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MTFPQARSHGKTLPSEANSVATEKRAANASRSRASARRRETILDAALTVAAAGGYEAVQMRTVAERVGIA VGTLYRYFPAKTHLLVAALTREFRRLDSAGDWASGEGPPLERLERLTAHLHDRWQRDPRLTTAMTRAFAV ADTRAAAELDRAADEIQILLARTLRGGEPTPTDLHVAGVISDIWLANLVAFSGHRATAADTRERIDRATR RVVTSAARPTANR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_4581 | - | - | 100% (223) | TetR family transcriptional regulator |
| M. gilvum PYR-GCK | Mflv_1459 | - | 3e-45 | 48.95% (190) | TetR family transcriptional regulator |
| M. gilvum PYR-GCK | Mflv_4953 | - | 1e-07 | 33.09% (136) | TetR family transcriptional regulator |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3605 | - | 1e-45 | 49.73% (183) | transcriptional regulatory protein TetR-family |
| M. tuberculosis H37Rv | Rv3574 | - | 1e-45 | 49.73% (183) | transcriptional regulatory protein TetR-family |
| M. leprae Br4923 | MLBr_00815 | - | 2e-05 | 29.89% (87) | putative TetR-family transcriptional regulator |
| M. abscessus ATCC 19977 | MAB_0579c | - | 9e-44 | 50.28% (181) | TetR family transcriptional regulator |
| M. marinum M | MMAR_5069 | - | 2e-45 | 50.27% (183) | TetR family transcriptional regulator |
| M. avium 104 | MAV_3803 | - | 3e-46 | 53.98% (176) | transcriptional regulator, TetR family protein |
| M. smegmatis MC2 155 | MSMEG_6042 | - | 5e-47 | 50.26% (189) | transcriptional regulator, TetR family protein |
| M. thermoresistible (build 8) | TH_1745 | - | 2e-46 | 50.26% (189) | TRANSCRIPTIONAL REGULATORY PROTEIN (PROBABLY TETR-FAMILY) |
| M. ulcerans Agy99 | MUL_4145 | - | 2e-45 | 50.27% (183) | TetR family transcriptional regulator |
| M. vanbaalenii PYR-1 | Mvan_0321 | - | 1e-116 | 95.52% (223) | TetR family transcriptional regulator |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_4581|M.gilvum_PYR-GCK ------------------------MTFPQARSHGKTLPSEANSVATEKRA
Mvan_0321|M.vanbaalenii_PYR-1 ------------------------MTFPQARSRGTTLPSEANSVATEKRA
MAV_3803|M.avium_104 ------------------------MSAPTAAPR--------DRVRHPRRP
MMAR_5069|M.marinum_M ---------------------------------------------MAVLA
MUL_4145|M.ulcerans_Agy99 ---------------------------------------------MAVLA
Mb3605|M.bovis_AF2122/97 ---------------------------------------------MAVLA
Rv3574|M.tuberculosis_H37Rv ---------------------------------------------MAVLA
MSMEG_6042|M.smegmatis_MC2_155 ------------------------------------------MTNVAVLS
TH_1745|M.thermoresistible__bu MSSSTGTNPGRGSDSTGSETNGAAATGAGSGSTGTSRTRGRQVTNVAVLT
MAB_0579c|M.abscessus_ATCC_199 -------------MATPRTSSASEAAQSGDGDTDATS----QPAAVSALS
MLBr_00815|M.leprae_Br4923 -----------------------MNNLAKAAQRRTVRPIDRGRLSDDIAT
.
Mflv_4581|M.gilvum_PYR-GCK ANASRSRASARRRE-TILDAALTVAAAGGYEAVQMRTVAERVGIAVGTLY
Mvan_0321|M.vanbaalenii_PYR-1 ANASRSRASARRRE-TILDAALAVAAAGGYEAVQMRTVAERVGIAVGTLY
MAV_3803|M.avium_104 ADS-----VLVRRE-AILDAAWAVASAQGFDGVQMRAVAAQAGIAASSLY
MMAR_5069|M.marinum_M ESELGSEAQRERRK-RILDATMAIASKGGYEAVQMRAVADRADVAVGTLY
MUL_4145|M.ulcerans_Agy99 ESELGSEAQRERRK-RILDATMAIASKGGYEAVQMRAVADRADVAVGTLY
Mb3605|M.bovis_AF2122/97 ESELGSEAQRERRK-RILDATMAIASKGGYEAVQMRAVADRADVAVGTLY
Rv3574|M.tuberculosis_H37Rv ESELGSEAQRERRK-RILDATMAIASKGGYEAVQMRAVADRADVAVGTLY
MSMEG_6042|M.smegmatis_MC2_155 ESELGSEAQRERRK-RILDATLAIASKGGYEAVQMRAVAERADVAVGTLY
TH_1745|M.thermoresistible__bu DSELGSEAQRERRK-RILDATLAIASKGGYEAVQMRAVAERADVAVGTLY
MAB_0579c|M.abscessus_ATCC_199 DDDLGSSAQRERRK-RILDATLAIASKGGYEAVQMRTVAERADVAVGTLY
MLBr_00815|M.leprae_Br4923 PNQRSNRLSRDKRRGQLLIVASDVFVDHGYHAAGMDEIADRAGVSKPVLY
. :*. :* .: : *:... * :* :..:: **
Mflv_4581|M.gilvum_PYR-GCK RYFPAKTHLLVAALTREFRRLDSAGDWASGE-GPPLERLERLTAHLHDRW
Mvan_0321|M.vanbaalenii_PYR-1 RYFPAKTHLLVAALTREFRRLDSAGDWAGGE-GTPLERLERLTAHLHDRW
MAV_3803|M.avium_104 RHFRSKSHLLVTVLAREFERLDTEFDCTTGE-LAPQARLGRLTTHLHMAW
MMAR_5069|M.marinum_M RYFPSKVHLLVSALGREFSRIDAKTDRSAMTGGTPFQRLNFMVGKLNRAM
MUL_4145|M.ulcerans_Agy99 RYFPSKVHLLVSALGREFSRIDAKTDRSAMTGGTPFQRLNFMVGKLNRAM
Mb3605|M.bovis_AF2122/97 RYFPSKVHLLVSALGREFSRIDAKTDRSAVAGATPFQRLNFMVGKLNRAM
Rv3574|M.tuberculosis_H37Rv RYFPSKVHLLVSALGREFSRIDAKTDRSAVAGATPFQRLNFMVGKLNRAM
MSMEG_6042|M.smegmatis_MC2_155 RYFPSKVHLLVSALGREFERIDAKTDRAALAGGTPYQRLNFMVGKLNRAM
TH_1745|M.thermoresistible__bu RYFPSKVHLLVSALGREFERIDAKTDRSTLVGDTPYERLNFMVSRLNRAM
MAB_0579c|M.abscessus_ATCC_199 RYFPSKVHLLVSALEREFEQIDAKSDRNAVSGGTPYERLHAAITRLNRNM
MLBr_00815|M.leprae_Br4923 QHFSSKLELYLAVLERHMNNLVSSVQQALRTTTNNRQRLHAAVQAFFDFI
::* :* .* ::.* *.: .: : : ** :
Mflv_4581|M.gilvum_PYR-GCK QRDPRLTTAMTRAFAVADTRAAAELDRAAD-EIQILLARTLR-GGEPTPT
Mvan_0321|M.vanbaalenii_PYR-1 QRDPWLTTAMTRAFAVADTRAAAELDRAAD-EIQILLARTLR-GGEPTPA
MAV_3803|M.avium_104 QANPHLTEAMVRAFVVADSEAAGAIEHAVA-VIEDMLARALG-GPTPSAH
MMAR_5069|M.marinum_M QRNPLLTEAMTRAYVFADASAATEVDQVEK-LIDSMFARAMA-DGEPTED
MUL_4145|M.ulcerans_Agy99 QRNPLLTEAMTRAYVFADASAATEVDQVEK-LIDSMFARAMA-DGEPTED
Mb3605|M.bovis_AF2122/97 QRNPLLTEAMTRAYVFADASAASEVDQVEK-LIDSMFARAMA-NGEPTED
Rv3574|M.tuberculosis_H37Rv QRNPLLTEAMTRAYVFADASAASEVDQVEK-LIDSMFARAMA-NGEPTED
MSMEG_6042|M.smegmatis_MC2_155 QRNPLLTEAMTRAFVFADASAAGEVDHVGK-LMDSMFARAMS-DGEPTED
TH_1745|M.thermoresistible__bu QRNPLLTEAMTRAFVFADASAAGEVDHVGR-LMDSMFARAMA-DGEPTED
MAB_0579c|M.abscessus_ATCC_199 QRNPLLTEAMTRALVFADASAAGEVDHVGR-LMDGIFARAMAGEDDPTDA
MLBr_00815|M.leprae_Br4923 EHDGQGYRLIFENDNITEPRVAAQVRVATESCIDAVFALISADSRLDPHR
: : : . .::. .* : . :: ::* .
Mflv_4581|M.gilvum_PYR-GCK DLHVAGVISDIWLANLVAFSGHRATAADTRERIDRATRRVVTSAARPTAN
Mvan_0321|M.vanbaalenii_PYR-1 DLHVAGVISDIWLANLVAFSGDRATAADTRDRIDRATRRVVTNAARPTAN
MAV_3803|M.avium_104 DRDVASLIADVWLANLIAVIGGRIDADLARERIDRTTRQLVHGTDTTT--
MMAR_5069|M.marinum_M QYHIARVISDVWLSNLLAWLTRRASATDVSKRLDLAVRLLIGDQEATA--
MUL_4145|M.ulcerans_Agy99 QYHIARVISDVWLSNLLAWLTRRASATDVSKRLDLAVRLLIGDQEATA--
Mb3605|M.bovis_AF2122/97 QYHIARVISDVWLSNLLAWLTRRASATDVSKRLDLAVRLLIGDQDSA---
Rv3574|M.tuberculosis_H37Rv QYHIARVISDVWLSNLLAWLTRRASATDVSKRLDLAVRLLIGDQDSA---
MSMEG_6042|M.smegmatis_MC2_155 QYHIARVISDVWLSNLLAWLTRRASATDVSKRLDLAVRLLIGTEEQPKI-
TH_1745|M.thermoresistible__bu QYHIARVISDVWLSNLLAWLTRRASATDVSKRLELAVRLLVGDGKNPKV-
MAB_0579c|M.abscessus_ATCC_199 QFHIARVISDVWTSNMIAWLTRRASATDVSHRLDRTVRLLLGIT------
MLBr_00815|M.leprae_Br4923 ARMVAVGLVGISVDCARYWLDTNRPISKS-DAVEGTVQFAWGGLSHVPLT
:* : .: . . :: :.:
Mflv_4581|M.gilvum_PYR-GCK R-
Mvan_0321|M.vanbaalenii_PYR-1 R-
MAV_3803|M.avium_104 --
MMAR_5069|M.marinum_M --
MUL_4145|M.ulcerans_Agy99 --
Mb3605|M.bovis_AF2122/97 --
Rv3574|M.tuberculosis_H37Rv --
MSMEG_6042|M.smegmatis_MC2_155 --
TH_1745|M.thermoresistible__bu --
MAB_0579c|M.abscessus_ATCC_199 --
MLBr_00815|M.leprae_Br4923 RL