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DRTTASTVESTALGQVDDQDKPGRELRGWTYGLVAVVAFAVAVLTIWQVFRPLSQGSQYYLIVFLSGTLP LVYLVYRSGWRWSDPEDRPGVLDWALAFVAVLVCLYPVLAPAIGAAGGGYNAFLDRQGMLDPLDVVMGAL LLVLIIEACRRTTGWALPIVCAAFLVYGYYGGLMPQGWAIAHAGLDFDQIVDALYNSGSGFFGTPLDVAA TYIVLFTIYGAVLELSGGARFFVNLSVAAFRRSRSAAGRTAVASGFLLGTVSGSGTATAVSVGAVTWPIM RRAGYTPERAGGVLAAAGVGALLSPPTLGAAAFIVAEYLEVSYLTVLGWAMIPTGLYYLGILLAVEIDAR RFGMKAANLDAESPWKLLGRFGYHFSSLIAIVVLLAVGMSATRAVIFATALAFVLSFADRRFRLTPRRLF GALSSGVLGVLPVVAVCAAAGVITAMTTKTGLGAQFSSVLVGGVDAITDNRTVMLALTAVFAAVALALLG LAIPVTASFVIGWVIIGPALLALDVPAPAAAMFVFYYSVLSEVTPPTALAAVGASAVTGGQAIPTMWQAL RYAAPAFLVPIAFVLTGPGEYLLARGPVLGVLWASAAACVGIVALSFAAGGWVLGVGAMGPPARVLTAVA ALLLLYLHPVSIAAGFTCLLCAVAFTFITDKRRRP*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_4420 | - | - | 100% (666) | TRAP transporter, 4TM/12TM fusion protein |
| M. gilvum PYR-GCK | Mflv_3578 | - | 1e-05 | 25.44% (342) | hypothetical protein Mflv_3578 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0231c | - | 1e-05 | 26.42% (212) | transmembrane protein |
| M. tuberculosis H37Rv | Rv0226c | - | 1e-05 | 26.42% (212) | transmembrane protein |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_2273 | - | 6e-06 | 28.30% (212) | MFS family transporter |
| M. marinum M | MMAR_0475 | - | 2e-05 | 26.22% (347) | transmembrane protein |
| M. avium 104 | MAV_4712 | - | 4e-05 | 27.18% (390) | transporter, major facilitator family protein |
| M. smegmatis MC2 155 | MSMEG_0984 | - | 0.0 | 58.99% (651) | trap transporter, 4tm/12tm fusion protein |
| M. thermoresistible (build 8) | - | - | - | - | - |
| M. ulcerans Agy99 | MUL_1125 | - | 3e-05 | 27.52% (218) | transmembrane protein |
| M. vanbaalenii PYR-1 | Mvan_1934 | - | 0.0 | 86.73% (663) | TRAP transporter, 4TM/12TM fusion protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0231c|M.bovis_AF2122/97 ----------------------------------------MRWFRPGYAL
Rv0226c|M.tuberculosis_H37Rv ----------------------------------------MRWFRPGYAL
MMAR_0475|M.marinum_M ----------------------MRAKMARGEGAGWASPRCACWWRPGYAL
MUL_1125|M.ulcerans_Agy99 --------------------------MARGEGAGWASPRCACWWRPRYAL
Mflv_4420|M.gilvum_PYR-GCK MDRTTAS----------TVESTALGQVDDQDKPGRELRGWTYGLVAVVAF
Mvan_1934|M.vanbaalenii_PYR-1 MDRSSAEEPGGPPTVVATAEPPAVPQVDDQEKPARELRGWTQRFVAGVAF
MSMEG_0984|M.smegmatis_MC2_155 MGERETPQP-------APLNDAAAAAAYEDEKPARQLSGWVGHVVAAGCV
MAV_4712|M.avium_104 --------------------------------------------------
MAB_2273|M.abscessus_ATCC_1997 --------------------------------------------------
Mb0231c|M.bovis_AF2122/97 VLVLLLAAPLLRPG------YLLLRDAVSTPRSYVS--------------
Rv0226c|M.tuberculosis_H37Rv VLVLLLAAPLLRPG------YLLLRDAVSTPRSYVS--------------
MMAR_0475|M.marinum_M VLALLVVGPVLGPG------YLLLRDAVSTPRSYLS--------------
MUL_1125|M.ulcerans_Agy99 VLALLVVGPVLGPG------YLLLRDAVSTPRSYLS--------------
Mflv_4420|M.gilvum_PYR-GCK AVAVLTIWQVFRPLSQGSQYYLIVFLSGTLPLVYLVYRSG------WRWS
Mvan_1934|M.vanbaalenii_PYR-1 GVAILTIWQVFRPLSQGSQYYLIVFLAGSLPLVFLAYRSG------IRSS
MSMEG_0984|M.smegmatis_MC2_155 LLGLSAVYQVFFPLAQGNQFALILFLAAVLPLTLLSYRSGLALPARWRRD
MAV_4712|M.avium_104 --------------------------------------------------
MAB_2273|M.abscessus_ATCC_1997 --------------------------------------------------
Mb0231c|M.bovis_AF2122/97 -----------------ANALGLTSAPRATPQDFAVALAS----------
Rv0226c|M.tuberculosis_H37Rv -----------------ANALGLTSAPRATPQDFAVALAS----------
MMAR_0475|M.marinum_M -----------------DSALGLMAAPRATPQDFAIALAS----------
MUL_1125|M.ulcerans_Agy99 -----------------DSALGLMAAPRATPQDFAIALAS----------
Mflv_4420|M.gilvum_PYR-GCK -DPEDR-------PGVLDWALAFVAVLVCLYPVLAPAIGAAGGGYNAFLD
Mvan_1934|M.vanbaalenii_PYR-1 RSSQQE-------PGALDWSLALVTLLVCLYPILPVRIGAGGGGYNAFLD
MSMEG_0984|M.smegmatis_MC2_155 RSPNRETEPRRDSPSPLDWVLAVVALVACLYPVLPIEIGDGGGGFDEFLG
MAV_4712|M.avium_104 ----------------------MTDSSPPAKGTFTVEMLS----------
MAB_2273|M.abscessus_ATCC_1997 ----------------------MTATLRDETHMISAAALR----------
. :.
Mb0231c|M.bovis_AF2122/97 --------HLVDGGVVVKALLLLGLWLAGWGAARLVATALPAAGAAGQFV
Rv0226c|M.tuberculosis_H37Rv --------HLVDGGVVVKALLLLGLWLAGWGAARLVATALPAAGAAGQFV
MMAR_0475|M.marinum_M --------QVIDGGILVKALLVLGLWLAGWGAAVLVARALPAAGAGGQFV
MUL_1125|M.ulcerans_Agy99 --------QVIDGGILVKALLVLGLWLAGWGAAVLVARALPAADAGGQFV
Mflv_4420|M.gilvum_PYR-GCK RQGMLDPLDVVMGALLLVLIIEACRRTTGWALPIVCAAFLVYGYYGGLMP
Mvan_1934|M.vanbaalenii_PYR-1 RQGMLEPIDVAMGALLLVLILEACRRTTGWALPVVCAMFLAYGYYGGLMP
MSMEG_0984|M.smegmatis_MC2_155 RQGTPGMIDVLVGTIVLLLVLEACRRTTGLALPIVCVLAIGYAYYGGYLP
MAV_4712|M.avium_104 -------------------------RAKRGVTAVFVAHGLLFASWAAHIP
MAB_2273|M.abscessus_ATCC_1997 -------------------------RGRLMVLAAILLFALCLRSAVTSLS
. . : :
Mb0231c|M.bovis_AF2122/97 AITLAIWNPYVAERLLQGHWSLLVG-YGCLPWVATAMLTMRTTVGAGWFG
Rv0226c|M.tuberculosis_H37Rv AITLAIWNPYVAERLLQGHWSLLVG-YGCLPWVATAMLTMRTTVGAGWFG
MMAR_0475|M.marinum_M AITLAIWNPYVAERLLQGHWSLLLG-YGCLPWVAATMLGLRASEAS-QTG
MUL_1125|M.ulcerans_Agy99 AITLAIWNPYVAERLLQGHWSLLLG-YGCLPWVAATMLGLRAPEAS-QTG
Mflv_4420|M.gilvum_PYR-GCK QGWAIAHAGLDFDQIVDALYNSGSGFFGTPLDVAATYIVLFTIYGAVLEL
Mvan_1934|M.vanbaalenii_PYR-1 QGWAIAHAGLDFDQIIDALYNSGSGFFGTPLDVAATYIVLFTIYGAVLEL
MSMEG_0984|M.smegmatis_MC2_155 QGAAIAHAGVDWEQIVSSSFLQSTGLYGVPLDVAATYIVLFTIYGAVLEA
MAV_4712|M.avium_104 QVKAGLG--LDDAALGTALFGAPLG------------SVLATLAGHWALP
MAB_2273|M.abscessus_ATCC_1997 PLLTQISHEIGFGSAVIGVFGMLPT----------AMFAIAGLVTPALTE
. : :
Mb0231c|M.bovis_AF2122/97 LFGLAFWVALAGLTP---------------------SGLLLAATVAVVCV
Rv0226c|M.tuberculosis_H37Rv LFGLAFWVALAGLTP---------------------SGLLLAATVAVVCV
MMAR_0475|M.marinum_M FFGLAFWIALAGLTP---------------------TGLLLAATVALTCV
MUL_1125|M.ulcerans_Agy99 FFGLAFWIALAGLTP---------------------TGLLLAATVALTCV
Mflv_4420|M.gilvum_PYR-GCK SGGARFFVNLSVAAFRRSRSAAGRTAVASGFLLGTVSGSGTATAVSVGAV
Mvan_1934|M.vanbaalenii_PYR-1 SGGARFFVDLSVAAFRRSRSAAGRTTVASGFLLGTVSGSGTATAVSVGAI
MSMEG_0984|M.smegmatis_MC2_155 SGASRFFINLSFAAFRKSRAAPGRTVTLAGFLLGSVSGSGTATAVSLGTV
MAV_4712|M.avium_104 RWGSHRLIPVTVAGY-----------------------------------
MAB_2273|M.abscessus_ATCC_1997 RFGLERTTLAAVVAT-----------------------------------
. :
Mb0231c|M.bovis_AF2122/97 AMPGAGRPRWQCGVAALGSALVGALPWLTASALGSSLTSHTAANQLGVTA
Rv0226c|M.tuberculosis_H37Rv AMPGAGRPRWQCGVAALGSALVGALPWLTASALGSSLTSHTAANQLGVTA
MMAR_0475|M.marinum_M AAPGGGKPRWLCATAALTAALVGALPWLTASALGSSLTTHTAANGLGVAA
MUL_1125|M.ulcerans_Agy99 AAPGGGKPRWLCATAALAAALVGALPWLTASALGSSLTTHTAANGLGVAA
Mflv_4420|M.gilvum_PYR-GCK TWPIMRRAGYTPERAGGVLAAAGVGALLSPPTLG--AAAFIVAEYLEVSY
Mvan_1934|M.vanbaalenii_PYR-1 TWPIMRRAGYTPERAGGVLAAAGVGALLSPPTLG--AAAFIVAEYLEVSY
MSMEG_0984|M.smegmatis_MC2_155 AWPVLRKAGYPKENAGGMLAAAGIGAILSPPTLG--AAAFIIAEYLGVPY
MAV_4712|M.avium_104 -AAAGTTVGLARSGPALFAALALWGMFQGALDVAMNTQAGTVERRAGAPM
MAB_2273|M.abscessus_ATCC_1997 ------VIGMAARTAMNSTGGLLVLSCLALLGMG---IGNVVIPPLVKRY
. . :.
Mb0231c|M.bovis_AF2122/97 FAPRAEPGLGT-LGSLASLGGIWNGEAVPSSRTTLFAVASAVVLLAMVAI
Rv0226c|M.tuberculosis_H37Rv FAPRAEPGLGT-LGSLASLGGIWNGEAVPSSRTTLFAVASAVVLLAMVAI
MMAR_0475|M.marinum_M FAPRAEPGLGT-LLSLASLGGIWNGDAVPGSRTTLFAVASAAVLLVVVAV
MUL_1125|M.ulcerans_Agy99 FAPRAEPGLGT-LLSLASLGGIWNGDAVPGSRTTLFAVASAAVLLVVVAV
Mflv_4420|M.gilvum_PYR-GCK LTVLGWAMIPTGLYYLGILLAVEIDARRFGMKAANLDAESPWKLLGRFGY
Mvan_1934|M.vanbaalenii_PYR-1 LTVLGWAMIPTVLYYLGILLAVEIDARRFGMKPAHQQSESPWKLLARFGY
MSMEG_0984|M.smegmatis_MC2_155 LTVLVWAIVPTLLYYLGILLAVEIDARRYGTREVEVATTSAWRLLARFGY
MAV_4712|M.avium_104 MARFHG------MWSLGTLAGALIGAACVG---AGIGLTAQLTVLG----
MAB_2273|M.abscessus_ATCC_1997 FSHRVA------LMSAAYLTVLQIGTTVPALTAVPLADAYGWRFSLVAWV
:: : . * . . . .
Mb0231c|M.bovis_AF2122/97 GLPTVARRPVAVPLLTLAAVSVMVPAVLATGPGLHALRVVVDAAPGLGVL
Rv0226c|M.tuberculosis_H37Rv GLPTVARRPVAVPLLTLAAVSVMVPAVLATGPGLHALRVVVDAAPGLGVL
MMAR_0475|M.marinum_M GLPTVARRPALVPLLVLAAVSVLVPAALATGPGLHILAAAVDAAPGLGVL
MUL_1125|M.ulcerans_Agy99 GLPTVARRPALVPLLVLAAVSVLVPAALATGPGLHILAAAVDAAPGLGVL
Mflv_4420|M.gilvum_PYR-GCK HFSSLIAIVVLLAVGMSATRAVIFATALAFVLSFADRRFRLTPRRLFGAL
Mvan_1934|M.vanbaalenii_PYR-1 HFSSLVAIVVLLAAGMSATRAVVYATALAFVLSFLDRWGRLTPRRLFDAL
MSMEG_0984|M.smegmatis_MC2_155 HLASLVLIVVLLAMDVSAVRAVVYATVAAILLSFLDREHRLTPARLYSAL
MAV_4712|M.avium_104 AVVLLVVVMLTRRLLPDAADSVAAPPEPAAGRRVTPAVAILAAVSFASFL
MAB_2273|M.abscessus_ATCC_1997 LVPVAALLPWIGVVIARRGHDVEDHSAEPHADSAAVGQVWRSPLAWGMAG
. * . . .
Mb0231c|M.bovis_AF2122/97 RDGQKWVALAVPGYTLSGAGTVLTLRRWLRPAT------------AAVVC
Rv0226c|M.tuberculosis_H37Rv RDGQKWVALAVPGYTLSGAGTVLTLRRWLRPAT------------AAVVC
MMAR_0475|M.marinum_M RDGQKWVALAMPGYAVSAAAAVSTLSRCKTAATP------LKSTLAASAC
MUL_1125|M.ulcerans_Agy99 RDGQKWVALAMPGYAVSAAAAVSTLSRCKTAATP------LKSTLAASAC
Mflv_4420|M.gilvum_PYR-GCK SSGVLGVLPVVAVCAAAGVITAMTTKTGLGAQFSSVLVGGVDAITDNRTV
Mvan_1934|M.vanbaalenii_PYR-1 SVGVRGVLPVVAVCAAAGVITAMTTKTGLGAQFSSVLVGGVDALTDNRTL
MSMEG_0984|M.smegmatis_MC2_155 ATGVRGVLSVAAVCAAAGVVAAMITRTGLGLQLNSILVNTARSIAENPTA
MAV_4712|M.avium_104 CEGAATDWSATYLRDVVGAGPSVAAAS---------------------YA
MAB_2273|M.abscessus_ATCC_1997 MFGMTSLVTYSMFTWIPAILASAGGSAKLG---------------GVMVA
* . .
Mb0231c|M.bovis_AF2122/97 CLALVLTLPDLAWGVWGKVAPVH--YPSGWAAVAAAINADPRTVAVLPAG
Rv0226c|M.tuberculosis_H37Rv CLALVLTLPDLAWGVWGKVAPVH--YPSGWAAVAAAINADPRTVAVLPAG
MMAR_0475|M.marinum_M CLALVLALPDLAWGVLGRVAPVH--YPPGWTAVATAINHQPGTVAVLPIG
MUL_1125|M.ulcerans_Agy99 CLALVLALPDLAWGVLGRAAPVH--YPPGWTAVATAINHQPGTVAVLPIG
Mflv_4420|M.gilvum_PYR-GCK MLALTAVFAAVALALLGLAIPVTASFVIGWVIIGPALLALD---VPAPAA
Mvan_1934|M.vanbaalenii_PYR-1 MLALTAVFAAVALALLGLAIPVTASFVIGWVIIGPALLALD---VPAPAA
MSMEG_0984|M.smegmatis_MC2_155 VLILTAIFAALAVSVLGLAVPVTASFVIAWVIIGPALQDLG---VAAPAV
MAV_4712|M.avium_104 AYTLTMVVTRFAAGRLHARLPSR---------------------RLLPAL
MAB_2273|M.abscessus_ATCC_1997 LFSAVGFVGTLAIPPLAARMRNP---------------------FPLVVA
. . .*
Mb0231c|M.bovis_AF2122/97 TMRRFSWSGSAPVLDPLPRWVRADVLTTGDLVISGVTVPGEDAHARAVQE
Rv0226c|M.tuberculosis_H37Rv TMRRFSWSGSAPVLDPLPRWVRADVLTTGDLVISGVTVPGEDAHARAVQE
MMAR_0475|M.marinum_M TMRRFSWAGRAPVLDPLPRWVRPDVLSSGDLVISGVLVPGDGVRARTVQK
MUL_1125|M.ulcerans_Agy99 TMRRFSWSGRAPVLDPLPRWVRPDVLSSGDLVISGVLVPGDGVRARTVQK
Mflv_4420|M.gilvum_PYR-GCK AMFVFYYSVLSEVTPPT------ALAAVGASAVTGGQAIPTMWQALRYAA
Mvan_1934|M.vanbaalenii_PYR-1 AMFVFYYSVLSEVTPPT------ALAAVGASAVTGGRAIPTMWQALRYAA
MSMEG_0984|M.smegmatis_MC2_155 AMFVFYFAVLSEVTPPT------ALASVAASAITGGRVIATMMQAFKYAL
MAV_4712|M.avium_104 AVL--------------------AVAGMSVTLATADAAAGVLGFAALGVG
MAB_2273|M.abscessus_ATCC_1997 CLVCFLIGFAGLLWLP--------MHGTAVWVVALGFGPSTFPLGLTLVN
: : . : .
Mb0231c|M.bovis_AF2122/97 LLLTGPHPSTLAAAGVGWLVVESDSAGDMGAAARTLGRLAAAHRDDELAL
Rv0226c|M.tuberculosis_H37Rv LLLTGPHPSTLAAAGVGWLVVESDSAGDMGAAARTLGRLAAAHRDDELAL
MMAR_0475|M.marinum_M LLLAGADPAALAQAGVGWLVVEVHGGGEVGEAGRTLDRLTPTYRDDELAL
MUL_1125|M.ulcerans_Agy99 LLLAGADPEALAQAGVGWLVVEVHGGGEVGEAGRTLDRLTPTYRDDELAL
Mflv_4420|M.gilvum_PYR-GCK PAFLVPIAFVLTGPGEYLLARGPVLGVLWASAAACVGIVALSFAAGGWVL
Mvan_1934|M.vanbaalenii_PYR-1 PAFLVPIAFVLTAPGEYLLGRGPVLGVIWASVAACAGIVALSFAAGGWVL
MSMEG_0984|M.smegmatis_MC2_155 PAFLVPFAFVLTENGQGLIGLRSFTDAVWTMAVVALGVVALAVLTGGWMV
MAV_4712|M.avium_104 VALLVPTAFSAAYG------------------ARGAGSAIAIVAATGWLG
MAB_2273|M.abscessus_ATCC_1997 LRTRTPAGSAALSG-------------------FTQGVGYAVACLGPLLF
. .
Mb0231c|M.bovis_AF2122/97 YRVGGQTSGASSARLKATMLAHWAWLSMLLVGGAGAAGYWVRRHLHHCED
Rv0226c|M.tuberculosis_H37Rv YRVGGQTSGASSARLKATMLAHWAWLSMLLVGGAGAAGYWVRRHLHHCED
MMAR_0475|M.marinum_M YRIGGRSAGVPAGDRRAMMLAHWAWLSMLLAGGAGMAAGRVRRHLSGREE
MUL_1125|M.ulcerans_Agy99 YRIGGRSAGVPAGDRRAMMLAHWAWLSMLLAGGAGMAAGLVRRHLSGREE
Mflv_4420|M.gilvum_PYR-GCK GVGAMGPPARVLTAVAALLLLYLHPVSIAAGFTCLLCAVAFTFITDKRRR
Mvan_1934|M.vanbaalenii_PYR-1 GVGALAPVPRAFTAIAALLLLFLQPATIAAGSACLLGAVAFTFITDKRRR
MSMEG_0984|M.smegmatis_MC2_155 RR--AGWPERALCAPAAALLLYLQPLTIAVGAGLLVLALALNLGLARFRG
MAV_4712|M.avium_104 YLLGPPLIGHLSEWVGLSGALVTIPVMMTIVAVAIRYTPAFDTADEFHRA
MAB_2273|M.abscessus_ATCC_1997 GVLHDVSGGWYAPFGLLLVAITVLGVGAFQACKPRTLEDTWNRGSGAVVS
Mb0231c|M.bovis_AF2122/97 TPASRAQD----
Rv0226c|M.tuberculosis_H37Rv TPASRAQD----
MMAR_0475|M.marinum_M SPTDLAAD----
MUL_1125|M.ulcerans_Agy99 SPTDLAAD----
Mflv_4420|M.gilvum_PYR-GCK P-----------
Mvan_1934|M.vanbaalenii_PYR-1 T-----------
MSMEG_0984|M.smegmatis_MC2_155 DEAQSLSATPGT
MAV_4712|M.avium_104 PAG---------
MAB_2273|M.abscessus_ATCC_1997 S-----------