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MSLAGKTMFISGASRGIGLAIAKRAAADGANIALVAKTAEPHPKLPGTVYTAAEEIEEAGGQALPIVGDV RDGDSVVAAVAQAVEKFGGIDICVNNASAINLGSIEDVPLKRFDLMNGIQVRGTYAVSQACIPHMKGRDN PHILTLSPPILLESKWLRPTPYMMAKFGMTLCALGIAEELRDARVASNTLWPRTMVATAAVQNLLGGDES MARSRKPEVYSDAAYAILTKPSSFTGNTLLCEDVLLEAGVTDLSVYDCVPGSELGVDFWVDSANPPGYTG P
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_4691 | - | - | 100% (281) | short chain dehydrogenase |
| M. gilvum PYR-GCK | Mflv_2386 | - | 9e-67 | 47.62% (273) | short chain dehydrogenase |
| M. gilvum PYR-GCK | Mflv_2396 | - | 2e-32 | 38.61% (202) | short-chain dehydrogenase/reductase SDR |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3251 | - | 1e-137 | 84.59% (279) | short chain dehydrogenase |
| M. tuberculosis H37Rv | Rv3224 | - | 1e-137 | 84.59% (279) | short chain dehydrogenase |
| M. leprae Br4923 | MLBr_01094 | - | 4e-07 | 24.58% (179) | short chain alcohol dehydrogenase |
| M. abscessus ATCC 19977 | MAB_3946c | - | 3e-87 | 59.27% (275) | putative short chain dehydrogenase/reductase |
| M. marinum M | MMAR_1333 | - | 1e-136 | 82.27% (282) | iron-regulated short-chain dehydrogenase/reductase |
| M. avium 104 | MAV_4172 | - | 1e-139 | 84.75% (282) | short chain dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_1894 | - | 1e-142 | 86.07% (280) | short chain dehydrogenase |
| M. thermoresistible (build 8) | TH_0664 | - | 1e-148 | 89.32% (281) | POSSIBLE IRON-REGULATED SHORT-CHAIN DEHYDROGENASE/REDUCTASE |
| M. ulcerans Agy99 | MUL_2546 | - | 1e-135 | 81.91% (282) | short chain dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_1776 | - | 1e-153 | 93.95% (281) | short chain dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_4691|M.gilvum_PYR-GCK ------MSLAGKTMFISGASRGIGLAIAKRAAADGANIALVAKTAEPHPK
Mvan_1776|M.vanbaalenii_PYR-1 ------MSLAGKTMFISGASRGIGLAIAKRAAADGANIALVAKTAEPHPK
TH_0664|M.thermoresistible__bu ------MSLRGKTMFISGGSRGIGLAIAKRVAADGANVALVAKSAEPHPK
Mb3251|M.bovis_AF2122/97 ------MSLNGKTMFISGASRGIGLAIAKRAARDGANIALIAKTAEPHPK
Rv3224|M.tuberculosis_H37Rv ------MSLNGKTMFISGASRGIGLAIAKRAARDGANIALIAKTAEPHPK
MMAR_1333|M.marinum_M ------MSLNGKTMFISGASRGIGLAIAKRAAQDGANIALIAKTAEPHPK
MUL_2546|M.ulcerans_Agy99 ------MSLNGKTMFISGASRGIGLAIAKRAAQDGANIALIAKTAEPHPK
MAV_4172|M.avium_104 ------MSLNGKTMFISGASRGIGLAIAKRAAQDGANIALIAKTAEPHPK
MSMEG_1894|M.smegmatis_MC2_155 MVRMAQAPLSGKTMFISGASRGIGLAIAKRAAADGANIALIAKTAEPHPK
MAB_3946c|M.abscessus_ATCC_199 -----MGSLAGKTIIMSGGSRGIGLAIALRAARDGANVAIMAKTAEPHPK
MLBr_01094|M.leprae_Br4923 -----MEGFAGKVAVVTGAGSGIGQALAIELARSGAKLAISDVDGEGLAQ
: **. .::*.. *** *:* . * .**::*: .* .:
Mflv_4691|M.gilvum_PYR-GCK LPGTVYTAAEEIEEAGGQALPIVGDVRDGDSVVAAVAQAVEKFGGIDICV
Mvan_1776|M.vanbaalenii_PYR-1 LPGTVYTAAKEIEEVGGQALPIVGDVRDGDSVAAAVAKTVEQFGGIDMCV
TH_0664|M.thermoresistible__bu LPGTIYTAAKEIEEAGGQALPIVGDIRDGDAVAAAVAKTVEQFGGIDICV
Mb3251|M.bovis_AF2122/97 LPGTVFTAAKELEEAGGQALPIVGDIRDPDAVASAVATTVEQFGGIDICV
Rv3224|M.tuberculosis_H37Rv LPGTVFTAAKELEEAGGQALPIVGDIRDPDAVASAVATTVEQFGGIDICV
MMAR_1333|M.marinum_M LPGTVYTAAKELEEAGGQALPIVGDVRDPDSVSAAVAKTVEQFGGIDICV
MUL_2546|M.ulcerans_Agy99 LPGTVYTAAKELEEAGGQALPIVGDVRDPDSVSAAVAKTVEQFGGIDICV
MAV_4172|M.avium_104 LPGTVYTAAKELEEAGGQALPIVGDVRDPESVEAAVAKTVEQFGGIDICV
MSMEG_1894|M.smegmatis_MC2_155 LEGTIYTAAEEIEDAGGQALPIVGDVRDGDSVAAAVTKAVEQFGGIDICV
MAB_3946c|M.abscessus_ATCC_199 LPGTIYTAAEEIEAAGGHALPLLGDVRDDEVVASAVAQTVEKFGGIDIVV
MLBr_01094|M.leprae_Br4923 TEG-------QLKAIGASARTDRLDVTEREAFLTYADVVHENFGKVNQIY
* ::: *. * . *: : : . : . . *:** ::
Mflv_4691|M.gilvum_PYR-GCK NNASAINLGSIEDVPLKRFDLMNGIQVRGTYAVSQACIPHMKGRDNPHIL
Mvan_1776|M.vanbaalenii_PYR-1 NNASAINLGSIEEVPLKRFDLMNGIQVRGTYAVSQACIPHMKGRDNPHIL
TH_0664|M.thermoresistible__bu NNASAINLGSIEEVPLKRFDLMNGIQVRGTYAVSQSCIPHMKGRDNPHIL
Mb3251|M.bovis_AF2122/97 NNASAINLGSITEVPMKRFDLMNGIQVRGTYAVSQACIPHMKGRENPHIL
Rv3224|M.tuberculosis_H37Rv NNASAINLGSITEVPMKRFDLMNGIQVRGTYAVSQACIPHMKGRENPHIL
MMAR_1333|M.marinum_M NNASAINLGSITEVPMKRFDLMNGIQVRGTYAVSQACIPHLKGRENPHIL
MUL_2546|M.ulcerans_Agy99 NNASAINLGSITEVPMKRFDLMNGIQVRGTYAVSQACIPHLKGRENPHIL
MAV_4172|M.avium_104 NNASAINLGPITEVPMKRFDLMNGIQVRGTYAVSQACIPHLKGRENPHIL
MSMEG_1894|M.smegmatis_MC2_155 NNASAINLGSIEEVPLKRFDLMNGIQIRGTYAVSQACIPHMKGRENPHIL
MAB_3946c|M.abscessus_ATCC_199 NNASALNLAPSESISMKAYDLMQDINARGSFSLSTSAIGALKEADNPHIL
MLBr_01094|M.leprae_Br4923 NNAGIAFTGDVEVSHFKDIERVMDVDYWGVVNGTKAFLPYLISSGDGHVI
***. . :* : : .:: * : : : : : *::
Mflv_4691|M.gilvum_PYR-GCK TLSPPILLESKWLR--PTPYMMAKFGMTLCALGIAEELRDAR--VASNTL
Mvan_1776|M.vanbaalenii_PYR-1 TLSPPILLESKWLR--PTPYMMAKFGMTLCALGIAEEMRDAG--IASNTL
TH_0664|M.thermoresistible__bu TLSPPIRLEPKWLR--PTPYMMAKYGMTLCALGIAEELRDAG--IASNTL
Mb3251|M.bovis_AF2122/97 TLSPPILLEKKWLR--PTAYMMAKYGMTLCALGIAEEMRADG--IASNTL
Rv3224|M.tuberculosis_H37Rv TLSPPILLEKKWLR--PTAYMMAKYGMTLCALGIAEEMRADG--IASNTL
MMAR_1333|M.marinum_M TLSPPVQLDKKWLK--PTAYMMAKFGMTLCALGIAEEMRDEG--IASNTL
MUL_2546|M.ulcerans_Agy99 TLSPPVQLDKKWLK--PTAYMMAKFGMTLCALGIAEEMRDEG--IASNTL
MAV_4172|M.avium_104 TLSPPVLLGKEWLK--PTAYMMAKFGMTLCALGIAEEMREAG--IASNTL
MSMEG_1894|M.smegmatis_MC2_155 TLSPPVRLEPEWLK--PTAYMMAKFGMTLCALGIAEEMREHG--IASNTL
MAB_3946c|M.abscessus_ATCC_199 TLSPPITLEPKWFERTTTAYTISKFSMSLVAIGLAAELRQYG--IASNAL
MLBr_01094|M.leprae_Br4923 NISSVFGLFSVPGQ---AAYNSAKFAVRGFTEALREEMALAGRPVNVTTV
.:*. . * . :.* :*:.: : .: *: : .::
Mflv_4691|M.gilvum_PYR-GCK WPRTMVATAAVQNLLGGDESMARSRKPEVYSDAAYAILTKPSS-FTGNTL
Mvan_1776|M.vanbaalenii_PYR-1 WPRTMVATAAVQNLLGGDESMARSRKPEVYSDAAYAVLTKPSS-FTGHTL
TH_0664|M.thermoresistible__bu WPRTTVATAAVQNLLGGDEAMARSRKPEVYADAAYVVLNKPSS-YTGNTL
Mb3251|M.bovis_AF2122/97 WPRTMVATAAVQNLLGGDEAMARSRKPEVYADAAYVIVNKPATEYTGKTL
Rv3224|M.tuberculosis_H37Rv WPRTMVATAAVQNLLGGDEAMARSRKPEVYADAAYVIVNKPATEYTGKTL
MMAR_1333|M.marinum_M WPRTLVATAAVQNLLGGDEAMGRARKPDVYADAAYVILNKNSREYTGNSA
MUL_2546|M.ulcerans_Agy99 WPRTLVATAAVQNLLGGEEAMGRARKPDVYADAAYVILNKNSREYTGNSA
MAV_4172|M.avium_104 WPRTLVATAAVQNLLGGDEAMGRARKPEVYSDAAYVILNKPAREFTGNML
MSMEG_1894|M.smegmatis_MC2_155 WPRTLVATAAVQNLLGGDEAMARARKPQVYADAAYAVFTKPAREFTGNTL
MAB_3946c|M.abscessus_ATCC_199 WPRTTIDTAAIRNILG-AELVARCRSAQIMADAAYEILTKPSREVSGNCF
MLBr_01094|M.leprae_Br4923 YP-GGIKTAIARNATAAEGLDVSKIASRFDTWVAHTSPQHAARIILKAVR
:* : ** :* . . . : .*: : :
Mflv_4691|M.gilvum_PYR-GCK LCED-VLLEAGVTDLSVYDCVPGSELGVDFWVDSANPPGYTGP
Mvan_1776|M.vanbaalenii_PYR-1 LCED-VLLESGVTDLSVYDCVPGSDLGVDFWVEGANPPGYTGP
TH_0664|M.thermoresistible__bu LCED-VLLESGVTDLSVYDCVPGSELGVDLWVDSPNPPGYTGP
Mb3251|M.bovis_AF2122/97 LCED-VLVESGVTDLSVYDCVPGATLGVDLWVEDANPPGYLPA
Rv3224|M.tuberculosis_H37Rv LCED-VLVESGVTDLSVYDCVPGATLGVDLWVEDANPPGYLPA
MMAR_1333|M.marinum_M LCED-VLLESGVSDLSIYNCVPGAKLGVDLWVEEVNPPGYTQP
MUL_2546|M.ulcerans_Agy99 LCED-VLLESGVSDLSIYNCVPGAKLGVDLWVEEVNPPGYTQP
MAV_4172|M.avium_104 LCED-VLVESGVTDLSVYNCVPGSQLGVDFWVDGVNPPGYTGP
MSMEG_1894|M.smegmatis_MC2_155 LCED-VLLDSGVTDLSVYDCVPGGELGVDLWVDTPNPPGYTGP
MAB_3946c|M.abscessus_ATCC_199 IDDE-VLREAGVTDFSQYRECAEEDLELDFWMERA--------
MLBr_01094|M.leprae_Br4923 KKKARVLVGPDAKVANVVVRFSGGAGYQRLFAQVASRLILNQR
. ** .... . . :: :