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M. gilvum PYR-GCK Mflv_4347 (-)

annotation: acyl-CoA dehydrogenase domain-containing protein
coordinates: 4623026 - 4624063
length: 345

DRYELRRLDYSLSEDHQALQAAYKDLFATRCTIDTVRAAEESGFDKNLWERLCAMGATTMALPESVGGDG
ATLVDLTLVAEEIGRSLAPVPWIDHVVAARLLARLGSVDADVVNGKNLVALDPAPDSAGVRLIPAGSIAD
RLLVRDGDEIVALSFSSRPARVDNIGKLPMAWVDPAAADSRTVLASGAAALAEYQRALDEWQLLTAAALV
GLVEETMTIAAEFSKTRYTLGVPISTLQAISHPLANIAIVVQGGRNLARRAAWFLDNEPDERRELAPSAF
VFMAEEAAKAATMAVHVQGGLGVSAEAAATAYLVRARGWAIAGGDPGVTAKYIAQIVADREGRS*

Operon Prediction Model: Genebank

Paralogs

species id gene e-value identity (len) annotation
M. gilvum PYR-GCK Mflv_4347 - - 100% (345) acyl-CoA dehydrogenase domain-containing protein
M. gilvum PYR-GCK Mflv_1477 - 2e-23 27.44% (317) acyl-CoA dehydrogenase domain-containing protein
M. gilvum PYR-GCK Mflv_2335 - 4e-22 29.28% (345) acyl-CoA dehydrogenase domain-containing protein

Closest Orthologs (e-value cutoff: 1e-4)

species id gene e-value identity (len) annotation
M. bovis AF2122 / 97 Mb3594 fadE33 3e-24 27.71% (314) acyl-CoA dehydrogenase FADE33
M. tuberculosis H37Rv Rv3564 fadE33 3e-24 27.71% (314) acyl-CoA dehydrogenase FADE33
M. leprae Br4923 MLBr_00737 fadE25 6e-09 21.55% (362) putative acyl-CoA dehydrogenase
M. abscessus ATCC 19977 MAB_0593c - 8e-25 27.90% (319) acyl-CoA dehydrogenase FadE
M. marinum M MMAR_4011 - 1e-153 80.06% (346) acyl-CoA dehydrogenase
M. avium 104 MAV_1594 - 1e-164 83.67% (343) putative acyl-CoA dehydrogenase
M. smegmatis MC2 155 MSMEG_2233 - 1e-149 77.68% (345) acyl-CoA dehydrogenase domain-containing protein
M. thermoresistible (build 8) TH_0531 - 4e-65 88.41% (138) acyl-CoA dehydrogenase, C- domain protein
M. ulcerans Agy99 MUL_2176 fadE18_1 4e-23 28.37% (349) acyl-CoA dehydrogenase FadE18_1
M. vanbaalenii PYR-1 Mvan_1997 - 1e-177 90.46% (346) acyl-CoA dehydrogenase domain-containing protein

CLUSTAL 2.0.9 multiple sequence alignment


Mb3594|M.bovis_AF2122/97            ----------MTPP--EERQMLRETVASLVAKHAGPAAVRAAMASDRGYD
Rv3564|M.tuberculosis_H37Rv         ----------MTPP--EERQMLRETVASLVAKHAGPAAVRAAMASDRGYD
MAB_0593c|M.abscessus_ATCC_199      ----------MSPSGNTERQMLRDTVRSLVTKRADSAAVRTAFESERGYD
MUL_2176|M.ulcerans_Agy99           -------MSTGDLLYSDTEEALRASVGQLFAERCPPESVVAAYDSPPADF
Mflv_4347|M.gilvum_PYR-GCK          --MDRYELRRLDYSLSEDHQALQAAYKDLFATRCTIDTVRAAEES--GFD
Mvan_1997|M.vanbaalenii_PYR-1       --MDRYELRRLDYSLSEDHQALQAAYKDFFATRCTIETVRAAEET--GFD
MAV_1594|M.avium_104                --MDRYELRRLDYSLTDDHQALQAAYRDFFTTHCPIETVRAAEET--GFD
MSMEG_2233|M.smegmatis_MC2_155      --MDRYELRRLDYSLSEDHIDLQNAYRQFFKTHCSIEAVRAAEAT--GFD
TH_0531|M.thermoresistible__bu      --------------------------------------------------
MMAR_4011|M.marinum_M               --MNRFELRRLDYSLSEDHLALQSAYRQFLATHCPIETVRAAEPS--GFD
MLBr_00737|M.leprae_Br4923          MVGWSGNPLFDLFKLPEEHNELRATIRALAEKEIAPHAADVDQRAR--FP
                                                                                      

Mb3594|M.bovis_AF2122/97            ESLWRLLCEQVGAAALVIPEELGGAGGELADAAIVVQELGRALVPSPLLG
Rv3564|M.tuberculosis_H37Rv         ESLWRLLCEQVGAAALVIPEELGGAGGELADAAIVVQELGRALVPSPLLG
MAB_0593c|M.abscessus_ATCC_199      ENLWAVLCEQVGAAALLIPEESGGAGGELADAAVVVEELGRGLVPSPLMG
MUL_2176|M.ulcerans_Agy99           AKLWRTLAAELGVAGLLVPESLGGAGASAREAAVVMEEVGRAVAPVPFLS
Mflv_4347|M.gilvum_PYR-GCK          KNLWERLCAMG-ATTMALPESVGGDGATLVDLTLVAEEIGRSLAPVPWID
Mvan_1997|M.vanbaalenii_PYR-1       KNLWERLCAMD-ATTMALPESVGGDGATLVDLTLVAEEIGRSLAPVPWID
MAV_1594|M.avium_104                KNLWERLCAMG-ATSMAVPESAGGDGATLVDLTLVAEEIGRSLAPVPWID
MSMEG_2233|M.smegmatis_MC2_155      KSLWERLCAMG-ATTMALPESVGGDGATLVDLTLVAEEIGRALAPVPWID
TH_0531|M.thermoresistible__bu      --------------------------------------------------
MMAR_4011|M.marinum_M               KNLWERLCAMG-ATTMAVPESAGGDGATLVDLTLVAEEIGRALAPVPWID
MLBr_00737|M.leprae_Br4923          EEALAALNASG-FNAIHVPEEYGGQGADSVAACIVIEEVARVDASASLIP
                                                                                      

Mb3594|M.bovis_AF2122/97            -T-----------------TLAELALLAAAKPDAQALTELAQGSAIGALV
Rv3564|M.tuberculosis_H37Rv         -T-----------------TLAELALLAAAKPDAQALTELAQGSAIGALV
MAB_0593c|M.abscessus_ATCC_199      -T-----------------LWAELALLEAG-YEGELLEALAAGESIGAVA
MUL_2176|M.ulcerans_Agy99           SA-----------------VLATVALLHSG--ETETLSELAQGELTAALV
Mflv_4347|M.gilvum_PYR-GCK          -------------------HVVAARLLARLGSVDA---DVVNGKNLVALD
Mvan_1997|M.vanbaalenii_PYR-1       -------------------HICAARLLARLGSVEA---DVVNGRQIVALD
MAV_1594|M.avium_104                -------------------QVCTARLLARLGAVEP---DVVHGKRLAGFD
MSMEG_2233|M.smegmatis_MC2_155      -------------------HVVAARLLDRLGALPPR-SEILDGTHLVGFD
TH_0531|M.thermoresistible__bu      --------------------------------------------------
MMAR_4011|M.marinum_M               -------------------HVCAARLLARLGTEDAETAAVTEGKRVAGLD
MLBr_00737|M.leprae_Br4923          AVNKLGTMGLILRGSEELKKQVLPSLAAEGAMASYALSEREAGSDAASMR
                                                                                      

Mb3594|M.bovis_AF2122/97            LDPDYVVN----------------------GDIADIVVAATS--------
Rv3564|M.tuberculosis_H37Rv         LDPDYVVN----------------------GDIADIVVAATS--------
MAB_0593c|M.abscessus_ATCC_199      FDPGYVVN----------------------GDIADVVLTVQG--------
MUL_2176|M.ulcerans_Agy99           VPLATAPGDPVAGASRGSAGLSGRVCGVAGAREADVLVVPVAG-ADGVEL
Mflv_4347|M.gilvum_PYR-GCK          PAPD-SAGVRLIP----------------AGSIADRLLVRDGDEIVALSF
Mvan_1997|M.vanbaalenii_PYR-1       PLQDNVSGVRLIP----------------AGSVADHIIVRDGDDVVLLSF
MAV_1594|M.avium_104                PQHDSLSGPRLIP----------------TGSIADAIIVRDGDDVVALSF
MSMEG_2233|M.smegmatis_MC2_155      AQQVPPTGSRLIG----------------SASIADHIVIRDGDDVVQLSF
TH_0531|M.thermoresistible__bu      --------------------------------------------------
MMAR_4011|M.marinum_M               ARIDSGYGTRLIP----------------TGSIADHIVVRDGDAIVLLSF
MLBr_00737|M.leprae_Br4923          TRAKADGDDWILNGFKCWITNGGKSTWYTVMAVTDPDKGANGISAFIVHK
                                                                                      

Mb3594|M.bovis_AF2122/97            -GQLTRWTRFS-AQPVATMDPTRRLARLQSEETEPLCPDPG--------I
Rv3564|M.tuberculosis_H37Rv         -GQLTRWTRFS-AQPVATMDPTRRLARLQSEETEPLCPDPG--------I
MAB_0593c|M.abscessus_ATCC_199      -ETVCRAGQVT-ALALSTLDPTRRLASIAVGAAEPVGTAPG--------L
MUL_2176|M.ulcerans_Agy99           HTVRANAPGVE-IVPLLAFDMTRPLADVVFSGAASAPVGLGSAEAALAEA
Mflv_4347|M.gilvum_PYR-GCK          SSRPARVDNIG-KLPMAWVDPAAADSRTVLASGAAALAEYQR-------A
Mvan_1997|M.vanbaalenii_PYR-1       STRPVRVDNIG-KLPMAWVDPAAADSRTVLASGAQASAEYQL-------A
MAV_1594|M.avium_104                GTRPAKVDNIG-RLPMAWVDPAAADTRTVLAGGSDALAEYQR-------A
MSMEG_2233|M.smegmatis_MC2_155      STRPTKVDNIG-KLPMAWVDPAAADHRVVLGSGPQALAHHQR-------A
TH_0531|M.thermoresistible__bu      --------------------------------------------------
MMAR_4011|M.marinum_M               SSRPARVDNIG-RLPMAWIDPGTADLRSVLAQGPDALANYQR-------A
MLBr_00737|M.leprae_Br4923          DDEGFSIGPKEKKLGIKGSPTTELYFDKCRIPGDRIIGEPGTGFKTALAT
                                                                                      

Mb3594|M.bovis_AF2122/97            ADTAAILLAAEQIGAAERCLQLTVEYAKSRVQFGRPIGSFQALKHRMADL
Rv3564|M.tuberculosis_H37Rv         ADTAAILLAAEQIGAAERCLQLTVEYAKSRVQFGRPIGSFQALKHRMADL
MAB_0593c|M.abscessus_ATCC_199      IDKAGLLLAAEQVGAAARALDLTVEYTKTRVQFGRAIGSFQALKHRMADL
MUL_2176|M.ulcerans_Agy99           LQTGAALLASEQLGIAQWCFDTTLAYTKQRKQFGRAIGSYQAIKHRLADL
Mflv_4347|M.gilvum_PYR-GCK          LDEWQLLTAAALVGLVEETMTIAAEFSKTRYTLGVPISTLQAISHPLANI
Mvan_1997|M.vanbaalenii_PYR-1       LDEWRLLTGAALVGLVEETMTIAAEFSKTRYTLGVPISTLQAISHPLANI
MAV_1594|M.avium_104                LDEWRVLTAAALVGLVEETMTIAAEFAKTRYTLGVPISTLQGISHPLANI
MSMEG_2233|M.smegmatis_MC2_155      LDEWRLLTAAALVGLVEETMTIAAEFAKTRYTLGVPISTLQAISHPLANM
TH_0531|M.thermoresistible__bu      ------LTAAALVGLVEETMTIAAEFAKTRYTLGVPISTLQAISHPLANM
MMAR_4011|M.marinum_M               LDEWRLLSAAALVGLVEATMEIAAEFAKTRYTLGVPISTLQAISHPLANM
MLBr_00737|M.leprae_Br4923          LDHTRPTIGAQAVGIAQGALDAAIVYTKDRKQFGESISTFQSIQFMLADM
                                            .:  :* .   :  :  ::* *  :* .*.: *.:.. :*::

Mb3594|M.bovis_AF2122/97            YVTIAAARAVVADACHAPTPTN------AATARLAASEALSTAAAEGIQL
Rv3564|M.tuberculosis_H37Rv         YVTIAAARAVVADACHAPTPTN------AATARLAASEALSTAAAEGIQL
MAB_0593c|M.abscessus_ATCC_199      YVLVESARATVYQAIHDLTPEG------ATVARIKASEALSAVSGDSIQL
MUL_2176|M.ulcerans_Agy99           WLEVGSARAAARYGADTCARGDEDAAIAAAIAAAYCGDVAVHAAEECVQL
Mflv_4347|M.gilvum_PYR-GCK          AIVVQGGRNLARRAAWFLDNEPDERRELAPSAFVFMAEEAAKAATMAVHV
Mvan_1997|M.vanbaalenii_PYR-1       AITVQGGRNLARRAAWFLDNEPGERRELAPSVFVFMAEEAAKAATMAVHV
MAV_1594|M.avium_104                AITVQGGRNLARRAAWFLDNEPDERPELAPSAFVFMAEEAAKAATMAVHV
MSMEG_2233|M.smegmatis_MC2_155      AITVCSGRGLSHRAAWFLDNEPDERPELAPSAFVFMAEEAAKAATMAVHI
TH_0531|M.thermoresistible__bu      AIVVQGGRNLARRAAWFLDNEPDERPELAPSAFVFMAEEAPRHATMAVHI
MMAR_4011|M.marinum_M               AITVQGGRNLARRAAWFLDNEPEARPELGLSAFVFMAEEAAKAATMAVHI
MLBr_00737|M.leprae_Br4923          AMKVEAARLIVYAAAARAERGEPDLGFISAASKCFASDIAMEVTTDAVQL
                                     : : ..*     .              .       .:     :   :::

Mb3594|M.bovis_AF2122/97            HGGIAITWEHDMHLYFKRAHGSAQLLESPREVLRRLESEVWESP------
Rv3564|M.tuberculosis_H37Rv         HGGIAITWEHDMHLYFKRAHGSAQLLESPREVLRRLESEVWESP------
MAB_0593c|M.abscessus_ATCC_199      HGGIAITWEHDAHLYFKRAHGSALLLGTPRQLLPNLETAAGL--------
MUL_2176|M.ulcerans_Agy99           HGGIGMTWEYPAHLYLKRAKSDQLALGTAYRHRGRLAKLVNLPVS-----
Mflv_4347|M.gilvum_PYR-GCK          QGGLGVSAEAAATAYLVRARGWAIAGGDPGVTAKYIAQIVADRE-GRS--
Mvan_1997|M.vanbaalenii_PYR-1       QGGLGVSAEAAATAYLVRARGWAVAGGDPGVTAKYIAQIVADRE-GRS--
MAV_1594|M.avium_104                QGGLGVSAEAAATAYLVRARGWALAGGDPGASAKYIGELVAARESGKGA-
MSMEG_2233|M.smegmatis_MC2_155      QGGLGVSAEAAATAYLVRARGWPLAGGDPGATAVHIADIVATREAAQV--
TH_0531|M.thermoresistible__bu      QGGLGVSSEAAATAYLVRARGWPLAAGDPGATAKHIAHLVAERESAHV--
MMAR_4011|M.marinum_M               QGGLGVSAEAAATAYLVRARGWALAGGDPGVTARRIAEIVAGRESSEQTA
MLBr_00737|M.leprae_Br4923          FGGAGYTSDFPVERFMRDAKITQIYEGTNQIQRVVMSRALLR--------
                                     ** . : :     ::  *:               :              

Mb3594|M.bovis_AF2122/97            --
Rv3564|M.tuberculosis_H37Rv         --
MAB_0593c|M.abscessus_ATCC_199      --
MUL_2176|M.ulcerans_Agy99           --
Mflv_4347|M.gilvum_PYR-GCK          --
Mvan_1997|M.vanbaalenii_PYR-1       --
MAV_1594|M.avium_104                --
MSMEG_2233|M.smegmatis_MC2_155      --
TH_0531|M.thermoresistible__bu      --
MMAR_4011|M.marinum_M               GV
MLBr_00737|M.leprae_Br4923          --

species	id	gene	e-value	identity (len)	annotation
M. gilvum PYR-GCK	Mflv_4347	-	-	100% (345)	acyl-CoA dehydrogenase domain-containing protein
M. gilvum PYR-GCK	Mflv_1477	-	2e-23	27.44% (317)	acyl-CoA dehydrogenase domain-containing protein
M. gilvum PYR-GCK	Mflv_2335	-	4e-22	29.28% (345)	acyl-CoA dehydrogenase domain-containing protein