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VAPGALDGVTVLDLTTVVMGPFATSMLGDLGAEVIKVEALDGDITRRMGPQRNPGMTALTLGLQRNKRSI ALDLKTAEGKEVLARLVRESDVVVSNLRPQSREDLGLSYPALRAIRADVILCTAQAYAEASPQRNEPAYD DMVQAASGLTSLVEAVDGVPRYAPYVIADKVSGLYIVIAVLSALMHRAATGSGQHVEVPMVDAMVHFNLV EHLSGQTFAPPAGDFGWKRVLVPERAPYRTSDGYVCILPYTDANWRGFFTLTGLTDLLTDPRFTDVDKRH QNMGYLHSMISRITPQRSTQEWLDLCRDNDIPAARPLDLTRVTEDPYVMDHGVLQRNSHPTEGDYFSALT PLRMSGSPVSLRRHAPILGAHTAEVLSELGYTDDEITSLSDNAVVVIK
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_3391 | - | - | 100% (398) | L-carnitine dehydratase/bile acid-inducible protein F |
| M. smegmatis MC2 155 | MSMEG_5623 | - | 2e-65 | 35.64% (376) | L-carnitine dehydratase/bile acid-inducible protein F |
| M. smegmatis MC2 155 | MSMEG_6773 | - | 5e-53 | 33.50% (391) | CaiB/BaiF family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3300 | - | 7e-40 | 31.09% (386) | hypothetical protein Mb3300 |
| M. gilvum PYR-GCK | Mflv_1791 | - | 1e-68 | 36.60% (377) | L-carnitine dehydratase/bile acid-inducible protein F |
| M. tuberculosis H37Rv | Rv3272 | - | 4e-40 | 31.09% (386) | hypothetical protein Rv3272 |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_0824 | - | 4e-36 | 29.74% (380) | putative L-carnitine dehydratase |
| M. marinum M | MMAR_0311 | - | 3e-67 | 36.95% (387) | hypothetical protein MMAR_0311 |
| M. avium 104 | MAV_5204 | - | 9e-68 | 37.27% (373) | L-carnitine dehydratase/bile acid-inducible protein F |
| M. thermoresistible (build 8) | TH_3725 | - | 9e-64 | 35.73% (375) | PUTATIVE L-carnitine dehydratase/bile acid-inducible protein F |
| M. ulcerans Agy99 | MUL_4811 | - | 4e-67 | 36.34% (377) | hypothetical protein MUL_4811 |
| M. vanbaalenii PYR-1 | Mvan_4959 | - | 2e-70 | 36.87% (377) | L-carnitine dehydratase/bile acid-inducible protein F |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_1791|M.gilvum_PYR-GCK ----------------MADSGPLAGIRVVDLTAMVMGPYCTQIMADMGAD
Mvan_4959|M.vanbaalenii_PYR-1 ----------------MAENGPLAGIRVVDLTAMVMGPYCTQIMADMGAE
TH_3725|M.thermoresistible__bu -------------------------VRVVDLTAMVMGPYCTQIMADMGAE
MAV_5204|M.avium_104 ----------------------MAGVRVIDLTAMVMGPYCTQIMADMGAD
MMAR_0311|M.marinum_M MSNCGSDCDSSLGAGAGKRTGPLSGVRVVDLTAMVMGPYCTQIMADMGAD
MUL_4811|M.ulcerans_Agy99 -----------MGAGAGNRTGPLSGVRVVDLTAMVMGPYCTQIMADMGAD
MSMEG_3391|M.smegmatis_MC2_155 -----------------MAPGALDGVTVLDLTTVVMGPFATSMLGDLGAE
Mb3300|M.bovis_AF2122/97 -------------MPTSNPAKPLDGFRVLDFTQNVAGPLAGQVLVDLGAE
Rv3272|M.tuberculosis_H37Rv -------------MPTSNPAKPLDGFRVLDFTQNVAGPLAGQVLVDLGAE
MAB_0824|M.abscessus_ATCC_1997 -----------------MTAAALDGLLVVDFSRVLAGPYATMMLGDFGAE
. *:*:: : ** . :: *:**:
Mflv_1791|M.gilvum_PYR-GCK VIKVEPPQGDNTRYISVGP--VSGMSGVFVNVNRGKRSIVLDLRSVEGKA
Mvan_4959|M.vanbaalenii_PYR-1 VIKVEPPEGDNTRFISVGP--VPGMSGVFVNVNRGKRSVVLDLRSDEGRA
TH_3725|M.thermoresistible__bu VIKVEPPAGDNTRFISVGP--RSGMSGVFVNVNRGKRSVVLDLRSEDGAG
MAV_5204|M.avium_104 VIKVEPPQGDNTRYISVGP--APGMSGVFVNVNRGKRSVVLDLQTDAGAR
MMAR_0311|M.marinum_M VIKIEPPQGDDTRYVSVGP--AAGMSGVFVNVNRGKRSAVIDLKSDSGQA
MUL_4811|M.ulcerans_Agy99 VIKIEPPQGDDTRYVSVGP--AAGMSGVFVNVNRGKRSAVIDLKSDSGQA
MSMEG_3391|M.smegmatis_MC2_155 VIKVEALDGDITRRMGPQR--NPGMTALTLGLQRNKRSIALDLKTAEGKE
Mb3300|M.bovis_AF2122/97 VIKVEAPGGEAARQITSVLPGRPPLATYFLPNNRGKKSVTVDLTTEQAKQ
Rv3272|M.tuberculosis_H37Rv VIKVEAPGGEAARQITSVLPGRPPLATYFLPNNRGKKSVTVDLTTEQAKQ
MAB_0824|M.abscessus_ATCC_1997 VIKIERPVLGDDTRQWGPPYDSDGQATYFNSVNRNKQSVVLDLTSPDGQH
***:* : :*.*:* .:** : .
Mflv_1791|M.gilvum_PYR-GCK ALRALIERADVFIHSMRSKAIAKLGFGYDDVAAVNPTIIYTNCYGYGRRG
Mvan_4959|M.vanbaalenii_PYR-1 AVRALVGRADVFIHSMRAKAITKLGLGYDDVAAVNPSIVYTNCYGYGRRG
TH_3725|M.thermoresistible__bu ALRALIARADVFIHSMRAKAIAKLGFGYPDVAAINPAIVYTNCYGYGRRG
MAV_5204|M.avium_104 ALRGLVETADVFIHSMRAKAIARLGFGYDDVAAINPAVVYTNCYGYGRRG
MMAR_0311|M.marinum_M AVRALIEGADVFIHSMRAKAIARLGLSYPEVAAINPAIVYTNCYGYGRRG
MUL_4811|M.ulcerans_Agy99 AVRALIEGADVFIHSMRAKAIARLGLSYPEVAAINPAIVYTNCYGYGRRG
MSMEG_3391|M.smegmatis_MC2_155 VLARLVRESDVVVSNLRPQSREDLGLSYPALRAIRADVILCTAQAYAEAS
Mb3300|M.bovis_AF2122/97 QMLRLADTADVVLEAFRPGTMEKLGLGPDDLRSRNPNLIYARLTAYGGNG
Rv3272|M.tuberculosis_H37Rv QMLRLADTADVVLEAFRPGTMEKLGLGPDDLRSRNPNLIYARLTAYGGNG
MAB_0824|M.abscessus_ATCC_1997 RARELAGRADVVVENFRAGTMEKFGLGYQSLKQLNPGLIYCAITGFG-RG
* :**.: :*. : :*:. : .. :: .:. .
Mflv_1791|M.gilvum_PYR-GCK PERDRPAYDDTIQAECGLPAVQKQLTGEADYVGTIMADKVAGLTALYATM
Mvan_4959|M.vanbaalenii_PYR-1 PERDRPAYDDTIQAECGIPAVQQQLTGEPDYVGTIMADKVAGLTALYATT
TH_3725|M.thermoresistible__bu PDADRPAYDDTIQAECGLPAVQEQLTGEANYVGTIMADKVAGLTALYATM
MAV_5204|M.avium_104 PDRDRPAYDDTIQAECGLPAVQQQLTGQADYVGTIMADKIAGLTALYATT
MMAR_0311|M.marinum_M PNRDLPAYDDTIQAACGLPSVQEQLTGEPSYVGTIMADKVAGLTALYATM
MUL_4811|M.ulcerans_Agy99 PNRDLPAYDDTIQAACGLPSVQEQLTGEPSYVGTIMADKVAGLTALYATM
MSMEG_3391|M.smegmatis_MC2_155 PQRNEPAYDDMVQAASGLTSLVEAVDGVPRYAPYVIADKVSGLYIVIAVL
Mb3300|M.bovis_AF2122/97 PHGSRPGIDLVVAAEAGMTTGMPTPEGKPQIIPFQLVDNASGHVLAQAVL
Rv3272|M.tuberculosis_H37Rv PHGSRPGIDLVVAAEAGMTTGMPTPEGKPQIIPFQLVDNASGHVLAQAVL
MAB_0824|M.abscessus_ATCC_1997 AGADLPGYDLLVQAVGGLMSVTGPDAAHPSKVGVALVDVLTALHALSGIL
. . *. * : * *: : . . :.* :. .
Mflv_1791|M.gilvum_PYR-GCK MALFHRERTGEGQEVEVAMFETMASFMLVEHANGAMFDPPLGPAVYPRT-
Mvan_4959|M.vanbaalenii_PYR-1 MALFHRQRTGEGQEVEVAMFETMASFMLVEHANGAMFDPPLGPAVYPRT-
TH_3725|M.thermoresistible__bu MALFHRERTGEGQEVEVAMFETMASFMLVEHANGAMFDPPLGPAVYPRT-
MAV_5204|M.avium_104 MALFHRERTGQGQEVEVAMFETMASFMLVEHANGALFDPPLGPAVYPRT-
MMAR_0311|M.marinum_M MALFHRERTGQGQEVEIGMFEAVASFMLVEHANGAMFDPPLGPAVYPRT-
MUL_4811|M.ulcerans_Agy99 MALFHRERTGQGQEVEIGMFEAVASFMLVEHANGAMFDPPLGPAVYPRT-
MSMEG_3391|M.smegmatis_MC2_155 SALMHRAATGSGQHVEVPMVDAMVHFNLVEHLSGQTFAPPAGDFGWKRV-
Mb3300|M.bovis_AF2122/97 AALLHRERNGVADVVQVAMYDVAVGLQANQLMMHLNRAASDQPKPEPAPK
Rv3272|M.tuberculosis_H37Rv AALLHRERNGVADVVQVAMYDVAVGLQANQLMMHLNRAASDQPKPEPAPK
MAB_0824|M.abscessus_ATCC_1997 AALSYRDRTGQGQRVDTDLMSVLLSSLVNQASGYLGAGVVPEALGNRHP-
** :* .* .: *: : .. :
Mflv_1791|M.gilvum_PYR-GCK ---------VAPNRRPYRTKDGHIAALIYNDKHWNAFIAAVRPPWASE--
Mvan_4959|M.vanbaalenii_PYR-1 ---------VAPNRRPYRTKDGYIAVLIYNDKHWNAFIDAVQPPWSSD--
TH_3725|M.thermoresistible__bu ---------VAPNRRPYETKDGHIAALIYNDKHWQAFVDAVAPAWYEENR
MAV_5204|M.avium_104 ---------VAPNRRPYRTSDGYIAALIYNDKHWNAFMNAVRPPWASE--
MMAR_0311|M.marinum_M ---------VAPNRRPYRTSDGYLAALIYNDKHWAAFVDAVRPPWASE--
MUL_4811|M.ulcerans_Agy99 ---------VAPNRRPYRTSDGYLAALIYNDKHWAAFVDAVRPPWASE--
MSMEG_3391|M.smegmatis_MC2_155 ---------LVPERAPYRTSDGYVCILPYTDANWRGFFTLTGLTDLLTDP
Mb3300|M.bovis_AF2122/97 AKRRKGVGFATQPSDAFRTADGYIVISAYVPKHWQKLCYLIGRPDLVEDQ
Rv3272|M.tuberculosis_H37Rv AKRRKGVGFATQPSDAFRTADGYIVISAYVPKHWQKLCYLIGRPDLVEDQ
MAB_0824|M.abscessus_ATCC_1997 ---------SIAPYQTFETADRPIAIAVGNDKQFRLLVQALEMPRLARDD
.:.* * : :: : .
Mflv_1791|M.gilvum_PYR-GCK -LYSTLESRAHQIDTVYGLVAETLAERTTEEWLNLFRELEIPAAPLNTPD
Mvan_4959|M.vanbaalenii_PYR-1 -LYSTLEARAHRIDTVYGLVAETLAERTTADWLDLFRELEIPAAPLNTPD
TH_3725|M.thermoresistible__bu TRYATLENRARHIDTVYSLIAETLKERTTDEWLTLFRELEIPAAPINTPD
MAV_5204|M.avium_104 -LYATLEQRAAQIDTVYGLVAETMKERSTAEWLELLGELEIPAAPLNSPG
MMAR_0311|M.marinum_M -QYATLEGRARQIDTVYALLAETFAARTTQEWLDLLEELEIPASALSSPA
MUL_4811|M.ulcerans_Agy99 -QYATLEGRARQIDTVYALLAETFAARTTQEWLDLLEELEIPASALSSPA
MSMEG_3391|M.smegmatis_MC2_155 -RFTDVDKRHQNMGYLHSMISRITPQRSTQEWLDLCRDNDIPAARPLDLT
Mb3300|M.bovis_AF2122/97 -RFAEQRSRSINYAELTAELELALASKTATEWVQLLQANGLMACLAHTWK
Rv3272|M.tuberculosis_H37Rv -RFAEQRSRSINYAELTAELELALASKTATEWVQLLQANGLMACLAHTWK
MAB_0824|M.abscessus_ATCC_1997 -RFATNPLRVRHRGELVRVLEQRLREKNADDWYDTLTAVGVPAGPINDIA
:: * . : : :.: :* : *
Mflv_1791|M.gilvum_PYR-GCK ALFDDPHLNAVGLFETVDTPHGPVKFPG-VPTWFSRTPGKVRGPAPELGA
Mvan_4959|M.vanbaalenii_PYR-1 ALFDDPHLNAVGLFETVDTPHGPVRFPG-VPTWFSRTPGKVRGPAPELGA
TH_3725|M.thermoresistible__bu ALFDNEHLNAVGLFETVDTPHGPVRFPG-VPTWFSRTPGRVGGTAPELGA
MAV_5204|M.avium_104 ALFDDPHLNAVGMFQTVDTPHGPVRFPG-VPTWFSQTPGRVAGPAPELGA
MMAR_0311|M.marinum_M ELFDNQHLNAVGFFETIDTAHGPVRFPG-VPTWFSRTPGRVSGPAPQLGA
MUL_4811|M.ulcerans_Agy99 ELFDNQHLNAVGFFETIDTAHGPVRFPG-VPTWFSRTPGRVLGPAPQLGA
MSMEG_3391|M.smegmatis_MC2_155 RVTEDPYVMDHGVLQRNSHPTEGDYFSALTPLRMSGSPVSLRRHAPILGA
Mb3300|M.bovis_AF2122/97 QVVDTPLFAESDLTLEVGRGADTITVIR-TPARYASFRAVVTDPPPTAGE
Rv3272|M.tuberculosis_H37Rv QVVDTPLFAENDLTLEVGRGADTITVIR-TPARYASFRAVVTDPPPTAGE
MAB_0824|M.abscessus_ATCC_1997 EAFRFAERLGLDVAVTVPGSPE--PQVA-NPISMSKTPVVYRNGPPRLGQ
.. * : .* *
Mflv_1791|M.gilvum_PYR-GCK DTAAVLAELGLDTVAAEQVS--------
Mvan_4959|M.vanbaalenii_PYR-1 DTAAVLDELGLGG---------------
TH_3725|M.thermoresistible__bu DTEAVLAELGLTPQAGREPAQGMS----
MAV_5204|M.avium_104 HTDEVLAEIGAR--EGKEL---------
MMAR_0311|M.marinum_M DTSAVLEELGINAADAQPAGPA------
MUL_4811|M.ulcerans_Agy99 DTSAVLEELGINAADAQPAGPA------
MSMEG_3391|M.smegmatis_MC2_155 HTAEVLSELGYTDDEITSLSDNAVVVIK
Mb3300|M.bovis_AF2122/97 HNAVFLARP-------------------
Rv3272|M.tuberculosis_H37Rv HNAVFLARP-------------------
MAB_0824|M.abscessus_ATCC_1997 SRA-------------------------