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NRFELRRLDYSLSEDHLALQSAYRQFLATHCPIETVRAAEPSGFDKNLWERLCAMGATTMAVPESAGGDG ATLVDLTLVAEEIGRALAPVPWIDHVCAARLLARLGTEDAETAAVTEGKRVAGLDARIDSGYGTRLIPTG SIADHIVVRDGDAIVLLSFSSRPARVDNIGRLPMAWIDPGTADLRSVLAQGPDALANYQRALDEWRLLSA AALVGLVEATMEIAAEFAKTRYTLGVPISTLQAISHPLANMAITVQGGRNLARRAAWFLDNEPEARPELG LSAFVFMAEEAAKAATMAVHIQGGLGVSAEAAATAYLVRARGWALAGGDPGVTARRIAEIVAGRESSEQT AGV*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_4011 | - | - | 100% (354) | acyl-CoA dehydrogenase |
| M. marinum M | MMAR_5053 | fadE33 | 1e-24 | 26.79% (336) | acyl-CoA dehydrogenase FadE33 |
| M. marinum M | MMAR_1954 | fadE18_1 | 3e-23 | 29.64% (361) | acyl-CoA dehydrogenase FadE18_1 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3594 | fadE33 | 2e-27 | 28.35% (328) | acyl-CoA dehydrogenase FADE33 |
| M. gilvum PYR-GCK | Mflv_4347 | - | 1e-153 | 80.06% (346) | acyl-CoA dehydrogenase domain-containing protein |
| M. tuberculosis H37Rv | Rv3564 | fadE33 | 2e-27 | 28.35% (328) | acyl-CoA dehydrogenase FADE33 |
| M. leprae Br4923 | MLBr_00737 | fadE25 | 2e-07 | 28.46% (123) | putative acyl-CoA dehydrogenase |
| M. abscessus ATCC 19977 | MAB_0593c | - | 1e-27 | 27.62% (315) | acyl-CoA dehydrogenase FadE |
| M. avium 104 | MAV_1594 | - | 1e-158 | 80.23% (349) | putative acyl-CoA dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_2233 | - | 1e-149 | 76.79% (349) | acyl-CoA dehydrogenase domain-containing protein |
| M. thermoresistible (build 8) | TH_0531 | - | 9e-62 | 85.00% (140) | acyl-CoA dehydrogenase, C- domain protein |
| M. ulcerans Agy99 | MUL_4129 | fadE33 | 7e-25 | 26.79% (336) | acyl-CoA dehydrogenase FadE33 |
| M. vanbaalenii PYR-1 | Mvan_1997 | - | 1e-153 | 78.32% (346) | acyl-CoA dehydrogenase domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3594|M.bovis_AF2122/97 ----------MTPP--EERQMLRETVASLVAKHAGPAAVRAAMASDRGYD
Rv3564|M.tuberculosis_H37Rv ----------MTPP--EERQMLRETVASLVAKHAGPAAVRAAMASDRGYD
MUL_4129|M.ulcerans_Agy99 ----------MT----EEREMLRETVAALVNKHASPAAVRSAMESERGYD
MAB_0593c|M.abscessus_ATCC_199 ----------MSPSGNTERQMLRDTVRSLVTKRADSAAVRTAFESERGYD
MSMEG_2233|M.smegmatis_MC2_155 --MDRYELRRLDYSLSEDHIDLQNAYRQFFKTHCSIEAVRAAEAT--GFD
TH_0531|M.thermoresistible__bu --------------------------------------------------
Mflv_4347|M.gilvum_PYR-GCK --MDRYELRRLDYSLSEDHQALQAAYKDLFATRCTIDTVRAAEES--GFD
Mvan_1997|M.vanbaalenii_PYR-1 --MDRYELRRLDYSLSEDHQALQAAYKDFFATRCTIETVRAAEET--GFD
MAV_1594|M.avium_104 --MDRYELRRLDYSLTDDHQALQAAYRDFFTTHCPIETVRAAEET--GFD
MMAR_4011|M.marinum_M --MNRFELRRLDYSLSEDHLALQSAYRQFLATHCPIETVRAAEPS--GFD
MLBr_00737|M.leprae_Br4923 MVGWSGNPLFDLFKLPEEHNELRATIRALAEKEIAPHAADVDQRAR--FP
Mb3594|M.bovis_AF2122/97 ESLWRLLCEQVGAAALVIPEELGGAGGELADAAIVVQELGRALVPSPLLG
Rv3564|M.tuberculosis_H37Rv ESLWRLLCEQVGAAALVIPEELGGAGGELADAAIVVQELGRALVPSPLLG
MUL_4129|M.ulcerans_Agy99 ETLWRLLCEQVGAAALVIPEELGGAGGELADAAIVLQELGRALVPSPLLG
MAB_0593c|M.abscessus_ATCC_199 ENLWAVLCEQVGAAALLIPEESGGAGGELADAAVVVEELGRGLVPSPLMG
MSMEG_2233|M.smegmatis_MC2_155 KSLWERLCAMG-ATTMALPESVGGDGATLVDLTLVAEEIGRALAPVPWID
TH_0531|M.thermoresistible__bu --------------------------------------------------
Mflv_4347|M.gilvum_PYR-GCK KNLWERLCAMG-ATTMALPESVGGDGATLVDLTLVAEEIGRSLAPVPWID
Mvan_1997|M.vanbaalenii_PYR-1 KNLWERLCAMD-ATTMALPESVGGDGATLVDLTLVAEEIGRSLAPVPWID
MAV_1594|M.avium_104 KNLWERLCAMG-ATSMAVPESAGGDGATLVDLTLVAEEIGRSLAPVPWID
MMAR_4011|M.marinum_M KNLWERLCAMG-ATTMAVPESAGGDGATLVDLTLVAEEIGRALAPVPWID
MLBr_00737|M.leprae_Br4923 EEALAALNASG-FNAIHVPEEYGGQGADSVAACIVIEEVARVDASASLIP
Mb3594|M.bovis_AF2122/97 TT----LAELALLAAAKPDAQALTELAQ--------------GSAIGALV
Rv3564|M.tuberculosis_H37Rv TT----LAELALLAAAKPDAQALTELAQ--------------GSAIGALV
MUL_4129|M.ulcerans_Agy99 TT----LAELALLAAAEPDAKTLAGLAE--------------GSSIGALV
MAB_0593c|M.abscessus_ATCC_199 TL----WAELALLEAGY-EGELLEALAA--------------GESIGAVA
MSMEG_2233|M.smegmatis_MC2_155 HV----VAARLLDRLGALPPR-SEILDGTHLVGFDAQQVPPTGSRLIGSA
TH_0531|M.thermoresistible__bu --------------------------------------------------
Mflv_4347|M.gilvum_PYR-GCK HV----VAARLLARLGSVDA---DVVNGKNLVALDPAPD-SAGVRLIPAG
Mvan_1997|M.vanbaalenii_PYR-1 HI----CAARLLARLGSVEA---DVVNGRQIVALDPLQDNVSGVRLIPAG
MAV_1594|M.avium_104 QV----CTARLLARLGAVEP---DVVHGKRLAGFDPQHDSLSGPRLIPTG
MMAR_4011|M.marinum_M HV----CAARLLARLGTEDAETAAVTEGKRVAGLDARIDSGYGTRLIPTG
MLBr_00737|M.leprae_Br4923 AVNKLGTMGLILRGSEELKKQVLPSLAAEGAMASYALSEREAGSDAASMR
Mb3594|M.bovis_AF2122/97 LDPDY-------------VVNGDIADIVVAATSGQLTRWTR---------
Rv3564|M.tuberculosis_H37Rv LDPDY-------------VVNGDIADIVVAATSGQLTRWTR---------
MUL_4129|M.ulcerans_Agy99 LDPDY-------------VLNGDTADVVVASTEGQLSRWTR---------
MAB_0593c|M.abscessus_ATCC_199 FDPGY-------------VVNGDIADVVLTVQGETVCRAGQ---------
MSMEG_2233|M.smegmatis_MC2_155 SIADH-------------IVIRDGDDVVQLSFSTRPTKVDN---------
TH_0531|M.thermoresistible__bu --------------------------------------------------
Mflv_4347|M.gilvum_PYR-GCK SIADR-------------LLVRDGDEIVALSFSSRPARVDN---------
Mvan_1997|M.vanbaalenii_PYR-1 SVADH-------------IIVRDGDDVVLLSFSTRPVRVDN---------
MAV_1594|M.avium_104 SIADA-------------IIVRDGDDVVALSFGTRPAKVDN---------
MMAR_4011|M.marinum_M SIADH-------------IVVRDGDAIVLLSFSSRPARVDN---------
MLBr_00737|M.leprae_Br4923 TRAKADGDDWILNGFKCWITNGGKSTWYTVMAVTDPDKGANGISAFIVHK
Mb3594|M.bovis_AF2122/97 -----------------FSAQPVATMDPTRR-LARLQSEETEPLCPDPGI
Rv3564|M.tuberculosis_H37Rv -----------------FSAQPVATMDPTRR-LARLQSEETEPLCPDPGI
MUL_4129|M.ulcerans_Agy99 -----------------FSAHRVATMDPTRR-LAQLRAEETAFLGENPGL
MAB_0593c|M.abscessus_ATCC_199 -----------------VTALALSTLDPTRR-LASIAVGAAEPVGTAPGL
MSMEG_2233|M.smegmatis_MC2_155 -----------------IGKLPMAWVDPAAADHRVVLGSGPQALAHHQRA
TH_0531|M.thermoresistible__bu --------------------------------------------------
Mflv_4347|M.gilvum_PYR-GCK -----------------IGKLPMAWVDPAAADSRTVLASGAAALAEYQRA
Mvan_1997|M.vanbaalenii_PYR-1 -----------------IGKLPMAWVDPAAADSRTVLASGAQASAEYQLA
MAV_1594|M.avium_104 -----------------IGRLPMAWVDPAAADTRTVLAGGSDALAEYQRA
MMAR_4011|M.marinum_M -----------------IGRLPMAWIDPGTADLRSVLAQGPDALANYQRA
MLBr_00737|M.leprae_Br4923 DDEGFSIGPKEKKLGIKGSPTTELYFDKCRIPGDRIIGEPGTGFKTALAT
Mb3594|M.bovis_AF2122/97 ADTAAILLAAEQIGAAERCLQLTVEYAKSRVQFGRPIGSFQALKHRMADL
Rv3564|M.tuberculosis_H37Rv ADTAAILLAAEQIGAAERCLQLTVEYAKSRVQFGRPIGSFQALKHRMADL
MUL_4129|M.ulcerans_Agy99 ADAAGILLAAEQIGAAERCLELTVEYAKSRVQFGRPIGSFQALKHRMADL
MAB_0593c|M.abscessus_ATCC_199 IDKAGLLLAAEQVGAAARALDLTVEYTKTRVQFGRAIGSFQALKHRMADL
MSMEG_2233|M.smegmatis_MC2_155 LDEWRLLTAAALVGLVEETMTIAAEFAKTRYTLGVPISTLQAISHPLANM
TH_0531|M.thermoresistible__bu ------LTAAALVGLVEETMTIAAEFAKTRYTLGVPISTLQAISHPLANM
Mflv_4347|M.gilvum_PYR-GCK LDEWQLLTAAALVGLVEETMTIAAEFSKTRYTLGVPISTLQAISHPLANI
Mvan_1997|M.vanbaalenii_PYR-1 LDEWRLLTGAALVGLVEETMTIAAEFSKTRYTLGVPISTLQAISHPLANI
MAV_1594|M.avium_104 LDEWRVLTAAALVGLVEETMTIAAEFAKTRYTLGVPISTLQGISHPLANI
MMAR_4011|M.marinum_M LDEWRLLSAAALVGLVEATMEIAAEFAKTRYTLGVPISTLQAISHPLANM
MLBr_00737|M.leprae_Br4923 LDHTRPTIGAQAVGIAQGALDAAIVYTKDRKQFGESISTFQSIQFMLADM
.* :* . : : ::* * :* .*.::*.:.. :*::
Mb3594|M.bovis_AF2122/97 YVTIAAARAVVADACHAP------TPTNAATARLAASEALSTAAAEGIQL
Rv3564|M.tuberculosis_H37Rv YVTIAAARAVVADACHAP------TPTNAATARLAASEALSTAAAEGIQL
MUL_4129|M.ulcerans_Agy99 YVEVAAARAVVTEACTAP------TPTSAATARLAACEALCAVAAEGIQL
MAB_0593c|M.abscessus_ATCC_199 YVLVESARATVYQAIHDL------TPEGATVARIKASEALSAVSGDSIQL
MSMEG_2233|M.smegmatis_MC2_155 AITVCSGRGLSHRAAWFLDNEPDERPELAPSAFVFMAEEAAKAATMAVHI
TH_0531|M.thermoresistible__bu AIVVQGGRNLARRAAWFLDNEPDERPELAPSAFVFMAEEAPRHATMAVHI
Mflv_4347|M.gilvum_PYR-GCK AIVVQGGRNLARRAAWFLDNEPDERRELAPSAFVFMAEEAAKAATMAVHV
Mvan_1997|M.vanbaalenii_PYR-1 AITVQGGRNLARRAAWFLDNEPGERRELAPSVFVFMAEEAAKAATMAVHV
MAV_1594|M.avium_104 AITVQGGRNLARRAAWFLDNEPDERPELAPSAFVFMAEEAAKAATMAVHV
MMAR_4011|M.marinum_M AITVQGGRNLARRAAWFLDNEPEARPELGLSAFVFMAEEAAKAATMAVHI
MLBr_00737|M.leprae_Br4923 AMKVEAARLIVYAAAARAERGEPDLGFISAASKCFASDIAMEVTTDAVQL
: : ..* * . .: : .:::
Mb3594|M.bovis_AF2122/97 HGGIAITWEHDMHLYFKRAHGSAQLLESPREVLRRLESEVWES-P-----
Rv3564|M.tuberculosis_H37Rv HGGIAITWEHDMHLYFKRAHGSAQLLESPREVLRRLESEVWES-P-----
MUL_4129|M.ulcerans_Agy99 HGGIAITWEHDMHLYFKRAHGSTHLLASPPELLRRLESEALGAGPSIP--
MAB_0593c|M.abscessus_ATCC_199 HGGIAITWEHDAHLYFKRAHGSALLLGTPRQLLPNLETAAGL--------
MSMEG_2233|M.smegmatis_MC2_155 QGGLGVSAEAAATAYLVRARGWPLAGGDPGATAVHIADIVATREAAQV--
TH_0531|M.thermoresistible__bu QGGLGVSSEAAATAYLVRARGWPLAAGDPGATAKHIAHLVAERESAHV--
Mflv_4347|M.gilvum_PYR-GCK QGGLGVSAEAAATAYLVRARGWAIAGGDPGVTAKYIAQIVADRE-GRS--
Mvan_1997|M.vanbaalenii_PYR-1 QGGLGVSAEAAATAYLVRARGWAVAGGDPGVTAKYIAQIVADRE-GRS--
MAV_1594|M.avium_104 QGGLGVSAEAAATAYLVRARGWALAGGDPGASAKYIGELVAARESGKGA-
MMAR_4011|M.marinum_M QGGLGVSAEAAATAYLVRARGWALAGGDPGVTARRIAEIVAGRESSEQTA
MLBr_00737|M.leprae_Br4923 FGGAGYTSDFPVERFMRDAKITQIYEGTNQIQRVVMSRALLR--------
** . : : :: *: :
Mb3594|M.bovis_AF2122/97 --
Rv3564|M.tuberculosis_H37Rv --
MUL_4129|M.ulcerans_Agy99 --
MAB_0593c|M.abscessus_ATCC_199 --
MSMEG_2233|M.smegmatis_MC2_155 --
TH_0531|M.thermoresistible__bu --
Mflv_4347|M.gilvum_PYR-GCK --
Mvan_1997|M.vanbaalenii_PYR-1 --
MAV_1594|M.avium_104 --
MMAR_4011|M.marinum_M GV
MLBr_00737|M.leprae_Br4923 --