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RWFRPGYALVLVLLLAAPLLRPGYLLLRDAVSTPRSYVSANALGLTSAPRATPQDFAVALASHLVDGGVV VKALLLLGLWLAGWGAARLVATALPAAGAAGQFVAITLAIWNPYVAERLLQGHWSLLVGYGCLPWVATAM LTMRTTVGAGWFGLFGLAFWVALAGLTPSGLLLAATVAVVCVAMPGAGRPRWQCGVAALGSALVGALPWL TASALGSSLTSHTAANQLGVTAFAPRAEPGLGTLGSLASLGGIWNGEAVPSSRTTLFAVASAVVLLAMVA IGLPTVARRPVAVPLLTLAAVSVMVPAVLATGPGLHALRVVVDAAPGLGVLRDGQKWVALAVPGYTLSGA GTVLTLRRWLRPATAAVVCCLALVLTLPDLAWGVWGKVAPVHYPSGWAAVAAAINADPRTVAVLPAGTMR RFSWSGSAPVLDPLPRWVRADVLTTGDLVISGVTVPGEDAHARAVQELLLTGPHPSTLAAAGVGWLVVES DSAGDMGAAARTLGRLAAAHRDDELALYRVGGQTSGASSARLKATMLAHWAWLSMLLVGGAGAAGYWVRR HLHHCEDTPASRAQD*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv0226c | - | - | 100% (576) | PROBABLE CONSERVED TRANSMEMBRANE PROTEIN |
| M. tuberculosis H37Rv | Rv2414c | - | 4e-05 | 26.45% (276) | hypothetical protein Rv2414c |
| M. tuberculosis H37Rv | Rv1004c | - | 5e-05 | 27.87% (244) | hypothetical protein Rv1004c |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0231c | - | 0.0 | 100.00% (576) | transmembrane protein |
| M. gilvum PYR-GCK | Mflv_0422 | - | 0.0 | 58.39% (596) | hypothetical protein Mflv_0422 |
| M. leprae Br4923 | MLBr_02582 | - | 0.0 | 70.12% (579) | hypothetical protein MLBr_02582 |
| M. abscessus ATCC 19977 | MAB_4475 | - | 1e-164 | 54.73% (550) | hypothetical protein MAB_4475 |
| M. marinum M | MMAR_0475 | - | 0.0 | 73.62% (580) | transmembrane protein |
| M. avium 104 | MAV_4944 | - | 0.0 | 75.13% (563) | hypothetical protein MAV_4944 |
| M. smegmatis MC2 155 | MSMEG_0315 | - | 1e-173 | 59.29% (560) | transmembrane protein |
| M. thermoresistible (build 8) | TH_2903 | - | 9e-39 | 50.00% (186) | PUTATIVE conserved hypothetical protein |
| M. ulcerans Agy99 | MUL_1125 | - | 0.0 | 73.28% (580) | transmembrane protein |
| M. vanbaalenii PYR-1 | Mvan_0249 | - | 0.0 | 60.99% (564) | hypothetical protein Mvan_0249 |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_0422|M.gilvum_PYR-GCK ---------------------MAPAYALALTVAVTAPLLQPGYLLLRDAV
Mvan_0249|M.vanbaalenii_PYR-1 -----------------------------MTLGVTAPLLAPGHLLLRDAV
Rv0226c|M.tuberculosis_H37Rv ------------------MRWFRPGYALVLVLLLAAPLLRPGYLLLRDAV
Mb0231c|M.bovis_AF2122/97 ------------------MRWFRPGYALVLVLLLAAPLLRPGYLLLRDAV
MMAR_0475|M.marinum_M MRAKMARGEGAGWASPRCACWWRPGYALVLALLVVGPVLGPGYLLLRDAV
MUL_1125|M.ulcerans_Agy99 ----MARGEGAGWASPRCACWWRPRYALVLALLVVGPVLGPGYLLLRDAV
MAV_4944|M.avium_104 ------------------MRWTRPGYALVLALLVVGPLLRPGYLLLRDAV
MLBr_02582|M.leprae_Br4923 ---------MSRELYHRSMSWSRPSYALGMALLVVGPLMRPGYLLLRDAV
MSMEG_0315|M.smegmatis_MC2_155 ----------------------MPAYALVLSVLVTAPLLAPGYLLLRDAV
MAB_4475|M.abscessus_ATCC_1997 ---------------MRRIGLIPPLYALALAAAVTAPLAAPGYLLIRDAV
TH_2903|M.thermoresistible__bu --------------------------------------------------
Mflv_0422|M.gilvum_PYR-GCK STPRSYLTDAALGLTQAAPRALPQDFLVALVSTVVDGGVVVKALLMLGLW
Mvan_0249|M.vanbaalenii_PYR-1 STPRSYLTDGALGLTQAAPRALPQDFAVALASTVVDGGVVVKALLMLGLW
Rv0226c|M.tuberculosis_H37Rv STPRSYVSANALGLT-SAPRATPQDFAVALASHLVDGGVVVKALLLLGLW
Mb0231c|M.bovis_AF2122/97 STPRSYVSANALGLT-SAPRATPQDFAVALASHLVDGGVVVKALLLLGLW
MMAR_0475|M.marinum_M STPRSYLSDSALGLM-AAPRATPQDFAIALASQVIDGGILVKALLVLGLW
MUL_1125|M.ulcerans_Agy99 STPRSYLSDSALGLM-AAPRATPQDFAIALASQVIDGGILVKALLVLGLW
MAV_4944|M.avium_104 STPRSYLSDTALGLT-AAPRAVPQDFAVALASHLLDGGVVVKTLLLLGLW
MLBr_02582|M.leprae_Br4923 STPRSYLSDAALGLT-SAPRSTPQDFAVAMASHLVDGGIVVKSALVLGLW
MSMEG_0315|M.smegmatis_MC2_155 STPRSYVTDAALGLTEAAPRALPQDFAVALASSVLDGGVVVKALLLAGLA
MAB_4475|M.abscessus_ATCC_1997 STPRSYVTDTALGVGEAAPRAVPQDFFIAVMTVLVDGGVLVKMLLALGLW
TH_2903|M.thermoresistible__bu --------------------------------------------------
Mflv_0422|M.gilvum_PYR-GCK LAGWGAARLVAEVL-QAGVAGQCVAVTIAIWNPYVAERLLQGHWSLLVGY
Mvan_0249|M.vanbaalenii_PYR-1 LAGWGAARLVATVLPDAGTAGQCVAVTIAIWNPYVAERLLQGHWSLLVGY
Rv0226c|M.tuberculosis_H37Rv LAGWGAARLVATALPAAGAAGQFVAITLAIWNPYVAERLLQGHWSLLVGY
Mb0231c|M.bovis_AF2122/97 LAGWGAARLVATALPAAGAAGQFVAITLAIWNPYVAERLLQGHWSLLVGY
MMAR_0475|M.marinum_M LAGWGAAVLVARALPAAGAGGQFVAITLAIWNPYVAERLLQGHWSLLLGY
MUL_1125|M.ulcerans_Agy99 LAGWGAAVLVARALPAADAGGQFVAITLAIWNPYVAERLLQGHWSLLLGY
MAV_4944|M.avium_104 LAGWGAARLVALVLPGAGMPGEFVATTLAIWNPYVAERLLQGHWSLLVGY
MLBr_02582|M.leprae_Br4923 LAGWGAARLVVTALPSAGVAGQFVASTLAVWNPYVAERLLQGHWSLLVGY
MSMEG_0315|M.smegmatis_MC2_155 AAGWGAARLVGHVLFDAGLAGRFTAATLAIWNPYVAERLLQGHWSLLVGY
MAB_4475|M.abscessus_ATCC_1997 LAGWGAARLAAQLVPAAGIPGELVAATIAIWNPYVAERLLQGHWSLLVGY
TH_2903|M.thermoresistible__bu --------------------------------------------------
Mflv_0422|M.gilvum_PYR-GCK GCLPWVAVSMLSLRAGSPRMSMSPPAAPNLHSSRQSASRRLLECNFGGVA
Mvan_0249|M.vanbaalenii_PYR-1 GCLPWVALCF----------------APKLHSSSGSASGPLLECNFGRVG
Rv0226c|M.tuberculosis_H37Rv GCLPWVATAMLT-----------------MRTTVGAG--------WFGLF
Mb0231c|M.bovis_AF2122/97 GCLPWVATAMLT-----------------MRTTVGAG--------WFGLF
MMAR_0475|M.marinum_M GCLPWVAATMLG-----------------LRASEAS---------QTGFF
MUL_1125|M.ulcerans_Agy99 GCLPWVAATMLG-----------------LRAPEAS---------QTGFF
MAV_4944|M.avium_104 GCLPWVATAMLG-----------------LRTGGAG------------FF
MLBr_02582|M.leprae_Br4923 GCLPWVAEAMLM-----------------LRSSDNASR-----PGLLGFF
MSMEG_0315|M.smegmatis_MC2_155 GCLPWVAVSVLR-----------------LRERASWT----------PVA
MAB_4475|M.abscessus_ATCC_1997 GCLPWIALTVIR-----------------LRTATNLG----------AWC
TH_2903|M.thermoresistible__bu --------------------------------------------------
Mflv_0422|M.gilvum_PYR-GCK AVVFWVALAGLTPTGLMLAATIALTCALAPGAG----RPRWWCAAVGMAA
Mvan_0249|M.vanbaalenii_PYR-1 ALLFWIALAGLTPTGLMLAATIALACSMA--AG----RSRWRCAGLSLAA
Rv0226c|M.tuberculosis_H37Rv GLAFWVALAGLTPSGLLLAATVAVVCVAMPGAG----RPRWQCGVAALGS
Mb0231c|M.bovis_AF2122/97 GLAFWVALAGLTPSGLLLAATVAVVCVAMPGAG----RPRWQCGVAALGS
MMAR_0475|M.marinum_M GLAFWIALAGLTPTGLLLAATVALTCVAAPGGG----KPRWLCATAALTA
MUL_1125|M.ulcerans_Agy99 GLAFWIALAGLTPTGLLLAATVALTCVAAPGGG----KPRWLCATAALAA
MAV_4944|M.avium_104 GLAFFIALAGLTPTGLLLAAAVALACVPVAGAG----RRRWVWAAAAIGA
MLBr_02582|M.leprae_Br4923 ALACWIALAGLTPTGLMLAATVALICVAVPVEGPGEPRPRWLCAAATLGS
MSMEG_0315|M.smegmatis_MC2_155 PLVFWMALAGLTPTGLVLAATVALVCVAAPGDG----WRRARVAGLGLGV
MAB_4475|M.abscessus_ATCC_1997 PLAFWIAVAGLTPTGTVLALIVGLAAATDRRSR-----------VGVLAI
TH_2903|M.thermoresistible__bu --------------------------------------------------
Mflv_0422|M.gilvum_PYR-GCK ALAAALPWLVATVVAPGWAAADAGQKAGVEAFAARAEPGLGTLGTLAGLG
Mvan_0249|M.vanbaalenii_PYR-1 SMIAALPWLVASAVGGGWAAAAD-QQPGVAAFAARAEPGLATLGSLASLG
Rv0226c|M.tuberculosis_H37Rv ALVGALPWLTASALGSSLTSHTAANQLGVTAFAPRAEPGLGTLGSLASLG
Mb0231c|M.bovis_AF2122/97 ALVGALPWLTASALGSSLTSHTAANQLGVTAFAPRAEPGLGTLGSLASLG
MMAR_0475|M.marinum_M ALVGALPWLTASALGSSLTTHTAANGLGVAAFAPRAEPGLGTLLSLASLG
MUL_1125|M.ulcerans_Agy99 ALVGALPWLTASALGSSLTTHTAANGLGVAAFAPRAEPGLGTLLSLASLG
MAV_4944|M.avium_104 AAVAALPWLVAAVTGAALPSHTPANRLGVEAFAPRAEPGLGTLTSLASLG
MLBr_02582|M.leprae_Br4923 ALGAALPWLTASAVGTSLTAHTVANTLGVTVFAPRAEPGLGTLASLASLG
MSMEG_0315|M.smegmatis_MC2_155 AVAAACPWLVAAFVSGAVSSSPDP-GAGVRAFAARAEPGLATLGSLAGLG
MAB_4475|M.abscessus_ATCC_1997 SVLAAMPWLVASGLGAAVP---AGDAAGVHAFAARAEPGLGTLGSLASLG
TH_2903|M.thermoresistible__bu --------------------------------------------------
Mflv_0422|M.gilvum_PYR-GCK GIWNADAVPASRTTLFAIVSTVVLLAIVAVGVPLLVRRRVPVPLLVLAVV
Mvan_0249|M.vanbaalenii_PYR-1 GIWNAEAVPASRTTLFALASAGVLLAIVAAGVPLLIRRRTALPLLVVAAA
Rv0226c|M.tuberculosis_H37Rv GIWNGEAVPSSRTTLFAVASAVVLLAMVAIGLPTVARRPVAVPLLTLAAV
Mb0231c|M.bovis_AF2122/97 GIWNGEAVPSSRTTLFAVASAVVLLAMVAIGLPTVARRPVAVPLLTLAAV
MMAR_0475|M.marinum_M GIWNGDAVPGSRTTLFAVASAAVLLVVVAVGLPTVARRPALVPLLVLAAV
MUL_1125|M.ulcerans_Agy99 GIWNGDAVPGSRTTLFAVASAAVLLVVVAVGLPTVARRPALVPLLVLAAV
MAV_4944|M.avium_104 GIWNADAVPGSRTTLFAVASAVVLLGVVAVGLPAVARRPAAVPLLVLAAA
MLBr_02582|M.leprae_Br4923 GIWNGEAVPTSRTTLFAVLSATVLLGVVVAGLPVAVRRPAVVPLLVLAAV
MSMEG_0315|M.smegmatis_MC2_155 GIWNGDAVPASRTSLFAVVATVVLLGVVAAGLPVVARRRAAVPLLVLAAG
MAB_4475|M.abscessus_ATCC_1997 GMWNASAVPASRTTLFALVFSVVLLIVVAVGAAVLWRARKALGLLGIAVA
TH_2903|M.thermoresistible__bu --------------------------------------------------
Mflv_0422|M.gilvum_PYR-GCK AVVAPALMATGPGLLAVEAVIGAVPGLGVLRDGQKWVALAMPAYALAGAA
Mvan_0249|M.vanbaalenii_PYR-1 AVVIPTLMATGPGLAAVDAVIGAVPGLGVIRDGQKWVALAMPAYALAGAA
Rv0226c|M.tuberculosis_H37Rv SVMVPAVLATGPGLHALRVVVDAAPGLGVLRDGQKWVALAVPGYTLSGAG
Mb0231c|M.bovis_AF2122/97 SVMVPAVLATGPGLHALRVVVDAAPGLGVLRDGQKWVALAVPGYTLSGAG
MMAR_0475|M.marinum_M SVLVPAALATGPGLHILAAAVDAAPGLGVLRDGQKWVALAMPGYAVSAAA
MUL_1125|M.ulcerans_Agy99 SVLVPAALATGPGLHILAAAVDAAPGLGVLRDGQKWVALAMPGYAVSAAA
MAV_4944|M.avium_104 AVLIPAGLATGPGLRLLGAVVDAAPGVGVLRDGQKWVALAVPGYALAGAG
MLBr_02582|M.leprae_Br4923 AVATPAALATGPGIDMLKAVVNAVPGLGVLRDGQKWVALAVPGYSLAGAG
MSMEG_0315|M.smegmatis_MC2_155 AVIMPALMASAPGLVVVEALIDAVPGLGIVRDGQKWVALAMPGYALAAGA
MAB_4475|M.abscessus_ATCC_1997 AVIIPALLATGPGLTLTTWLITEVPGLGILRDGQKWVALAMPAYAVAGAA
TH_2903|M.thermoresistible__bu --------------------------------------------------
Mflv_0422|M.gilvum_PYR-GCK TVLTLRSRIPTLA------TGAVCCAALIATLPDLAWGVGGRVTPVDYPP
Mvan_0249|M.vanbaalenii_PYR-1 AVIALRPRVPAAA------TAAVFAAALVATLPDLAWGVGGRVNPVQYPA
Rv0226c|M.tuberculosis_H37Rv TVLTLRRWLRPAT------AAVVCCLALVLTLPDLAWGVWGKVAPVHYPS
Mb0231c|M.bovis_AF2122/97 TVLTLRRWLRPAT------AAVVCCLALVLTLPDLAWGVWGKVAPVHYPS
MMAR_0475|M.marinum_M AVSTLSRCKTAATPLKSTLAASACCLALVLALPDLAWGVLGRVAPVHYPP
MUL_1125|M.ulcerans_Agy99 AVSTLSRCKTAATPLKSTLAASACCLALVLALPDLAWGVLGRAAPVHYPP
MAV_4944|M.avium_104 AVLTLRRRLFGAAA-----PALVCCLALILALPDLVWGVGGRVSPVRYPR
MLBr_02582|M.leprae_Br4923 AVVTLGRWLRPSRPLSPVVTALACCLALILALPDLAWGVWGKVQPVHYPS
MSMEG_0315|M.smegmatis_MC2_155 APMMLRRLRIPAAA-----AAAVCCAALIAVLPDLTWGVGNQMRAVRYPQ
MAB_4475|M.abscessus_ATCC_1997 AVIAVRERSSQYL------AAGLACAALIFTLPDLAWGVGGRMTAVKYPS
TH_2903|M.thermoresistible__bu --------------------------------------VGGQLGSVRYPP
* .: .* **
Mflv_0422|M.gilvum_PYR-GCK GWSAAAAVIN---ADPATVAVLPVDSMRRFAWAPG--------APVLDPL
Mvan_0249|M.vanbaalenii_PYR-1 GWSAAAAVIN---ADPAPVAVLPVDSMRHFSWAGE--------VPVLDPL
Rv0226c|M.tuberculosis_H37Rv GWAAVAAAIN---ADPRTVAVLPAGTMRRFSWSGS--------APVLDPL
Mb0231c|M.bovis_AF2122/97 GWAAVAAAIN---ADPRTVAVLPAGTMRRFSWSGS--------APVLDPL
MMAR_0475|M.marinum_M GWTAVATAIN---HQPGTVAVLPIGTMRRFSWAGR--------APVLDPL
MUL_1125|M.ulcerans_Agy99 GWTAVATAIN---HQPGTVAVLPIGTMRRFSWSGR--------APVLDPL
MAV_4944|M.avium_104 GWPAVAAAIN---ARPDAVAVLPAGTMRLFSWSGP--------APVLDPL
MLBr_02582|M.leprae_Br4923 GWAAVAATINDRGEGPGWVAVLPAGTMRRFSWSGT--------APVLDPL
MSMEG_0315|M.smegmatis_MC2_155 SWAQVAATIN---ADPRPVVALPADSIREFSWAG----------TVLDPL
MAB_4475|M.abscessus_ATCC_1997 GWNAVAAHIN---ADPHPVAVLPPETMRQYPWGPSS-------IPVLDPF
TH_2903|M.thermoresistible__bu AWPAAAAMIN---ADPRPVAVLPPDVMRTFAWTRPGLGADAGPAPVLDPL
.* .*: ** * *..** :* :.* .****:
Mflv_0422|M.gilvum_PYR-GCK PRWLRADVLSTGDLTIAGTTVLGEGARAREVQQMLASGADRDELAAAGVG
Mvan_0249|M.vanbaalenii_PYR-1 PRWVRADVLSTGDLTIAGRTVPGEGTRAREVQQMLISGADADQLAAAGVG
Rv0226c|M.tuberculosis_H37Rv PRWVRADVLTTGDLVISGVTVPGEDAHARAVQELLLTGPHPSTLAAAGVG
Mb0231c|M.bovis_AF2122/97 PRWVRADVLTTGDLVISGVTVPGEDAHARAVQELLLTGPHPSTLAAAGVG
MMAR_0475|M.marinum_M PRWVRPDVLSSGDLVISGVLVPGDGVRARTVQKLLLAGADPAALAQAGVG
MUL_1125|M.ulcerans_Agy99 PRWVRPDVLSSGDLVISGVLVPGDGVRARTVQKLLLAGADPEALAQAGVG
MAV_4944|M.avium_104 PRWVRADVLSTGDLVISGTTIAGEGAHARAVQELLLSGPDPAALAAAGVG
MLBr_02582|M.leprae_Br4923 PRWVRDDVLTTGDLIISGVMVAGEGNHARAAQDLLLSGPNPSALTAAGVA
MSMEG_0315|M.smegmatis_MC2_155 PRWLRADVLTTGDLLIGGRTVPGEGARARAVQGLLRDGASPQQLAEAGVG
MAB_4475|M.abscessus_ATCC_1997 PRWIRADTVSSGDLRVDGHDVRGDGTRGRQVEELLRAGAAPRELAAHGVG
TH_2903|M.thermoresistible__bu PRWVRAEVLATGDLRVGERTVPGEGRHARKVQDLLLSGADAAALTAAGVG
***:* :.:::*** : : *:. :.* .: :* *. *: **.
Mflv_0422|M.gilvum_PYR-GCK WVVVEGSG---------VRLALPESYRDENLTVYRVGG-DSPS---SAHR
Mvan_0249|M.vanbaalenii_PYR-1 WVVVEGTADG------TPELRLPVAYRDDDLTVYAVGG-DAAG---SPHR
Rv0226c|M.tuberculosis_H37Rv WLVVESDSAGDMGAAARTLGRLAAAHRDDELALYRVGG-QTSG-ASSARL
Mb0231c|M.bovis_AF2122/97 WLVVESDSAGDMGAAARTLGRLAAAHRDDELALYRVGG-QTSG-ASSARL
MMAR_0475|M.marinum_M WLVVEVHGGGEVGEAGRTLDRLTPTYRDDELALYRIGG-RSAG-VPAGDR
MUL_1125|M.ulcerans_Agy99 WLVVEVHGGGEVGEAGRTLDRLTPTYRDDELALYRIGG-RSAG-VPAGDR
MAV_4944|M.avium_104 WLVLEADSAGEVGAAAHTLGAAAPVYRDDEIALYRIGG-HTAG-VAADRR
MLBr_02582|M.leprae_Br4923 WLVVESDTAGDMGASARTLAALQPTYRDDAIGLYRIGG-SNAKTAPSPYR
MSMEG_0315|M.smegmatis_MC2_155 WLVRETDSG---------------------ITAQRIGG-EAPS---SPHR
MAB_4475|M.abscessus_ATCC_1997 WVVVQADTPGQQAVSSKTLAQLDTAYRDGDIALYRVPGPWNPIAAPPGRR
TH_2903|M.thermoresistible__bu WVVVENPGDS-------PDLDLPVAYRDADLAVYRVSG-DRPG---SPYR
*:* : : : * . .
Mflv_0422|M.gilvum_PYR-GCK GVVIAAHSVWLAALGVGFLGMLVARRRSRRAHGREQEVDRPQAGDQ-
Mvan_0249|M.vanbaalenii_PYR-1 TVLLAAHTVWLAALGAGLIAMLVGLLRSRHAHRRQQDVDGPERGDQ-
Rv0226c|M.tuberculosis_H37Rv KATMLAHWAWLSMLLVGGAG-AAGYWVRRHLHHCEDTPASRAQD---
Mb0231c|M.bovis_AF2122/97 KATMLAHWAWLSMLLVGGAG-AAGYWVRRHLHHCEDTPASRAQD---
MMAR_0475|M.marinum_M RAMMLAHWAWLSMLLAGGAG-MAAGRVRRHLSGREESPTDLAAD---
MUL_1125|M.ulcerans_Agy99 RAMMLAHWAWLSMLLAGGAG-MAAGLVRRHLSGREESPTDLAAD---
MAV_4944|M.avium_104 AATLIAHLAWLVLLLGSGAGVLLGAWWRRGVSRAR------------
MLBr_02582|M.leprae_Br4923 GLLIAAHLTWLVILVMAVVG----MQITRHTHFRDVSSVALLSRR--
MSMEG_0315|M.smegmatis_MC2_155 GLLIAAHLVWLAALAGGALG-LVAGRVGRVLSRRTWRHRPRPG----
MAB_4475|M.abscessus_ATCC_1997 AAVIAAHLVWIALLAAGGVAVFRRQHTRQVGSGGTQDPKICTPDSDN
TH_2903|M.thermoresistible__bu PVMIAAHLVWVGVLLGGFAAMARSVWSRRVAARRD------------
: ** .*: * . . :