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MRTDVRRPLLGVATAVVILAVVALSVSLFRGSFIKSVPITVLTQRAGLVMNPDAKVKLHGAQVGRVQAIE SLPDGRAALHLAMEPAYLDLIPANVGVDIAAPTVFGAKSIELVPPPNPDPQPLRAGQVLSADHVTVEINT IFEKLSTVLSKIEPHKLNQTLGALSVAVDGRGDQIGQMLTEFDAFLTKIDPSLPTLDHELAVAPHVLDAY ADVAPELLTTVDAATTVSRTIVEERHNVDGLLLSMIGLSDIGIDVVGANRQAITDAAHLLAPTTDLTNEY HQALTCGLGGAVQLAKAPGSPVPGGLLLQTVVLGQERYRYPDNLPKVAAKGGPQCTDLPKVPFQKHPPFV ITDVNANPAQYGNEGILLNSDGLKQMLYGPIAGPPRNSAQIGQPG
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_2855 | - | - | 100% (395) | virulence factor Mce family protein |
| M. smegmatis MC2 155 | MSMEG_4794 | - | e-125 | 55.78% (389) | virulence factor |
| M. smegmatis MC2 155 | MSMEG_0346 | - | 2e-57 | 39.20% (324) | virulence factor |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3529c | mce4A | 3e-56 | 35.33% (368) | MCE-family protein MCE4A |
| M. gilvum PYR-GCK | Mflv_4538 | - | 1e-169 | 72.66% (395) | virulence factor Mce family protein |
| M. tuberculosis H37Rv | Rv1966 | mce3A | 2e-58 | 40.98% (327) | MCE-family protein MCE3A |
| M. leprae Br4923 | MLBr_02589 | mce1A | 3e-46 | 31.52% (368) | putative cell invasion protein |
| M. abscessus ATCC 19977 | MAB_4153c | - | 2e-61 | 36.50% (389) | MCE-family protein |
| M. marinum M | MMAR_4710 | - | 1e-132 | 59.38% (389) | MCE-family protein |
| M. avium 104 | MAV_0948 | - | 1e-133 | 58.76% (388) | virulence factor Mce family protein, putative |
| M. thermoresistible (build 8) | TH_2722 | - | 1e-178 | 75.95% (395) | PUTATIVE virulence factor Mce family protein |
| M. ulcerans Agy99 | MUL_3918 | mce3A_1 | 1e-61 | 40.64% (342) | MCE-family protein Mce3A_1 |
| M. vanbaalenii PYR-1 | Mvan_2851 | - | 1e-172 | 72.77% (393) | virulence factor Mce family protein |
CLUSTAL 2.0.9 multiple sequence alignment
Rv1966|M.tuberculosis_H37Rv -------------------------MRRGPGRHRLHDAWWTLILFAVIGV
MUL_3918|M.ulcerans_Agy99 ---------------------------MDDRKEGLHPAWHTLILVLLFVA
Mb3529c|M.bovis_AF2122/97 --------------------------MSGGGSRRTSVRVAAALLAGLMVG
MAB_4153c|M.abscessus_ATCC_199 --------------------------MSDTSTRR-AVRLAGTVLASVLVL
MSMEG_2855|M.smegmatis_MC2_155 ------------------------------MRTDVRRPLLGVATAVVILA
TH_2722|M.thermoresistible__bu ----------MDNTGMDNTGMDNAGMGSAGMSTEWKRRLAGFATASVIVL
Mflv_4538|M.gilvum_PYR-GCK ------------------------------MTTRPGRPLIGLATVLALAA
Mvan_2851|M.vanbaalenii_PYR-1 ----------------------------MAIDSSVRRPLIGLATVLAVAA
MMAR_4710|M.marinum_M MSRNLGPNPMHRSETASAAAPVAASPGRHFGVSSYARPLAGLATVLVIAL
MAV_0948|M.avium_104 MTQNVPAG-----RGAIAGRPPRPGHAHPPAGRNYLPPLLGLATILIIGL
MLBr_02589|M.leprae_Br4923 ----------------------MTSSTKINASRKPPYKLAGVGLLVVAVV
Rv1966|M.tuberculosis_H37Rv AVLVTAVSFTGSLRSTVPVTLAADRSGLVMDSGAKVMMRGVQVGRVAQIG
MUL_3918|M.ulcerans_Agy99 AMWVTYALFMGSLRSVVPVTLTSERSGLVMETNAKVKLRGVQVGRVASIV
Mb3529c|M.bovis_AF2122/97 SAVLTYLSYTAAFTSTDTVTVSSPRAGLVMEKGAKVKYRGIQVGKVTDIS
MAB_4153c|M.abscessus_ATCC_199 LTVLTYLAYNDAFADTKPITVVSPRAGLVMEEGGKVKFHGLQIGKVTSIS
MSMEG_2855|M.smegmatis_MC2_155 VVALSVSLFRGSFIKSVPITVLTQRAGLVMNPDAKVKLHGAQVGRVQAIE
TH_2722|M.thermoresistible__bu LVAMAIGFFRGSFTRTVPVTVLSERAGLVMNPDAKVKLHGAQVGSVRSID
Mflv_4538|M.gilvum_PYR-GCK VIAVAVGLFRGSFTSTVPVTVLSQRAGLVMDADAKVKWHGAQVGSVESIE
Mvan_2851|M.vanbaalenii_PYR-1 VIAVAVGLFRGSFTKTVPVTVLSQRAGLVMNADAKVKLHGAQVGSVHSIE
MMAR_4710|M.marinum_M IVAVAVGLFRGDFTQSVPVTVVSPRAGLVMNPDAKVKMRGVEVGKVAAID
MAV_0948|M.avium_104 IFAVAVGLFQGSFTETVPVTVISQRAGLVMNPDAKVKMRGVQVGKVASIE
MLBr_02589|M.leprae_Br4923 IFGLVYGQFRGNFTPKSKLTMLADRAGLVMDRGSKITYNGVKIGRVADIS
: : : :*: : *:****: ..*: .* ::* * *
Rv1966|M.tuberculosis_H37Rv RIE-WAQNGASLRLEIDPDQIRYIPANVEAQISATTAFGAKFVDLVMPQN
MUL_3918|M.ulcerans_Agy99 GGG-KGATPVALTLEIDSDQIRYIPANVQAEIRATTVFGAKFVDLIYPED
Mb3529c|M.bovis_AF2122/97 Y---SGN-QARLKLAIDSGEMGFIPSNATVRIAGNTIFGAKSVEFIPPKT
MAB_4153c|M.abscessus_ATCC_199 Y---AND-QAKLELAVNAKDLRLIPSNATVRIAGTTVFGAKSVEFLAPQK
MSMEG_2855|M.smegmatis_MC2_155 S---LPDGRAALHLAMEPAYLDLIPANVGVDIAAPTVFGAKSIELVPPPN
TH_2722|M.thermoresistible__bu T---LPDGRAAIQLAMNPAYLHLIPANVRVDISSPTVFGAKAVELVPPHR
Mflv_4538|M.gilvum_PYR-GCK S---LPDGRASIQLAMDPSYMGIIPSDVRVDIASSTVFGSKYVELVPPAE
Mvan_2851|M.vanbaalenii_PYR-1 A---LPDGRAAIHLAMDPSYMDIIPSDVRVDIASSTVFGSKFVELVPPAD
MMAR_4710|M.marinum_M V---RSNGDAVLHLAMDPSQIRLIPSNVLVDIASTSVFGAKFVELVPPEQ
MAV_0948|M.avium_104 S---LPNGQAAIHLAMDPSQMHFIPSNVLVDIASSTVFGAKSIQLVEPAQ
MLBr_02589|M.leprae_Br4923 ETVRNGRPVAEFTLDVYPRYLSLIPANVNADIKATTVFGGKYVSLTTPEH
. : * : . : **::. . * . : **.* :.: *
Rv1966|M.tuberculosis_H37Rv PSRARLSAGAVLHSKNVSTEINTVFENVVDLLNMIDPLKLNAVLTAVADA
MUL_3918|M.ulcerans_Agy99 PSPQRLKAGQVLMSRNVTSEANTVFQNLVAVLDQIDPAKLNAALSALAEG
Mb3529c|M.bovis_AF2122/97 PSPKPLSPNAHVAASQVQLEVNTLFQSLIDLLHKIDPLETNATLSALSEG
MAB_4153c|M.abscessus_ATCC_199 PSDSSLRPGATVTAEAVALEVNTVFENLTRLLGKIDPVNLNATLTAVGEG
MSMEG_2855|M.smegmatis_MC2_155 PDPQPLRAGQVLSADHVTVEINTIFEKLSTVLSKIEPHKLNQTLGALSVA
TH_2722|M.thermoresistible__bu PDPEPLRPGQVLTADHVTVEINTVFEQLSSVLAKIEPQKLNQTLEALSAA
Mflv_4538|M.gilvum_PYR-GCK PSTQALRAGQVLTADHVTVEINTVFEQLSHVLGKIEPAKLNQTLGALGTA
Mvan_2851|M.vanbaalenii_PYR-1 PSAQPLQPGQVLDAEHVTVEINTVFEQLSSVLAKIEPAKLNQTLGALATA
MMAR_4710|M.marinum_M PSSESLQPHQVLEGKHVTVEVNTVFQQLTSLLSAIDPAKLNETLGAIASA
MAV_0948|M.avium_104 PSAQRLRAGQTLQGQHVMVEINTVFQELVSVLSHIDPPKLNESLGALAQA
MLBr_02589|M.leprae_Br4923 PSQKRLTPQTVIDARSVTTEINTLFQTITLIAEKVDPIKLNLTLSAAAQS
*. * . : . * * **:*: : : ::* : * * * . .
Rv1966|M.tuberculosis_H37Rv VRGQGERIGQATTDLNEVLEALNARGDTIGGNWRSLKNFTDTYDAAAQDI
MUL_3918|M.ulcerans_Agy99 LRGQGPLIGQATTDANQVLLELNPRYETVTADLRAVKDFNDTFSAAAQDI
Mb3529c|M.bovis_AF2122/97 LRGHGDDLGALLSGLNTLTRQANPKLPALQEDFRKAAVVANVYADAAGDL
MAB_4153c|M.abscessus_ATCC_199 LRGNGDNFGQGLVELDQYLDQLNPKLPALQQDFRQAGQVGQIYGDAAPDI
MSMEG_2855|M.smegmatis_MC2_155 VDGRGDQIGQMLTEFDAFLTKIDPSLPTLDHELAVAPHVLDAYADVAPEL
TH_2722|M.thermoresistible__bu LDGRGERIGQMLTDFDEFLARVEPSLPTLEHELALAPQVVEAYADVAPAL
Mflv_4538|M.gilvum_PYR-GCK LDGRGDQIGQTMVDFDAFLAQIEPSLPALERELALAPTVVGTYAEVAPQL
Mvan_2851|M.vanbaalenii_PYR-1 FDGRGDQLGQMMADVDGLLAEIEPSLPVMEHELAVAPQVIGTYADVAQEL
MMAR_4710|M.marinum_M VNGRGHKIGQMLSDLDSFLAKQDPSLPALSHDLAVLPVVSNAYADAAQDL
MAV_0948|M.avium_104 FSGRGPQLGQSLSDLDSFLARLEPSLPAFRHDLSVLPTVSNAYADAAPDL
MLBr_02589|M.leprae_Br4923 LAGLGERFGQSIVNGNSVLDDVNSQLPQARHDIQQLASLGDTYANSASDF
. * * :* : :. : . : * :
Rv1966|M.tuberculosis_H37Rv LTILNAASTTSATVVNHSTQLDALLLNAIGLSNAGTNLLGSSRDNLVGAA
MUL_3918|M.ulcerans_Agy99 LDTLNALSTTSTTITGHSTQLDALLLATIGLSNTGISLLAPNQANLIKAI
Mb3529c|M.bovis_AF2122/97 NTVFDNLPTINKTIVDQKDNLNDTLLATIGLSNNAYETLAPAEQNFIDAI
MAB_4153c|M.abscessus_ATCC_199 VRILDNLPALSRTVVDQQQDLKATLLAAIGLGNNGYETLAPAEKDLTAAL
MSMEG_2855|M.smegmatis_MC2_155 LTTVDAATTVSRTIVEERHNVDGLLLSMIGLSDIGIDVVGANRQAITDAA
TH_2722|M.thermoresistible__bu METATAATTTGRTIVDEQTNLDKLLLHVSGLADIGIDVIGTNRAAITDVA
Mflv_4538|M.gilvum_PYR-GCK VDTLDAATTISDTLVAEQGNLDSLLVSVIGLSDIGNEVVGGNRQAITDVM
Mvan_2851|M.vanbaalenii_PYR-1 VDTVEAVTTISQTVIDEQDNLDSLLVSVIGLSDNGIEVVGGNRQAITDVM
MMAR_4710|M.marinum_M VNTAENAIRISKSIVDEQQNLDAFLISSIGLADVGNDVVGGNRQALTDVL
MAV_0948|M.avium_104 VKTAANATRISKTLVDEQHNLDALLISAIGLADIGNDVLSTNRQPLTNVL
MLBr_02589|M.leprae_Br4923 FDFLNNSIVTSRTINQQQKDLDQVLLAAVGFGNTGADIFSRSGPYLARGA
. :: . ::. *: *:.: . . .. :
Rv1966|M.tuberculosis_H37Rv DILAPTTSLLFKYNPEYTCFLQGAK-------------------------
MUL_3918|M.ulcerans_Agy99 NALEPTTNLLYKYSPEYTCLLEGAK-------------------------
Mb3529c|M.bovis_AF2122/97 NRLRAPLKVTSDYSPVFGCLFKGI--------------------------
MAB_4153c|M.abscessus_ATCC_199 QRLRAPATLLGRYSPEIPCTLQAI--------------------------
MSMEG_2855|M.smegmatis_MC2_155 HLLAPTTDLTNEYHQALTCGLG----------------------------
TH_2722|M.thermoresistible__bu RLLVPTTDLLNRYHEALTCGLG----------------------------
Mflv_4538|M.gilvum_PYR-GCK ELLIPTTDLLNQYHQALNCGIG----------------------------
Mvan_2851|M.vanbaalenii_PYR-1 ELLVPTTDLLNRYHTALNCGLG----------------------------
MMAR_4710|M.marinum_M DLLVPTSDLLYEYRQALWCGIS----------------------------
MAV_0948|M.avium_104 HLLVPTTDLTNEYAPALTCSFG----------------------------
MLBr_02589|M.leprae_Br4923 ADLVPTAQLLDTYSPAIFCTLRNYHDIEPKVTSFLGGNGYSINDHVELLS
* .. : * * :
Rv1966|M.tuberculosis_H37Rv ---WYLDNGGYAAWGGADGRTLQLDVALLFG------NDPYVYPDNLPVV
MUL_3918|M.ulcerans_Agy99 ---YLLDHGGYEAPGG-NGRSLVLDAALALG------DDPYRFPDNLPII
Mb3529c|M.bovis_AF2122/97 ----ARGVKEFAPLIGVRKAGLFTSSSFVLG------APSYTYPESLPIV
MAB_4153c|M.abscessus_ATCC_199 ----SKALVTFTPLIGGVRPGLFLTNSFPLG------APVYTYPDSLPIV
MSMEG_2855|M.smegmatis_MC2_155 ------GAVQLAKAPGSPVPGGLLLQTVVLG------QERYRYPDNLPKV
TH_2722|M.thermoresistible__bu ------GAAQLAKAPGSPVPGGLLLQTIVLG------QERYRYPANLPKV
Mflv_4538|M.gilvum_PYR-GCK ------GAVQLAKAPGTPVPGGLLLQTVVLG------QERYRYPQNLPKV
Mvan_2851|M.vanbaalenii_PYR-1 ------GAVQLAKAPGTPVPGGLLLQTIVLG------QERYRYPQNLPKV
MMAR_4710|M.marinum_M ------GSLVNLHAPPLPEPMIKVLVYLGFG------AERYRYPSNLPKV
MAV_0948|M.avium_104 ------GLITIAHGPPLSEPSINISASLTWG------GERYRYPTNLPKV
MLBr_02589|M.leprae_Br4923 GLGFLLNPTSAISIIGAGVLSQGLLAPLGLAGVVNGAANPYIYPENLPRV
. . * :* .** :
Rv1966|M.tuberculosis_H37Rv AAKGGPGGRPGCGPLPDATHNFPVRQLVTNTGWGTGLDIRPNPGIGHPCW
MUL_3918|M.ulcerans_Agy99 GAKGGPGGKPGCGSLPIVDNNWPVRNLVTNTGFGTGMDWRPNPGIGFPGW
Mb3529c|M.bovis_AF2122/97 NASGGPN----CRGLPDIPTKQTGGSFYRAPFLVTDNALIP---------
MAB_4153c|M.abscessus_ATCC_199 NASGGPN----CRGLPNIPTKMQNGSWFRSPFLVTDNAYIP---------
MSMEG_2855|M.smegmatis_MC2_155 AAKGGPQ----CTDLPKVPFQKH------PPFVITDVNANP---------
TH_2722|M.thermoresistible__bu AAKGGPQ----CTDLPKVPFQKS------PPFVITDINANP---------
Mflv_4538|M.gilvum_PYR-GCK AAKGGPQ----CTDLPRVPFEKH------PPFVITDVNANP---------
Mvan_2851|M.vanbaalenii_PYR-1 AAKGGPQ----CTDLPKVGFEKH------PPFVITDVNANP---------
MMAR_4710|M.marinum_M AATGGPQ----CYDLPLVPFDKA------PPFVVADVGANP---------
MAV_0948|M.avium_104 AATGGPK----CMGLPTLPFNTN------PPQFITDIGANP---------
MLBr_02589|M.leprae_Br4923 NARGGPGGAPGCWQHITRDLWPTP-----ELVMDTGNSIAP---------
* *** * :. *
Rv1966|M.tuberculosis_H37Rv ANYFPVTRAVPEPPSIRQCIPGPAIGPNPAAGEQP---------------
MUL_3918|M.ulcerans_Agy99 ANYFPVTRGTPEPPSIRNLFGGPAPGPIPYPGAPPYGAELYAPDGTPLWP
Mb3529c|M.bovis_AF2122/97 -YQPFTELQVDAPSTLQFLFNGAFAERDDF--------------------
MAB_4153c|M.abscessus_ATCC_199 -YKPLEELQVNAPDTLQYLYNGAFAKRSEF--------------------
MSMEG_2855|M.smegmatis_MC2_155 -AQYGNEGILLNSDGLKQMLYGPIAGPPRNSAQIGQPG------------
TH_2722|M.thermoresistible__bu -AQYGNQGILLNSDGLKQMLYGPIDGPPRNTAQIGQPG------------
Mflv_4538|M.gilvum_PYR-GCK -AQYGNQGIILNSDGLKQMLFGPIDGPPRNGGQIGHPG------------
Mvan_2851|M.vanbaalenii_PYR-1 -AQYGNQGIVLNSDGLKQLLFGPIDGPPRNTPQIGQPG------------
MMAR_4710|M.marinum_M -MQYGNPQLLLNSDALKQLLYGPIDGPPRNTMQIGQPG------------
MAV_0948|M.avium_104 -VGYGNPQLLINSDLLKQLLYGPIAGPPRNSAQVGMPG------------
MLBr_02589|M.leprae_Br4923 ----YNHLDSGSPYAIEYVWGRQVGDNTINP-------------------
. :.
Rv1966|M.tuberculosis_H37Rv -------------------------------------------------
MUL_3918|M.ulcerans_Agy99 GLPPAPPPGAPRESGPTPGSEPFVVPASAQAQPTPLPPAPLPQEVAPSP
Mb3529c|M.bovis_AF2122/97 -------------------------------------------------
MAB_4153c|M.abscessus_ATCC_199 -------------------------------------------------
MSMEG_2855|M.smegmatis_MC2_155 -------------------------------------------------
TH_2722|M.thermoresistible__bu -------------------------------------------------
Mflv_4538|M.gilvum_PYR-GCK -------------------------------------------------
Mvan_2851|M.vanbaalenii_PYR-1 -------------------------------------------------
MMAR_4710|M.marinum_M -------------------------------------------------
MAV_0948|M.avium_104 -------------------------------------------------
MLBr_02589|M.leprae_Br4923 -------------------------------------------------