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VDRYELRRLDYSLSEDHQALQAAYKDFFATRCTIETVRAAEETGFDKNLWERLCAMDATTMALPESVGGD GATLVDLTLVAEEIGRSLAPVPWIDHICAARLLARLGSVEADVVNGRQIVALDPLQDNVSGVRLIPAGSV ADHIIVRDGDDVVLLSFSTRPVRVDNIGKLPMAWVDPAAADSRTVLASGAQASAEYQLALDEWRLLTGAA LVGLVEETMTIAAEFSKTRYTLGVPISTLQAISHPLANIAITVQGGRNLARRAAWFLDNEPGERRELAPS VFVFMAEEAAKAATMAVHVQGGLGVSAEAAATAYLVRARGWAVAGGDPGVTAKYIAQIVADREGRS
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_1997 | - | - | 100% (346) | acyl-CoA dehydrogenase domain-containing protein |
| M. vanbaalenii PYR-1 | Mvan_5289 | - | 4e-22 | 27.22% (327) | acyl-CoA dehydrogenase domain-containing protein |
| M. vanbaalenii PYR-1 | Mvan_0393 | - | 1e-21 | 27.61% (373) | acyl-CoA dehydrogenase domain-containing protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3594 | fadE33 | 3e-22 | 25.72% (311) | acyl-CoA dehydrogenase FADE33 |
| M. gilvum PYR-GCK | Mflv_4347 | - | 1e-177 | 90.46% (346) | acyl-CoA dehydrogenase domain-containing protein |
| M. tuberculosis H37Rv | Rv3564 | fadE33 | 3e-22 | 25.72% (311) | acyl-CoA dehydrogenase FADE33 |
| M. leprae Br4923 | MLBr_00737 | fadE25 | 8e-09 | 22.71% (361) | putative acyl-CoA dehydrogenase |
| M. abscessus ATCC 19977 | MAB_4159 | - | 6e-23 | 25.96% (366) | acyl-CoA dehydrogenase |
| M. marinum M | MMAR_4011 | - | 1e-153 | 78.32% (346) | acyl-CoA dehydrogenase |
| M. avium 104 | MAV_1594 | - | 1e-165 | 83.67% (343) | putative acyl-CoA dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_2233 | - | 1e-151 | 78.26% (345) | acyl-CoA dehydrogenase domain-containing protein |
| M. thermoresistible (build 8) | TH_0531 | - | 8e-63 | 85.51% (138) | acyl-CoA dehydrogenase, C- domain protein |
| M. ulcerans Agy99 | MUL_4068 | fadE27 | 1e-22 | 28.65% (363) | acyl-CoA dehydrogenase FadE27 |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3594|M.bovis_AF2122/97 ------------MTPPEERQMLRETVASLVAKHAGPAAVRAAMASDRGYD
Rv3564|M.tuberculosis_H37Rv ------------MTPPEERQMLRETVASLVAKHAGPAAVRAAMASDRGYD
Mvan_1997|M.vanbaalenii_PYR-1 --MDRYELRRLDYSLSEDHQALQAAYKDFFATRCTIETVRAAEET--GFD
Mflv_4347|M.gilvum_PYR-GCK --MDRYELRRLDYSLSEDHQALQAAYKDLFATRCTIDTVRAAEES--GFD
MAV_1594|M.avium_104 --MDRYELRRLDYSLTDDHQALQAAYRDFFTTHCPIETVRAAEET--GFD
MSMEG_2233|M.smegmatis_MC2_155 --MDRYELRRLDYSLSEDHIDLQNAYRQFFKTHCSIEAVRAAEAT--GFD
TH_0531|M.thermoresistible__bu --------------------------------------------------
MMAR_4011|M.marinum_M --MNRFELRRLDYSLSEDHLALQSAYRQFLATHCPIETVRAAEPS--GFD
MAB_4159|M.abscessus_ATCC_1997 ----------MDFSLTEAQTDLAGLTRTIASTISTPERQKELDKQDSRFD
MUL_4068|M.ulcerans_Agy99 ----------MDFSTTEAAQDLGGLVATIVDAVCTPEHQRQLDGLEQRFD
MLBr_00737|M.leprae_Br4923 MVGWSGNPLFDLFKLPEEHNELRATIRALAEKEIAPHAADVDQRA--RFP
Mb3594|M.bovis_AF2122/97 ESLWRLLCEQVGAAALVIPEELGGAGGELADAAIVVQELGRALVPSPLLG
Rv3564|M.tuberculosis_H37Rv ESLWRLLCEQVGAAALVIPEELGGAGGELADAAIVVQELGRALVPSPLLG
Mvan_1997|M.vanbaalenii_PYR-1 KNLWERLCAMD-ATTMALPESVGGDGATLVDLTLVAEEIGRSLAPVPWID
Mflv_4347|M.gilvum_PYR-GCK KNLWERLCAMG-ATTMALPESVGGDGATLVDLTLVAEEIGRSLAPVPWID
MAV_1594|M.avium_104 KNLWERLCAMG-ATSMAVPESAGGDGATLVDLTLVAEEIGRSLAPVPWID
MSMEG_2233|M.smegmatis_MC2_155 KSLWERLCAMG-ATTMALPESVGGDGATLVDLTLVAEEIGRALAPVPWID
TH_0531|M.thermoresistible__bu --------------------------------------------------
MMAR_4011|M.marinum_M KNLWERLCAMG-ATTMAVPESAGGDGATLVDLTLVAEEIGRALAPVPWID
MAB_4159|M.abscessus_ATCC_1997 RQLWTKLAEAD-ILSTAAPESVGGAGFGVLEQSSILVELGRELAAVPYLE
MUL_4068|M.ulcerans_Agy99 RELWRKLIDSD-ILSSAAATQVGGDGFGVLEQVAILVALGHQLAAVPYLE
MLBr_00737|M.leprae_Br4923 EEALAALNASG-FNAIHVPEEYGGQGADSVAACIVIEEVARVDASASLIP
Mb3594|M.bovis_AF2122/97 TTLAEL-ALLAAAKPDA-----------------QALTELAQGSA-----
Rv3564|M.tuberculosis_H37Rv TTLAEL-ALLAAAKPDA-----------------QALTELAQGSA-----
Mvan_1997|M.vanbaalenii_PYR-1 HICAAR-LLARLGSVEA------DVVNGRQIVALDPLQDNVSGVR-----
Mflv_4347|M.gilvum_PYR-GCK HVVAAR-LLARLGSVDA------DVVNGKNLVALDPAPD-SAGVR-----
MAV_1594|M.avium_104 QVCTAR-LLARLGAVEP------DVVHGKRLAGFDPQHDSLSGPR-----
MSMEG_2233|M.smegmatis_MC2_155 HVVAAR-LLDRLGALPPR----SEILDGTHLVGFDAQQVPPTGSR-----
TH_0531|M.thermoresistible__bu --------------------------------------------------
MMAR_4011|M.marinum_M HVCAAR-LLARLGTEDAET---AAVTEGKRVAGLDARIDSGYGTR-----
MAB_4159|M.abscessus_ATCC_1997 SVVLAAGALAAFGSEAMRNDWAAPAVAGKKVLTIALEGEPGEGPVAART-
MUL_4068|M.ulcerans_Agy99 SVVLAAGALARFGSEELQQSWGAAAVGGEKILAVALDAEMGEGPVQAAR-
MLBr_00737|M.leprae_Br4923 AVNKLGTMGLILRGSEELKKQVLPSLAAEGAMASYALSEREAGSDAASMR
Mb3594|M.bovis_AF2122/97 -----------------IGALVLDPDYVVNGDIAD---------IVVAAT
Rv3564|M.tuberculosis_H37Rv -----------------IGALVLDPDYVVNGDIAD---------IVVAAT
Mvan_1997|M.vanbaalenii_PYR-1 -----------------LIPAGSVADHIIVRDGDD---------VVLLSF
Mflv_4347|M.gilvum_PYR-GCK -----------------LIPAGSIADRLLVRDGDE---------IVALSF
MAV_1594|M.avium_104 -----------------LIPTGSIADAIIVRDGDD---------VVALSF
MSMEG_2233|M.smegmatis_MC2_155 -----------------LIGSASIADHIVIRDGDD---------VVQLSF
TH_0531|M.thermoresistible__bu --------------------------------------------------
MMAR_4011|M.marinum_M -----------------LIPTGSIADHIVVRDGDA---------IVLLSF
MAB_4159|M.abscessus_ATCC_1997 -----EGTGYVLTGNRVLVPFGVEADAYLVPAETET-----GTAVFLVSA
MUL_4068|M.ulcerans_Agy99 -----SGAGFRLTGTRTQVGYGPVADAFLVPAETDS-----GTVVFLVAA
MLBr_00737|M.leprae_Br4923 TRAKADGDDWILNGFKCWITNGGKSTWYTVMAVTDPDKGANGISAFIVHK
Mb3594|M.bovis_AF2122/97 SGQLTRWTRFS--------AQPVATMDPTRRLAR-LQSEETEPLCPDPGI
Rv3564|M.tuberculosis_H37Rv SGQLTRWTRFS--------AQPVATMDPTRRLAR-LQSEETEPLCPDPGI
Mvan_1997|M.vanbaalenii_PYR-1 STRPVRVDNIG--------KLPMAWVDPAAADSRTVLASGAQASAEYQLA
Mflv_4347|M.gilvum_PYR-GCK SSRPARVDNIG--------KLPMAWVDPAAADSRTVLASGAAALAEYQRA
MAV_1594|M.avium_104 GTRPAKVDNIG--------RLPMAWVDPAAADTRTVLAGGSDALAEYQRA
MSMEG_2233|M.smegmatis_MC2_155 STRPTKVDNIG--------KLPMAWVDPAAADHRVVLGSGPQALAHHQRA
TH_0531|M.thermoresistible__bu --------------------------------------------------
MMAR_4011|M.marinum_M SSRPARVDNIG--------RLPMAWIDPGTADLRSVLAQGPDALANYQRA
MAB_4159|M.abscessus_ATCC_1997 DDAGVTQQALH--------TTGKDSSAELILSEVPVPAERKVGGAEVVEW
MUL_4068|M.ulcerans_Agy99 DDPGVSVTALQ--------TTGLGSVGHLALDGTEVDAARGIGGSDVTAW
MLBr_00737|M.leprae_Br4923 DDEGFSIGPKEKKLGIKGSPTTELYFDKCRIPGDRIIGEPGTGFKTALAT
Mb3594|M.bovis_AF2122/97 ADTAAIL-LAAEQIGAAERCLQLTVEYAKSRVQFGRPIGSFQALKHRMAD
Rv3564|M.tuberculosis_H37Rv ADTAAIL-LAAEQIGAAERCLQLTVEYAKSRVQFGRPIGSFQALKHRMAD
Mvan_1997|M.vanbaalenii_PYR-1 LDEWRLL-TGAALVGLVEETMTIAAEFSKTRYTLGVPISTLQAISHPLAN
Mflv_4347|M.gilvum_PYR-GCK LDEWQLL-TAAALVGLVEETMTIAAEFSKTRYTLGVPISTLQAISHPLAN
MAV_1594|M.avium_104 LDEWRVL-TAAALVGLVEETMTIAAEFAKTRYTLGVPISTLQGISHPLAN
MSMEG_2233|M.smegmatis_MC2_155 LDEWRLL-TAAALVGLVEETMTIAAEFAKTRYTLGVPISTLQAISHPLAN
TH_0531|M.thermoresistible__bu ------L-TAAALVGLVEETMTIAAEFAKTRYTLGVPISTLQAISHPLAN
MMAR_4011|M.marinum_M LDEWRLL-SAAALVGLVEATMEIAAEFAKTRYTLGVPISTLQAISHPLAN
MAB_4159|M.abscessus_ATCC_1997 LRLRESLGHSAYQLGVLERALELTADYARTREQFGKPIGGFQAVAQRLAD
MUL_4068|M.ulcerans_Agy99 LRTINTLGRSAFQLGVLERGLQMTAEYARTREQFDRPIGSFQAVGQRLAD
MLBr_00737|M.leprae_Br4923 LDHTRPT-IGAQAVGIAQGALDAAIVYTKDRKQFGESISTFQSIQFMLAD
.* :* : : : ::: * :. .*. :*.: :*:
Mb3594|M.bovis_AF2122/97 LYVTIAAAR------AVVADACHAPTPTNAATARLAASEALSTAAAEGIQ
Rv3564|M.tuberculosis_H37Rv LYVTIAAAR------AVVADACHAPTPTNAATARLAASEALSTAAAEGIQ
Mvan_1997|M.vanbaalenii_PYR-1 IAITVQGGRNLARRAAWFLDNEPGERRELAPSVFVFMAEEAAKAATMAVH
Mflv_4347|M.gilvum_PYR-GCK IAIVVQGGRNLARRAAWFLDNEPDERRELAPSAFVFMAEEAAKAATMAVH
MAV_1594|M.avium_104 IAITVQGGRNLARRAAWFLDNEPDERPELAPSAFVFMAEEAAKAATMAVH
MSMEG_2233|M.smegmatis_MC2_155 MAITVCSGRGLSHRAAWFLDNEPDERPELAPSAFVFMAEEAAKAATMAVH
TH_0531|M.thermoresistible__bu MAIVVQGGRNLARRAAWFLDNEPDERPELAPSAFVFMAEEAPRHATMAVH
MMAR_4011|M.marinum_M MAITVQGGRNLARRAAWFLDNEPEARPELGLSAFVFMAEEAAKAATMAVH
MAB_4159|M.abscessus_ATCC_1997 GYIDVKGLCLTLWQAAWRVSEDLPSDVDVAT-AKFWAADAGHRVAHTAVH
MUL_4068|M.ulcerans_Agy99 GYIDVKGLRLTLTQAAWRVSEDLPAEIDVAS-AGFCAAEAGHRVAHTIVH
MLBr_00737|M.leprae_Br4923 MAMKVEAARLIVYAAAARAERGEPDLGFISAASKCFASDIAMEVTTDAVQ
: : . * . . :: : ::
Mb3594|M.bovis_AF2122/97 LHGGIAITWEHDMHLYFKRAHGSAQLLESPREVLRRLESEVWESP-----
Rv3564|M.tuberculosis_H37Rv LHGGIAITWEHDMHLYFKRAHGSAQLLESPREVLRRLESEVWESP-----
Mvan_1997|M.vanbaalenii_PYR-1 VQGGLGVSAEAAATAYLVRARGWAVAGGDPGVTAKYIAQIVADRE-GRS-
Mflv_4347|M.gilvum_PYR-GCK VQGGLGVSAEAAATAYLVRARGWAIAGGDPGVTAKYIAQIVADRE-GRS-
MAV_1594|M.avium_104 VQGGLGVSAEAAATAYLVRARGWALAGGDPGASAKYIGELVAARESGKGA
MSMEG_2233|M.smegmatis_MC2_155 IQGGLGVSAEAAATAYLVRARGWPLAGGDPGATAVHIADIVATREAAQV-
TH_0531|M.thermoresistible__bu IQGGLGVSSEAAATAYLVRARGWPLAAGDPGATAKHIAHLVAERESAHV-
MMAR_4011|M.marinum_M IQGGLGVSAEAAATAYLVRARGWALAGGDPGVTARRIAEIVAGRESSEQT
MAB_4159|M.abscessus_ATCC_1997 VHGGVGIDEDHPVHRYFLAAKRGEFASGSATEQLRRIGRELADTPA----
MUL_4068|M.ulcerans_Agy99 VHGGVGVDTDHPVHRYFLAAKEAEFALGGATTALRQIGRELAETPA----
MLBr_00737|M.leprae_Br4923 LFGGAGYTSDFPVERFMRDAKITQIYEGTNQIQRVVMSRALLR-------
: ** . : :: *: : :
Mb3594|M.bovis_AF2122/97 ---
Rv3564|M.tuberculosis_H37Rv ---
Mvan_1997|M.vanbaalenii_PYR-1 ---
Mflv_4347|M.gilvum_PYR-GCK ---
MAV_1594|M.avium_104 ---
MSMEG_2233|M.smegmatis_MC2_155 ---
TH_0531|M.thermoresistible__bu ---
MMAR_4011|M.marinum_M AGV
MAB_4159|M.abscessus_ATCC_1997 ---
MUL_4068|M.ulcerans_Agy99 ---
MLBr_00737|M.leprae_Br4923 ---