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MKLALTPDEAAFRDELRTFYTTRIPEDLRELVRQGQSPSRDEIVTCHKILNDHGLAVPNWPVEWGGKDWT PTQHQIWADEMQLASVPEPLNFNTKMVGPVIAEFGSQEIKQRFLPPTASLDIWWCQGFSEPEAGSDLASL RTTAVRDGDSYVVNGQKTWTTLGQYADWIFCLVRTDPQAPKRQAGISFLLIDMATPGITLRPIKTIDGGH EVNEVFFSDVRVPADQLVGQENQGWTYAKFLLGNERTGIAGVGRTKVRLAEVKKHAANNGLLDDPLFAAR LAEAENELLALELTQARVVTDSADGKPNPASSVLKLRGSQLQQVATELLVEVAGPDALPVGGAQAAGIAS PQWAQSSAPRYLNYRKTSIYGGSNEVQRNIIASTILGL
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_3737 | fadE17_1 | - | 100% (388) | acyl-CoA dehydrogenase FadE17_1 |
| M. marinum M | MMAR_2862 | fadE17 | 6e-61 | 36.91% (401) | acyl-CoA dehydrogenase FadE17 |
| M. marinum M | MMAR_4992 | fadE26 | 1e-58 | 35.77% (397) | acyl-CoA dehydrogenase FadE26 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1969c | fadE17 | 6e-57 | 36.25% (400) | acyl-CoA dehydrogenase FADE17 |
| M. gilvum PYR-GCK | Mflv_2287 | - | 0.0 | 81.96% (388) | acyl-CoA dehydrogenase domain-containing protein |
| M. tuberculosis H37Rv | Rv1934c | fadE17 | 6e-57 | 36.25% (400) | acyl-CoA dehydrogenase FADE17 |
| M. leprae Br4923 | MLBr_00737 | fadE25 | 7e-23 | 26.88% (346) | putative acyl-CoA dehydrogenase |
| M. abscessus ATCC 19977 | MAB_2495 | - | 4e-75 | 41.71% (410) | acyl-CoA dehydrogenase |
| M. avium 104 | MAV_1766 | - | 0.0 | 88.69% (389) | acyl-CoA dehydrogenase domain-containing protein |
| M. smegmatis MC2 155 | MSMEG_6511 | - | 0.0 | 81.96% (388) | acyl-CoA dehydrogenase domain-containing protein |
| M. thermoresistible (build 8) | TH_3063 | - | 1e-174 | 76.55% (388) | PUTATIVE acyl-CoA dehydrogenase domain protein |
| M. ulcerans Agy99 | MUL_3681 | fadE17_1 | 0.0 | 100.00% (388) | acyl-CoA dehydrogenase FadE17_1 |
| M. vanbaalenii PYR-1 | Mvan_4379 | - | 0.0 | 81.96% (388) | acyl-CoA dehydrogenase domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1969c|M.bovis_AF2122/97 ----------MDVSYPPEAEAFRDRIREFVAEHLPPGWPGPGALPP--HE
Rv1934c|M.tuberculosis_H37Rv ----------MDVSYPPEAEAFRDRIREFVAEHLPPGWPGPGALPP--HE
MMAR_3737|M.marinum_M ----------MKLALTPDEAAFRDELRTFYTTRIPEDLRELVRQGQ-SPS
MUL_3681|M.ulcerans_Agy99 ----------MKLALTPDEAAFRDELRTFYTTRIPEDLRELVRQGQ-SPS
MAV_1766|M.avium_104 ----------MQLALTPEEAAFRDELRTIYTTKIPEELRERVRRGS-AEV
MSMEG_6511|M.smegmatis_MC2_155 ----------MQLALTPEEAAFRDELRTFYRTEIPEDIRARHAKG--GEL
Mflv_2287|M.gilvum_PYR-GCK ----------MQLALTPEEAEFRDELRNFYRTKIPAEIRERTRTG--SEA
Mvan_4379|M.vanbaalenii_PYR-1 ----------MQLALTAEEAAFRDELRTFYRTKIPAEIRERTRSG--TEA
TH_3063|M.thermoresistible__bu ----------VKLALSDADAAFRAEMREFFTTEIPADIRDRMRAG--RPR
MAB_2495|M.abscessus_ATCC_1997 ----------MDLAFSAEEEQFRTEVREFLDANLTAELRAAGRLQTSVYS
MLBr_00737|M.leprae_Br4923 MVGWSGNPLFDLFKLPEEHNELRATIRALAEKEIAPHAADVDQRAR----
. . :* :* : .:.
Mb1969c|M.bovis_AF2122/97 REEFARHWRRALAGAGLVAVSWPTEYGGGGLSPMEQVVLAEEFARAGAPE
Rv1934c|M.tuberculosis_H37Rv REEFARHWRRALAGAGLVAVSWPTEYGGGGLSPMEQVVLAEEFARAGAPE
MMAR_3737|M.marinum_M -RDEIVTCHKILNDHGLAVPNWPVEWGGKDWTPTQHQIWADEMQLASVPE
MUL_3681|M.ulcerans_Agy99 -RDEIVTCHKILNDHGLAVPNWPVEWGGKDWTPTQHQIWADEMQLASVPE
MAV_1766|M.avium_104 NRDDIVTSHKILHEHGLAVPNWPVEWGGKDWTPTQHQIWADEMQLACVPE
MSMEG_6511|M.smegmatis_MC2_155 LKDDIVTTHKILHKHGLAVPNWPVEWGGKDWTPTQHQIWLDEMQLACVPE
Mflv_2287|M.gilvum_PYR-GCK NRDDIVTANKILNDHGLMVPNWPVEWGGKDWTPIQHQIWLDEMQLASVPE
Mvan_4379|M.vanbaalenii_PYR-1 NRDDIVTANKILNDHGLMVPNWPVEWGGKDWTPIQHQIWLDEMQLASVPE
TH_3063|M.thermoresistible__bu YPDDIVTTQRILNAHGLAVPNWPVEWGGRDWSPLQRQIWSDEMQLAAVPE
MAB_2495|M.abscessus_ATCC_1997 DHEASMRWQAILHRKGWAAPAWPVKYGGQPWSLAQHYIFSVESMVAGAPS
MLBr_00737|M.leprae_Br4923 ---FPEEALAALNASGFNAIHVPEEYGGQGADSVAACIVIEEVARVDASA
* * . * ::** : * . ..
Mb1969c|M.bovis_AF2122/97 RAENDLLGIDLLGNTLIALGSEAQKRHFLPRILSGEHRWCQGFSEPEAGS
Rv1934c|M.tuberculosis_H37Rv RAENDLLGIDLLGNTLIALGSEAQKRHFLPRILSGEHRWCQGFSEPEAGS
MMAR_3737|M.marinum_M PLN---FNTKMVGPVIAEFGSQEIKQRFLPPTASLDIWWCQGFSEPEAGS
MUL_3681|M.ulcerans_Agy99 PLN---FNTKMVGPVIAEFGSQEIKQRFLPPTASLDIWWCQGFSEPEAGS
MAV_1766|M.avium_104 PLN---FNTKMVGPVIAEFGSEEVKQRFLPPTASLDIWWCQGFSEPDAGS
MSMEG_6511|M.smegmatis_MC2_155 PLT---FNAKMIGPVIAEFASQEMKERFLPATAALDIFWCQGFSEPEAGS
Mflv_2287|M.gilvum_PYR-GCK PLT---FNAKMVGPVIAEFGSQEIKERFLPPTAAVDIWWCQGFSEPEAGS
Mvan_4379|M.vanbaalenii_PYR-1 PLT---FNAKMVGPVIAEFGSQELKERFLPPTAAVDIWWCQGFSEPEAGS
TH_3063|M.thermoresistible__bu PLA---FNANMVGPVIARFGSQQLKERFLPPTANLDIWWCQGFSEPEAGS
MAB_2495|M.abscessus_ATCC_1997 LSP---MGIRMVAHAIIKFGSPEQKEFFLPRILTGEVFFCQGYSEPESGS
MLBr_00737|M.leprae_Br4923 SLIP--AVNKLGTMGLILRGSEELKKQVLPSLAAEGAMASYALSEREAGS
: : .* *. .** . . ** ::**
Mb1969c|M.bovis_AF2122/97 DLASVRTRGVLDGDEWVINGHKIWTSAGTTANWIFLLARTDPSAAKHRG-
Rv1934c|M.tuberculosis_H37Rv DLASVRTRGVLDGDEWVINGHKIWTSAGTTANWIFLLARTDPSAAKHRG-
MMAR_3737|M.marinum_M DLASLRTTAVRDGDSYVVNGQKTWTTLGQYADWIFCLVRTDPQAPKRQAG
MUL_3681|M.ulcerans_Agy99 DLASLRTTAVRDGDSYVVNGQKTWTTLGQYADWIFCLVRTDPQAPKRQAG
MAV_1766|M.avium_104 DLASLRTTAVRDGDHYIVNGQKTWTTLGQYADWIFCLVRTDPQAPKRQAG
MSMEG_6511|M.smegmatis_MC2_155 DLASLRTTAVRDGDTYVVNGQKTWTTLGQYADWIFCLVRTDPQAPKRQAG
Mflv_2287|M.gilvum_PYR-GCK DLASLRTTALRDGDSYVVNGQKTWTTLGQYADWIFCLVRTDPNAPKKQAG
Mvan_4379|M.vanbaalenii_PYR-1 DLASLRTTALRDGDSYVVNGQKTWTTLGQYADWIFCLVRTDPDAPKKQAG
TH_3063|M.thermoresistible__bu DLASLRTTAVRDGDSYVVNGQKTWTTLGQYADWIFLLARTDPDAPKRQAG
MAB_2495|M.abscessus_ATCC_1997 DLASLQMSAVADGDDFVLNGSKIWTTHAREANWMFALVRTT-KGPKKQLG
MLBr_00737|M.leprae_Br4923 DAASMRTRAKADGDDWILNGFKCWITNGGKSTWYTVMAVTDPDKGANGIS
* **:: . *** :::** * * : . : * :. * . .
Mb1969c|M.bovis_AF2122/97 LSFLLVPMDQPGVVVRPIVNAAGHSSFSEVFLTDARTSAGNVVGRVGDGW
Rv1934c|M.tuberculosis_H37Rv LSFLLVPMDQPGVVVRPIVNAAGHSSFSEVFLTDARTSAGNVVGRVGDGW
MMAR_3737|M.marinum_M ISFLLIDMATPGITLRPIKTIDGGHEVNEVFFSDVRVPADQLVGQENQGW
MUL_3681|M.ulcerans_Agy99 ISFLLIDMATPGITLRPIKTIDGGHEVNEVFFSDVRVPADQLVGQENQGW
MAV_1766|M.avium_104 ISFLLFDMKSPGITLRPIKTIDGGHEINEVFFEDVRVPADQLVGEENQGW
MSMEG_6511|M.smegmatis_MC2_155 ISMLLIDLDTPGITMRPIKLVDGSVEVNEVFFEDVRVPADQLVGEENQGW
Mflv_2287|M.gilvum_PYR-GCK ISFLLIDMNTPGITLRPIKLIDGSYEVNEVFFEDVRVPADQLVGEENQGW
Mvan_4379|M.vanbaalenii_PYR-1 ISFLLIDMNTPGITLRPIKLIDGSYEVNEVFFEDVRVPADQLVGEENQGW
TH_3063|M.thermoresistible__bu ISFLLADMNTPGITLRPIKLIDGGHEVNEVFFEDVRIPADQLVGEENHGW
MAB_2495|M.abscessus_ATCC_1997 ITFILIDFTSPGIDVKPLVMSSGEEVQNVVFFDNVRVPRANVLGEVDQGW
MLBr_00737|M.leprae_Br4923 AFIVHKDDEGFSIGPKEKKLGIKGSPTTELYFDKCRIPGDRIIGEPGTGF
:: .: : . ::: . * . .::*. . *:
Mb1969c|M.bovis_AF2122/97 STAMTLLGFERGS---HIATAAIDFERDLQRLCELARDRGLHTDPRVRDG
Rv1934c|M.tuberculosis_H37Rv STAMTLLGFERGS---HIATAAIDFERDLQRLCELARDRGLHTDPRVRDG
MMAR_3737|M.marinum_M TYAKFLLGNERTG-----IAGVGRTKVRLAEVKKHAANNGLLDDPLFAAR
MUL_3681|M.ulcerans_Agy99 TYAKFLLGNERTG-----IAGVGRTKVRLAEVKKHAANNGLLDDPLFAAR
MAV_1766|M.avium_104 TYAKFLLGNERTG-----IAGVGRTKVRLAEVKKHAAATGVLDDPLFAAR
MSMEG_6511|M.smegmatis_MC2_155 TYAKFLLGNERTG-----ITGVARTKVRLAQAKERAAANGLLNDPLFAAR
Mflv_2287|M.gilvum_PYR-GCK SYAKFLLGNERTG-----ITQIGRTKLKLAEVKERAKANGLFDDPLFAAR
Mvan_4379|M.vanbaalenii_PYR-1 SYAKFLLGNERTG-----ITQIGRTKLRLSEVKERAKASGLLDDPLFAAR
TH_3063|M.thermoresistible__bu AYAKFLLSNERTG-----IARIGATKLWLSQVKSRAAECSLLDDPLFAAR
MAB_2495|M.abscessus_ATCC_1997 TVAKYLLEFERGGGAVAPMLQVGLDQLSVDARSVPAENGTLADDPVFCAK
MLBr_00737|M.leprae_Br4923 KTALATLDHTRPTIG---AQAVGIAQGALDAAIVYTKDRKQFGESISTFQ
* * * : : : :.
Mb1969c|M.bovis_AF2122/97 LAWCYARVQIMRYRGYRDLTLALTGRPPGAEAAITKVIWSEYFRRYTDLA
Rv1934c|M.tuberculosis_H37Rv LAWCYARVQIMRYRGYRDLTLALTGRPPGAEAAITKVIWSEYFRRYTDLA
MMAR_3737|M.marinum_M LAEAENELLALELTQARVVTDSADG-KPNPASSVLKLRGSQLQQVATELL
MUL_3681|M.ulcerans_Agy99 LAEAENELLALELTQARVVTDSADG-KPNPASSVLKLRGSQLQQVATELL
MAV_1766|M.avium_104 LAEAENELLALELTQSRVTTDSANG-QPNPASSVLKLRGSQLQQVATELL
MSMEG_6511|M.smegmatis_MC2_155 LAEAENDVLALELTQMRVTSDSSDG-KPNPASSVLKLRGTQLQQLATELL
Mflv_2287|M.gilvum_PYR-GCK LAETENDVLALELTQMRVATGSKDG-KPNPASSVLKLRASELQQAATELL
Mvan_4379|M.vanbaalenii_PYR-1 LAETENDVLALELTQMRVASGSKDG-KPNPASSVLKLRASELQQAATELL
TH_3063|M.thermoresistible__bu IAELENDLLALELTQLRVSGSEGEG-KPNPASSILKLRGSQLQQAVTELA
MAB_2495|M.abscessus_ATCC_1997 LADLAIRVDVLEVLEHRVLAVVAGGGNPGAASSMLKILGTELSQALTTLT
MLBr_00737|M.leprae_Br4923 SIQFMLADMAMKVEAARLIVYAAAA-RAERGEPDLGFISAASKCFASDIA
:. * . . . . : : :
Mb1969c|M.bovis_AF2122/97 VEILGLEALGPRG------------PGNGGARLVPEAGTPNSPACWMDEL
Rv1934c|M.tuberculosis_H37Rv VEILGLEALGPRG------------PGNGGARLVPEAGTPNSPACWMDEL
MMAR_3737|M.marinum_M VEVAGPDALPVG-------------GAQAAGIASPQWAQSSAP-----RY
MUL_3681|M.ulcerans_Agy99 VEVAGPDALPVG-------------GAQAAGIASPQWAQSSAP-----RY
MAV_1766|M.avium_104 VEVAGPDALP----------------AKADDIASPSWAQSSAP-----HY
MSMEG_6511|M.smegmatis_MC2_155 VEVAGADALP----------------CEAEGIASPEWAQLTAP-----QY
Mflv_2287|M.gilvum_PYR-GCK VEVAGADALP----------------FGTDSIASADWAQDAAP-----RY
Mvan_4379|M.vanbaalenii_PYR-1 VEVAGADALP----------------FGSHGIASADWAQDAAP-----RY
TH_3063|M.thermoresistible__bu VEVAGTDALP---------------YAAGDDIASPEWAQLAAP-----RY
MAB_2495|M.abscessus_ATCC_1997 LEAAGPRGRAYQPHVTKPGGPVVEYTPPADGYHSGELWQAVAPL----HY
MLBr_00737|M.leprae_Br4923 MEVTTDAVQLFG----------------GAGYTSDFPVERFMR-------
:*
Mb1969c|M.bovis_AF2122/97 LYARAATIYAGSSQIQRNVIGERLLGLPKEPRPEVLC
Rv1934c|M.tuberculosis_H37Rv LYARAATIYAGSSQIQRNVIGERLLGLPKEPRPEVLC
MMAR_3737|M.marinum_M LNYRKTSIYGGSNEVQRNIIASTILGL----------
MUL_3681|M.ulcerans_Agy99 LNYRKTSIYGGSNEVQRNIIASTILGL----------
MAV_1766|M.avium_104 LNYRKTSIYGGSSEVQRNIIASTILGL----------
MSMEG_6511|M.smegmatis_MC2_155 LNYRKTSIYGGSNEVQRTIISSTILGL----------
Mflv_2287|M.gilvum_PYR-GCK LNYRKTSIYGGSNEVQRTIIASTILGL----------
Mvan_4379|M.vanbaalenii_PYR-1 LNYRKTSIYGGSNEVQRTIIASTILGL----------
TH_3063|M.thermoresistible__bu LNYRKTSIYGGTNEVQRTIIASTILGL----------
MAB_2495|M.abscessus_ATCC_1997 FNDRAGSIYAGSNEIQRNILAKAQLGL----------
MLBr_00737|M.leprae_Br4923 -DAKITQIYEGTNQIQRVVMSRALLR-----------
: ** *:.::** ::. *