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AAAPHELRHRLVRRVAQRDPDNDALRRALRAAAVVPLAAALSFALAGGSAQTPLFTIFGSTALLVFSDFP GNRQNRAVAYAGLGFNGFVLITLGTLVAPHPWPAVAVMFALGVVVTFSGVLSETIAAGQRATLLTFVLPA CTPAGPVGERLLGWAIALAVCVPAALFVLPPRHHGQLRRRAARACRALADRLDGSATPADVQRAMDALRA TFLGADFRPVGLTAGSRALVRVVDDLEWVADRVGRNTGVALRDKDAVVRVLRCAAAVLQISRPADRDAAR ADLEAALITLRTVARGRWRDDLDAILSAPDDAQAVDLGRDLLRRRTIAATIGATGRVISAAAAADARPVW ARALGLRLPPTGASDRLLPETVAAAQITSGFLANRSVAVRNSLRTGLGLALAVAVTHLFPVEHGFWVVLG ALSVLRSSALTTGTRVWRAVFGTAIGFLFGAVLISLVGVNPVLLWLLMPVVVFGSAYVPEIASFTAAQAA FTMMVLIFFNLIAPTGWQVGLIRVEDVVMGTLVAAAVSMLLWPRGATASVTRAIDSARTVFATYLRTAVL RITRGASEARTDEVATRSHAALAASRVIDDAVRQYLSESSGETDFRAPIVRSFNRAIRLRGAADLVADIP TPPPLGTYPSVRAVVESHADAICERVAGRADPDHSWEPISDDFVRALRSEARGDDLGLSAALPLLTAAAA LGELELIYPRPATG*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_0100 | - | - | 100% (715) | membrane protein-like protein |
| M. vanbaalenii PYR-1 | Mvan_3048 | - | 3e-13 | 23.42% (696) | protein of unknown function DUF893, YccS/YhfK |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | - | - | - | - | - |
| M. gilvum PYR-GCK | Mflv_0746 | - | 0.0 | 83.21% (703) | membrane protein-like protein |
| M. tuberculosis H37Rv | - | - | - | - | - |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | - | - | - | - | - |
| M. marinum M | MMAR_0945 | - | 1e-13 | 21.76% (703) | hypothetical protein MMAR_0945 |
| M. avium 104 | MAV_4566 | - | 1e-13 | 22.68% (732) | hypothetical protein MAV_4566 |
| M. smegmatis MC2 155 | MSMEG_0090 | - | 0.0 | 65.92% (713) | hypothetical protein MSMEG_0090 |
| M. thermoresistible (build 8) | TH_4065 | - | 2e-05 | 25.72% (311) | PUTATIVE putative conserved hypothetical protein |
| M. ulcerans Agy99 | - | - | - | - | - |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_0100|M.vanbaalenii_PYR-1 ----------------MAAAPHELRHRLVRRVAQRDPDNDALRRALRAAA
Mflv_0746|M.gilvum_PYR-GCK --------------------MLSLRQRVADRVAQRDPDRDALRRAVRAAV
MSMEG_0090|M.smegmatis_MC2_155 ----------------MLLTPAKLWRRAAERLRERDPEYDALRRAARAGV
MMAR_0945|M.marinum_M MSRRDDVQGRPAVDTRIPESMAARLQRAQSWAIGSDPGLLRLRMATRTTA
MAV_4566|M.avium_104 -------------------------------MIGSDPGLLRLRMATRTTA
TH_4065|M.thermoresistible__bu --------------------------------------------------
Mvan_0100|M.vanbaalenii_PYR-1 VVPLAAALSFALAGGSAQTPLFTIFGSTALLVFSDFPGNRQNR--AVAYA
Mflv_0746|M.gilvum_PYR-GCK VVPAAGAVSFAVAGGSTQTPLFTIFGAVALLVFSDFPGNRQNR--AVAYG
MSMEG_0090|M.smegmatis_MC2_155 VLPIAAAIGFAVGGGS-QTPLFSIFGAVSLLITADFPGNRPAR--ALAFA
MMAR_0945|M.marinum_M ALGCSLLVLYLLTMATGQPLTVALIGVVITMIAARSVDDPDSRQQQITMA
MAV_4566|M.avium_104 ALGLSLLALWLLTRATGQPLTVALLGVVITMVASRSVNEPDPRQQRITMA
TH_4065|M.thermoresistible__bu --------------------------------------------------
Mvan_0100|M.vanbaalenii_PYR-1 GLGFNGFVLITLGTLVAPHPWPAVAVMFALGVVVTFSGVLSETIAAGQRA
Mflv_0746|M.gilvum_PYR-GCK GLGLNGFLLITLGTLVAPYPWPAVAAMFVIGVAVTFSGVLSETLAAGQRA
MSMEG_0090|M.smegmatis_MC2_155 GLAFNGAVLIVLGTLIAPHVWLSVVSMFVIGVVVSFSGVLSEVVAAGQRA
MMAR_0945|M.marinum_M LLPVPAALSISVAALLAPHLIAAEVAFVVIVFAAVYVRRFGPRGRALGMV
MAV_4566|M.avium_104 LLPVPAAVAITAAAVLAPHPVAGDVVFVLIVFAAAYIRRFGARGRALGMV
TH_4065|M.thermoresistible__bu --------------------------------------------------
Mvan_0100|M.vanbaalenii_PYR-1 TLLTFVLPACTPA--GPVGERLLGWAIALAVCVPAALFVLPPRHHGQLRR
Mflv_0746|M.gilvum_PYR-GCK TLLTFVLPACTPP--GPVAERLLGWTIALAVCVPAALFLLPPRHHGQLRR
MSMEG_0090|M.smegmatis_MC2_155 TLLLFVLPLCTPV--GPIADRLLGWVIALVVCVPAALFLFPPRHHDELRR
MMAR_0945|M.marinum_M AFMAYFFSLYLRAGVAQLPWMIGAVLVGTLCTFVMSTYVLPDRPESVLRA
MAV_4566|M.avium_104 AFMSYFFTLYLRARVSELPWMIGAVAVGTVCTYVMTSHVLPDRPERVLRA
TH_4065|M.thermoresistible__bu --------------------------------------------------
Mvan_0100|M.vanbaalenii_PYR-1 RAARACRALADRLDGSATPADVQRAMDALRATFLGADFRPVGLTAGSRAL
Mflv_0746|M.gilvum_PYR-GCK RAARACTALADRLDGTVTPDDVQRAMDALRKTFLGADFRPVGLTAGSRAL
MSMEG_0090|M.smegmatis_MC2_155 TAARVCRVLAYRLEGSASARDVNRAMNELYESFLGADYRPVALTAGSRAL
MMAR_0945|M.marinum_M TIRSLRARMAIVVDTAADTVRAGRLDERRRRRMRARIARLNETALLVQSQ
MAV_4566|M.avium_104 TIRALRARMAIVIDTTAEAVRTGRLDERRRRRMRARTVRLNETALMVQSQ
TH_4065|M.thermoresistible__bu --------------------------------------------------
Mvan_0100|M.vanbaalenii_PYR-1 VRVVDDLEWVADRVGRNTGVALRDK-DAVVRVLRCAAAVLQISRPADRDA
Mflv_0746|M.gilvum_PYR-GCK VRVVDDLEWVADRTGRGTGVTLRDK-DAVVRVLRASAAVLSISRPADREM
MSMEG_0090|M.smegmatis_MC2_155 VRVVDDLGWISDRVTDSTGEILGEMRDPVVRVLRDSAALLRIHDPARRAE
MMAR_0945|M.marinum_M IEDKTHPATLWPGISAEQLAPWLFDAELSVEWVAIAGHRAMAIAEEIPAA
MAV_4566|M.avium_104 IEDRADPGTLWPGVTAEQLAPWLLDAELAIEWVATAGRRAAALGAELPEA
TH_4065|M.thermoresistible__bu --------------------------------------------------
Mvan_0100|M.vanbaalenii_PYR-1 ARADLEAALITLRTVARGRWRDDLDAILSAPDDAQAVDLGRDLLRRRTIA
Mflv_0746|M.gilvum_PYR-GCK ARAELEGALLALRTLARGRWREDIDEILGAADDEQAVAQGRDLLRRRTIA
MSMEG_0090|M.smegmatis_MC2_155 RSADLRAALEELRTVSQGTYREGIAAILGTPDDADAVEVGKALLVRRTIA
MMAR_0945|M.marinum_M TRIELADTLTQLAWAIRGPRTEGLHQAASRAQRLLDGQPAPAPTDDPSQG
MAV_4566|M.avium_104 VRAELVSALTQLGRAIRLPEPGGLRDAASRARRLLD----AATDDRPAGT
TH_4065|M.thermoresistible__bu --------------------------------------------------
Mvan_0100|M.vanbaalenii_PYR-1 ATIGATGRVISAA-AAADARPVWARALGLRLPPTGASDR----LLPETVA
Mflv_0746|M.gilvum_PYR-GCK ATVSATGRVIAAA-AAADARPVWARALGLRLPPTGASDR----LLPETVA
MSMEG_0090|M.smegmatis_MC2_155 ATVAVTGRVIRNA-ALADARPVWARVLGRRLPETGSADW----IMPETTA
MMAR_0945|M.marinum_M AVRRLGLAIVAAATATSEVRELIGDAT-AAPPDPDNND----VVQPVPED
MAV_4566|M.avium_104 EVRRLALAIINAATATADVRAIVDGAAGAAVPDVAGSERPPAAAGVAAEE
TH_4065|M.thermoresistible__bu -----------XAAQVSDAVALRFGRLHRRTPG----------------D
* ::. : *
Mvan_0100|M.vanbaalenii_PYR-1 AAQITSGFLANRSVAVRNSLRTGLGLALAVAVTHLFPVEHGFWVVLGALS
Mflv_0746|M.gilvum_PYR-GCK AAKITTGFVENRSVAVRNSLRTGLGLALAVTVTHVFPVEHGFWVVLGALS
MSMEG_0090|M.smegmatis_MC2_155 VAEIAKGFLSTRAVVLRNSLRTGLGLALAVAVTHVFPVEHGFWVVLGAMS
MMAR_0945|M.marinum_M TAADGGPGEAGLAPTTRQAIQVSIAASLAIVTGELVSPLHWYWAVIAAFV
MAV_4566|M.avium_104 PAEQEEEQPAGLRPTTRQAIQVSVAASLAIITGELVSPARWYWAVIAAFV
TH_4065|M.thermoresistible__bu VLAAVQAQLTWPSPVLRHALRLAVGTAGAIALARYGDLDQGHWMALTVLL
. *:::: .:. : *: . : .* .: .:
Mvan_0100|M.vanbaalenii_PYR-1 VLR--SSALTTGTRVWRAVFGTAIGFLFGAVLISLVGVNPVLLWLLMPVV
Mflv_0746|M.gilvum_PYR-GCK VLR--SSALTTGTRVWRAVVGTGIGFLLGALLISLVGVDPVVMWILMPLA
MSMEG_0090|M.smegmatis_MC2_155 VLR--SSALTTGTRVVRAVAGTALGFVIGAVLIELVGVQPVVLWILLPIV
MMAR_0945|M.marinum_M VFAGTNSWGETLTKGWQRLLGTVLGVPCGVLVATVVAGDKVFSVVMIFAC
MAV_4566|M.avium_104 IFAGTNSWGETLTKGWQRLLGTMLGVPAGVLVATLLTGHEAAALAGIFVC
TH_4065|M.thermoresistible__bu VLR--PETAHTYTRCGGRILGLATGVAVATVPIVLWRPD-GLVAATVAAL
:: . * *: : * *. ..: : . :
Mvan_0100|M.vanbaalenii_PYR-1 VFGSAYVPEIASFTAAQAAFTMMVLIFFNLIAPTGWQVGLIRVEDVVMGT
Mflv_0746|M.gilvum_PYR-GCK VFGSAYVPEIASFIAAQAAFTMMVLISFNLIAPTGWEVGLIRVEDVFVGA
MSMEG_0090|M.smegmatis_MC2_155 AFGSAYVPEVASFIAGQAAFTMMVLINFNLIAPTGWQVGLIRIEDVVVGA
MMAR_0945|M.marinum_M LFFAVYFMQVT-YSLMTFWITTMLALLYGLLGKFTFGVLMLRIEETAIGA
MAV_4566|M.avium_104 LFCAFYFMTVT-YSLMTFWITTMLALLYGLLGQFSFGVLMLRIEETALGA
TH_4065|M.thermoresistible__bu LVAATYLALRYGFIAVNVALGAALMFVLAIGDTGLPATFTGPVFAVVLGG
. : *. : : : : : . : . :*
Mvan_0100|M.vanbaalenii_PYR-1 LVAAAVSMLLWPRGATASVTRAIDSARTVFATYLRTAVLRITRGASEART
Mflv_0746|M.gilvum_PYR-GCK LVGVVVSVLLWPRGATASVTRAIDSARFVAARYLRAAVLRITRGAYEERT
MSMEG_0090|M.smegmatis_MC2_155 LVGIVVSILLWPRGARASVTKAIDAARAAGAELLEAAVLRVTRGASEEAT
MMAR_0945|M.marinum_M VIGVAVAILVLPTTIGTVVRRDTRAFLTTLSELIEISIATMFDDDVTDSP
MAV_4566|M.avium_104 VIGATVAVVVLPTNTRTAIRADTRAFLTSLSALIEACAAAMSGG--AASP
TH_4065|M.thermoresistible__bu AV-AIMAHVALPDDGLVRLRQRAGELLKTEIDYAALVVKAFVHG--VDRP
: :: : * . : . . .
Mvan_0100|M.vanbaalenii_PYR-1 DEVATRSHAALAASRVIDDAVRQYLSESSGE-------------TDFRAP
Mflv_0746|M.gilvum_PYR-GCK NEVVTLGHAALDASRVVDDAVRHYLSESSGE-------------TDFRAP
MSMEG_0090|M.smegmatis_MC2_155 DRVIALSHSALEASRTLDDTVRHYLSESGGP-------------SDQRAP
MMAR_0945|M.marinum_M TERARELDRDLQQFRVTAKPMLAGVAGFAGRRSIQHSVRLLTICDRYARI
MAV_4566|M.avium_104 SEQARQLDRDLQQFRVTAKPLLAGVAGLAGRRGIRRALRIFTACDRYGRA
TH_4065|M.thermoresistible__bu NEVLAAVWQRAFRARAAFEAASGMTRVDSRE------------LRRWLRT
. *. .. .
Mvan_0100|M.vanbaalenii_PYR-1 IVRSFNRAIRLRGAADLVADIPTPPPLGTYPSVRAVVESHADAICERVAG
Mflv_0746|M.gilvum_PYR-GCK VVRSSNRATRLRGAADLIADIPTPPPLGTYPKVRSVLEAHADAICARVSG
MSMEG_0090|M.smegmatis_MC2_155 IVRSATRAIRVRAAAELIADV-VPPPLEAYQETRKTIEAHARIICARLTG
MMAR_0945|M.marinum_M LARRSEQYLD-PGCPHGLSDAITTAAAQIRRNIDALVTALDGTQDVAITP
MAV_4566|M.avium_104 LARSSEQYRGSPGPGPQLAQAFSAAAAQTRRNLDALLEAIDSGHPPTLVS
TH_4065|M.thermoresistible__bu FRAAVNAVTG--ACVALETNLPDQPSAKLDREFVAAVDEYIDALRGSPPN
. . :: .. . :
Mvan_0100|M.vanbaalenii_PYR-1 RADPDHSWEPISDDFVRALRSEARGDD----LGLSAALP-----LLTAAA
Mflv_0746|M.gilvum_PYR-GCK TSEPVGAWAPISEDFVRALRSEAPEDT----LGVAAALP-----LLTAAA
MSMEG_0090|M.smegmatis_MC2_155 -EDTTSVFVPIGETFVLALRAEATGGD----LAVSAALP-----LVTVAA
MMAR_0945|M.marinum_M AADSLDAAEAVVRQHADALDRADPGSNPRHLLAAVNSLRRIEGAVVNAAV
MAV_4566|M.avium_104 AADELDAAETAARQHDSDGD-GETRPDVRRFLTAVHALRQIERAVISTAT
TH_4065|M.thermoresistible__bu PAAAWTVDTAALTAADQKVREVAGRLP-----RDDRAARVLVAELGTITR
. : : . :
Mvan_0100|M.vanbaalenii_PYR-1 ALGELELIYPRPATG--
Mflv_0746|M.gilvum_PYR-GCK ALGELELIYPWDTGPS-
MSMEG_0090|M.smegmatis_MC2_155 HIGELELLYPQPVESVH
MMAR_0945|M.marinum_M HFGADADLMAHDQPG--
MAV_4566|M.avium_104 NLGGREDVRTATAAPR-
TH_4065|M.thermoresistible__bu SLLAVAATREPTSAG--
: