae Br4923 | MLBr_02088 | - | 3e-53 | 33.83% (405) | putative cytochrome p450 |
| M. abscessus ATCC 19977 | MAB_1216c | - | 1e-169 | 72.22% (396) | cytochrome P450 |
| M. marinum M | MMAR_4930 | cyp123A3 | 0.0 | 99.26% (406) | cytochrome P450 123A3 Cyp123A3 |
| M. avium 104 | MAV_0916 | - | 1e-68 | 37.31% (402) | cytochrome P450 monooxygenase |
| M. smegmatis MC2 155 | MSMEG_5861 | - | 1e-172 | 75.25% (396) | cytochrome P450 109 |
| M. thermoresistible (build 8) | TH_2506 | - | 0.0 | 83.63% (397) | PUTATIVE cytochrome P450 |
| M. vanbaalenii PYR-1 | Mvan_5159 | - | 0.0 | 83.63% (397) | cytochrome P450 |
CLUSTAL 2.0.9 multiple sequence alignment
MUL_0475|M.ulcerans_Agy99 --------------------------MSVHV-GGPELVLDPYDYDFHEDP
MMAR_4930|M.marinum_M --------------------------MSVHV-GGPELVLDPYDYDFHEDP
Mflv_1598|M.gilvum_PYR-GCK --------------------------MTTS-----AVRLDPYNYDFHEDP
Mvan_5159|M.vanbaalenii_PYR-1 --------------------------MTIS-----EVRLDPYNYDFHEDP
TH_2506|M.thermoresistible__bu --------------------------MTVT-----ELILDPYDYDFHEDP
MSMEG_5861|M.smegmatis_MC2_155 --------------------------MSLP---TVEPVLDPYDYDFHEDP
Mb0789c|M.bovis_AF2122/97 --------------------------MTVRVGDPE-LVLDPYDYDFHEDP
Rv0766c|M.tuberculosis_H37Rv --------------------------MTVRVGDPE-LVLDPYDYDFHEDP
MAB_1216c|M.abscessus_ATCC_199 --------------------------MTVAETSAVPLVFDPYDYDFHEDP
MAV_0916|M.avium_104 --------------------------MTKP-----KLVFDPYSEDYFNNP
MLBr_02088|M.leprae_Br4923 MRTCVPTRTCVYAFIEYLSHNRPMGTNPPSLVEAQMLLLRLIDPGTRADP
. : . . :*
MUL_0475|M.ulcerans_Agy99 YPYYRRLRNEAPLYHNQELGFWALSRRRDVHQGFRNSTTLSNRDGVSLDP
MMAR_4930|M.marinum_M YPYYRRLRDEAPLYHNQELGFWALSRHRDVHQGFRNSTTLSNRDGVSLDP
Mflv_1598|M.gilvum_PYR-GCK YPYYQRLRDEAPLYRNDELGFWALSRHADVLKGFRNSTTLSNKFGVSLDP
Mvan_5159|M.vanbaalenii_PYR-1 YPYYKRLRDEAPLYRNEELGFWALSRHADVLKGFRNSTTLSNKFGVSLDP
TH_2506|M.thermoresistible__bu YPYYKRLRDEAPLYHNEDLGFWALSRHADVLKGFRNSVNLSNKYGVSLDP
MSMEG_5861|M.smegmatis_MC2_155 YPYYKRLRDEAPLYRNDERNFWALSRHEDVLKGFRNSTALSNKHGVSLDP
Mb0789c|M.bovis_AF2122/97 YPYYRRLRDEAPLYRNEERNFWAVSRHHDVLQGFRDSTALSNAYGVSLDP
Rv0766c|M.tuberculosis_H37Rv YPYYRRLRDEAPLYRNEERNFWAVSRHHDVLQGFRDSTALSNAYGVSLDP
MAB_1216c|M.abscessus_ATCC_199 YPYYRRLRDEAPLYRNDDLKFWALSRHHDVLQGFRNSEALSNANGVSMDK
MAV_0916|M.avium_104 YEIYRRMREEAPLYYDEKEDFYALTRHVDVAAAFKDYETYSSARGCDLAM
MLBr_02088|M.leprae_Br4923 FPVYRALIDYGPMQLPG-MPLTVFSSFSDCDEALRHPLSASDRLKATLAQ
: *: : : .*: : ..: * .::. *. :
MUL_0475|M.ulcerans_Agy99 VSRGPHATKT----MSFLAIDDPAHLRLRTLVSKGFTPRRIRELEPRVTE
MMAR_4930|M.marinum_M VSRGPHATKT----MSFLAMDDPAHLRLRTLVSKGFTPRRIRELEPRVTE
Mflv_1598|M.gilvum_PYR-GCK ASRGPHASKT----MSFLAMDDPDHLRLRTLVSKGFTPRRIRELEPRVTE
Mvan_5159|M.vanbaalenii_PYR-1 ASRGPHASKT----MSFLAMDDPAHLRLRTLVSKGFTPRRIRELEPRVTE
TH_2506|M.thermoresistible__bu ASRGPHASKT----MSFLAMDDPEHLRLRTLVSKGFTPRRVRELEPRVTE
MSMEG_5861|M.smegmatis_MC2_155 VSRNDEAHRV----MSFLALDDPAHLRLRTLVSKGFTPRRIRELEARVTE
Mb0789c|M.bovis_AF2122/97 SSRTSEAYRV----MSMLAMDDPAHLRMRTLVSKGFTPRRIRELEPQVLE
Rv0766c|M.tuberculosis_H37Rv SSRTSEAYRV----MSMLAMDDPAHLRMRTLVSKGFTPRRIRELEPQVLE
MAB_1216c|M.abscessus_ATCC_199 ASFGPHAKLV----MSFLAMDDPEHLRLRALVSKGFTPRRIRELEGQVVA
MAV_0916|M.avium_104 VRRG-ISPEQ----KSIIFMDPPEHRHMRSLLNKAFTPRAIQSQRETIIE
MLBr_02088|M.leprae_Br4923 QAIAAGAEPRPFYASSFMFLDPPDHTRLRKLVSKAFAPKVVQALEGDIAA
: *:: :* * * ::* *:.*.*:*: :: . :
MUL_0475|M.ulcerans_Agy99 LAVAHLDTMLDMAGGSQTVDYVAEFAGKLPMDVISELMGVPVADR-----
MMAR_4930|M.marinum_M LAVAHLDTMLDMAGGSQTVDYVAEFAGKLPMDVISELMGVPVADR-----
Mflv_1598|M.gilvum_PYR-GCK IANQHLDSMLEAAASGATVDYVDEFAGKLPMDVISELMGVPNADR-----
Mvan_5159|M.vanbaalenii_PYR-1 IAVTHLDAMLEQATTGDAVDYVDEFAGKLPMDVISELMGVPDADR-----
TH_2506|M.thermoresistible__bu IATQHLDTMLARAGDNETVDYVDEFAGKLPMDVISELMGVPEPDR-----
MSMEG_5861|M.smegmatis_MC2_155 IAVQHLEIALQ----SDSFDFVDDFAGKLPMDVISELMGVPEEDR-----
Mb0789c|M.bovis_AF2122/97 LARIHLDSALQ-TES---FDFVAEFAGKLPMDVISELIGVPDTDR-----
Rv0766c|M.tuberculosis_H37Rv LARIHLDSALQ-TES---FDFVAEFAGKLPMDVISELIGVPDTDR-----
MAB_1216c|M.abscessus_ATCC_199 LARTHLDRALA-NASDRSFDFIAEYAGKLPMDVISELMGVPESDR-----
MAV_0916|M.avium_104 VVDKYLSAADP-----DNFDVVQDFSGPFPVEVITRMAGVPEEYR-----
MLBr_02088|M.leprae_Br4923 LVDSLLDKGAAAG----QFDVIADLAFPLAVAVICRLLGVPYEDAPEFGR
:. *. .* : : : :.: ** .: ***
MUL_0475|M.ulcerans_Agy99 --DQIRAMADGVMHREDGVTDVPASAIEASINLIVYYQQMIAERRKKPSD
MMAR_4930|M.marinum_M --DQIRAMADGVMHREDGVTDVPASAIEASINLIVYYQQMIAERRKKPSD
Mflv_1598|M.gilvum_PYR-GCK --AQVRAWADAVMHREDGVTDVPDSAIEASLNLIVYYQEMVKQRRTALTD
Mvan_5159|M.vanbaalenii_PYR-1 --VQVRAWADAVMHRDDGVTDVPDSAIEASLNLIVYYQEMVAERRKKLTD
TH_2506|M.thermoresistible__bu --AQLRAWADGVMHREEGVTDVPPAAVEASINLIVYYQQMVAERRRKPTD
MSMEG_5861|M.smegmatis_MC2_155 --VRIRALADGVMHREDGVADVPASAIAASGELLVYYADMVKRRRRNVSD
Mb0789c|M.bovis_AF2122/97 --ARIRALADAVLHREDGVADVPPPAMAASIELMRYYADLIAEFRRRPAN
Rv0766c|M.tuberculosis_H37Rv --ARIRALADAVLHREDGVADVPPPAMAASIELMRYYADLIAEFRRRPAN
MAB_1216c|M.abscessus_ATCC_199 --ARIRELADGVMHREDGLADVPPEAIQASFDLMTYYIEMVRERRRRPTE
MAV_0916|M.avium_104 --QQVRHWIDTSLHHEPGQIEVSEAGMQANIDTAMYYFGLVQERRQNPQD
MLBr_02088|M.leprae_Br4923 VSALLVQSVDPFITITGEPPEATEERLRAGVWLRDYLEQLVKCRRGTPGE
: * : :.. : *. * :: * :
MUL_0475|M.ulcerans_Agy99 DLTSALLAADVDGD-----RLTDEEVLGFMFLMVIAGNETTTKLLANAAF
MMAR_4930|M.marinum_M DLTSALLAADVDGD-----RLTDEEVLGFMFLMVIAGNETTTKLLANAAF
Mflv_1598|M.gilvum_PYR-GCK DLTSALLEAEIDGD-----RLTDDEIIGFMFLMVIAGNETTTKLLANAAF
Mvan_5159|M.vanbaalenii_PYR-1 DLTSALLEAEIDGD-----RLTDDEIIGFMFLMVIAGNETTTKLLANAAF
TH_2506|M.thermoresistible__bu DLTTALLEAEIDGD-----RLTDDEILGFMFLMVIAGNETTTKLLANAMY
MSMEG_5861|M.smegmatis_MC2_155 DLTSALVEAEIDGD-----KLTDDEIMAFLFLMVVAGNETTTKLLANAAY
Mb0789c|M.bovis_AF2122/97 NLTSALLAAELDGD-----RLSDQEIMAFLFLMVIAGNETTTKLLANAVY
Rv0766c|M.tuberculosis_H37Rv NLTSALLAAELDGD-----RLSDQEIMAFLFLMVIAGNETTTKLLANAVY
MAB_1216c|M.abscessus_ATCC_199 DLTSALLQAEIDGD-----RLTDEEVLAFLFLMVIAGNETTTKLLANAVY
MAV_0916|M.avium_104 DMISRLIAAEIPGENGQMRKLDDIEITGFATLLGGAGAETVTKLLGNAAV
MLBr_02088|M.leprae_Br4923 DLISRLIELDESGD-----QLTEEEIIATCGLLLVAGHETTVNLIANAVL
:: : *: : *: :* : *: . *: ** **..:*:.**
MUL_0475|M.ulcerans_Agy99 WGHKNTDQLTPIYADLSRVPLWVEETLRYDTSSQILARTVVGELTLYDTT
MMAR_4930|M.marinum_M WGHKNTDQLTPIYADLSRVPLWVEETLRYDTSSQILARTVVGELTLYDTT
Mflv_1598|M.gilvum_PYR-GCK WGHRNPDQLGPVFDDHERIPLWVEETLRYDTSSQILARTVIGELELYDTV
Mvan_5159|M.vanbaalenii_PYR-1 WGHRNPDQLTSVYQDLARVPLWVEETLRFDTSSQILARTVSGELTLYDTT
TH_2506|M.thermoresistible__bu WAHRNPDQIAPLYDDLDRIPQWVEETLRYDTSSQILARTVVGDLTLYDTR
MSMEG_5861|M.smegmatis_MC2_155 WGFKNPDQLAPVFDDHSQIPLWVEETLRYDTSSQILARAVVEDLTFYGTT
Mb0789c|M.bovis_AF2122/97 WAAHHPGQLARVFADHSRIPMWVEETLRYDTSSQILARTVAHDLTLYDTT
Rv0766c|M.tuberculosis_H37Rv WAAHHPGQLARVFADHSRIPMWVEETLRYDTSSQILARTVAHDLTLYDTT
MAB_1216c|M.abscessus_ATCC_199 WGHRNPDQLATVHADHDRIPLWVEESLRYDTSSQILARTVAEDITVYDTK
MAV_0916|M.avium_104 IFARHPDQWQKLQDDRDKIPGAVEELLRYEGPVQYNVRYTLKEAHVSGGV
MLBr_02088|M.leprae_Br4923 AMLRNPSQWKALSSNPQRAPLVVEETLRYDPAIHLIGRVAAKDMTIGQTT
::..* : : : * *** **:: . : * . : .
MUL_0475|M.ulcerans_Agy99 IPEGDVVLLLPGSAHRDERAFRDPDEYLIGR-EIGSKLLSFGSGAHFCLG
MMAR_4930|M.marinum_M IPEGDVVLLLPGSAHRDERAFRDPDEYLIGR-EIGSKLLSFGSGAHFCLG
Mflv_1598|M.gilvum_PYR-GCK LPDGDVVLLLPGSAHRDERVFQNPDDFVIGR-EIGSKLMSFGSGAHFCLG
Mvan_5159|M.vanbaalenii_PYR-1 IPDGDVVLLLPGSAHRDERVFENPDDYVIGR-EIGSKLMSFGSGAHFCLG
TH_2506|M.thermoresistible__bu IPEGDVVLLLPGSAHRDERVFDDPDRYLIGR-EIGSKLVSFGSGAHFCLG
MSMEG_5861|M.smegmatis_MC2_155 VPAGDVLVLLAGSANRDERAFDDPDEYRIGR-DIGSKLVSFGSGAHFCLG
Mb0789c|M.bovis_AF2122/97 IPEGEVLLLLPGSANRDDRVFDDPDDYRIGR-EIGCKLVSFGSGAHFCLG
Rv0766c|M.tuberculosis_H37Rv IPEGEVLLLLPGSANRDDRVFDDPDDYRIGR-EIGCKLVSFGSGAHFCLG
MAB_1216c|M.abscessus_ATCC_199 IPAGDILLLLPGSANRDDRVFDDADQYRIGR-EIGAKLVSFGSGAHFCLG
MAV_0916|M.avium_104 IPAGKPVFLCGAAANRDPEAFTDADTFDIERDQTEAQHLGLGYGIHSCLG
MLBr_02088|M.leprae_Br4923 LTEGDTMVLLLAAANRDPAVYSRPDEFDPDR--PSSRHLAFAVGSHFCLG
:. *. :.* .:*:** .: .* : * .: :.:. * * ***
MUL_0475|M.ulcerans_Agy99 AHLARMEARVALTELFKRIRGYQVDEGNAVRVHSSNVRGFAHLPITVEVA
MMAR_4930|M.marinum_M AHLARMEARVALTELFKRIRGYQVDEGNAVRVHSSNVRGFAHLPITVEVA
Mflv_1598|M.gilvum_PYR-GCK AHLARMEARVALAELFKRIRGYEVDEDNAVRVHSSNVRGFAHLPISVKVS
Mvan_5159|M.vanbaalenii_PYR-1 AHLARMEARVALAELFKRIRGYEVDEANAVRVHSSNVRGFAHLPIRVEIR
TH_2506|M.thermoresistible__bu AHLARMEARVALTELFKRIRGYEVDEANAVRVHSSNVRGFAHLPITVEVR
MSMEG_5861|M.smegmatis_MC2_155 AHLARMEARVALAELFKRIRGYDVDESASVRVHSSSVRGFAHLPITVEKR
Mb0789c|M.bovis_AF2122/97 AHLARMEARVALGALLRRIRNYEVDDDNVVRVHSSNVRGFAHLPISVQAR
Rv0766c|M.tuberculosis_H37Rv AHLARMEARVALGALLRRIRNYEVDDDNVVRVHSSNVRGFAHLPISVQAR
MAB_1216c|M.abscessus_ATCC_199 AHLARMEAKVALTELFTRISGYEIDERNSVRVHSSNVRGFAHLPMTVQLR
MAV_0916|M.avium_104 AALARLESRIALERLLDFMPRYEVDWAGCRRVTMQNVAGWKNVPVKVLR-
MLBr_02088|M.leprae_Br4923 AALARLEATVTLSAISARFPQVQLAG-ELVYKPNVAMRGMSALPVQV---
* ***:*: ::* : : :: : * :*: *
MUL_0475|M.ulcerans_Agy99 ---
MMAR_4930|M.marinum_M ---
Mflv_1598|M.gilvum_PYR-GCK ---
Mvan_5159|M.vanbaalenii_PYR-1 ---
TH_2506|M.thermoresistible__bu ---
MSMEG_5861|M.smegmatis_MC2_155 ---
Mb0789c|M.bovis_AF2122/97 ---
Rv0766c|M.tuberculosis_H37Rv ---
MAB_1216c|M.abscessus_ATCC_199 EGR
MAV_0916|M.avium_104 ---
MLBr_02088|M.leprae_Br4923 ---