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MLSLRQRVADRVAQRDPDRDALRRAVRAAVVVPAAGAVSFAVAGGSTQTPLFTIFGAVALLVFSDFPGNR QNRAVAYGGLGLNGFLLITLGTLVAPYPWPAVAAMFVIGVAVTFSGVLSETLAAGQRATLLTFVLPACTP PGPVAERLLGWTIALAVCVPAALFLLPPRHHGQLRRRAARACTALADRLDGTVTPDDVQRAMDALRKTFL GADFRPVGLTAGSRALVRVVDDLEWVADRTGRGTGVTLRDKDAVVRVLRASAAVLSISRPADREMARAEL EGALLALRTLARGRWREDIDEILGAADDEQAVAQGRDLLRRRTIAATVSATGRVIAAAAAADARPVWARA LGLRLPPTGASDRLLPETVAAAKITTGFVENRSVAVRNSLRTGLGLALAVTVTHVFPVEHGFWVVLGALS VLRSSALTTGTRVWRAVVGTGIGFLLGALLISLVGVDPVVMWILMPLAVFGSAYVPEIASFIAAQAAFTM MVLISFNLIAPTGWEVGLIRVEDVFVGALVGVVVSVLLWPRGATASVTRAIDSARFVAARYLRAAVLRIT RGAYEERTNEVVTLGHAALDASRVVDDAVRHYLSESSGETDFRAPVVRSSNRATRLRGAADLIADIPTPP PLGTYPKVRSVLEAHADAICARVSGTSEPVGAWAPISEDFVRALRSEAPEDTLGVAAALPLLTAAAALGE LELIYPWDTGPS
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_0746 | - | - | 100% (712) | membrane protein-like protein |
| M. gilvum PYR-GCK | Mflv_3327 | - | 3e-13 | 23.86% (700) | protein of unknown function DUF893, YccS/YhfK |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2601c | - | 6e-08 | 24.79% (242) | transmembrane alanine and valine and leucine rich protein |
| M. tuberculosis H37Rv | Rv2571c | - | 6e-08 | 24.79% (242) | transmembrane alanine and valine and leucine rich protein |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | - | - | - | - | - |
| M. marinum M | MMAR_0945 | - | 6e-12 | 22.28% (561) | hypothetical protein MMAR_0945 |
| M. avium 104 | MAV_4566 | - | 4e-12 | 23.67% (562) | hypothetical protein MAV_4566 |
| M. smegmatis MC2 155 | MSMEG_0090 | - | 0.0 | 66.05% (704) | hypothetical protein MSMEG_0090 |
| M. thermoresistible (build 8) | - | - | - | - | - |
| M. ulcerans Agy99 | - | - | - | - | - |
| M. vanbaalenii PYR-1 | Mvan_0100 | - | 0.0 | 83.21% (703) | membrane protein-like protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_0746|M.gilvum_PYR-GCK --------------------MLSLRQRVADRVAQRDPDRDALRRAVRAAV
Mvan_0100|M.vanbaalenii_PYR-1 ----------------MAAAPHELRHRLVRRVAQRDPDNDALRRALRAAA
MSMEG_0090|M.smegmatis_MC2_155 ----------------MLLTPAKLWRRAAERLRERDPEYDALRRAARAGV
MMAR_0945|M.marinum_M MSRRDDVQGRPAVDTRIPESMAARLQRAQSWAIGSDPGLLRLRMATRTTA
MAV_4566|M.avium_104 -------------------------------MIGSDPGLLRLRMATRTTA
Mb2601c|M.bovis_AF2122/97 --------------------------------------------------
Rv2571c|M.tuberculosis_H37Rv --------------------------------------------------
Mflv_0746|M.gilvum_PYR-GCK VVPAAGAVSFAVAGGSTQTPLFTIFGAVALLVFSDFPGNRQNR--AVAYG
Mvan_0100|M.vanbaalenii_PYR-1 VVPLAAALSFALAGGSAQTPLFTIFGSTALLVFSDFPGNRQNR--AVAYA
MSMEG_0090|M.smegmatis_MC2_155 VLPIAAAIGFAVGGGS-QTPLFSIFGAVSLLITADFPGNRPAR--ALAFA
MMAR_0945|M.marinum_M ALGCSLLVLYLLTMATGQPLTVALIGVVITMIAARSVDDPDSRQQQITMA
MAV_4566|M.avium_104 ALGLSLLALWLLTRATGQPLTVALLGVVITMVASRSVNEPDPRQQRITMA
Mb2601c|M.bovis_AF2122/97 --------------------------------------------------
Rv2571c|M.tuberculosis_H37Rv --------------------------------------------------
Mflv_0746|M.gilvum_PYR-GCK GLGLNGFLLITLGTLVAPYPWPAVAAMFVIGVAVTFSGVLSETLAAGQRA
Mvan_0100|M.vanbaalenii_PYR-1 GLGFNGFVLITLGTLVAPHPWPAVAVMFALGVVVTFSGVLSETIAAGQRA
MSMEG_0090|M.smegmatis_MC2_155 GLAFNGAVLIVLGTLIAPHVWLSVVSMFVIGVVVSFSGVLSEVVAAGQRA
MMAR_0945|M.marinum_M LLPVPAALSISVAALLAPHLIAAEVAFVVIVFAAVYVRRFGPRGRALGMV
MAV_4566|M.avium_104 LLPVPAAVAITAAAVLAPHPVAGDVVFVLIVFAAAYIRRFGARGRALGMV
Mb2601c|M.bovis_AF2122/97 --------------------------------------------------
Rv2571c|M.tuberculosis_H37Rv --------------------------------------------------
Mflv_0746|M.gilvum_PYR-GCK TLLTFVLPACTPP--GPVAERLLGWTIALAVCVPAALFLLPPRHHGQLRR
Mvan_0100|M.vanbaalenii_PYR-1 TLLTFVLPACTPA--GPVGERLLGWAIALAVCVPAALFVLPPRHHGQLRR
MSMEG_0090|M.smegmatis_MC2_155 TLLLFVLPLCTPV--GPIADRLLGWVIALVVCVPAALFLFPPRHHDELRR
MMAR_0945|M.marinum_M AFMAYFFSLYLRAGVAQLPWMIGAVLVGTLCTFVMSTYVLPDRPESVLRA
MAV_4566|M.avium_104 AFMSYFFTLYLRARVSELPWMIGAVAVGTVCTYVMTSHVLPDRPERVLRA
Mb2601c|M.bovis_AF2122/97 --------------------------------------------------
Rv2571c|M.tuberculosis_H37Rv --------------------------------------------------
Mflv_0746|M.gilvum_PYR-GCK RAARACTALADRLDGTVTPDDVQRAMDALRKTFLGADFRPVGLTAGSRAL
Mvan_0100|M.vanbaalenii_PYR-1 RAARACRALADRLDGSATPADVQRAMDALRATFLGADFRPVGLTAGSRAL
MSMEG_0090|M.smegmatis_MC2_155 TAARVCRVLAYRLEGSASARDVNRAMNELYESFLGADYRPVALTAGSRAL
MMAR_0945|M.marinum_M TIRSLRARMAIVVDTAADTVRAGRLDERRRRRMRARIARLNETALLVQSQ
MAV_4566|M.avium_104 TIRALRARMAIVIDTTAEAVRTGRLDERRRRRMRARTVRLNETALMVQSQ
Mb2601c|M.bovis_AF2122/97 --------------------------------------------------
Rv2571c|M.tuberculosis_H37Rv --------------------------------------------------
Mflv_0746|M.gilvum_PYR-GCK VRVVDDLEWVADRTGRGTGVTLRDK-DAVVRVLRASAAVLSISRPADREM
Mvan_0100|M.vanbaalenii_PYR-1 VRVVDDLEWVADRVGRNTGVALRDK-DAVVRVLRCAAAVLQISRPADRDA
MSMEG_0090|M.smegmatis_MC2_155 VRVVDDLGWISDRVTDSTGEILGEMRDPVVRVLRDSAALLRIHDPARRAE
MMAR_0945|M.marinum_M IEDKTHPATLWPGISAEQLAPWLFDAELSVEWVAIAGHRAMAIAEEIPAA
MAV_4566|M.avium_104 IEDRADPGTLWPGVTAEQLAPWLLDAELAIEWVATAGRRAAALGAELPEA
Mb2601c|M.bovis_AF2122/97 --------------------------------------------------
Rv2571c|M.tuberculosis_H37Rv --------------------------------------------------
Mflv_0746|M.gilvum_PYR-GCK ARAELEGALLALRTLARGRWREDIDEILGAADDEQAVAQGRDLLRRRTIA
Mvan_0100|M.vanbaalenii_PYR-1 ARADLEAALITLRTVARGRWRDDLDAILSAPDDAQAVDLGRDLLRRRTIA
MSMEG_0090|M.smegmatis_MC2_155 RSADLRAALEELRTVSQGTYREGIAAILGTPDDADAVEVGKALLVRRTIA
MMAR_0945|M.marinum_M TRIELADTLTQLAWAIRGPRTEGLHQAASRAQRLLDGQPAPAPTDDPSQG
MAV_4566|M.avium_104 VRAELVSALTQLGRAIRLPEPGGLRDAASRARRLLD----AATDDRPAGT
Mb2601c|M.bovis_AF2122/97 --------------------------------------------------
Rv2571c|M.tuberculosis_H37Rv --------------------------------------------------
Mflv_0746|M.gilvum_PYR-GCK ATVSATGRVIAAA-AAADARPVWARALGLRLPPTGASDR----LLPETVA
Mvan_0100|M.vanbaalenii_PYR-1 ATIGATGRVISAA-AAADARPVWARALGLRLPPTGASDR----LLPETVA
MSMEG_0090|M.smegmatis_MC2_155 ATVAVTGRVIRNA-ALADARPVWARVLGRRLPETGSADW----IMPETTA
MMAR_0945|M.marinum_M AVRRLGLAIVAAATATSEVRELIGDAT-AAPPDPDNND----VVQPVPED
MAV_4566|M.avium_104 EVRRLALAIINAATATADVRAIVDGAAGAAVPDVAGSERPPAAAGVAAEE
Mb2601c|M.bovis_AF2122/97 ------------------------------------------MSASLLVR
Rv2571c|M.tuberculosis_H37Rv ------------------------------------------MSASLLVR
Mflv_0746|M.gilvum_PYR-GCK AAKITTGFVENRSVAVRNSLRTGLGLALAVTVT-HVFPVEHGFWVVLGAL
Mvan_0100|M.vanbaalenii_PYR-1 AAQITSGFLANRSVAVRNSLRTGLGLALAVAVT-HLFPVEHGFWVVLGAL
MSMEG_0090|M.smegmatis_MC2_155 VAEIAKGFLSTRAVVLRNSLRTGLGLALAVAVT-HVFPVEHGFWVVLGAM
MMAR_0945|M.marinum_M TAADGGPGEAGLAPTTRQAIQVSIAASLAIVTG-ELVSPLHWYWAVIAAF
MAV_4566|M.avium_104 PAEQEEEQPAGLRPTTRQAIQVSVAASLAIITG-ELVSPARWYWAVIAAF
Mb2601c|M.bovis_AF2122/97 TACGGRAVAQRLRTVLWPITQTSVVAGLAWYLTHDVFNHPQAFFAPISAV
Rv2571c|M.tuberculosis_H37Rv TACGGRAVAQRLRTVLWPITQTSVVAGLAWYLTHDVFNHPQAFFAPISAV
* . :..: .** .:. : ::. :.*.
Mflv_0746|M.gilvum_PYR-GCK SVLR--SSALTTGTRVWRAVVGTGIGFLLGALLISLVGVDPVVMWILMPL
Mvan_0100|M.vanbaalenii_PYR-1 SVLR--SSALTTGTRVWRAVFGTAIGFLFGAVLISLVGVNPVLLWLLMPV
MSMEG_0090|M.smegmatis_MC2_155 SVLR--SSALTTGTRVVRAVAGTALGFVIGAVLIELVGVQPVVLWILLPI
MMAR_0945|M.marinum_M VVFAGTNSWGETLTKGWQRLLGTVLGVPCGVLVATVVAGDKVFSVVMIFA
MAV_4566|M.avium_104 VIFAGTNSWGETLTKGWQRLLGTMLGVPAGVLVATLLTGHEAAALAGIFV
Mb2601c|M.bovis_AF2122/97 VCMS--ATNVLRARRAQQMIVGVALGIVLGAGVHALLGSGPIAMGVVVFI
Rv2571c|M.tuberculosis_H37Rv VCMS--ATNVLRARRAQQMIVGVALGIVLGAGVHALLGSGPIAMGVVVFI
: : : : : *. :*. *. : :: :
Mflv_0746|M.gilvum_PYR-GCK AVFGSAYVPEIASFIAAQAAFTMMVLISFNLIAPTGWEVGLIRVEDVFVG
Mvan_0100|M.vanbaalenii_PYR-1 VVFGSAYVPEIASFTAAQAAFTMMVLIFFNLIAPTGWQVGLIRVEDVVMG
MSMEG_0090|M.smegmatis_MC2_155 VAFGSAYVPEVASFIAGQAAFTMMVLINFNLIAPTGWQVGLIRIEDVVVG
MMAR_0945|M.marinum_M CLFFAVYFMQVT-YSLMTFWITTMLALLYGLLGKFTFGVLMLRIEETAIG
MAV_4566|M.avium_104 CLFCAFYFMTVT-YSLMTFWITTMLALLYGLLGQFSFGVLMLRIEETALG
Mb2601c|M.bovis_AF2122/97 ALSVAVLCARGLVAQGLMFINQAAVSAVLVLVFASNGSVVFERLFDALVG
Rv2571c|M.tuberculosis_H37Rv ALSVAVLCARGLVAQGLMFINQAAVSAVLVLVFASNGSVVFERLFDALVG
: : *: * : *: :. :*
Mflv_0746|M.gilvum_PYR-GCK ALVGVVVSVLLWPRGATASVTRAIDSARFVAARYLRAAVLRITRGAYEER
Mvan_0100|M.vanbaalenii_PYR-1 TLVAAAVSMLLWPRGATASVTRAIDSARTVFATYLRTAVLRITRGASEAR
MSMEG_0090|M.smegmatis_MC2_155 ALVGIVVSILLWPRGARASVTKAIDAARAAGAELLEAAVLRVTRGASEEA
MMAR_0945|M.marinum_M AVIGVAVAILVLPTTIGTVVRRDTRAFLTTLSELIEISIATMFDDDVTDS
MAV_4566|M.avium_104 AVIGATVAVVVLPTNTRTAIRADTRAFLTSLSALIEACAAAMSGG--AAS
Mb2601c|M.bovis_AF2122/97 GGLAIVFSILLFPPDPVVMLCSARADVLAAVRDILAELVNTVSDPTSAPP
Rv2571c|M.tuberculosis_H37Rv GGLAIVFSILLFPPDPVVMLCSARADVLAAVRDILAELVNTVSDPTSAPP
:. ..:::: * . : : :
Mflv_0746|M.gilvum_PYR-GCK TNEVVTLGHAALDASRVVDDAVRHYLSESSGETDFR-------------A
Mvan_0100|M.vanbaalenii_PYR-1 TDEVATRSHAALAASRVIDDAVRQYLSESSGETDFR-------------A
MSMEG_0090|M.smegmatis_MC2_155 TDRVIALSHSALEASRTLDDTVRHYLSESGGPSDQR-------------A
MMAR_0945|M.marinum_M PTERARELDRDLQQFRVTAKPMLAGVAGFAGRRSIQHSVRLLTICDRYAR
MAV_4566|M.avium_104 PSEQARQLDRDLQQFRVTAKPLLAGVAGLAGRRGIRRALRIFTACDRYGR
Mb2601c|M.bovis_AF2122/97 DWPMAAADRLHQQLNGLIEVRANAAMVARRAPRRWG--------------
Rv2571c|M.tuberculosis_H37Rv DWPMAAADRLHQQLNGLIEVRANAAMVARRAPRRWG--------------
: .
Mflv_0746|M.gilvum_PYR-GCK PVVRSSNRATRLRGAADLIADIPTPPPLGTYPKVRSVLEAHADAICARVS
Mvan_0100|M.vanbaalenii_PYR-1 PIVRSFNRAIRLRGAADLVADIPTPPPLGTYPSVRAVVESHADAICERVA
MSMEG_0090|M.smegmatis_MC2_155 PIVRSATRAIRVRAAAELIADV-VPPPLEAYQETRKTIEAHARIICARLT
MMAR_0945|M.marinum_M ILARRSEQYLD-PGCPHGLSDAITTAAAQIRRNIDALVTALDGTQDVAIT
MAV_4566|M.avium_104 ALARSSEQYRGSPGPGPQLAQAFSAAAAQTRRNLDALLEAIDSGHPPTLV
Mb2601c|M.bovis_AF2122/97 -VRSTVRDLDQQAVYLALLVSSVLHLARTIAGPGGDKLPTPVHAVLTDLA
Rv2571c|M.tuberculosis_H37Rv -VRSTVRDLDQQAVYLALLVSSVLHLARTIAGPGGDKLPTPVHAVLTDLA
: : . . : : :
Mflv_0746|M.gilvum_PYR-GCK GTSEPVGAWAPISEDFVRALRSEAPEDT----LGVAAALP-----LLTAA
Mvan_0100|M.vanbaalenii_PYR-1 GRADPDHSWEPISDDFVRALRSEARGDD----LGLSAALP-----LLTAA
MSMEG_0090|M.smegmatis_MC2_155 G-EDTTSVFVPIGETFVLALRAEATGGD----LAVSAALP-----LVTVA
MMAR_0945|M.marinum_M PAADSLDAAEAVVRQHADALDRADPGSNPRHLLAAVNSLRRIEGAVVNAA
MAV_4566|M.avium_104 SAADELDAAETAARQHDSDGD-GETRPDVRRFLTAVHALRQIERAVISTA
Mb2601c|M.bovis_AF2122/97 AGTGLADADPTAANEHAAAARATASTLQS----AACGSNEVVRADIVQAC
Rv2571c|M.tuberculosis_H37Rv AGTGLADADPTAANEHAAAARATASTLQS----AACGSNEVVRADIVQAC
. . : :: ..
Mflv_0746|M.gilvum_PYR-GCK AALGELELIYPWDTGPS-
Mvan_0100|M.vanbaalenii_PYR-1 AALGELELIYPRPATG--
MSMEG_0090|M.smegmatis_MC2_155 AHIGELELLYPQPVESVH
MMAR_0945|M.marinum_M VHFGADADLMAHDQPG--
MAV_4566|M.avium_104 TNLGGREDVRTATAAPR-
Mb2601c|M.bovis_AF2122/97 VTDLQRVIERPGPSGMSA
Rv2571c|M.tuberculosis_H37Rv VTDLQRVIERPGPSGMSA
. .