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SVHVAGDENAPTSGAPTYEVPTHEILVIGAGFSGIGVGIKLLKEGFSDFLIVDEAQGVGGTWYWNTYPGI AVDIPSYSYQFSFEKRPSWSRTYAPGIELKNYAKHCVKKYGLASRIRFGVTVVRAEFDEESTLWRLFTST DEELTARFVINASGVLTRPKSPDIPGVGDFGGVTMHTSRWDHQQTLTGKRVAVIGTGASAVQLIPSIAKD VDTLTVFQRTPIWCLPKFDFAVPRPLSALLRLAPGAQIAARGASQAFVELTFPVAAHFHTAIPLASAIER AAISYMRRQVTDPVVREKLTPRYALGCKRPSFHNEYLKTFNRENVLLETNPITRVDETAVITADGVRHEI DVLVLATGFKVMESDSMPTYSLRGVAGRDQAQWWDENRLQAYEGVSVPGFPNHFSVFGPYGYNGSSYFAL IEAQAGHILRCLRHARTADSNYVEVREEANQRFFAEMLARRHTQVFWQDSCAGANSYYFDKHGDVPLRPT TTVESIWRSRRFDLADYRFERRPAKKADTAPQKVDTAG*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_4607 | - | - | 100% (529) | cyclohexanone monooxygenase |
| M. gilvum PYR-GCK | Mflv_3736 | - | e-158 | 61.98% (434) | cyclohexanone monooxygenase |
| M. gilvum PYR-GCK | Mflv_3377 | - | e-112 | 42.18% (486) | FAD dependent oxidoreductase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1428c | - | 0.0 | 65.64% (489) | monoxygenase |
| M. tuberculosis H37Rv | Rv1393c | - | 0.0 | 65.64% (489) | monoxygenase |
| M. leprae Br4923 | MLBr_00065 | - | 8e-20 | 22.71% (436) | putative monooxygenase |
| M. abscessus ATCC 19977 | MAB_4024c | - | 1e-142 | 48.93% (515) | monooxygenase |
| M. marinum M | MMAR_3138 | - | 0.0 | 69.59% (490) | monooxygenase |
| M. avium 104 | MAV_3378 | - | 0.0 | 65.10% (490) | lipolytic enzyme |
| M. smegmatis MC2 155 | MSMEG_0816 | - | 1e-113 | 42.13% (489) | flavin-binding monooxygenase |
| M. thermoresistible (build 8) | TH_4080 | - | 3e-82 | 35.27% (499) | PUTATIVE conserved hypothetical protein |
| M. ulcerans Agy99 | MUL_1793 | - | 0.0 | 63.37% (486) | monoxygenase |
| M. vanbaalenii PYR-1 | Mvan_2671 | - | 1e-179 | 61.66% (493) | cyclohexanone monooxygenase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_4607|M.gilvum_PYR-GCK MSVHVAGDENAPTSGAPTYEVPTHEILVIGAGFSGIGVGIKLL-KEGFSD
MMAR_3138|M.marinum_M -----MGSE----SGQ------HYEIVIVGAGFSGIGTAISLL-KAGFAD
Mb1428c|M.bovis_AF2122/97 -------------------MMPDYHALIVGAGFSGIGAAIKLD-RAGFSD
Rv1393c|M.tuberculosis_H37Rv -------------------MMPDYHALIVGAGFSGIGAAIKLD-RAGFSD
MAV_3378|M.avium_104 ---------------MSSPAVPDHHTLIIGAGFSGIGAAIKLD-KAGLPD
MUL_1793|M.ulcerans_Agy99 --------------------------MIVGAGFSGIGAAISLD-KAGFGD
Mvan_2671|M.vanbaalenii_PYR-1 --------------------MHDVETVIVGAGFSGIGAAIGLD-RVGMSD
MAB_4024c|M.abscessus_ATCC_199 ------MSPAARHATTAELEQPDHEVAVIGAGFGGIGTGISLQ-RKGIHD
MSMEG_0816|M.smegmatis_MC2_155 ------------------MRPVVHDAVIVGAGFAGLGAAIQLK-KMSFDD
TH_4080|M.thermoresistible__bu -MTVTEPSADITPANTPTQPPVRTRALIVGTGFSGLGMAIALQ-RRGI-D
MLBr_00065|M.leprae_Br4923 --------------MVVMAETEYLDVVIVGAGISGVSAAWHLQDRCPNKS
::*:*:.*:. . * : .
Mflv_4607|M.gilvum_PYR-GCK FLIVDEAQGVGGTWYWNTYPGIAVDIPSYSYQFSFEKRPSWSRTYAPGIE
MMAR_3138|M.marinum_M FLIVDDADGVGGTWHWNTYPGIAVDIPSYSYQFSYEMRTSWSRTYAHGDE
Mb1428c|M.bovis_AF2122/97 YLVVEAGDGVGGTWHWNTYPGIAVDIPSFSYQFSFEQSRHWSRTYAPGHE
Rv1393c|M.tuberculosis_H37Rv YLVVEAGDGVGGTWHWNTYPGIAVDIPSFSYQFSFEQSRHWSRTYAPGHE
MAV_3378|M.avium_104 YRVIEAGDGVGGTWHWNTYPGIAVDIPSFSYQFSFEQSRHWSRTYAPGRE
MUL_1793|M.ulcerans_Agy99 YLVIEAGDAVGGTWFWNTYPGIAVDIPSFSYQFSFEQSPDWSRSYAPGRE
Mvan_2671|M.vanbaalenii_PYR-1 YVVVEAGDEPGGTWYWNTYPGIAVDIPSFSYQFSFEQSSAWSRTYAHGHE
MAB_4024c|M.abscessus_ATCC_199 FIILDKWDQVGGTWHANTYPGVAVDIPSVVYSFSYEQRGDWSRLFAPGIE
MSMEG_0816|M.smegmatis_MC2_155 FVILEREDDLGGTWYVNHYPGLAVDVPTTTYSYFFEPNPSWSRLFSTGRE
TH_4080|M.thermoresistible__bu FLMLEKADDIGGTWRDNTYPGCACDIPSHLYSFSFEPKADWRHLFSYQDE
MLBr_00065|M.leprae_Br4923 YVILEKRAGMGGTWDLFRYPGIRSDSDMYTLGFRFRP-WTKCQAIADGKP
: ::: **** *** * : :. : :
Mflv_4607|M.gilvum_PYR-GCK LKNYAKHCVKKYGLASRIRFGVTVVRAEFDEESTLWRLFTSTDE---ELT
MMAR_3138|M.marinum_M LKAYAERCVEKYGLQNYIRFNTTVDEACFDEGAALWRLSCSSGQ---NLT
Mb1428c|M.bovis_AF2122/97 LKAYAEHCVDKYGIRSRIRLNTKVLAAEFDDEHSLWRVQTDPGG---EIT
Rv1393c|M.tuberculosis_H37Rv LKAYAEHCVDKYGIRSRIRLNTKVLAAEFDDEHSLWRVQTDPGG---EIT
MAV_3378|M.avium_104 LKAYAEHCADKYGIRSRIRFNTKVLAAEFDDEQRLWRVQTDPGG---EVT
MUL_1793|M.ulcerans_Agy99 LRAYAEHCADKYGIRPRIRFNTKVLGAELDDERSLWRLQTDPGG---DLI
Mvan_2671|M.vanbaalenii_PYR-1 LKTYAEHCVDKYGLRPRIRFATTVRSADFDEAQGIWRLALDTADGPATLS
MAB_4024c|M.abscessus_ATCC_199 LQQYAESMVHKYGLRDKLRLGTSITRAEFDERNSLWRLATDGGK---EIT
MSMEG_0816|M.smegmatis_MC2_155 IKRYADDVADKYDVRRHIRFGTTVTGARWDEDDNVWQVSLTDGE---QLQ
TH_4080|M.thermoresistible__bu IQEYLQGVTAKYGLRRYIHFDSLVDRAHWDDTEHRWHVFTADGR---EYI
MLBr_00065|M.leprae_Br4923 ILEYIKSTAVMHGIDKYIRLNHKVTGADWSSIENRWTVQVENNGTPRMIS
: * . . :.: ::: : * .. * :
Mflv_4607|M.gilvum_PYR-GCK ARFVINASGVLTRPK--SPDIPGVGDFGGVTMHTSRWDHQQTLTGKRVAV
MMAR_3138|M.marinum_M ARFVINCSGVLSRPK--WPDIPGVRDFAGVTLHTARWDHTKDLTGKRVAV
Mb1428c|M.bovis_AF2122/97 ARFLISACGILTVPK--LPDIDGVDSFEGVTMHTARWDHTQDLTGKRVGI
Rv1393c|M.tuberculosis_H37Rv ARFLISACGILTVPK--LPDIDGVDSFEGVTMHTARWDHTQDLTGKRVGI
MAV_3378|M.avium_104 ARFLISACGVLTVPN--LPDIDGVDSFAGITMHTARWDHGQDLRGKRVAV
MUL_1793|M.ulcerans_Agy99 TRFIINASGVLTVPK--LPDIAGVDSFAGVTMHTARWDHSQELTGKRVGI
Mvan_2671|M.vanbaalenii_PYR-1 ARFLVNAGGVLTVPK--LPDIAGVDSFAGVTMHTARWDHTQDLRGKRVAI
MAB_4024c|M.abscessus_ATCC_199 ARYCVMAVGGLERPK--MPDIPGVHDFGGTLMHTALWDHDVALAGKRVAV
MSMEG_0816|M.smegmatis_MC2_155 ARFLITATGFLSQPH--TPDIPGITEFDGKVIHTTDWDDGCSLYGRRAAV
TH_4080|M.thermoresistible__bu AQFLISCAGALHIPS--IPDFPGRDQFAGPAFHSAQWDHSVDLTGKRVAV
MLBr_00065|M.leprae_Br4923 CSFLFLCSGYYNYEQGYAPTFLGSEDFTGPIIHPQHWPEDLDYAAKNIVV
: . . * * : * .* * :*. * . .:. :
Mflv_4607|M.gilvum_PYR-GCK IGTGASAVQLIPSIAKD-VDTLTVFQRTPIWCLPKFDFAVPRPLSALLRL
MMAR_3138|M.marinum_M IGTGASAVQLIPEVAKI-ASSLTVFQRTPIYCLPKPDFSIPSWAATVMRL
Mb1428c|M.bovis_AF2122/97 IGTGASAVQVIPEMAPI-VSHLTVFQRTPIWCFPKFDVPLPTAVRWAMR-
Rv1393c|M.tuberculosis_H37Rv IGTGASAVQVIPEMAPI-VSHLTVFQRTPIWCFPKFDVPLPTAVRWAMR-
MAV_3378|M.avium_104 IGTGASAVQVIPEIAPI-VSSLTVFQRTPIWCFPKLDVPLPAPARWAMR-
MUL_1793|M.ulcerans_Agy99 IGTGASAVQVIPEIAPI-VKHLTVFQRTPIWCFPKFDFPLPAALRWAMR-
Mvan_2671|M.vanbaalenii_PYR-1 IGTGASAVQVIPEIAPI-VERLTVFQRTPIWCFPKFDVPLSKTAQTMMR-
MAB_4024c|M.abscessus_ATCC_199 IGTGATSLQLVPAIVDE-TSHLTVFQRTPIWVGPKFDLEIGPLGRIILG-
MSMEG_0816|M.smegmatis_MC2_155 VGTGATAVQLIPELAER-VAELTVYQRTPIWVVPKVDVRFPPAVRALFAR
TH_4080|M.thermoresistible__bu IGTGASAIQIVPEIIDR-VAQLQLYQRTPAWVVPRTNDELPAWLRRALEN
MLBr_00065|M.leprae_Br4923 IGSGATAVTLVPALANSGAKHVTMLQRSPTYIVSQPAKDKIAARLNRWLP
:*:**::: ::* : . : : **:* : .:
Mflv_4607|M.gilvum_PYR-GCK APGAQIAARGASQAFVELTFP--VAAHFHTAIPLASAIERAAISYMRRQV
MMAR_3138|M.marinum_M VPGAQLMTRTASQAFVEFTFP--IAAHFHSLIPVSDLMEEAAKRYMRRAV
Mb1428c|M.bovis_AF2122/97 IPGGKAVHRLLSQAFVEATFP--IAAHYFAVFPLAKHMESAGRRYLRQQV
Rv1393c|M.tuberculosis_H37Rv IPGGKAVHRLLSQAFVEATFP--IAAHYFAVFPLAKHMESAGRRYLRQQV
MAV_3378|M.avium_104 FPGGKALQRLLSQAYVELTFP--ISAHYFTVIPLAKRMAALGRAYLRRQV
MUL_1793|M.ulcerans_Agy99 IPGGKALQRLLSQAYVEATFP--ISAHYFTVFPLARWSAVLGRRYLRQRV
Mvan_2671|M.vanbaalenii_PYR-1 LPFGKSLQRLISQAFVELTFP--LAAQYFTVNPMAKRMGAVGRAYLRKQV
MAB_4024c|M.abscessus_ATCC_199 NSRIRSAIRAIATVGIEMAMSGQVAGPAWLINAVRRAGEAPMRRWMRSQV
MSMEG_0816|M.smegmatis_MC2_155 VPLTQRVVRAITDAIYAFMVDTAVLKHRYFRR-LNIAAADLGRLHLAASI
TH_4080|M.thermoresistible__bu IPGLRLALRGGIYALQEALAVG-----MTKYPGMLRIGHLLGKWNINRSV
MLBr_00065|M.leprae_Br4923 DKYAYTAVRWKNILRQSALYG---ACQKWPQRMRNILLGHVARRLPKGYD
*
Mflv_4607|M.gilvum_PYR-GCK TDPVVREKLTPRYALGCKRPSFHNEYLKTFNRENVLLETNPITRVDETAV
MMAR_3138|M.marinum_M DDPVTRDQLIPRYSLGCKRPSFHNSYLATYNRRNVSLETSGITHVDHASV
Mb1428c|M.bovis_AF2122/97 HDPVVREQLTPRYAVGCKRPGFHNTYLSTFNRDNVRLVTEPIDKITPTAV
Rv1393c|M.tuberculosis_H37Rv HDPVVREQLTPRYAVGCKRPGFHNTYLSTFNRDNVRLVTEPIDKITPTAV
MAV_3378|M.avium_104 RDPAVREQLTPRYAVGCKRPGFHNGYLATFNRDNVRLVTEPIDKITPDAV
MUL_1793|M.ulcerans_Agy99 DDPVVRDQLTPRYAVDCKRPGFHNGYLSTFNRDNVQLVTEPIEKITPTSV
Mvan_2671|M.vanbaalenii_PYR-1 DDPVLRDKLTPRYAVGCKRPGFHNTYLSTFNRDNVDLVTEPIDKITGSGV
MAB_4024c|M.abscessus_ATCC_199 DDPVIREKLIPRYGLGCKRPSMSNEYLKTFNRDDVSLITESIECVTPDGV
MSMEG_0816|M.smegmatis_MC2_155 RDPDLRSKLTPDYDFGCKRPTFSNSYYRTFTKPHVHLQADGIDHVEPDGI
TH_4080|M.thermoresistible__bu KDPQLRAKLTPDYRLGCKRILNSSTYYPAVADPRTEVITESIDRITTDGI
MLBr_00065|M.leprae_Br4923 VQKHFGPHYNPWEQRLCLVP--DGDLFRAIRKGTVDMVTDAIDRFTSTGI
: : * * . : . : :. * . .:
Mflv_4607|M.gilvum_PYR-GCK ITADGVRHEIDVLVLATGFKVMES----DSMPTYSLRGVAGRDQAQWWDE
MMAR_3138|M.marinum_M HTEDGKSYPIDVMVLATGFKVMES----GNMPTYVLKGRGGVEQSAWWDE
Mb1428c|M.bovis_AF2122/97 ATTDGASHEIDVLVLATGFKVLDT----DSIPTYAVTGTGGASLSRFWDE
Rv1393c|M.tuberculosis_H37Rv ATTDGASHEIDVLVLATGFKVLDT----DSIPTYAVTGTGGASLSRFWDE
MAV_3378|M.avium_104 ATTDGETHEIDVLILATGFKVMDP----DSVPTFAVTGSGGRSLSRFWDE
MUL_1793|M.ulcerans_Agy99 ATDDGTDHEIDVLILATGFKVLDT----DDVLTYPVIGRAGRSLSQFWEE
Mvan_2671|M.vanbaalenii_PYR-1 STTDGSLHEVDVLILATGFKVFAAHDGDDSVATFPVTGPGGRSLARFWDD
MAB_4024c|M.abscessus_ATCC_199 RTVDGVEHVVDVLICATGFRLWDK----GSVPPFPVHGRGGQDLGEFWDR
MSMEG_0816|M.smegmatis_MC2_155 VNADGSKTVIDTLVLATGFDLWEA-----NFPAIEVIGRQGRDLGKWWRE
TH_4080|M.thermoresistible__bu VTSDGTERAVDVIVYATGFHVSDS------YKYVQIKGLNGEDIVDRFNR
MLBr_00065|M.leprae_Br4923 RLKSGNELRADIIVTATGLNLQLFG------------GAVATVDGQPVDL
.* * :: ***: : * .
Mflv_4607|M.gilvum_PYR-GCK NRLQAYEGVSVPGFPNHFSVFGP-YGYNGSSYFALIEAQAGHILRCLRHA
MMAR_3138|M.marinum_M HRLQAFEGVSVPGFPNHFNIFGP-YGYNGSSYFTLIEAQSRHIVRCLRRA
Mb1428c|M.bovis_AF2122/97 HRLQAYEGVSVPGYPNFFTVFGP-YGYVGSSYFALIETQAHHIIRCLKRA
Rv1393c|M.tuberculosis_H37Rv HRLQAYEGVSVPGYPNFFTVFGP-YGYVGSSYFALIETQAHHIIRCLKRA
MAV_3378|M.avium_104 HRLQAYEGVTVPGFPNLFTVFGP-YGYVGSSYFALIEAQTHHIVRCLKRA
MUL_1793|M.ulcerans_Agy99 HRAQAYQGVSVPGYRNFFAVFGP-YGYVGSSYFALIETQTHHILRCLKRA
Mvan_2671|M.vanbaalenii_PYR-1 NRLQAYEGVSVPGFPNFFTVFGP-YGYVGSSYFALIEAQTRHIVRCLDAA
MAB_4024c|M.abscessus_ATCC_199 HRFQSYQGVSVPGYPNMFSITGP-YGFVLGSYLWMIEATSAHLARAIAET
MSMEG_0816|M.smegmatis_MC2_155 TRFQAYQGVSMPYFPNYLSLAGP-YAFLGLNFFNTMEYQMRLMERLLGEV
TH_4080|M.thermoresistible__bu EGPMAHRGTAVADLPNAYLLLGPNTGLGHNSMVYMIESQINYVIEAIKAV
MLBr_00065|M.leprae_Br4923 AQTMSYKGMMLSGLPNMIYTVGY-TNASWTLKADLVSEFFCRLLNYMNAN
:..* :. * * :. : . :
Mflv_4607|M.gilvum_PYR-GCK RTADSNYVEVREEANQRFFAEMLARRHTQVFWQDSCAGANSYYFDKHGDV
MMAR_3138|M.marinum_M RTLKADYVEVRQQANDRYFGDMVSRRHRQVFWQPSCSNANSYYFDKHGDV
Mb1428c|M.bovis_AF2122/97 RRTGATRIEVTEEANARYFAEVMRRRHRQVFWQDSCRLANSYYFDKNGDV
Rv1393c|M.tuberculosis_H37Rv RRTGATRIEVTEEANARYFAEVMRRRHRQVFWQDSCRLANSYYFDKNGDV
MAV_3378|M.avium_104 QRLGATRVEVSEEANDRYFAEMMRRRHRQIFWQDSCRLANSYYFDKNGDV
MUL_1793|M.ulcerans_Agy99 RRDGATRVEVTEEANARYFAEMMRRRYRQVFWQDSCRRANSYYFDKNGDV
Mvan_2671|M.vanbaalenii_PYR-1 RRRRATRVEVRREANDRYFAEMMRKRHRQIFWQDSCQLSNSYYFDQHGDV
MAB_4024c|M.abscessus_ATCC_199 KRRGATVCEIRQEAHDEYFRKCLKRQEKNFLFTDVCAGSNTYYLDQNGDS
MSMEG_0816|M.smegmatis_MC2_155 ARRDARTFEVTEEANRRYLDRMTDALGDSLFTLGNCASARSYYFNPSGEA
TH_4080|M.thermoresistible__bu DKAGAQALAPTREAQDRYNAELQARLGRSVWNTGGCR---SWYLDEHGNN
MLBr_00065|M.leprae_Br4923 DFDTVAVEYPGSDVEERPFMDFTPGYVLRSLDALPKQGSRTPWRLNQNYL
:.. . : : .
Mflv_4607|M.gilvum_PYR-GCK -PLRPTTTVESIWRSRRFDLADYRFERRPAKKADTAPQKVDTAG
MMAR_3138|M.marinum_M -PLRPSTTLETYWRSRTFRLSDYRFERR----AESVGAR-----
Mb1428c|M.bovis_AF2122/97 -PLRPTTTVEAYWRSRRFDLGDYRISS-----------------
Rv1393c|M.tuberculosis_H37Rv -PLRPTTTVEAYWRSRRFDLGDYRISS-----------------
MAV_3378|M.avium_104 -PLRPGTTPEVYWRSRRFDLDDYRFTG-----------------
MUL_1793|M.ulcerans_Agy99 -PLRPTTTVEAYWRGRHFDLDDYRFGR-----------------
Mvan_2671|M.vanbaalenii_PYR-1 -PLRPASTPEAYWRSRRFPIDDYEFSC-----------------
MAB_4024c|M.abscessus_ATCC_199 -PFRPTTHGEMYWQNRHYNLDVYRYSTASVVPETVASTAGESV-
MSMEG_0816|M.smegmatis_MC2_155 TLLRPMTTRRAVAEASRFPLSDYTFA------------------
TH_4080|M.thermoresistible__bu RVLWGGFTWQYRLATRTLDPAEYRFWG-----------------
MLBr_00065|M.leprae_Br4923 RDIRLIRRGKVADEGLLFAKKTTPVTV-----------------
: .