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TSTFERVRNEDGTALAADVYRHESARAVVILLHGGGQNRHAWATTARRLHARGYTVVAYDARGHGDSEWD PDGRYDLDRLASDLLSIRRYASDGRPPAVVGASLGGMTVLGTHLVAPADLWGAVVLVDITPRMEFHGARR VVSFMGAHPDGFDTLDAAADVIAQYNRHRARPKNLDGLRKVLQQRDDGRWIWRWDPAFIASNFEFLQGDP ATGAKEFGAISDLLIEGARRVRAPTLLIRGVHSDVTSQQSVEEFLEVVPHAEAVDVSGTGHMVAGDDNDA FTSAVADFLDRTLNDSSD*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_4622 | - | - | 100% (299) | alpha/beta hydrolase fold |
| M. gilvum PYR-GCK | Mflv_3026 | - | e-160 | 89.30% (299) | alpha/beta hydrolase fold |
| M. gilvum PYR-GCK | Mflv_2096 | - | 1e-59 | 42.27% (291) | alpha/beta hydrolase fold |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3502c | bpoA | 4e-53 | 43.56% (264) | peroxidase BpoA |
| M. tuberculosis H37Rv | Rv3473c | bpoA | 4e-53 | 43.56% (264) | peroxidase BpoA |
| M. leprae Br4923 | MLBr_02297 | - | 1e-07 | 25.76% (264) | putative hydrolase |
| M. abscessus ATCC 19977 | MAB_2045 | - | 1e-123 | 69.20% (289) | putative hydrolase (alpha/beta fold) |
| M. marinum M | MMAR_4837 | - | 1e-125 | 70.75% (294) | hydrolase |
| M. avium 104 | MAV_1846 | - | 4e-63 | 47.35% (283) | hydrolase, alpha/beta fold family protein |
| M. smegmatis MC2 155 | MSMEG_5209 | - | 1e-60 | 44.29% (289) | hydrolase, alpha/beta fold family protein |
| M. thermoresistible (build 8) | TH_2112 | - | 2e-51 | 43.77% (265) | hydrolase, alpha/beta fold family protein |
| M. ulcerans Agy99 | MUL_0147 | bpoB | 8e-56 | 41.61% (286) | peroxidase BpoB |
| M. vanbaalenii PYR-1 | Mvan_0315 | - | 1e-122 | 70.85% (295) | alpha/beta hydrolase fold |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3502c|M.bovis_AF2122/97 --------------------------------------------------
Rv3473c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_4837|M.marinum_M --MAATETPDSQRLTTSDHMTISQGRIRTSDGITLVADCYRH----AATR
Mvan_0315|M.vanbaalenii_PYR-1 ------------------MTSAVQHRVRTQDGITLAADCYDH----EDAR
Mflv_4622|M.gilvum_PYR-GCK -------------------MTSTFERVRNEDGTALAADVYRH----ESAR
MAB_2045|M.abscessus_ATCC_1997 ----------MSAKRTGDSSAPVVERVPTADGLALAVDLYHC----DAPR
MSMEG_5209|M.smegmatis_MC2_155 --------------MSTAQTESQTVAFRGVDDLTLVGDEWNKGAERAADR
MUL_0147|M.ulcerans_Agy99 --------------MSAMSNNPRTVEFSGTEGITLVADEWNR-DTAASGR
TH_2112|M.thermoresistible__bu --------------LNSTHSKPQTVRFRGAQGLTLVADQWNR-GSGPKDR
MAV_1846|M.avium_104 -------------MASPAASTPQAALTIPADDITMAADAFGD-----PAD
MLBr_02297|M.leprae_Br4923 MAMSNPSVTRIAGPWHHLDVHANGIRFHVVEAVPTQPAGQDCAP-SATAR
Mb3502c|M.bovis_AF2122/97 --MVFLHGGGQTRRSWGRAAAAVAERGWQAVTIDLRGHGESDWSSEGDYR
Rv3473c|M.tuberculosis_H37Rv --MVFLHGGGQTRRSWGRAAAAVAERGWQAVTIDLRGHGESDWSSEGDYR
MMAR_4837|M.marinum_M PVVLLLHGGGQNRHAWATTARRLHSHGYTVVAYDTRGHGDSDWDPSGQYD
Mvan_0315|M.vanbaalenii_PYR-1 PVVLLLHGGGQNRHAWSASARRLHACGYTVVAYDTRGHGDSDWDPAGRYD
Mflv_4622|M.gilvum_PYR-GCK AVVILLHGGGQNRHAWATTARRLHARGYTVVAYDARGHGDSEWDPDGRYD
MAB_2045|M.abscessus_ATCC_1997 AVVLLLHGGGQSRHAWDVTAQRLHQRGYTVAAYDTRGHGDSDWDPDGRYD
MSMEG_5209|M.smegmatis_MC2_155 PTVLLLHGGGQNRYSWKNTGQILADQGFHVIALDARGHGDSDRSPSANYS
MUL_0147|M.ulcerans_Agy99 PTILMLHGGCQNRFSWKNTGQILADTGLHVIALDTRGHGDSDRAPDADYA
TH_2112|M.thermoresistible__bu PTILLLHGGGQNRFSWKNTGQILADKGWHVVALDSRGHGDSDRSPTADYQ
MAV_1846|M.avium_104 PPVVLLHGGGQTRHSWKATAADLGGLGWYALTVDLRGHGDSGWSADGRYG
MLBr_02297|M.leprae_Br4923 PLVMLLHGFGSFWWSWRHQLRGLTEA--RLVAVDLRGYGGSDKPPRG-YD
:::*** . :* : : * **:* * . . *
Mb3502c|M.bovis_AF2122/97 LVSFAGDIQEVLRNLP--GQPALVGASLGGFAAMLLAGELSPGIASAVVL
Rv3473c|M.tuberculosis_H37Rv LVSFAGDIQEVLRNLP--GQPALVGASLGGFAAMLLAGELSPGIASAVVL
MMAR_4837|M.marinum_M VERFVSDLISVRDHVSPDSPPAVVGASLGGLIILATHLLAPPDLWAAVVL
Mvan_0315|M.vanbaalenii_PYR-1 LERLATDLLAVREHFSAATAPAVVGASLGGMTVLGTHLLTSGASWAAVVL
Mflv_4622|M.gilvum_PYR-GCK LDRLASDLLSIRRYASDGRPPAVVGASLGGMTVLGTHLVAPADLWGAVVL
MAB_2045|M.abscessus_ATCC_1997 MDRLGSDLLAVRSYADSGRPVAAIGASLGGLTILGTHLLAPPDLWQAVVL
MSMEG_5209|M.smegmatis_MC2_155 VDAMCGDVLAVLYQIS--RPVALIGASMGGLTGLLAAHEAGPERVTQLVL
MUL_0147|M.ulcerans_Agy99 IETLTSDIRHVLDAIG--RPVVLIGASMGGLTGILVADSAGPDRVTGLVL
TH_2112|M.thermoresistible__bu LDDLCADTLSVVDQIG--RPVSLIGASMGGLTGILVADRAGADKVTELVL
MAV_1846|M.avium_104 LDRFASDVVRVTEFLA--RPPVLVGASLGG-NASLAALGSRPDLALGLVL
MLBr_02297|M.leprae_Br4923 GWTLAGDTAGLIRALG-HSSATLVGHAEGGLACWATALLHPR-------L
: * : :* : ** *
Mb3502c|M.bovis_AF2122/97 VDIVPNMDLAGASRIHAFMAERVESGFGSLDEVADVIANYNPHRPRPSD-
Rv3473c|M.tuberculosis_H37Rv VDIVPNMDLAGASRIHAFMAERVESGFGSLDEVADVIANYNPHRPRPSD-
MMAR_4837|M.marinum_M VDITPRMEFDGAHRIVSFMAAH-PDGFGTLDDAADVIAEYNPRRARPEN-
Mvan_0315|M.vanbaalenii_PYR-1 VDVTPRLEFQGARRVVTFMAAH-PDGFGTLTDAAEVIAAYNPHRSRPAN-
Mflv_4622|M.gilvum_PYR-GCK VDITPRMEFHGARRVVSFMGAH-PDGFDTLDAAADVIAQYNRHRARPKN-
MAB_2045|M.abscessus_ATCC_1997 VDVTPRMEMDGARRVVAFMSAH-PEGFDSLESAADVIAAYNPHRPRPEN-
MSMEG_5209|M.smegmatis_MC2_155 VDVVPNFEKSGSARIRDFMASN-VDGFDTLEEAADAVAAYLPHRRRPRN-
MUL_0147|M.ulcerans_Agy99 VDVVPKYEKDGSARIRDFMFTN-LHGFATLEEAADAVATYLPHRTKPRS-
TH_2112|M.thermoresistible__bu VDVVPRVEQAGTDRIRDFMMTN-VAGFETLEEAADAVAAYLPHRRRPRS-
MAV_1846|M.avium_104 VDVSPFLQPSGTNRIRDFMVSHAEEGFGTLEEVADAVAAYLPHRPRPRN-
MLBr_02297|M.leprae_Br4923 VRAIALINSPHPAALRRSMLTHRNQGYALLPTLLRYQLPIWPERLLTRNN
* . : . : * . *: * .* . .
Mb3502c|M.bovis_AF2122/97 PDGLVANLRRR-GDRWYWHWDPQFIGGIAAFPP------------VEVTD
Rv3473c|M.tuberculosis_H37Rv PDGLVANLRRR-GDRWYWHWDPQFIGGIAAFPP------------VEVTD
MMAR_4837|M.marinum_M LDGLHKVLRQRSDGRWIWRWDPAFISSNFDVLQGN----LMTGSEEFDAI
Mvan_0315|M.vanbaalenii_PYR-1 VDGLRKVLRQRHDGRWIWRWDPAFIHSNFDFLRDE----STTGTEQFDAI
Mflv_4622|M.gilvum_PYR-GCK LDGLRKVLQQRDDGRWIWRWDPAFIASNFEFLQGD----PATGAKEFGAI
MAB_2045|M.abscessus_ATCC_1997 LDGLRKVLARREDGRWSWRWDPAFVTSNFQFLQGD----PDEGAEYFEMM
MSMEG_5209|M.smegmatis_MC2_155 PEGLKKNLRLR-DGRWYWHWDPAFLGKPHD---------------DPFVR
MUL_0147|M.ulcerans_Agy99 PEGLKKNLRLR-DGRWYWHWDPAMMTAPGD---------------DPELR
TH_2112|M.thermoresistible__bu PEGLKKNLRHR-DGRWHWHWDPAFVTRVG----------------EQFVD
MAV_1846|M.avium_104 LDGLRKNLRLR-DGRWYWHWDPAFMASPTDLPV----------QRDQLVD
MLBr_02297|M.leprae_Br4923 AAEIERLVRSRSSAKWQACEDFAVTIDHLRIAIQIPAAAHCALEYQRWAV
: : * . :* * .
Mb3502c|M.bovis_AF2122/97 VDRMNAAVATILRDE-----VPVLLVRGQVSDIVRQESADQFLSRFPQVE
Rv3473c|M.tuberculosis_H37Rv VDRMNAAVATILRDE-----VPVLLVRGQVSDIVRQESADQFLSRFPQVE
MMAR_4837|M.marinum_M SGFLADAARRIT--------APTLLVRGALSDVVSQDTVNEFLQLVPHAE
Mvan_0315|M.vanbaalenii_PYR-1 SHLLIDGARRVS--------APTLLVRGLLSDVVSQATVDEFQQLVPHAE
Mflv_4622|M.gilvum_PYR-GCK SDLLIEGARRVR--------APTLLIRGVHSDVTSQQSVEEFLEVVPHAE
MAB_2045|M.abscessus_ATCC_1997 SAFLLDGARQVS--------APTLLVRGLLSDIVSEETVRHFLTVVPHAQ
MSMEG_5209|M.smegmatis_MC2_155 VERLEQAAVNLT--------VPILLIRGKLSDVVSPEGVAEFLEKVPAAE
MUL_0147|M.ulcerans_Agy99 TENFERAAMNLT--------IPILLIRGKLSDVVTSEGVQDFLDKVPHAE
TH_2112|M.thermoresistible__bu VDVLERAALRLT--------VPILLVRGKLSDVVSAEGVEEFLAKVPSAE
MAV_1846|M.avium_104 PARLGAAASSLR--------LPTLLVRGGESDVLSVDDAVRFLELVPHAE
MLBr_02297|M.leprae_Br4923 RSQLRNEGRKFMKSMSRPFSVPLLHVRGDADPYLLADSVDRTRRYAPHGR
: . * * :** . . * .
Mb3502c|M.bovis_AF2122/97 FTDVRGAGHMVAGDRNDAFAGAVLDFLARHVGVR----------------
Rv3473c|M.tuberculosis_H37Rv FTDVRGAGHMVAGDRNDAFAGAVLDFLARHVGVR----------------
MMAR_4837|M.marinum_M TTDVTGTGHMVAGDNNDAFTAAVTDFLDRTMGMT----------------
Mvan_0315|M.vanbaalenii_PYR-1 TVDVSGTGHMIAGDDNDAFSSAVTEFLGRSILQPPP--------------
Mflv_4622|M.gilvum_PYR-GCK AVDVSGTGHMVAGDDNDAFTSAVADFLDRTLNDSSD--------------
MAB_2045|M.abscessus_ATCC_1997 TVDVSGAGHMIAGDNNDAFSTAVVEFLDRTI-------------------
MSMEG_5209|M.smegmatis_MC2_155 FVELSDAGHTAAGDDNDAFTQVVVEFVNR---------------------
MUL_0147|M.ulcerans_Agy99 FVELSNAGHTAAGDDNDAFTEVVVDFVKRRAATG----------------
TH_2112|M.thermoresistible__bu FVELSAAXXXATIPARGSPRRCVTSPVCRRRPPTSRPAPSPRSAPRHGNV
MAV_1846|M.avium_104 FASVAGAHHMVAGDDNAVFEDVLGDFLARRVRSRLNLLNHR---------
MLBr_02297|M.leprae_Br4923 YVSVSDAGHFSHEEAPEEINRYLTRFLKQVHGPRLS--------------
..: : : : :
Mb3502c|M.bovis_AF2122/97 ----------
Rv3473c|M.tuberculosis_H37Rv ----------
MMAR_4837|M.marinum_M ----------
Mvan_0315|M.vanbaalenii_PYR-1 ----------
Mflv_4622|M.gilvum_PYR-GCK ----------
MAB_2045|M.abscessus_ATCC_1997 ----------
MSMEG_5209|M.smegmatis_MC2_155 ----------
MUL_0147|M.ulcerans_Agy99 ----------
TH_2112|M.thermoresistible__bu AGPGANAVRR
MAV_1846|M.avium_104 ----------
MLBr_02297|M.leprae_Br4923 ----------