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QLALTPEEAAFRDELRTIYTTKIPEELRERVRRGSAEVNRDDIVTSHKILHEHGLAVPNWPVEWGGKDWT PTQHQIWADEMQLACVPEPLNFNTKMVGPVIAEFGSEEVKQRFLPPTASLDIWWCQGFSEPDAGSDLASL RTTAVRDGDHYIVNGQKTWTTLGQYADWIFCLVRTDPQAPKRQAGISFLLFDMKSPGITLRPIKTIDGGH EINEVFFEDVRVPADQLVGEENQGWTYAKFLLGNERTGIAGVGRTKVRLAEVKKHAAATGVLDDPLFAAR LAEAENELLALELTQSRVTTDSANGQPNPASSVLKLRGSQLQQVATELLVEVAGPDALPAKADDIASPSW AQSSAPHYLNYRKTSIYGGSSEVQRNIIASTILGL*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_1766 | - | - | 100% (386) | acyl-CoA dehydrogenase domain-containing protein |
| M. avium 104 | MAV_1268 | - | 3e-64 | 38.23% (395) | acyl-CoA dehydrogenase domain-containing protein |
| M. avium 104 | MAV_1909 | - | 2e-58 | 36.41% (401) | acyl-CoA dehydrogenase domain-containing protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3590c | fadE30 | 7e-55 | 38.10% (336) | acyl-CoA dehydrogenase FADE30 |
| M. gilvum PYR-GCK | Mflv_2287 | - | 0.0 | 80.83% (386) | acyl-CoA dehydrogenase domain-containing protein |
| M. tuberculosis H37Rv | Rv3560c | fadE30 | 7e-55 | 38.10% (336) | acyl-CoA dehydrogenase FADE30 |
| M. leprae Br4923 | MLBr_00737 | fadE25 | 6e-20 | 26.99% (289) | putative acyl-CoA dehydrogenase |
| M. abscessus ATCC 19977 | MAB_2495 | - | 9e-75 | 40.73% (410) | acyl-CoA dehydrogenase |
| M. marinum M | MMAR_3737 | fadE17_1 | 0.0 | 88.69% (389) | acyl-CoA dehydrogenase FadE17_1 |
| M. smegmatis MC2 155 | MSMEG_6511 | - | 0.0 | 81.61% (386) | acyl-CoA dehydrogenase domain-containing protein |
| M. thermoresistible (build 8) | TH_3063 | - | 1e-171 | 74.68% (387) | PUTATIVE acyl-CoA dehydrogenase domain protein |
| M. ulcerans Agy99 | MUL_3681 | fadE17_1 | 0.0 | 88.69% (389) | acyl-CoA dehydrogenase FadE17_1 |
| M. vanbaalenii PYR-1 | Mvan_4379 | - | 0.0 | 80.57% (386) | acyl-CoA dehydrogenase domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3590c|M.bovis_AF2122/97 ---------------MQDVEEFRAQVRGWLADNLAGEFAALKGLGGPGRE
Rv3560c|M.tuberculosis_H37Rv ---------------MQDVEEFRAQVRGWLADNLAGEFAALKGLGGPGRE
MMAR_3737|M.marinum_M ----------MKLALTPDEAAFRDELRTFYTTRIPEDLRELVRQGQ---S
MUL_3681|M.ulcerans_Agy99 ----------MKLALTPDEAAFRDELRTFYTTRIPEDLRELVRQGQ---S
MAV_1766|M.avium_104 ----------MQLALTPEEAAFRDELRTIYTTKIPEELRERVRRGS---A
MSMEG_6511|M.smegmatis_MC2_155 ----------MQLALTPEEAAFRDELRTFYRTEIPEDIRARHAKG----G
Mflv_2287|M.gilvum_PYR-GCK ----------MQLALTPEEAEFRDELRNFYRTKIPAEIRERTRTG----S
Mvan_4379|M.vanbaalenii_PYR-1 ----------MQLALTAEEAAFRDELRTFYRTKIPAEIRERTRSG----T
TH_3063|M.thermoresistible__bu ----------VKLALSDADAAFRAEMREFFTTEIPADIRDRMRAG----R
MAB_2495|M.abscessus_ATCC_1997 ----------MDLAFSAEEEQFRTEVREFLDANLTAELRAAGRLQTS--V
MLBr_00737|M.leprae_Br4923 MVGWSGNPLFDLFKLPEEHNELRATIRALAEKEIAPHAADVDQRAR----
:* :* .:. .
Mb3590c|M.bovis_AF2122/97 HEAFEERRAWNQRLAAAGLTCLGWPEEHGGRGLSTAHRVAFYEEYARADA
Rv3560c|M.tuberculosis_H37Rv HEAFEERRAWNQRLAAAGLTCLGWPEEHGGRGLSTAHRVAFYEEYARADA
MMAR_3737|M.marinum_M PS-RDEIVTCHKILNDHGLAVPNWPVEWGGKDWTPTQHQIWADEMQLASV
MUL_3681|M.ulcerans_Agy99 PS-RDEIVTCHKILNDHGLAVPNWPVEWGGKDWTPTQHQIWADEMQLASV
MAV_1766|M.avium_104 EVNRDDIVTSHKILHEHGLAVPNWPVEWGGKDWTPTQHQIWADEMQLACV
MSMEG_6511|M.smegmatis_MC2_155 ELLKDDIVTTHKILHKHGLAVPNWPVEWGGKDWTPTQHQIWLDEMQLACV
Mflv_2287|M.gilvum_PYR-GCK EANRDDIVTANKILNDHGLMVPNWPVEWGGKDWTPIQHQIWLDEMQLASV
Mvan_4379|M.vanbaalenii_PYR-1 EANRDDIVTANKILNDHGLMVPNWPVEWGGKDWTPIQHQIWLDEMQLASV
TH_3063|M.thermoresistible__bu PRYPDDIVTTQRILNAHGLAVPNWPVEWGGRDWSPLQRQIWSDEMQLAAV
MAB_2495|M.abscessus_ATCC_1997 YSDHEASMRWQAILHRKGWAAPAWPVKYGGQPWSLAQHYIFSVESMVAGA
MLBr_00737|M.leprae_Br4923 -----FPEEALAALNASGFNAIHVPEEYGGQGADSVAACIVIEEVARVDA
* * * : **: * . .
Mb3590c|M.bovis_AF2122/97 PDKVNHFGEELLGPTLIAFGTPQQQRRFLPRIRDVTELWCQGYSEPGAGS
Rv3560c|M.tuberculosis_H37Rv PDKVNHFGEELLGPTLIAFGTPQQQRRFLPRIRDVTELWCQGYSEPGAGS
MMAR_3737|M.marinum_M PEPLN-FNTKMVGPVIAEFGSQEIKQRFLPPTASLDIWWCQGFSEPEAGS
MUL_3681|M.ulcerans_Agy99 PEPLN-FNTKMVGPVIAEFGSQEIKQRFLPPTASLDIWWCQGFSEPEAGS
MAV_1766|M.avium_104 PEPLN-FNTKMVGPVIAEFGSEEVKQRFLPPTASLDIWWCQGFSEPDAGS
MSMEG_6511|M.smegmatis_MC2_155 PEPLT-FNAKMIGPVIAEFASQEMKERFLPATAALDIFWCQGFSEPEAGS
Mflv_2287|M.gilvum_PYR-GCK PEPLT-FNAKMVGPVIAEFGSQEIKERFLPPTAAVDIWWCQGFSEPEAGS
Mvan_4379|M.vanbaalenii_PYR-1 PEPLT-FNAKMVGPVIAEFGSQELKERFLPPTAAVDIWWCQGFSEPEAGS
TH_3063|M.thermoresistible__bu PEPLA-FNANMVGPVIARFGSQQLKERFLPPTANLDIWWCQGFSEPEAGS
MAB_2495|M.abscessus_ATCC_1997 PSLSP-MGIRMVAHAIIKFGSPEQKEFFLPRILTGEVFFCQGYSEPESGS
MLBr_00737|M.leprae_Br4923 SASLIPAVNKLGTMGLILRGSEELKKQVLPSLAAEGAMASYALSEREAGS
. .: : .: : :. .** . . ** :**
Mb3590c|M.bovis_AF2122/97 DLASVATTAELDGDQWVINGQKVWTSLAHLSQWCFVLARTE-KGSQRHAG
Rv3560c|M.tuberculosis_H37Rv DLASVATTAELDGDQWVINGQKVWTSLAHLSQWCFVLARTE-KGSQRHAG
MMAR_3737|M.marinum_M DLASLRTTAVRDGDSYVVNGQKTWTTLGQYADWIFCLVRTDPQAPKRQAG
MUL_3681|M.ulcerans_Agy99 DLASLRTTAVRDGDSYVVNGQKTWTTLGQYADWIFCLVRTDPQAPKRQAG
MAV_1766|M.avium_104 DLASLRTTAVRDGDHYIVNGQKTWTTLGQYADWIFCLVRTDPQAPKRQAG
MSMEG_6511|M.smegmatis_MC2_155 DLASLRTTAVRDGDTYVVNGQKTWTTLGQYADWIFCLVRTDPQAPKRQAG
Mflv_2287|M.gilvum_PYR-GCK DLASLRTTALRDGDSYVVNGQKTWTTLGQYADWIFCLVRTDPNAPKKQAG
Mvan_4379|M.vanbaalenii_PYR-1 DLASLRTTALRDGDSYVVNGQKTWTTLGQYADWIFCLVRTDPDAPKKQAG
TH_3063|M.thermoresistible__bu DLASLRTTAVRDGDSYVVNGQKTWTTLGQYADWIFLLARTDPDAPKRQAG
MAB_2495|M.abscessus_ATCC_1997 DLASLQMSAVADGDDFVLNGSKIWTTHAREANWMFALVRTT-KGPKKQLG
MLBr_00737|M.leprae_Br4923 DAASMRTRAKADGDDWILNGFKCWITNGGKSTWYTVMAVTDPDKGAN--G
* **: * *** :::** * * : . : * :. * . . *
Mb3590c|M.bovis_AF2122/97 LSYLLVPLDQPGVQIRPIVQITGT--AEFNEVFFDDARTDADLVVGAPGD
Rv3560c|M.tuberculosis_H37Rv LSYLLVPLDQPGVQIRPIVQITGT--AEFNEVFFDDARTDADLVVGAPGD
MMAR_3737|M.marinum_M ISFLLIDMATPGITLRPIKTIDGG--HEVNEVFFSDVRVPADQLVGQENQ
MUL_3681|M.ulcerans_Agy99 ISFLLIDMATPGITLRPIKTIDGG--HEVNEVFFSDVRVPADQLVGQENQ
MAV_1766|M.avium_104 ISFLLFDMKSPGITLRPIKTIDGG--HEINEVFFEDVRVPADQLVGEENQ
MSMEG_6511|M.smegmatis_MC2_155 ISMLLIDLDTPGITMRPIKLVDGS--VEVNEVFFEDVRVPADQLVGEENQ
Mflv_2287|M.gilvum_PYR-GCK ISFLLIDMNTPGITLRPIKLIDGS--YEVNEVFFEDVRVPADQLVGEENQ
Mvan_4379|M.vanbaalenii_PYR-1 ISFLLIDMNTPGITLRPIKLIDGS--YEVNEVFFEDVRVPADQLVGEENQ
TH_3063|M.thermoresistible__bu ISFLLADMNTPGITLRPIKLIDGG--HEVNEVFFEDVRIPADQLVGEENH
MAB_2495|M.abscessus_ATCC_1997 ITFILIDFTSPGIDVKPLVMSSGE--EVQNVVFFDNVRVPRANVLGEVDQ
MLBr_00737|M.leprae_Br4923 ISAFIVHKDDEGFSIGPKEKKLGIKGSPTTELYFDKCRIPGDRIIGEPGT
:: :: *. : * * . ::*.. * ::* .
Mb3590c|M.bovis_AF2122/97 GWRVAMATLTFERGVS---TLGQQIVYARELSNLVELARRTAAADDPLIR
Rv3560c|M.tuberculosis_H37Rv GWRVAMATLTFERGVS---TLGQQIVYARELSNLVELARRTAAADDPLIR
MMAR_3737|M.marinum_M GWTYAKFLLGNERTG-----IAGVGRTKVRLAEVKKHAANNGLLDDPLFA
MUL_3681|M.ulcerans_Agy99 GWTYAKFLLGNERTG-----IAGVGRTKVRLAEVKKHAANNGLLDDPLFA
MAV_1766|M.avium_104 GWTYAKFLLGNERTG-----IAGVGRTKVRLAEVKKHAAATGVLDDPLFA
MSMEG_6511|M.smegmatis_MC2_155 GWTYAKFLLGNERTG-----ITGVARTKVRLAQAKERAAANGLLNDPLFA
Mflv_2287|M.gilvum_PYR-GCK GWSYAKFLLGNERTG-----ITQIGRTKLKLAEVKERAKANGLFDDPLFA
Mvan_4379|M.vanbaalenii_PYR-1 GWSYAKFLLGNERTG-----ITQIGRTKLRLSEVKERAKASGLLDDPLFA
TH_3063|M.thermoresistible__bu GWAYAKFLLSNERTG-----IARIGATKLWLSQVKSRAAECSLLDDPLFA
MAB_2495|M.abscessus_ATCC_1997 GWTVAKYLLEFERGGGAVAPMLQVGLDQLSVDARSVPAENGTLADDPVFC
MLBr_00737|M.leprae_Br4923 GFKTALATLDHTRPTIG---AQAVGIAQGALDAAIVYTKDRKQFGESIST
*: * * * : : .:.:
Mb3590c|M.bovis_AF2122/97 ERLTRAWTGLRAMRSYALATMEGPAVE--QPGQDNVSKLLWANWHRNLGE
Rv3560c|M.tuberculosis_H37Rv ERLTRAWTGLRAMRSYALATMEGPAVE--QPGQDNVSKLLWANWHRNLGE
MMAR_3737|M.marinum_M ARLAEAENELLALELTQARVVTDSADG-KPNPASSVLKLRGSQLQQVATE
MUL_3681|M.ulcerans_Agy99 ARLAEAENELLALELTQARVVTDSADG-KPNPASSVLKLRGSQLQQVATE
MAV_1766|M.avium_104 ARLAEAENELLALELTQSRVTTDSANG-QPNPASSVLKLRGSQLQQVATE
MSMEG_6511|M.smegmatis_MC2_155 ARLAEAENDVLALELTQMRVTSDSSDG-KPNPASSVLKLRGTQLQQLATE
Mflv_2287|M.gilvum_PYR-GCK ARLAETENDVLALELTQMRVATGSKDG-KPNPASSVLKLRASELQQAATE
Mvan_4379|M.vanbaalenii_PYR-1 ARLAETENDVLALELTQMRVASGSKDG-KPNPASSVLKLRASELQQAATE
TH_3063|M.thermoresistible__bu ARIAELENDLLALELTQLRVSGSEGEG-KPNPASSILKLRGSQLQQAVTE
MAB_2495|M.abscessus_ATCC_1997 AKLADLAIRVDVLEVLEHRVLAVVAGGGNPGAASSMLKILGTELSQALTT
MLBr_00737|M.leprae_Br4923 FQSIQFMLADMAMKVEAARLIVYAAAA-RAERGEPDLGFISAASKCFASD
: .:. . : :
Mb3590c|M.bovis_AF2122/97 LAMDVIG-----------------------KPGMTMPDGEFDEWQRLYLF
Rv3560c|M.tuberculosis_H37Rv LAMDVIG-----------------------KPGMTMPDGEFDEWQRLYLF
MMAR_3737|M.marinum_M LLVEVAGPDALPVG-------------GAQAAGIASPQWAQSSAP-RYLN
MUL_3681|M.ulcerans_Agy99 LLVEVAGPDALPVG-------------GAQAAGIASPQWAQSSAP-RYLN
MAV_1766|M.avium_104 LLVEVAGPDALP----------------AKADDIASPSWAQSSAP-HYLN
MSMEG_6511|M.smegmatis_MC2_155 LLVEVAGADALP----------------CEAEGIASPEWAQLTAP-QYLN
Mflv_2287|M.gilvum_PYR-GCK LLVEVAGADALP----------------FGTDSIASADWAQDAAP-RYLN
Mvan_4379|M.vanbaalenii_PYR-1 LLVEVAGADALP----------------FGSHGIASADWAQDAAP-RYLN
TH_3063|M.thermoresistible__bu LAVEVAGTDALP---------------YAAGDDIASPEWAQLAAP-RYLN
MAB_2495|M.abscessus_ATCC_1997 LTLEAAGPRGRAYQPHVTKPGGPVVEYTPPADGYHSGELWQAVAPLHYFN
MLBr_00737|M.leprae_Br4923 IAMEVTTDAVQLFG----------------GAGYTSDFPVERFMR----D
: ::. .
Mb3590c|M.bovis_AF2122/97 TRADTIYGGSNEIQRNIIAERVLGLPREAKG
Rv3560c|M.tuberculosis_H37Rv TRADTIYGGSNEIQRNIIAERVLGLPREAKG
MMAR_3737|M.marinum_M YRKTSIYGGSNEVQRNIIASTILGL------
MUL_3681|M.ulcerans_Agy99 YRKTSIYGGSNEVQRNIIASTILGL------
MAV_1766|M.avium_104 YRKTSIYGGSSEVQRNIIASTILGL------
MSMEG_6511|M.smegmatis_MC2_155 YRKTSIYGGSNEVQRTIISSTILGL------
Mflv_2287|M.gilvum_PYR-GCK YRKTSIYGGSNEVQRTIIASTILGL------
Mvan_4379|M.vanbaalenii_PYR-1 YRKTSIYGGSNEVQRTIIASTILGL------
TH_3063|M.thermoresistible__bu YRKTSIYGGTNEVQRTIIASTILGL------
MAB_2495|M.abscessus_ATCC_1997 DRAGSIYAGSNEIQRNILAKAQLGL------
MLBr_00737|M.leprae_Br4923 AKITQIYEGTNQIQRVVMSRALLR-------
: ** *:.::** ::: *