For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
MSFEDTYGPWALVVGASDGIGSAFAEELAERGLNVVLLSRRGQVLAALAERIESRFGVTTRVVTADLADE SAADAVIEATADLDIGTLVYCAGADPEFKPFLAQPVGAAEAMLRRNCLTLMRLCHHYAGPMVSRGRGAVV VLGSGAGLAGGPNMVAYSATKAFDMVFAEALWTELHGKGVDVLGLILGKTDTPALRRLEHARGNLASLDE RPKDTATVDDVIAEAFANLTNGPTWIVGQDMRAAAQMMGSVSRSDAVRFIMQASAAAMGDG
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_2380 | - | - | 100% (271) | short-chain dehydrogenase/reductase SDR |
| M. gilvum PYR-GCK | Mflv_4545 | - | 6e-39 | 36.67% (240) | short-chain dehydrogenase/reductase SDR |
| M. gilvum PYR-GCK | Mflv_3538 | - | 7e-26 | 36.64% (232) | short-chain dehydrogenase/reductase SDR |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1571 | - | 2e-22 | 34.51% (226) | ketoacyl reductase |
| M. tuberculosis H37Rv | Rv1544 | - | 2e-22 | 34.51% (226) | ketoacyl reductase |
| M. leprae Br4923 | MLBr_00429 | - | 1e-20 | 35.16% (182) | putative oxidoreductase |
| M. abscessus ATCC 19977 | MAB_1537c | - | 2e-25 | 34.11% (214) | putative short chain dehydrogenase/reductase |
| M. marinum M | MMAR_3509 | - | 2e-28 | 36.59% (205) | short-chain alcohol dehydrogenase |
| M. avium 104 | MAV_5238 | - | 1e-100 | 67.29% (269) | oxidoreductase, short-chain dehydrogenase/reductase family |
| M. smegmatis MC2 155 | MSMEG_6592 | - | 3e-92 | 63.12% (263) | short-chain dehydrogenase/reductase SDR |
| M. thermoresistible (build 8) | TH_2749 | - | 4e-37 | 37.50% (240) | PUTATIVE short-chain dehydrogenase/reductase SDR |
| M. ulcerans Agy99 | MUL_1543 | - | 2e-21 | 35.36% (181) | ketoacyl reductase |
| M. vanbaalenii PYR-1 | Mvan_2633 | - | 3e-38 | 39.39% (231) | short-chain dehydrogenase/reductase SDR |
CLUSTAL 2.0.9 multiple sequence alignment
MAV_5238|M.avium_104 ------------MSFAARYGPWALVAGASDGVGAAFAEGLAERGVNVALL
MSMEG_6592|M.smegmatis_MC2_155 ------------MDFNQRYGPWALVAGASDGVGAAMAHALARRGLNVVLL
Mflv_2380|M.gilvum_PYR-GCK ------------MSFEDTYGPWALVVGASDGIGSAFAEELAERGLNVVLL
TH_2749|M.thermoresistible__bu ------------VTDLTRYGPTAVIAGGSEGVGAEFARLLADAGIDLVLI
Mvan_2633|M.vanbaalenii_PYR-1 MLPDTRRGDDVTVTDLTGYGPWAVVAGGSEGVGAEFAAQLARAGVNLVLV
MMAR_3509|M.marinum_M -----------------------------------------------MLI
Mb1571|M.bovis_AF2122/97 -----------MSLPKPNNQTTVVITGASSGIGVELARGLAGRGFPLMLV
Rv1544|M.tuberculosis_H37Rv -----------MSLPKPNNQTTVVITGASSGIGVELARGLAGRGFPLMLV
MUL_1543|M.ulcerans_Agy99 -----------MTLPKPNKQATVVITGASSGIGVELARGLAGRGFPLMLV
MLBr_00429|M.leprae_Br4923 -----------MPIPAPSPEARAVVTGASQNIGEALATELAAHGHSLIVI
MAB_1537c|M.abscessus_ATCC_199 -----------MPIPAPSPDARAVVTGASQGIGAALAEELAARGHNLIIT
:
MAV_5238|M.avium_104 ARRQDVLDRVAARIRARTSAQTRTLAIDLAHPGAAKAIAAATADVTIGML
MSMEG_6592|M.smegmatis_MC2_155 ARRQPVLDTVAAQIRDTAGVETRTLAIDLAEAGAAQRIIESTAGLDIGFL
Mflv_2380|M.gilvum_PYR-GCK SRRGQVLAALAERIESRFGVTTRVVTADLADESAADAVIEATADLDIGTL
TH_2749|M.thermoresistible__bu ARKPGPLEDTAADCRARG-VEVRTISADLTDPAAVHRVLAECAGLEVGLL
Mvan_2633|M.vanbaalenii_PYR-1 ARTPEPLERTAARCREFG-VQTRTLAVDLVD--ATHEVIAATADLEVGLL
MMAR_3509|M.marinum_M ARAPGPLADTARRCRETG-VHVRTIAVDLVDPEAVALICSETADLEVGLL
Mb1571|M.bovis_AF2122/97 ARRRERLDELADQLRQEHCVGVEVLPLDLADTQARAQLADRLRSDAIAGL
Rv1544|M.tuberculosis_H37Rv ARRRERLDELADQLRQEHCVGVEVLPLDLADTQARAQLADRLRSDAIAGL
MUL_1543|M.ulcerans_Agy99 ARRRERLEELADDLRDKFSIAVEVLPLDLSDAQARTQLADRLRSDSIAGL
MLBr_00429|M.leprae_Br4923 ARREDVLVDLAARLADKYRVAVEVRPADLTDPSERVKLADELTVRPISIL
MAB_1537c|M.abscessus_ATCC_199 ARRGEILNDLANALSEKTGVIVEVRAVDLADPGARDALCTELSERNISIL
:* * * ... . ** . : :. *
MAV_5238|M.avium_104 VYCAGADPDFKPFLANRIEAAEAMVQRNCMVPMQLCHHYAPAMVERGAGG
MSMEG_6592|M.smegmatis_MC2_155 VYCAGSDTNVTPFLDTPLDVAESMVQRNCMVPVQLCHHYAKPMADRGRGG
Mflv_2380|M.gilvum_PYR-GCK VYCAGADPEFKPFLAQPVGAAEAMLRRNCLTLMRLCHHYAGPMVSRGRGA
TH_2749|M.thermoresistible__bu IYNAGANTCSEEFLDGELADFDKVLRLNIDTMLTLVQHFGRPMRERRSGG
Mvan_2633|M.vanbaalenii_PYR-1 IYNAGANTCSEEFLDADLAEFGRVVDLNVTAMMTLVQHYGRPMRERRRGG
MMAR_3509|M.marinum_M IYNAGANTCREQFLDAELTELGRVIDLNVTRMLELVQHFGRPMRARRRGG
Mb1571|M.bovis_AF2122/97 CNSAGFG-TSGRFWELPFARESEEVVLNALALMELTHAALPGMVKRGAGA
Rv1544|M.tuberculosis_H37Rv CNSAGFG-TSGRFWELPFARESEEVVLNALALMELTHAALPGMVKRGAGA
MUL_1543|M.ulcerans_Agy99 CNSAGFG-TSGRFCELPPERESEQVTLNALALMEFTRAALPGMVERGAGA
MLBr_00429|M.leprae_Br4923 CANAGTA-TFGPVSALDPAGEKAQVQLNAVAVHDLTLAVLPGMIERKAGG
MAB_1537c|M.abscessus_ATCC_199 CNNAGTA-TFGPIRGLDPAGERKQVQLNAVAVHDLTLAVLPGMLARGAGG
** . : * : * * *.
MAV_5238|M.avium_104 IVLFGSGAGLAGGPNMVAYGASKAFDMVFAEALWAELHDKGVDVLGLILG
MSMEG_6592|M.smegmatis_MC2_155 IVIFGSGAGLAGAPNMVAYSASKAFDMVLAEALWSELHTKGVDVLGLILG
Mflv_2380|M.gilvum_PYR-GCK VVVLGSGAGLAGGPNMVAYSATKAFDMVFAEALWTELHGKGVDVLGLILG
TH_2749|M.thermoresistible__bu ILLVGSMAGYLGSARHTVYGGVKAFGRIFAESLWLELRDHGVDVLELVLG
Mvan_2633|M.vanbaalenii_PYR-1 ILLVGSMAGYLGSVRHTVYGGVKAFGRIFAEGLWLELRDHDVHVLELVLG
MMAR_3509|M.marinum_M IVLVGSTAATYGAMRQSAYAGAKAFSRLFAESLWLELRETGVDVLELVLG
Mb1571|M.bovis_AF2122/97 VLNIASIAGFQPIPYMAVYSATKAFVLTFSEAVQEELHGTGVSVTALCPG
Rv1544|M.tuberculosis_H37Rv VLNIASIAGFQPIPYMAVYSATKAFVLTFSEAVQEELHGTGVSVTALCPG
MUL_1543|M.ulcerans_Agy99 VLNIASIAGFQPIPFMAVYSASKAFVLTFSEAVQEELHGTGVSVTALCPG
MLBr_00429|M.leprae_Br4923 ILISGSAAGNSPIPYNATYAATKAFANTFSESLRGELHGSGVHVTLLAPG
MAB_1537c|M.abscessus_ATCC_199 ILISGSAAGNSPIPNNATYAATKAFANTFSESLRGELKGTGVHVTLLAPG
:: .* *. .*.. *** ::*.: **: .* * * *
MAV_5238|M.avium_104 KTDTPALRALEYSRGQIASPDQAPSDAAAVSDVIAEAFENLGNGPTLMVG
MSMEG_6592|M.smegmatis_MC2_155 KTDTPALRALEFRRGQIASPDTAPPGAAPVDDVVAAAFANLTAGPTCLVG
Mflv_2380|M.gilvum_PYR-GCK KTDTPALRRLEHARGNLASLDERPKDTATVDDVIAEAFANLTNGPTWIVG
TH_2749|M.thermoresistible__bu VTRTPAMERAGLN------FDVPGLRVADPADVAREGLERLPHGPVHVAG
Mvan_2633|M.vanbaalenii_PYR-1 VTRTPAMERVGLN------FDVPGLRVSEPAEVAAEGLRQLPHGPVHVVN
MMAR_3509|M.marinum_M VTRTPAMQRAGLN------FDAPGISVSDPADVAREGLDNLANGPVVIAG
Mb1571|M.bovis_AF2122/97 PVPTEWAEIASA---ERFSIPLAQVSPHDVAEAAIAGML--SGKRTVVPG
Rv1544|M.tuberculosis_H37Rv PVPTEWAEIASA---ERFSIPLAQVSPHDVAEAAIAGML--SGKRTVVPG
MUL_1543|M.ulcerans_Agy99 PVPTEWAEIASA---ERFSIPLARVSPHDVAEAAIEGML--TGKRTVVPG
MLBr_00429|M.leprae_Br4923 PVRTELPDHDEASLVEKLVPDFLWISTEHTARLSLDALE--RNKMRVVPG
MAB_1537c|M.abscessus_ATCC_199 PVRTVEPDPAEASIVDKVVPDFLWINGEYTARVSLNALE--RNKMRVVPG
. * .: : .
MAV_5238|M.avium_104 DTMRAAAQLLASLSRNQAVELFAQAAA------AAMGPDD------
MSMEG_6592|M.smegmatis_MC2_155 EDMQAVAELMASVSRNEAVHIIARAVEHRWVKPALPRPDQPRTSVR
Mflv_2380|M.gilvum_PYR-GCK QDMRAAAQMMGSVSRSDAVRFIMQASA------AAMGDG-------
TH_2749|M.thermoresistible__bu GNAEDVARRNDPDRAKVVLGAHRFVQKLIGQ-----A---------
Mvan_2633|M.vanbaalenii_PYR-1 GNEDDVARRNDPDRARVVLGAHRFMQKLIGG-----RGHR------
MMAR_3509|M.marinum_M DNAAHVHRGSGADRAAIVLRAHRAMQALIGSPPPPPKGDRA-----
Mb1571|M.bovis_AF2122/97 IVPKFVSTSGRFAPRSLLLPAIRIGNRLRGGPSR------------
Rv1544|M.tuberculosis_H37Rv IVPKFVSTSGRFAPRSLLLPAIRIGNRLRGGPSR------------
MUL_1543|M.ulcerans_Agy99 VVPKFVSTSGRYLPRSVLLPAIRIGNKLRGGPSH------------
MLBr_00429|M.leprae_Br4923 LTSKAMSVASRYAPRAIVASIVGNFYKKLGGG--------------
MAB_1537c|M.abscessus_ATCC_199 ITSKAMSVAAGYAPRAVVAPIVGSFYKKLGD---------------