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MDRYELRRLDYSLSEDHIDLQNAYRQFFKTHCSIEAVRAAEATGFDKSLWERLCAMGATTMALPESVGGD GATLVDLTLVAEEIGRALAPVPWIDHVVAARLLDRLGALPPRSEILDGTHLVGFDAQQVPPTGSRLIGSA SIADHIVIRDGDDVVQLSFSTRPTKVDNIGKLPMAWVDPAAADHRVVLGSGPQALAHHQRALDEWRLLTA AALVGLVEETMTIAAEFAKTRYTLGVPISTLQAISHPLANMAITVCSGRGLSHRAAWFLDNEPDERPELA PSAFVFMAEEAAKAATMAVHIQGGLGVSAEAAATAYLVRARGWPLAGGDPGATAVHIADIVATREAAQV
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_2233 | - | - | 100% (349) | acyl-CoA dehydrogenase domain-containing protein |
| M. smegmatis MC2 155 | MSMEG_6016 | - | 7e-27 | 28.48% (323) | putative acyl-CoA dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_6585 | - | 2e-21 | 26.70% (367) | acyl-CoA dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3594 | fadE33 | 3e-26 | 28.94% (311) | acyl-CoA dehydrogenase FADE33 |
| M. gilvum PYR-GCK | Mflv_4347 | - | 1e-149 | 77.68% (345) | acyl-CoA dehydrogenase domain-containing protein |
| M. tuberculosis H37Rv | Rv3564 | fadE33 | 3e-26 | 28.94% (311) | acyl-CoA dehydrogenase FADE33 |
| M. leprae Br4923 | MLBr_00737 | fadE25 | 4e-09 | 22.16% (361) | putative acyl-CoA dehydrogenase |
| M. abscessus ATCC 19977 | MAB_3123 | - | 5e-22 | 26.84% (354) | putative acyl-CoA dehydrogenase |
| M. marinum M | MMAR_4011 | - | 1e-149 | 76.79% (349) | acyl-CoA dehydrogenase |
| M. avium 104 | MAV_1594 | - | 1e-154 | 78.45% (348) | putative acyl-CoA dehydrogenase |
| M. thermoresistible (build 8) | TH_0531 | - | 2e-65 | 88.03% (142) | acyl-CoA dehydrogenase, C- domain protein |
| M. ulcerans Agy99 | MUL_4129 | fadE33 | 1e-23 | 27.27% (319) | acyl-CoA dehydrogenase FadE33 |
| M. vanbaalenii PYR-1 | Mvan_1997 | - | 1e-151 | 78.26% (345) | acyl-CoA dehydrogenase domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3594|M.bovis_AF2122/97 ---------------------------------MTPPEERQMLRETVASL
Rv3564|M.tuberculosis_H37Rv ---------------------------------MTPPEERQMLRETVASL
MUL_4129|M.ulcerans_Agy99 ---------------------------------MT--EEREMLRETVAAL
MAB_3123|M.abscessus_ATCC_1997 MSASEDHQTRMSASEDNQTRMSASEDNQAQINEFEFTEEHGDLRSLVRSW
MSMEG_2233|M.smegmatis_MC2_155 -----------------------MDRYELRRLDYSLSEDHIDLQNAYRQF
TH_0531|M.thermoresistible__bu --------------------------------------------------
Mflv_4347|M.gilvum_PYR-GCK -----------------------MDRYELRRLDYSLSEDHQALQAAYKDL
Mvan_1997|M.vanbaalenii_PYR-1 -----------------------MDRYELRRLDYSLSEDHQALQAAYKDF
MAV_1594|M.avium_104 -----------------------MDRYELRRLDYSLTDDHQALQAAYRDF
MMAR_4011|M.marinum_M -----------------------MNRFELRRLDYSLSEDHLALQSAYRQF
MLBr_00737|M.leprae_Br4923 ---------------------MVGWSGNPLFDLFKLPEEHNELRATIRAL
Mb3594|M.bovis_AF2122/97 VAKHAGPAAVRAAMASDRGYDESLWRLLCEQVGAAALVIPEELGGAGGEL
Rv3564|M.tuberculosis_H37Rv VAKHAGPAAVRAAMASDRGYDESLWRLLCEQVGAAALVIPEELGGAGGEL
MUL_4129|M.ulcerans_Agy99 VNKHASPAAVRSAMESERGYDETLWRLLCEQVGAAALVIPEELGGAGGEL
MAB_3123|M.abscessus_ATCC_1997 CERVWTPKHVRQIAEAG-SVDLDAWRALGSELGVVGLSLPEQHGGGGLGV
MSMEG_2233|M.smegmatis_MC2_155 FKTHCSIEAVRAAEATG--FDKSLWERLCA-MGATTMALPESVGGDGATL
TH_0531|M.thermoresistible__bu --------------------------------------------------
Mflv_4347|M.gilvum_PYR-GCK FATRCTIDTVRAAEESG--FDKNLWERLCA-MGATTMALPESVGGDGATL
Mvan_1997|M.vanbaalenii_PYR-1 FATRCTIETVRAAEETG--FDKNLWERLCA-MDATTMALPESVGGDGATL
MAV_1594|M.avium_104 FTTHCPIETVRAAEETG--FDKNLWERLCA-MGATSMAVPESAGGDGATL
MMAR_4011|M.marinum_M LATHCPIETVRAAEPSG--FDKNLWERLCA-MGATTMAVPESAGGDGATL
MLBr_00737|M.leprae_Br4923 AEKEIAPHAADVDQRAR--FPEEALAALNA-SGFNAIHVPEEYGGQGADS
Mb3594|M.bovis_AF2122/97 ADAAIVVQELGRALVPSPLLG-----------------TTLAELALLAAA
Rv3564|M.tuberculosis_H37Rv ADAAIVVQELGRALVPSPLLG-----------------TTLAELALLAAA
MUL_4129|M.ulcerans_Agy99 ADAAIVLQELGRALVPSPLLG-----------------TTLAELALLAAA
MAB_3123|M.abscessus_ATCC_1997 IELSIVAEELGRALACLPWISSAALGATA--LVSSGDDSALAEWVPALAA
MSMEG_2233|M.smegmatis_MC2_155 VDLTLVAEEIGRALAPVPWID---------------HVVAARLLDRLGAL
TH_0531|M.thermoresistible__bu --------------------------------------------------
Mflv_4347|M.gilvum_PYR-GCK VDLTLVAEEIGRSLAPVPWID---------------HVVAARLLARLGSV
Mvan_1997|M.vanbaalenii_PYR-1 VDLTLVAEEIGRSLAPVPWID---------------HICAARLLARLGSV
MAV_1594|M.avium_104 VDLTLVAEEIGRSLAPVPWID---------------QVCTARLLARLGAV
MMAR_4011|M.marinum_M VDLTLVAEEIGRALAPVPWID---------------HVCAARLLARLGTE
MLBr_00737|M.leprae_Br4923 VAACIVIEEVARVDASASLIPAVNKLGTMGLILRGSEELKKQVLPSLAAE
Mb3594|M.bovis_AF2122/97 KPDAQALTE----LAQGSAIG----------ALVLDPDYVVNGDIADIVV
Rv3564|M.tuberculosis_H37Rv KPDAQALTE----LAQGSAIG----------ALVLDPDYVVNGDIADIVV
MUL_4129|M.ulcerans_Agy99 EPDAKTLAG----LAEGSSIG----------ALVLDPDYVLNGDTADVVV
MAB_3123|M.abscessus_ATCC_1997 GEKTITLAGGRTRLADAITVSA--ESDTDGWKLTGDTEHVPDGATADVIL
MSMEG_2233|M.smegmatis_MC2_155 PPR-SEILDGTHLVGFDAQQVP--PTGSRLIGSASIADHIVIRDGDDVVQ
TH_0531|M.thermoresistible__bu --------------------------------------------------
Mflv_4347|M.gilvum_PYR-GCK DA---DVVNGKNLVALDPAPD---SAGVRLIPAGSIADRLLVRDGDEIVA
Mvan_1997|M.vanbaalenii_PYR-1 EA---DVVNGRQIVALDPLQDN--VSGVRLIPAGSVADHIIVRDGDDVVL
MAV_1594|M.avium_104 EP---DVVHGKRLAGFDPQHDS--LSGPRLIPTGSIADAIIVRDGDDVVA
MMAR_4011|M.marinum_M DAETAAVTEGKRVAGLDARIDS--GYGTRLIPTGSIADHIVVRDGDAIVL
MLBr_00737|M.leprae_Br4923 GAMASYALSEREAGSDAASMRTRAKADGDDWILNGFKCWITNGGKSTWYT
Mb3594|M.bovis_AF2122/97 AATSGQLTR--------WTRFSAQPVATMD-----------------PTR
Rv3564|M.tuberculosis_H37Rv AATSGQLTR--------WTRFSAQPVATMD-----------------PTR
MUL_4129|M.ulcerans_Agy99 ASTEGQLSR--------WTRFSAHRVATMD-----------------PTR
MAB_3123|M.abscessus_ATCC_1997 VLADTDSGPSLFAVDGDAPGVDRHSLATLD-----------------MTR
MSMEG_2233|M.smegmatis_MC2_155 LSFSTRPTK--------VDNIGKLPMAWVD-----------------PAA
TH_0531|M.thermoresistible__bu --------------------------------------------------
Mflv_4347|M.gilvum_PYR-GCK LSFSSRPAR--------VDNIGKLPMAWVD-----------------PAA
Mvan_1997|M.vanbaalenii_PYR-1 LSFSTRPVR--------VDNIGKLPMAWVD-----------------PAA
MAV_1594|M.avium_104 LSFGTRPAK--------VDNIGRLPMAWVD-----------------PAA
MMAR_4011|M.marinum_M LSFSSRPAR--------VDNIGRLPMAWID-----------------PGT
MLBr_00737|M.leprae_Br4923 VMAVTDPDKG-------ANGISAFIVHKDDEGFSIGPKEKKLGIKGSPTT
Mb3594|M.bovis_AF2122/97 RLARLQS-EETEPLCPDPG--------IADTAAILLAAEQIGAAERCLQL
Rv3564|M.tuberculosis_H37Rv RLARLQS-EETEPLCPDPG--------IADTAAILLAAEQIGAAERCLQL
MUL_4129|M.ulcerans_Agy99 RLAQLRA-EETAFLGENPG--------LADAAGILLAAEQIGAAERCLEL
MAB_3123|M.abscessus_ATCC_1997 RQANIHFNSAPARLIGAQGRGAEAVATALDVAATVLAAEQAGIAAHMLDV
MSMEG_2233|M.smegmatis_MC2_155 ADHRVVLGSGPQALAHHQR--------ALDEWRLLTAAALVGLVEETMTI
TH_0531|M.thermoresistible__bu ----------------------------------LTAAALVGLVEETMTI
Mflv_4347|M.gilvum_PYR-GCK ADSRTVLASGAAALAEYQR--------ALDEWQLLTAAALVGLVEETMTI
Mvan_1997|M.vanbaalenii_PYR-1 ADSRTVLASGAQASAEYQL--------ALDEWRLLTGAALVGLVEETMTI
MAV_1594|M.avium_104 ADTRTVLAGGSDALAEYQR--------ALDEWRVLTAAALVGLVEETMTI
MMAR_4011|M.marinum_M ADLRSVLAQGPDALANYQR--------ALDEWRLLSAAALVGLVEATMEI
MLBr_00737|M.leprae_Br4923 ELYFDKCRIPGDRIIGEPGTGFKTALATLDHTRPTIGAQAVGIAQGALDA
.* * . :
Mb3594|M.bovis_AF2122/97 TVEYAKSRVQFGRPIGSFQALKHRMADLYVTIAAARAVVADACHAPTP--
Rv3564|M.tuberculosis_H37Rv TVEYAKSRVQFGRPIGSFQALKHRMADLYVTIAAARAVVADACHAPTP--
MUL_4129|M.ulcerans_Agy99 TVEYAKSRVQFGRPIGSFQALKHRMADLYVEVAAARAVVTEACTAPTP--
MAB_3123|M.abscessus_ATCC_1997 TTEYAKSRIQFGRIIGSFQAVKHRLADMAAATGNVRGAAYHAAWSHDHPS
MSMEG_2233|M.smegmatis_MC2_155 AAEFAKTRYTLGVPISTLQAISHPLANMAITVCSGRGLSHRAAWFLDNEP
TH_0531|M.thermoresistible__bu AAEFAKTRYTLGVPISTLQAISHPLANMAIVVQGGRNLARRAAWFLDNEP
Mflv_4347|M.gilvum_PYR-GCK AAEFSKTRYTLGVPISTLQAISHPLANIAIVVQGGRNLARRAAWFLDNEP
Mvan_1997|M.vanbaalenii_PYR-1 AAEFSKTRYTLGVPISTLQAISHPLANIAITVQGGRNLARRAAWFLDNEP
MAV_1594|M.avium_104 AAEFAKTRYTLGVPISTLQGISHPLANIAITVQGGRNLARRAAWFLDNEP
MMAR_4011|M.marinum_M AAEFAKTRYTLGVPISTLQAISHPLANMAITVQGGRNLARRAAWFLDNEP
MLBr_00737|M.leprae_Br4923 AIVYTKDRKQFGESISTFQSIQFMLADMAMKVEAARLIVYAAAARAERGE
: ::* * :* *.::*.:.. :*:: * *.
Mb3594|M.bovis_AF2122/97 -----TNAATARLAASEALSTAAAEGIQLHGGIAITWEHDMHLYFKRAHG
Rv3564|M.tuberculosis_H37Rv -----TNAATARLAASEALSTAAAEGIQLHGGIAITWEHDMHLYFKRAHG
MUL_4129|M.ulcerans_Agy99 -----TSAATARLAACEALCAVAAEGIQLHGGIAITWEHDMHLYFKRAHG
MAB_3123|M.abscessus_ATCC_1997 LDDPALATSIAQQVASAGAVEVTAKAIQSHGGIGFTWEHPAHLYYKRAVS
MSMEG_2233|M.smegmatis_MC2_155 -DERPELAPSAFVFMAEEAAKAATMAVHIQGGLGVSAEAAATAYLVRARG
TH_0531|M.thermoresistible__bu -DERPELAPSAFVFMAEEAPRHATMAVHIQGGLGVSSEAAATAYLVRARG
Mflv_4347|M.gilvum_PYR-GCK -DERRELAPSAFVFMAEEAAKAATMAVHVQGGLGVSAEAAATAYLVRARG
Mvan_1997|M.vanbaalenii_PYR-1 -GERRELAPSVFVFMAEEAAKAATMAVHVQGGLGVSAEAAATAYLVRARG
MAV_1594|M.avium_104 -DERPELAPSAFVFMAEEAAKAATMAVHVQGGLGVSAEAAATAYLVRARG
MMAR_4011|M.marinum_M -EARPELGLSAFVFMAEEAAKAATMAVHIQGGLGVSAEAAATAYLVRARG
MLBr_00737|M.leprae_Br4923 -PDLGFISAASKCFASDIAMEVTTDAVQLFGGAGYTSDFPVERFMRDAKI
. :: .:: ** . : : : *
Mb3594|M.bovis_AF2122/97 SAQLLESPREVLRRLESEVWES-P-------
Rv3564|M.tuberculosis_H37Rv SAQLLESPREVLRRLESEVWES-P-------
MUL_4129|M.ulcerans_Agy99 STHLLASPPELLRRLESEALGAGPSIP----
MAB_3123|M.abscessus_ATCC_1997 NSALFGGRAVHAERIAKEVIDA---------
MSMEG_2233|M.smegmatis_MC2_155 WPLAGGDPGATAVHIADIVATREAAQV----
TH_0531|M.thermoresistible__bu WPLAAGDPGATAKHIAHLVAERESAHV----
Mflv_4347|M.gilvum_PYR-GCK WAIAGGDPGVTAKYIAQIVADRE-GRS----
Mvan_1997|M.vanbaalenii_PYR-1 WAVAGGDPGVTAKYIAQIVADRE-GRS----
MAV_1594|M.avium_104 WALAGGDPGASAKYIGELVAARESGKGA---
MMAR_4011|M.marinum_M WALAGGDPGVTARRIAEIVAGRESSEQTAGV
MLBr_00737|M.leprae_Br4923 TQIYEGTNQIQRVVMSRALLR----------
: