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VIRPVIGLISLAAVASLTAVSVTLFRDSFAESVPLTVISPRAGLVMNPDAKVQLHGVQVGKVVSIDYRDD GTAALHLAIDPARQNIIPADVTVDIASTTVFGAKSVRLVPPADPSPSPVHAGQILGADRVMIEANTLFEQ LVAVLDTITPEKLNQTLGAIATAMRGRGTMIGQGLADLNSALAQIDPSLPALEHDLSTAPAVLRSYADAA PDLMSIVAAATEIGSSIVETENELDALLVSAVGLGEVGSEVLADNGPPLTEVLRLLAPTTELLRDYHPAL SCGLGSLTVMANNPPLDVPGVEVLAGFFWGQDRYRYPADLPRVAATGGPQCTDLPKIPYGKAPPFVVTDT GANPWKYGNRGPIVNSDLLKQIMFGPIDGPPRNSAQIGQPG
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_4160 | - | - | 100% (391) | virulence factor Mce family protein |
| M. gilvum PYR-GCK | Mflv_4538 | - | e-125 | 56.56% (389) | virulence factor Mce family protein |
| M. gilvum PYR-GCK | Mflv_2508 | - | e-111 | 52.15% (395) | virulence factor Mce family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3529c | mce4A | 7e-56 | 36.46% (362) | MCE-family protein MCE4A |
| M. tuberculosis H37Rv | Rv3499c | mce4A | 7e-56 | 36.46% (362) | MCE-family protein MCE4A |
| M. leprae Br4923 | MLBr_02589 | mce1A | 3e-41 | 30.62% (369) | putative cell invasion protein |
| M. abscessus ATCC 19977 | MAB_4153c | - | 4e-66 | 40.00% (360) | MCE-family protein |
| M. marinum M | MMAR_4710 | - | 1e-124 | 55.78% (389) | MCE-family protein |
| M. avium 104 | MAV_0948 | - | 1e-127 | 55.41% (388) | virulence factor Mce family protein, putative |
| M. smegmatis MC2 155 | MSMEG_2855 | - | 1e-127 | 56.01% (391) | virulence factor Mce family protein |
| M. thermoresistible (build 8) | TH_2722 | - | 1e-124 | 55.78% (389) | PUTATIVE virulence factor Mce family protein |
| M. ulcerans Agy99 | MUL_4062 | mce4A | 3e-59 | 37.02% (362) | MCE-family protein Mce4A |
| M. vanbaalenii PYR-1 | Mvan_2851 | - | 1e-129 | 57.54% (391) | virulence factor Mce family protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3529c|M.bovis_AF2122/97 --------------------------MSGGGSRRTSVRVAAALLAGLMVG
Rv3499c|M.tuberculosis_H37Rv --------------------------MSGGGSRRTSVRVAAALLAGLMVG
MUL_4062|M.ulcerans_Agy99 --------------------------MAGGGSRRTSARVAAALLASLLVA
MAB_4153c|M.abscessus_ATCC_199 --------------------------MSDTSTRR-AVRLAGTVLASVLVL
MSMEG_2855|M.smegmatis_MC2_155 ------------------------------MRTDVRRPLLGVATAVVILA
TH_2722|M.thermoresistible__bu ----------MDNTGMDNTGMDNAGMGSAGMSTEWKRRLAGFATASVIVL
Mvan_2851|M.vanbaalenii_PYR-1 ----------------------------MAIDSSVRRPLIGLATVLAVAA
MMAR_4710|M.marinum_M MSRNLGPNPMHRSETASAAAPVAASPGRHFGVSSYARPLAGLATVLVIAL
MAV_0948|M.avium_104 MTQNVPAG-----RGAIAGRPPRPGHAHPPAGRNYLPPLLGLATILIIGL
Mflv_4160|M.gilvum_PYR-GCK ----------------------------------MIRPVIGLISLAAVAS
MLBr_02589|M.leprae_Br4923 ----------------------MTSSTKINASRKPPYKLAGVGLLVVAVV
: .
Mb3529c|M.bovis_AF2122/97 SAVLTYLSYTAAFTSTDTVTVSSPRAGLVMEKGAKVKYRGIQVGKVTDIS
Rv3499c|M.tuberculosis_H37Rv SAVLTYLSYTAAFTSTDTVTVSSPRAGLVMEKGAKVKYRGIQVGKVTDIS
MUL_4062|M.ulcerans_Agy99 GIALTYLSYTSAFTPTDTVVVSSPRAGLVMEKGAKVKYRGIQVGTVEDIY
MAB_4153c|M.abscessus_ATCC_199 LTVLTYLAYNDAFADTKPITVVSPRAGLVMEEGGKVKFHGLQIGKVTSIS
MSMEG_2855|M.smegmatis_MC2_155 VVALSVSLFRGSFIKSVPITVLTQRAGLVMNPDAKVKLHGAQVGRVQAIE
TH_2722|M.thermoresistible__bu LVAMAIGFFRGSFTRTVPVTVLSERAGLVMNPDAKVKLHGAQVGSVRSID
Mvan_2851|M.vanbaalenii_PYR-1 VIAVAVGLFRGSFTKTVPVTVLSQRAGLVMNADAKVKLHGAQVGSVHSIE
MMAR_4710|M.marinum_M IVAVAVGLFRGDFTQSVPVTVVSPRAGLVMNPDAKVKMRGVEVGKVAAID
MAV_0948|M.avium_104 IFAVAVGLFQGSFTETVPVTVISQRAGLVMNPDAKVKMRGVQVGKVASIE
Mflv_4160|M.gilvum_PYR-GCK LTAVSVTLFRDSFAESVPLTVISPRAGLVMNPDAKVQLHGVQVGKVVSID
MLBr_02589|M.leprae_Br4923 IFGLVYGQFRGNFTPKSKLTMLADRAGLVMDRGSKITYNGVKIGRVADIS
: : * . :.: : ******: ..*: .* ::* * *
Mb3529c|M.bovis_AF2122/97 YSGN----QARLKLAIDSGEMGFIPSNATVRIAGNTIFGAKSVEFIPPKT
Rv3499c|M.tuberculosis_H37Rv YSGN----QARLKLAIDSGEMGFIPSNATVRIAGNTIFGAKSVEFIPPKT
MUL_4062|M.ulcerans_Agy99 YSGD----QARLKLAIRSAEMHFIPSNATVHIAGNTIFGAKSVEFIPPKT
MAB_4153c|M.abscessus_ATCC_199 YAND----QAKLELAVNAKDLRLIPSNATVRIAGTTVFGAKSVEFLAPQK
MSMEG_2855|M.smegmatis_MC2_155 SLPDG---RAALHLAMEPAYLDLIPANVGVDIAAPTVFGAKSIELVPPPN
TH_2722|M.thermoresistible__bu TLPDG---RAAIQLAMNPAYLHLIPANVRVDISSPTVFGAKAVELVPPHR
Mvan_2851|M.vanbaalenii_PYR-1 ALPDG---RAAIHLAMDPSYMDIIPSDVRVDIASSTVFGSKFVELVPPAD
MMAR_4710|M.marinum_M VRSNG---DAVLHLAMDPSQIRLIPSNVLVDIASTSVFGAKFVELVPPEQ
MAV_0948|M.avium_104 SLPNG---QAAIHLAMDPSQMHFIPSNVLVDIASSTVFGAKSIQLVEPAQ
Mflv_4160|M.gilvum_PYR-GCK YRDDG---TAALHLAIDPARQNIIPADVTVDIASTTVFGAKSVRLVPPAD
MLBr_02589|M.leprae_Br4923 ETVRNGRPVAEFTLDVYPRYLSLIPANVNADIKATTVFGGKYVSLTTPEH
* : * : . :**::. . * . ::**.* : : *
Mb3529c|M.bovis_AF2122/97 PSPKPLSPNAHVAASQVQLEVNTLFQSLIDLLHKIDPLETNATLSALSEG
Rv3499c|M.tuberculosis_H37Rv PSPKPLSPNAHVAASQVQLEVNTLFQSLIDLLHKIDPLETNATLSALSEG
MUL_4062|M.ulcerans_Agy99 PSPTSLHPNAKVTASEVQLEVNTLFQSLIDLLHKIDPVELNGTLSALSEG
MAB_4153c|M.abscessus_ATCC_199 PSDSSLRPGATVTAEAVALEVNTVFENLTRLLGKIDPVNLNATLTAVGEG
MSMEG_2855|M.smegmatis_MC2_155 PDPQPLRAGQVLSADHVTVEINTIFEKLSTVLSKIEPHKLNQTLGALSVA
TH_2722|M.thermoresistible__bu PDPEPLRPGQVLTADHVTVEINTVFEQLSSVLAKIEPQKLNQTLEALSAA
Mvan_2851|M.vanbaalenii_PYR-1 PSAQPLQPGQVLDAEHVTVEINTVFEQLSSVLAKIEPAKLNQTLGALATA
MMAR_4710|M.marinum_M PSSESLQPHQVLEGKHVTVEVNTVFQQLTSLLSAIDPAKLNETLGAIASA
MAV_0948|M.avium_104 PSAQRLRAGQTLQGQHVMVEINTVFQELVSVLSHIDPPKLNESLGALAQA
Mflv_4160|M.gilvum_PYR-GCK PSPSPVHAGQILGADRVMIEANTLFEQLVAVLDTITPEKLNQTLGAIATA
MLBr_02589|M.leprae_Br4923 PSQKRLTPQTVIDARSVTTEINTLFQTITLIAEKVDPIKLNLTLSAAAQS
*. : . : . * * **:*: : : : * : * :* * . .
Mb3529c|M.bovis_AF2122/97 LRGHGDDLGALLSGLNTLTRQANPKLPALQEDFRKAAVVANVYADAAGDL
Rv3499c|M.tuberculosis_H37Rv LRGHGDDLGALLSGLNTLTRQANPKLPALQEDFRKAAVVANVYADAAGDL
MUL_4062|M.ulcerans_Agy99 LRGHGDDLGALLSGLNTLTRQANPKLPTLQEDFRKAAIVTNTYADAAPDL
MAB_4153c|M.abscessus_ATCC_199 LRGNGDNFGQGLVELDQYLDQLNPKLPALQQDFRQAGQVGQIYGDAAPDI
MSMEG_2855|M.smegmatis_MC2_155 VDGRGDQIGQMLTEFDAFLTKIDPSLPTLDHELAVAPHVLDAYADVAPEL
TH_2722|M.thermoresistible__bu LDGRGERIGQMLTDFDEFLARVEPSLPTLEHELALAPQVVEAYADVAPAL
Mvan_2851|M.vanbaalenii_PYR-1 FDGRGDQLGQMMADVDGLLAEIEPSLPVMEHELAVAPQVIGTYADVAQEL
MMAR_4710|M.marinum_M VNGRGHKIGQMLSDLDSFLAKQDPSLPALSHDLAVLPVVSNAYADAAQDL
MAV_0948|M.avium_104 FSGRGPQLGQSLSDLDSFLARLEPSLPAFRHDLSVLPTVSNAYADAAPDL
Mflv_4160|M.gilvum_PYR-GCK MRGRGTMIGQGLADLNSALAQIDPSLPALEHDLSTAPAVLRSYADAAPDL
MLBr_02589|M.leprae_Br4923 LAGLGERFGQSIVNGNSVLDDVNSQLPQARHDIQQLASLGDTYANSASDF
. * * :* : : :..** .:: : *.: * :
Mb3529c|M.bovis_AF2122/97 NTVFDNLPTINKTIVDQKDNLNDTLLATIGLSNNAYETLAPAEQNFIDAI
Rv3499c|M.tuberculosis_H37Rv NTVFDNLPTINKTIVDQKDNLNDTLLATIGLSNNAYETLAPAEQNFIDAI
MUL_4062|M.ulcerans_Agy99 NTVFDSLPTINKTVVDKQNDLDTTLLATIGLANNGYETLAPAEQDFIAAI
MAB_4153c|M.abscessus_ATCC_199 VRILDNLPALSRTVVDQQQDLKATLLAAIGLGNNGYETLAPAEKDLTAAL
MSMEG_2855|M.smegmatis_MC2_155 LTTVDAATTVSRTIVEERHNVDGLLLSMIGLSDIGIDVVGANRQAITDAA
TH_2722|M.thermoresistible__bu METATAATTTGRTIVDEQTNLDKLLLHVSGLADIGIDVIGTNRAAITDVA
Mvan_2851|M.vanbaalenii_PYR-1 VDTVEAVTTISQTVIDEQDNLDSLLVSVIGLSDNGIEVVGGNRQAITDVM
MMAR_4710|M.marinum_M VNTAENAIRISKSIVDEQQNLDAFLISSIGLADVGNDVVGGNRQALTDVL
MAV_0948|M.avium_104 VKTAANATRISKTLVDEQHNLDALLISAIGLADIGNDVLSTNRQPLTNVL
Mflv_4160|M.gilvum_PYR-GCK MSIVAAATEIGSSIVETENELDALLVSAVGLGEVGSEVLADNGPPLTEVL
MLBr_02589|M.leprae_Br4923 FDFLNNSIVTSRTINQQQKDLDQVLLAAVGFGNTGADIFSRSGPYLARGA
. :: : . ::. *: *:.: . : .. :
Mb3529c|M.bovis_AF2122/97 NRLRAPLKVTSDYSPVFGCLFKGIARGVKEFAPLIG--------------
Rv3499c|M.tuberculosis_H37Rv NRLRAPLKVTSDYSPVFGCLFKGIARGVKEFAPLIG--------------
MUL_4062|M.ulcerans_Agy99 NRLRAPVKVAHDYSPEFGCLFKGIGRGIKEFAPLIG--------------
MAB_4153c|M.abscessus_ATCC_199 QRLRAPATLLGRYSPEIPCTLQAISKALVTFTPLIG--------------
MSMEG_2855|M.smegmatis_MC2_155 HLLAPTTDLTNEYHQALTCGLG----GAVQLAKAPG--------------
TH_2722|M.thermoresistible__bu RLLVPTTDLLNRYHEALTCGLG----GAAQLAKAPG--------------
Mvan_2851|M.vanbaalenii_PYR-1 ELLVPTTDLLNRYHTALNCGLG----GAVQLAKAPG--------------
MMAR_4710|M.marinum_M DLLVPTSDLLYEYRQALWCGIS----GSLVNLHAPP--------------
MAV_0948|M.avium_104 HLLVPTTDLTNEYAPALTCSFG----GLITIAHGPP--------------
Mflv_4160|M.gilvum_PYR-GCK RLLAPTTELLRDYHPALSCGLG----SLTVMANNPP--------------
MLBr_02589|M.leprae_Br4923 ADLVPTAQLLDTYSPAIFCTLRNYHDIEPKVTSFLGGNGYSINDHVELLS
* .. : * : * :
Mb3529c|M.bovis_AF2122/97 ------VRKAGLFTSSSFVLGA----------------PSYTYPESLPIV
Rv3499c|M.tuberculosis_H37Rv ------VRKAGLFTSSSFVLGA----------------PSYTYPESLPIV
MUL_4062|M.ulcerans_Agy99 ------VRKAGLFTSSSFVLGS----------------PSYTYPESLPIV
MAB_4153c|M.abscessus_ATCC_199 ------GVRPGLFLTNSFPLGA----------------PVYTYPDSLPIV
MSMEG_2855|M.smegmatis_MC2_155 ------SPVPGGLLLQTVVLGQ----------------ERYRYPDNLPKV
TH_2722|M.thermoresistible__bu ------SPVPGGLLLQTIVLGQ----------------ERYRYPANLPKV
Mvan_2851|M.vanbaalenii_PYR-1 ------TPVPGGLLLQTIVLGQ----------------ERYRYPQNLPKV
MMAR_4710|M.marinum_M ------LPEPMIKVLVYLGFGA----------------ERYRYPSNLPKV
MAV_0948|M.avium_104 ------LSEPSINISASLTWGG----------------ERYRYPTNLPKV
Mflv_4160|M.gilvum_PYR-GCK ------LDVPGVEVLAGFFWGQ----------------DRYRYPADLPRV
MLBr_02589|M.leprae_Br4923 GLGFLLNPTSAISIIGAGVLSQGLLAPLGLAGVVNGAANPYIYPENLPRV
. . * ** .** *
Mb3529c|M.bovis_AF2122/97 NASGGPNCRGLPDIPTKQTGGSFYRAPFLVTDNALIPYQPFTELQVDAPS
Rv3499c|M.tuberculosis_H37Rv NASGGPNCRGLPDIPTKQTGGSFYRAPFLVTDNALIPYQPFTELQVDAPS
MUL_4062|M.ulcerans_Agy99 NASGGPNCRGLPDIPTKQTGGSFYRAPFLVTDNANIPYEPFTEVQVDAPS
MAB_4153c|M.abscessus_ATCC_199 NASGGPNCRGLPNIPTKMQNGSWFRSPFLVTDNAYIPYKPLEELQVNAPD
MSMEG_2855|M.smegmatis_MC2_155 AAKGGPQCTDLPKVPFQKH------PPFVITDVNANPAQYGNEGILLNSD
TH_2722|M.thermoresistible__bu AAKGGPQCTDLPKVPFQKS------PPFVITDINANPAQYGNQGILLNSD
Mvan_2851|M.vanbaalenii_PYR-1 AAKGGPQCTDLPKVGFEKH------PPFVITDVNANPAQYGNQGIVLNSD
MMAR_4710|M.marinum_M AATGGPQCYDLPLVPFDKA------PPFVVADVGANPMQYGNPQLLLNSD
MAV_0948|M.avium_104 AATGGPKCMGLPTLPFNTN------PPQFITDIGANPVGYGNPQLLINSD
Mflv_4160|M.gilvum_PYR-GCK AATGGPQCTDLPKIPYGKA------PPFVVTDTGANPWKYGNRGPIVNSD
MLBr_02589|M.leprae_Br4923 NARGGPGGAPGCWQHITRDLWP---TPELVMDTG-NSIAPYNHLDSGSPY
* *** .* .: * . .
Mb3529c|M.bovis_AF2122/97 TLQFLFNGAFAERDDF--------
Rv3499c|M.tuberculosis_H37Rv TLQFLFNGAFAERDDF--------
MUL_4062|M.ulcerans_Agy99 TLQFVFHGTFAERDDF--------
MAB_4153c|M.abscessus_ATCC_199 TLQYLYNGAFAKRSEF--------
MSMEG_2855|M.smegmatis_MC2_155 GLKQMLYGPIAGPPRNSAQIGQPG
TH_2722|M.thermoresistible__bu GLKQMLYGPIDGPPRNTAQIGQPG
Mvan_2851|M.vanbaalenii_PYR-1 GLKQLLFGPIDGPPRNTPQIGQPG
MMAR_4710|M.marinum_M ALKQLLYGPIDGPPRNTMQIGQPG
MAV_0948|M.avium_104 LLKQLLYGPIAGPPRNSAQVGMPG
Mflv_4160|M.gilvum_PYR-GCK LLKQIMFGPIDGPPRNSAQIGQPG
MLBr_02589|M.leprae_Br4923 AIEYVWGRQVGDNTINP-------
:: : .