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MDRSSAEEPGGPPTVVATAEPPAVPQVDDQEKPARELRGWTQRFVAGVAFGVAILTIWQVFRPLSQGSQY YLIVFLAGSLPLVFLAYRSGIRSSRSSQQEPGALDWSLALVTLLVCLYPILPVRIGAGGGGYNAFLDRQG MLEPIDVAMGALLLVLILEACRRTTGWALPVVCAMFLAYGYYGGLMPQGWAIAHAGLDFDQIIDALYNSG SGFFGTPLDVAATYIVLFTIYGAVLELSGGARFFVDLSVAAFRRSRSAAGRTTVASGFLLGTVSGSGTAT AVSVGAITWPIMRRAGYTPERAGGVLAAAGVGALLSPPTLGAAAFIVAEYLEVSYLTVLGWAMIPTVLYY LGILLAVEIDARRFGMKPAHQQSESPWKLLARFGYHFSSLVAIVVLLAAGMSATRAVVYATALAFVLSFL DRWGRLTPRRLFDALSVGVRGVLPVVAVCAAAGVITAMTTKTGLGAQFSSVLVGGVDALTDNRTLMLALT AVFAAVALALLGLAIPVTASFVIGWVIIGPALLALDVPAPAAAMFVFYYSVLSEVTPPTALAAVGASAVT GGRAIPTMWQALRYAAPAFLVPIAFVLTAPGEYLLGRGPVLGVIWASVAACAGIVALSFAAGGWVLGVGA LAPVPRAFTAIAALLLLFLQPATIAAGSACLLGAVAFTFITDKRRRT
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_1934 | - | - | 100% (677) | TRAP transporter, 4TM/12TM fusion protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0231c | - | 4e-05 | 24.13% (373) | transmembrane protein |
| M. gilvum PYR-GCK | Mflv_4420 | - | 0.0 | 86.73% (663) | TRAP transporter, 4TM/12TM fusion protein |
| M. tuberculosis H37Rv | Rv0226c | - | 5e-05 | 24.13% (373) | transmembrane protein |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_1935 | - | 7e-08 | 26.11% (406) | putative drug resistance transporter |
| M. marinum M | MMAR_0475 | - | 3e-06 | 27.03% (370) | transmembrane protein |
| M. avium 104 | MAV_4712 | - | 2e-05 | 26.32% (380) | transporter, major facilitator family protein |
| M. smegmatis MC2 155 | MSMEG_0984 | - | 0.0 | 60.06% (651) | trap transporter, 4tm/12tm fusion protein |
| M. thermoresistible (build 8) | - | - | - | - | - |
| M. ulcerans Agy99 | MUL_1125 | - | 2e-06 | 28.06% (278) | transmembrane protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_1934|M.vanbaalenii_PYR-1 -MDRSSAEEPGGPPTVVATAEPPAVPQVDDQEKPARELRGWTQRFVAGVA
Mflv_4420|M.gilvum_PYR-GCK -MDRTTAS----------TVESTALGQVDDQDKPGRELRGWTYGLVAVVA
MSMEG_0984|M.smegmatis_MC2_155 MGERETPQP--------APLNDAAAAAAYEDEKPARQLSGWVGHVVAAGC
Mb0231c|M.bovis_AF2122/97 -----------------------------------------MRWFRPGYA
Rv0226c|M.tuberculosis_H37Rv -----------------------------------------MRWFRPGYA
MMAR_0475|M.marinum_M -----------------------MRAKMARGEGAGWASPRCACWWRPGYA
MUL_1125|M.ulcerans_Agy99 ---------------------------MARGEGAGWASPRCACWWRPRYA
MAV_4712|M.avium_104 --------------------------------------------------
MAB_1935|M.abscessus_ATCC_1997 --------------------------------------------------
Mvan_1934|M.vanbaalenii_PYR-1 FGVAILTIWQVFRPLSQGSQYYLIVFLAGSLPLVFLAYRSG------IRS
Mflv_4420|M.gilvum_PYR-GCK FAVAVLTIWQVFRPLSQGSQYYLIVFLSGTLPLVYLVYRSG------WRW
MSMEG_0984|M.smegmatis_MC2_155 VLLGLSAVYQVFFPLAQGNQFALILFLAAVLPLTLLSYRSGLALPARWRR
Mb0231c|M.bovis_AF2122/97 LVLVLLLAAPLLRPG------YLLLRDAVSTPRSYVS-------------
Rv0226c|M.tuberculosis_H37Rv LVLVLLLAAPLLRPG------YLLLRDAVSTPRSYVS-------------
MMAR_0475|M.marinum_M LVLALLVVGPVLGPG------YLLLRDAVSTPRSYLS-------------
MUL_1125|M.ulcerans_Agy99 LVLALLVVGPVLGPG------YLLLRDAVSTPRSYLS-------------
MAV_4712|M.avium_104 --------------------------------------------------
MAB_1935|M.abscessus_ATCC_1997 --------------------------------------------------
Mvan_1934|M.vanbaalenii_PYR-1 SRSSQQE-------PGALDWSLALVTLLVCLYPILPVRIGAGGGGYNAFL
Mflv_4420|M.gilvum_PYR-GCK S-DPEDR-------PGVLDWALAFVAVLVCLYPVLAPAIGAAGGGYNAFL
MSMEG_0984|M.smegmatis_MC2_155 DRSPNRETEPRRDSPSPLDWVLAVVALVACLYPVLPIEIGDGGGGFDEFL
Mb0231c|M.bovis_AF2122/97 ------------------ANALGLTSAPRATPQDFAVALAS---------
Rv0226c|M.tuberculosis_H37Rv ------------------ANALGLTSAPRATPQDFAVALAS---------
MMAR_0475|M.marinum_M ------------------DSALGLMAAPRATPQDFAIALAS---------
MUL_1125|M.ulcerans_Agy99 ------------------DSALGLMAAPRATPQDFAIALAS---------
MAV_4712|M.avium_104 -----------------------MTDSSPPAKGTFTVEMLS---------
MAB_1935|M.abscessus_ATCC_1997 --------------------MILLAVCLAVFMLLLDMTIVS---------
. : :
Mvan_1934|M.vanbaalenii_PYR-1 DRQGMLEPIDVAMGALLLVLILEACRRTTGWALPVVCAMFLAYGYYGGLM
Mflv_4420|M.gilvum_PYR-GCK DRQGMLDPLDVVMGALLLVLIIEACRRTTGWALPIVCAAFLVYGYYGGLM
MSMEG_0984|M.smegmatis_MC2_155 GRQGTPGMIDVLVGTIVLLLVLEACRRTTGLALPIVCVLAIGYAYYGGYL
Mb0231c|M.bovis_AF2122/97 ---------HLVDGGVVVKALLLLGLWLAGWGAARLVATALPAAGAAGQF
Rv0226c|M.tuberculosis_H37Rv ---------HLVDGGVVVKALLLLGLWLAGWGAARLVATALPAAGAAGQF
MMAR_0475|M.marinum_M ---------QVIDGGILVKALLVLGLWLAGWGAAVLVARALPAAGAGGQF
MUL_1125|M.ulcerans_Agy99 ---------QVIDGGILVKALLVLGLWLAGWGAAVLVARALPAADAGGQF
MAV_4712|M.avium_104 --------------------------RAKRGVTAVFVAHGLLFASWAAHI
MAB_1935|M.abscessus_ATCC_1997 ---------------------------------SALADLQASLGADLSDL
. . . . :
Mvan_1934|M.vanbaalenii_PYR-1 PQGWAIAHAGLDFDQIIDALYNSGSGFFGTPLDVAATYIVLFTIYGAVLE
Mflv_4420|M.gilvum_PYR-GCK PQGWAIAHAGLDFDQIVDALYNSGSGFFGTPLDVAATYIVLFTIYGAVLE
MSMEG_0984|M.smegmatis_MC2_155 PQGAAIAHAGVDWEQIVSSSFLQSTGLYGVPLDVAATYIVLFTIYGAVLE
Mb0231c|M.bovis_AF2122/97 VAITLAIWNPYVAERLLQGHWSLLVG-YGCLPWVATAMLTMRTTVGAGWF
Rv0226c|M.tuberculosis_H37Rv VAITLAIWNPYVAERLLQGHWSLLVG-YGCLPWVATAMLTMRTTVGAGWF
MMAR_0475|M.marinum_M VAITLAIWNPYVAERLLQGHWSLLLG-YGCLPWVAATMLGLRASEAS-QT
MUL_1125|M.ulcerans_Agy99 VAITLAIWNPYVAERLLQGHWSLLLG-YGCLPWVAATMLGLRAPEAS-QT
MAV_4712|M.avium_104 PQVKAGLG--LDDAALGTALFGAPLG------------SVLATLAGHWAL
MAB_1935|M.abscessus_ATCC_1997 QWVIDAYALPMAGLLLTAATLGDRLG----RRRLYLLGMALFTTASLVCA
: . * : : .
Mvan_1934|M.vanbaalenii_PYR-1 LSGGARFFVDLSVAAFRRSRSAAGRTTVASGFLLGTVSGSGTATAVSVGA
Mflv_4420|M.gilvum_PYR-GCK LSGGARFFVNLSVAAFRRSRSAAGRTAVASGFLLGTVSGSGTATAVSVGA
MSMEG_0984|M.smegmatis_MC2_155 ASGASRFFINLSFAAFRKSRAAPGRTVTLAGFLLGSVSGSGTATAVSLGT
Mb0231c|M.bovis_AF2122/97 GLFGLAFWVALAGLTP---------------------SGLLLAATVAVVC
Rv0226c|M.tuberculosis_H37Rv GLFGLAFWVALAGLTP---------------------SGLLLAATVAVVC
MMAR_0475|M.marinum_M GFFGLAFWIALAGLTP---------------------TGLLLAATVALTC
MUL_1125|M.ulcerans_Agy99 GFFGLAFWIALAGLTP---------------------TGLLLAATVALTC
MAV_4712|M.avium_104 PRWGSHRLIPVTVAGY----------------------------------
MAB_1935|M.abscessus_ATCC_1997 LSGSAAMLIGVRAVQG----------------------------------
. : :
Mvan_1934|M.vanbaalenii_PYR-1 ITWPIMRRAGYTPERAGGVLAAAGVGALLSPPTLG--AAAFIVAEYLEVS
Mflv_4420|M.gilvum_PYR-GCK VTWPIMRRAGYTPERAGGVLAAAGVGALLSPPTLG--AAAFIVAEYLEVS
MSMEG_0984|M.smegmatis_MC2_155 VAWPVLRKAGYPKENAGGMLAAAGIGAILSPPTLG--AAAFIIAEYLGVP
Mb0231c|M.bovis_AF2122/97 VAMPGAGRPRWQCGVAALGSALVGALPWLTASALGSSLTSHTAANQLGVT
Rv0226c|M.tuberculosis_H37Rv VAMPGAGRPRWQCGVAALGSALVGALPWLTASALGSSLTSHTAANQLGVT
MMAR_0475|M.marinum_M VAAPGGGKPRWLCATAALTAALVGALPWLTASALGSSLTTHTAANGLGVA
MUL_1125|M.ulcerans_Agy99 VAAPGGGKPRWLCATAALAAALVGALPWLTASALGSSLTTHTAANGLGVA
MAV_4712|M.avium_104 --AAAGTTVGLARSGPALFAALALWGMFQGALDVAMNTQAGTVERRAGAP
MAB_1935|M.abscessus_ATCC_1997 TGGAILLAVSLPIIAAAYPQERRGGPIAIYGAVMGAGSAAGPLLGGFLVT
. .. :. : ..
Mvan_1934|M.vanbaalenii_PYR-1 YLTVLGWAMIPTVLYYLGILLAVEIDARRFGMKPAHQQSESPWKLLARFG
Mflv_4420|M.gilvum_PYR-GCK YLTVLGWAMIPTGLYYLGILLAVEIDARRFGMKAANLDAESPWKLLGRFG
MSMEG_0984|M.smegmatis_MC2_155 YLTVLVWAIVPTLLYYLGILLAVEIDARRYGTREVEVATTSAWRLLARFG
Mb0231c|M.bovis_AF2122/97 AFAPRAEPGLGT-LGSLASLGGIWNGEAVPSSRTTLFAVASAVVLLAMVA
Rv0226c|M.tuberculosis_H37Rv AFAPRAEPGLGT-LGSLASLGGIWNGEAVPSSRTTLFAVASAVVLLAMVA
MMAR_0475|M.marinum_M AFAPRAEPGLGT-LLSLASLGGIWNGDAVPGSRTTLFAVASAAVLLVVVA
MUL_1125|M.ulcerans_Agy99 AFAPRAEPGLGT-LLSLASLGGIWNGDAVPGSRTTLFAVASAAVLLVVVA
MAV_4712|M.avium_104 MMARFHG------MWSLGTLAGALIGAACVG---AGIGLTAQLTVLG---
MAB_1935|M.abscessus_ATCC_1997 HFGWQSIFLVNLPVGVIALIIAARHLPETRAEQTRPVDWVGTMLLTCGLL
: : :. : . . . :
Mvan_1934|M.vanbaalenii_PYR-1 YHFSSLVAIVVLLAAGMSATRAVVYATALAFVLSFLDRWGRLTPRRLFDA
Mflv_4420|M.gilvum_PYR-GCK YHFSSLIAIVVLLAVGMSATRAVIFATALAFVLSFADRRFRLTPRRLFGA
MSMEG_0984|M.smegmatis_MC2_155 YHLASLVLIVVLLAMDVSAVRAVVYATVAAILLSFLDREHRLTPARLYSA
Mb0231c|M.bovis_AF2122/97 IGLPTVARRPVAVPLLTLAAVSVMVPAVLATGPGLHALRVVVDAAPGLGV
Rv0226c|M.tuberculosis_H37Rv IGLPTVARRPVAVPLLTLAAVSVMVPAVLATGPGLHALRVVVDAAPGLGV
MMAR_0475|M.marinum_M VGLPTVARRPALVPLLVLAAVSVLVPAALATGPGLHILAAAVDAAPGLGV
MUL_1125|M.ulcerans_Agy99 VGLPTVARRPALVPLLVLAAVSVLVPAALATGPGLHILAAAVDAAPGLGV
MAV_4712|M.avium_104 -AVVLLVVVMLTRRLLPDAADSVAAPPEPAAGRRVTPAVAILAAVSFASF
MAB_1935|M.abscessus_ATCC_1997 TGVFAVISLHGGGIGARACAALALCAVVALALFLWWEGRTPAPMLSLRLV
. : .. . .
Mvan_1934|M.vanbaalenii_PYR-1 LSVGVRGVLPVVAVCAAAGVITAMTTKTGLGAQFSSVLVGGVDALTDNRT
Mflv_4420|M.gilvum_PYR-GCK LSSGVLGVLPVVAVCAAAGVITAMTTKTGLGAQFSSVLVGGVDAITDNRT
MSMEG_0984|M.smegmatis_MC2_155 LATGVRGVLSVAAVCAAAGVVAAMITRTGLGLQLNSILVNTARSIAENPT
Mb0231c|M.bovis_AF2122/97 LRDGQKWVALAVPGYTLSGAGTVLTLRRWLRPAT------------AAVV
Rv0226c|M.tuberculosis_H37Rv LRDGQKWVALAVPGYTLSGAGTVLTLRRWLRPAT------------AAVV
MMAR_0475|M.marinum_M LRDGQKWVALAMPGYAVSAAAAVSTLSRCKTAATP------LKSTLAASA
MUL_1125|M.ulcerans_Agy99 LRDGQKWVALAMPGYAVSAAAAVSTLSRCKTAATP------LKSTLAASA
MAV_4712|M.avium_104 LCEGAATDWSATYLRDVVGAGPSVAAAS---------------------Y
MAB_1935|M.abscessus_ATCC_1997 TSPGFAGVWVAAAAASGTLIGATNYLALYFMNTLG---------YNAFET
* . .
Mvan_1934|M.vanbaalenii_PYR-1 LMLALTAVFAAVALALLGLAIPVTASFVIGWVIIGPALLALD---VPAPA
Mflv_4420|M.gilvum_PYR-GCK VMLALTAVFAAVALALLGLAIPVTASFVIGWVIIGPALLALD---VPAPA
MSMEG_0984|M.smegmatis_MC2_155 AVLILTAIFAALAVSVLGLAVPVTASFVIAWVIIGPALQDLG---VAAPA
Mb0231c|M.bovis_AF2122/97 CCLALVLTLPDLAWGVWGKVAPVH--YPSGWAAVAAAINADPRTVAVLPA
Rv0226c|M.tuberculosis_H37Rv CCLALVLTLPDLAWGVWGKVAPVH--YPSGWAAVAAAINADPRTVAVLPA
MMAR_0475|M.marinum_M CCLALVLALPDLAWGVLGRVAPVH--YPPGWTAVATAINHQPGTVAVLPI
MUL_1125|M.ulcerans_Agy99 CCLALVLALPDLAWGVLGRAAPVH--YPPGWTAVATAINHQPGTVAVLPI
MAV_4712|M.avium_104 AAYTLTMVVTRFAAGRLHARLPSR-----------RLLPALAVL------
MAB_1935|M.abscessus_ATCC_1997 GLRAGPLTLATIAGAPLGILVGKR----------LPSVVTIPGG------
.. .* . :
Mvan_1934|M.vanbaalenii_PYR-1 AAMFVFYYSVLSEVTPPT------ALAAVGASAVTGGRAIPTMWQALRYA
Mflv_4420|M.gilvum_PYR-GCK AAMFVFYYSVLSEVTPPT------ALAAVGASAVTGGQAIPTMWQALRYA
MSMEG_0984|M.smegmatis_MC2_155 VAMFVFYFAVLSEVTPPT------ALASVAASAITGGRVIATMMQAFKYA
Mb0231c|M.bovis_AF2122/97 GTMRRFSWSGSAPVLDPLPRWVRADVLTTGDLVISGVTVPGEDAHARAVQ
Rv0226c|M.tuberculosis_H37Rv GTMRRFSWSGSAPVLDPLPRWVRADVLTTGDLVISGVTVPGEDAHARAVQ
MMAR_0475|M.marinum_M GTMRRFSWAGRAPVLDPLPRWVRPDVLSSGDLVISGVLVPGDGVRARTVQ
MUL_1125|M.ulcerans_Agy99 GTMRRFSWSGRAPVLDPLPRWVRPDVLSSGDLVISGVLVPGDGVRARTVQ
MAV_4712|M.avium_104 ------------------------AVAGMSVTLATADAAAGVLGFAALGV
MAB_1935|M.abscessus_ATCC_1997 -----------------------VALVAVGLWAATGAHAGTVWTHFIFGS
: . :. .
Mvan_1934|M.vanbaalenii_PYR-1 APAFLVPIAFVLTAPGEYLLGRGPVLGVIWA---SVAACAGIVALSFAAG
Mflv_4420|M.gilvum_PYR-GCK APAFLVPIAFVLTGPGEYLLARGPVLGVLWA---SAAACVGIVALSFAAG
MSMEG_0984|M.smegmatis_MC2_155 LPAFLVPFAFVLTENGQGLIGLRSFTDAVWT---MAVVALGVVALAVLTG
Mb0231c|M.bovis_AF2122/97 ELLLTGPHPSTLAAAGVGWLVVESDSAGDMG---AAARTLGRLAAAHRDD
Rv0226c|M.tuberculosis_H37Rv ELLLTGPHPSTLAAAGVGWLVVESDSAGDMG---AAARTLGRLAAAHRDD
MMAR_0475|M.marinum_M KLLLAGADPAALAQAGVGWLVVEVHGGGEVG---EAGRTLDRLTPTYRDD
MUL_1125|M.ulcerans_Agy99 KLLLAGADPEALAQAGVGWLVVEVHGGGEVG---EAGRTLDRLTPTYRDD
MAV_4712|M.avium_104 GVALLVPTAFSAAYG---------------------ARGAGSAIAIVAAT
MAB_1935|M.abscessus_ATCC_1997 ALAGLGLGALSAVTSDAALQFVPLDDAGMATGSVSTGRQIGILLGVAGMG
. . .
Mvan_1934|M.vanbaalenii_PYR-1 GWVLGVGALAPVPRAFTAIAALLLLFLQPATIAAGSACLLGAVAFTFITD
Mflv_4420|M.gilvum_PYR-GCK GWVLGVGAMGPPARVLTAVAALLLLYLHPVSIAAGFTCLLCAVAFTFITD
MSMEG_0984|M.smegmatis_MC2_155 GWMVRR--AGWPERALCAPAAALLLYLQPLTIAVGAGLLVLALALNLGLA
Mb0231c|M.bovis_AF2122/97 ELALYRVGGQTSGASSARLKATMLAHWAWLSMLLVGGAGAAGYWVRRHLH
Rv0226c|M.tuberculosis_H37Rv ELALYRVGGQTSGASSARLKATMLAHWAWLSMLLVGGAGAAGYWVRRHLH
MMAR_0475|M.marinum_M ELALYRIGGRSAGVPAGDRRAMMLAHWAWLSMLLAGGAGMAAGRVRRHLS
MUL_1125|M.ulcerans_Agy99 ELALYRIGGRSAGVPAGDRRAMMLAHWAWLSMLLAGGAGMAAGLVRRHLS
MAV_4712|M.avium_104 GWLGYLLGPPLIGHLSEWVGLSGALVTIPVMMTIVAVAIRYTPAFDTADE
MAB_1935|M.abscessus_ATCC_1997 VAFGLAAAGQSGPRAAGAAAINSVLAWGALAAACAAFVSLILLSVATISR
.
Mvan_1934|M.vanbaalenii_PYR-1 KRRRT-----------
Mflv_4420|M.gilvum_PYR-GCK KRRRP-----------
MSMEG_0984|M.smegmatis_MC2_155 RFRGDEAQSLSATPGT
Mb0231c|M.bovis_AF2122/97 HCEDTPASRAQD----
Rv0226c|M.tuberculosis_H37Rv HCEDTPASRAQD----
MMAR_0475|M.marinum_M GREESPTDLAAD----
MUL_1125|M.ulcerans_Agy99 GREESPTDLAAD----
MAV_4712|M.avium_104 FHRAPAG---------
MAB_1935|M.abscessus_ATCC_1997 SHDPATGESLAI----