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IVTVTLNPSLDRTVTLTAPLTRGAVQRVDSVTVEAGGKGINVAKALTSAGVDALALLPAATDDPLLTALR CADVPFAAVPIAEPVRTNIAITENDGTTTKLNERGATLDAAALDAITRCVVDEAQHAAWVVLSGSLPPGV PPQWYADLVAKLAPLPCRVAVDTSDAPLAALASKLSTASPELMKPNVEELASISGVAEADLETTVAEGDL SLVVAAAVKLVERGVGAVLATLGAAGAVLVDGTGAWFAAPPPITARSTVGAGDASLAGYLRAEVGGAEPS QRLRMAVAYGSAAAALPGSALPVPAQLDVDAVRVTGLITTNREVLQ*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_0086 | - | - | 100% (327) | 1-phosphofructokinase |
| M. smegmatis MC2 155 | MSMEG_1378 | - | 1e-42 | 41.37% (307) | 1-phosphofructokinase |
| M. smegmatis MC2 155 | MSMEG_3947 | - | 7e-20 | 28.57% (315) | 6-phosphofructokinase isozyme 2 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2054c | pfkB | 3e-23 | 31.82% (308) | phosphofructokinase pfkB (phosphohexokinase) |
| M. gilvum PYR-GCK | Mflv_0751 | - | 1e-116 | 66.46% (316) | ribokinase-like domain-containing protein |
| M. tuberculosis H37Rv | Rv2029c | pfkB | 3e-23 | 31.82% (308) | phosphofructokinase PfkB (phosphohexokinase) |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | - | - | - | - | - |
| M. marinum M | MMAR_3482 | pfkB_1 | 7e-20 | 30.10% (309) | phosphofructokinase, PfkB_1 |
| M. avium 104 | MAV_4667 | - | 3e-05 | 36.08% (97) | oxidoreductase |
| M. thermoresistible (build 8) | TH_1728 | pfkB | 3e-22 | 32.89% (304) | Probable phosphofructokinase PfkB (PHOSPHOHEXOKINASE) |
| M. ulcerans Agy99 | - | - | - | - | - |
| M. vanbaalenii PYR-1 | Mvan_0095 | - | 1e-117 | 67.72% (316) | ribokinase-like domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mb2054c|M.bovis_AF2122/97 MTEPAAWDEGKPRIITLTMNPALDITTSVDVVRPT-EKMRCGAPRYDPGG
Rv2029c|M.tuberculosis_H37Rv MTEPAAWDEGKPRIITLTMNPALDITTSVDVVRPT-EKMRCGAPRYDPGG
MMAR_3482|M.marinum_M MTSPADPAVRGPQIVTLTMNPALDITTCVGVVRPT-EKLRCSETRYDPGG
TH_1728|M.thermoresistible__bu ------------------MNPALDISTTTDRVHHT-SKVRCHGVRHDPGG
Mflv_0751|M.gilvum_PYR-GCK ------------MIVTVTPNPSIDRTVTLPSALTRGAVHRVTSVTSQAGG
Mvan_0095|M.vanbaalenii_PYR-1 ------------MIVTVTANPSIDRTVSLPSPLTRGAVHRVTSVTNQAGG
MSMEG_0086|M.smegmatis_MC2_155 ------------MIVTVTLNPSLDRTVTLTAPLTRGAVQRVDSVTVEAGG
MAV_4667|M.avium_104 -------------------------------MVGTGRNERVAVVTGASSG
* ..*
Mb2054c|M.bovis_AF2122/97 GGINVARIVHVLGGCSTALFPAGGSTGSLLMALLGDAGVPFRVIPIAAST
Rv2029c|M.tuberculosis_H37Rv GGINVARIVHVLGGCSTALFPAGGSTGSLLMALLGDAGVPFRVIPIAAST
MMAR_3482|M.marinum_M GGINVARIAHVLGGSVFAVFPVGGSHGAHVSKLLSEAGVAFGEIPIAAST
TH_1728|M.thermoresistible__bu GGINVARIAHVLGAPVTAVFPIGGHTGELLTDMLEHSGVSYHSVPIADLT
Mflv_0751|M.gilvum_PYR-GCK KGVNVAKVLTMAGVDTVAVLPAAAND--PLITALQAAAVPHRIVTTAEPA
Mvan_0095|M.vanbaalenii_PYR-1 KGVNVAKVLTMAGVDAVAVLPAAAND--PLLHALQIAAVPYRAVTTTEPA
MSMEG_0086|M.smegmatis_MC2_155 KGINVAKALTSAGVDALALLPAATDD--PLLTALRCADVPFAAVPIAEPV
MAV_4667|M.avium_104 IGEATARTLAAQG---------------------------FHVVAVARRA
* .*: * . :. : .
Mb2054c|M.bovis_AF2122/97 RESFTVNESRTAKQYRFVLPGPSLTVAEQEQCLDELRGAAASAAFVVASG
Rv2029c|M.tuberculosis_H37Rv RESFTVNESRTAKQYRFVLPGPSLTVAEQEQCLDELRGAAASAAFVVASG
MMAR_3482|M.marinum_M RESFTVNESSTGEQYRFVLPGPVLAPEEQAQCLQELGFAARSAQFVVASG
TH_1728|M.thermoresistible__bu RESLTVNEESTGHQYRFVLPGPFVTHEEQDAVLQRLREVAASAQFLVASG
Mflv_0751|M.gilvum_PYR-GCK RTNLTITEP-DGTTTKINEPGATLDDAALQAFSAAVLDASGNADWVVMSG
Mvan_0095|M.vanbaalenii_PYR-1 RTNLTITEP-DGTTTKINEPGAKLDAATLEAFTDAVLDAAGGADWVVMSG
MSMEG_0086|M.smegmatis_MC2_155 RTNIAITEN-DGTTTKLNERGATLDAAALDAITRCVVDEAQHAAWVVLSG
MAV_4667|M.avium_104 KRIHALANEIGGTA--------IVADVTDDAAVAALASKLSRVDVLVNNA
: :: : . : : . :* ..
Mb2054c|M.bovis_AF2122/97 SLPPGVAADYYQRVADICRRSSTPLILDTSGGGLQHIS-----SGVFLLK
Rv2029c|M.tuberculosis_H37Rv SLPPGVAADYYQRVADICRRSSTPLILDTSGGGLQHIS-----SGVFLLK
MMAR_3482|M.marinum_M SLPPGVPADFYQRVAEACRGLGARLILDTSGGGLSHIS-----AGVYLLK
TH_1728|M.thermoresistible__bu SLPPGVPADFYQRVADLCRELGVLLILDSSGGGLTQVR-----YGAFLVK
Mflv_0751|M.gilvum_PYR-GCK SLPPGIPASWYADITARLSGQGCRIAVDTSDAPLTALVDNLDRGAPDLIK
Mvan_0095|M.vanbaalenii_PYR-1 SLPPGVPASWYGDVVASLASRDCRVAVDTSDAPLAALIGSLDRGAPDLIK
MSMEG_0086|M.smegmatis_MC2_155 SLPPGVPPQWYADLVAKLAPLPCRVAVDTSDAPLAALASKLSTASPELMK
MAV_4667|M.avium_104 GGARGLEPVAEADLEHWRWMWETNVIG-----------------TLRVTR
. . *: . : : : :
Mb2054c|M.bovis_AF2122/97 ASVRELRECVGSELLTEP---------EQLAAAHELIDRGRAEVVVVSLG
Rv2029c|M.tuberculosis_H37Rv ASVRELRECVGSELLTEP---------EQLAAAHELIDRGRAEVVVVSLG
MMAR_3482|M.marinum_M ASVRELRECVGRPLVTEA---------EQLAAASELVETGRAEVVVVSLG
TH_1728|M.thermoresistible__bu PSKRELREYVGRDIPTTA---------DQIAAAHELIDRGVTQAVVVSLG
Mflv_0751|M.gilvum_PYR-GCK PNAEELAGVLGLDADVLENAVAQGDPAPVVAAGRQMIDRG-IGAVLATLG
Mvan_0095|M.vanbaalenii_PYR-1 PNAEELAGVLGLSAQSLEDAVLQGDPGPVVAAARQLIDRG-IGAVLATLG
MSMEG_0086|M.smegmatis_MC2_155 PNVEELASISGVAEADLETTVAEGDLSLVVAAAVKLVERG-VGAVLATLG
MAV_4667|M.avium_104 ALLPKLVDSGDGLIVTVT-----------SVAALEVYDGG-AGYTAAKHG
. :* . .*. :: : * . .. *
Mb2054c|M.bovis_AF2122/97 SQGALLATRHASHRFSSIPMTAV-SGVGAGDAMVAAITVGLSRGWSLIKS
Rv2029c|M.tuberculosis_H37Rv SQGALLATRHASHRFSSIPMTAV-SGVGAGDAMVAAITVGLSRGWSLIKS
MMAR_3482|M.marinum_M SDGALLATRRARHRFRAVEMRGG-SGVGAGDAMVAAITVGLARGWPLVKS
TH_1728|M.thermoresistible__bu ADGALLATADVDQKFEAIDVPVVLSGVGAGDAMVAGITVALSRRWSLSDA
Mflv_0751|M.gilvum_PYR-GCK AAGAVLVDKDGAWLAAPPPIVPR-STVGAGDSSLAGYLRAEVSGAAPPER
Mvan_0095|M.vanbaalenii_PYR-1 AAGAVLVDHNGAWMATPPPIVPR-STVGAGDSSLAGYVRAEVGGAVPPQR
MSMEG_0086|M.smegmatis_MC2_155 AAGAVLVDGTGAWFAAPPPITAR-STVGAGDASLAGYLRAEVGGAEPSQR
MAV_4667|M.avium_104 -QGALHRTLRGELLGKPVRLTEIAPGAVETEFSLVRFDGDQQRADAVYTG
**: . : . . : :.
Mb2054c|M.bovis_AF2122/97 VRLGNAAGAAMLLTPGTAACNRDDVERFFELAAEPTEVGQDQYVWHPIVN
Rv2029c|M.tuberculosis_H37Rv VRLGNAAGAAMLLTPGTAACNRDDVERFFELAAEPTEVGQDQYVWHPIVN
MMAR_3482|M.marinum_M VRLGIAAGAAMLLTPGTQACERADVERLFEHVAEPVEVA-----------
TH_1728|M.thermoresistible__bu VRYGVATGSAMLLTPGTAPCRPEDVERLFAQAAPPVDVTR-----SPARN
Mflv_0751|M.gilvum_PYR-GCK LQMAVAYGSAAAALPGTTLPSPAEIDVDGVRVTPISPVPVTQQQL-----
Mvan_0095|M.vanbaalenii_PYR-1 LQMAVAYGSAAAALPGTTLPSPAEIDLNAVQVSPISPIPATR--------
MSMEG_0086|M.smegmatis_MC2_155 LRMAVAYGSAAAALPGSALPVPAQLDVDAVRVTGLITTNREVLQ------
MAV_4667|M.avium_104 ITPLVAADVAEVIGFVASRPAHVNLDLIVMKPRDQASASRFNRRG-----
: * . * : :::
Mb2054c|M.bovis_AF2122/97 PEASP
Rv2029c|M.tuberculosis_H37Rv PEASP
MMAR_3482|M.marinum_M -----
TH_1728|M.thermoresistible__bu -----
Mflv_0751|M.gilvum_PYR-GCK -----
Mvan_0095|M.vanbaalenii_PYR-1 -----
MSMEG_0086|M.smegmatis_MC2_155 -----
MAV_4667|M.avium_104 -----