For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
EISGKKAVVIGGASGMGRATAELLAKRGADVAILDREGSDGKSVAEAIGAAFYPVDVTDFAGTEEILQTA VDRLGGLHVIVTTAGGGIAKRTLTKSGPHDLESFRSVVDLNLIATFNISRLAAAHMANNEPEDDERGVII NTASIAAFEGQIGQVAYTAAKAGIAGMCLTMARDLGSMGIRVLAIAPSLFLTGLTAMVPDEMAAQLVKDA AFPKRMGRPEEYAKLVAAIVDNPMLNGQCLRLDAGQRFAPK*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. ulcerans Agy99 | MUL_3412 | - | - | 100% (252) | short-chain type dehydrogenase/reductase |
| M. ulcerans Agy99 | MUL_0987 | - | 4e-59 | 49.03% (257) | short-chain type dehydrogenase/reductase |
| M. ulcerans Agy99 | MUL_3898 | fabG | 2e-28 | 36.61% (224) | 3-ketoacyl-(acyl-carrier-protein) reductase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1176 | - | 2e-59 | 49.21% (254) | short-chain type dehydrogenase/reductase |
| M. gilvum PYR-GCK | Mflv_4319 | - | 1e-107 | 74.90% (255) | short-chain dehydrogenase/reductase SDR |
| M. tuberculosis H37Rv | Rv1144 | - | 2e-59 | 49.21% (254) | short-chain type dehydrogenase/reductase |
| M. leprae Br4923 | MLBr_02565 | fabG | 6e-17 | 30.00% (200) | 3-ketoacyl-(acyl-carrier-protein) reductase |
| M. abscessus ATCC 19977 | MAB_0368 | - | 6e-53 | 43.85% (260) | Short-chain dehydrogenase/reductas |
| M. marinum M | MMAR_1624 | - | 1e-138 | 100.00% (252) | short-chain type dehydrogenase/reductase |
| M. avium 104 | MAV_3936 | - | 1e-125 | 88.49% (252) | 3-hydroxyacyl-CoA dehydrogenase type-2 |
| M. smegmatis MC2 155 | MSMEG_2279 | - | 1e-105 | 73.33% (255) | 3-hydroxyacyl-CoA dehydrogenase type-2 |
| M. thermoresistible (build 8) | TH_3183 | - | 1e-110 | 78.82% (255) | PUTATIVE short-chain dehydrogenase/reductase SDR |
| M. vanbaalenii PYR-1 | Mvan_2027 | - | 1e-108 | 76.47% (255) | short-chain dehydrogenase/reductase SDR |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1176|M.bovis_AF2122/97 --------------------------------------------------
Rv1144|M.tuberculosis_H37Rv --------------------------------------------------
MAB_0368|M.abscessus_ATCC_1997 --------------------------------------------------
MUL_3412|M.ulcerans_Agy99 --------------------------------------------------
MMAR_1624|M.marinum_M --------------------------------------------------
MAV_3936|M.avium_104 --------------------------------------------------
Mflv_4319|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_2027|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_3183|M.thermoresistible__bu --------------------------------------------------
MSMEG_2279|M.smegmatis_MC2_155 --------------------------------------------------
MLBr_02565|M.leprae_Br4923 MAPKCSSDLFSQIVSSGPGSFVAKQLGVPRPETLRRYRPSDAPLCGSLLI
Mb1176|M.bovis_AF2122/97 --------------------------------------------------
Rv1144|M.tuberculosis_H37Rv --------------------------------------------------
MAB_0368|M.abscessus_ATCC_1997 --------------------------------------------------
MUL_3412|M.ulcerans_Agy99 --------------------------------------------------
MMAR_1624|M.marinum_M --------------------------------------------------
MAV_3936|M.avium_104 --------------------------------------------------
Mflv_4319|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_2027|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_3183|M.thermoresistible__bu --------------------------------------------------
MSMEG_2279|M.smegmatis_MC2_155 --------------------------------------------------
MLBr_02565|M.leprae_Br4923 GGDGRLVEPLRATLEKDYDLVSNNLGGRWTDSFGGLVFDATGITAPAELK
Mb1176|M.bovis_AF2122/97 --------------------------------------------------
Rv1144|M.tuberculosis_H37Rv --------------------------------------------------
MAB_0368|M.abscessus_ATCC_1997 --------------------------------------------------
MUL_3412|M.ulcerans_Agy99 --------------------------------------------------
MMAR_1624|M.marinum_M --------------------------------------------------
MAV_3936|M.avium_104 --------------------------------------------------
Mflv_4319|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_2027|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_3183|M.thermoresistible__bu --------------------------------------------------
MSMEG_2279|M.smegmatis_MC2_155 --------------------------------------------------
MLBr_02565|M.leprae_Br4923 GLHNFFTPLLRNLGRCARVVVIGTTPDATTSTDERIAQRALEGFSRSLGK
Mb1176|M.bovis_AF2122/97 --------------------------------------------------
Rv1144|M.tuberculosis_H37Rv --------------------------------------------------
MAB_0368|M.abscessus_ATCC_1997 --------------------------------------------------
MUL_3412|M.ulcerans_Agy99 --------------------------------------------------
MMAR_1624|M.marinum_M --------------------------------------------------
MAV_3936|M.avium_104 --------------------------------------------------
Mflv_4319|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_2027|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_3183|M.thermoresistible__bu --------------------------------------------------
MSMEG_2279|M.smegmatis_MC2_155 --------------------------------------------------
MLBr_02565|M.leprae_Br4923 ELRRGATVALVYLSPDAKPAATGLESTMRFILSAKSAYVNGQVFYVGAAD
Mb1176|M.bovis_AF2122/97 --------MKTKDAVAVVTGGASGLGLATTKRLLDAGAQVVVVDLR----
Rv1144|M.tuberculosis_H37Rv --------MKTKDAVAVVTGGASGLGLATTKRLLDAGAQVVVVDLR----
MAB_0368|M.abscessus_ATCC_1997 --------MDINGVSAIVTGGASGLGAATARLLAAQGAKVVIADVQD--E
MUL_3412|M.ulcerans_Agy99 --------MEISGKKAVVIGGASGMGRATAELLAKRGADVAILDREG--S
MMAR_1624|M.marinum_M --------MEISGKKAVVIGGASGMGRATAELLAKRGADVAILDREG--S
MAV_3936|M.avium_104 --------MEINGKKAVVVGGASGMGRASAELFAARGADVAILDRES--S
Mflv_4319|M.gilvum_PYR-GCK --------MEIEGKKAIIVGGASGFGRATAEALAKRGATVAVLDRPQ--S
Mvan_2027|M.vanbaalenii_PYR-1 --------MEIEGKKAVVVGGASGFGRATAEALAKRGASVAVLDRPQ--S
TH_3183|M.thermoresistible__bu --------MEIEGKKAVVVGGASGFGRATAEALAKRGASVAVLDRPQ--S
MSMEG_2279|M.smegmatis_MC2_155 --------MEIEGKKAVIVGGASGFGRATAEALAKRGATVAVLDRPQ--S
MLBr_02565|M.leprae_Br4923 STPPTNWDRPLENKVAIVTGAARGIGAAIAEVVARDGARVVAIDVESAAE
.. *:: *.* *:* * :. . ** *. *
Mb1176|M.bovis_AF2122/97 -GDDVVGGLGDRARFAQADVTDEAAVSNALELADS-LGPVRVVVNCAGTG
Rv1144|M.tuberculosis_H37Rv -GDDVVGGLGDRARFAQADVTDEAAVSNALELADS-LGPVRVVVNCAGTG
MAB_0368|M.abscessus_ATCC_1997 KGEALAKELGG--AFVHTDVTSEADGIAAVDAAKE-LGPVRVLINCAGVG
MUL_3412|M.ulcerans_Agy99 DGKSVAEAIGA--AFYPVDVTDFAGTEEILQTAVDRLGGLHVIVTTAGGG
MMAR_1624|M.marinum_M DGKSVAEAIGA--AFYPVDVTDFAGTEEILQTAVDRLGGLHVIVTTAGGG
MAV_3936|M.avium_104 DGKAVAEGIGA--AFYPVDVTDFAGTEETLQSAVDKLGGLHVIVTTAGGG
Mflv_4319|M.gilvum_PYR-GCK KGKEVADQIGG--TFYEVDITDFEGTESVLNKVVEDLGGLHIAVTTAGGG
Mvan_2027|M.vanbaalenii_PYR-1 KGKEVADQIGG--SFFEVDITDFEGTESVLNQAVEALGGLHIAVTTAGGG
TH_3183|M.thermoresistible__bu KGKEVAEQIGG--SFFDVDVTDFDGTEKVLQQAVDALGGLHIAVTTAGGG
MSMEG_2279|M.smegmatis_MC2_155 KGQEVADSIGG--SFFAVDVTDFDGTEKVLQEAVDALGGLHIAVTTAGGG
MLBr_02565|M.leprae_Br4923 ALDETANRVGG--TTLSLDVTADDAVDKITEHLHDYQGGHADILVNNAGI
. . :* *:* : . * : .
Mb1176|M.bovis_AF2122/97 NAIRVLSRDGVFP----LAAFRKIVDINLVGTFNVLRLGAERIAKTEPIG
Rv1144|M.tuberculosis_H37Rv NAIRVLSRDGVFP----LAAFRKIVDINLVGTFNVLRLGAERIAKTEPIG
MAB_0368|M.abscessus_ATCC_1997 WPGRTIGKDGQYASAHSLDIFSKVIGINLIGSFNLIRLAATAISQEEPVD
MUL_3412|M.ulcerans_Agy99 IAKRTLTKSGPHD----LESFRSVVDLNLIATFNISRLAAAHMANNEPED
MMAR_1624|M.marinum_M IAKRTLTKSGPHD----LESFRSVVDLNLIATFNISRLAAAHMANNEPED
MAV_3936|M.avium_104 IAKRTLTKNGPHD----LESFQSVIDLNLIATFNISRLAAAHMAKNEPED
Mflv_4319|M.gilvum_PYR-GCK IAERTVKKDGPHS----LDSFRKSIDLNLIGTFNISRIAAWHMSKNEPVD
Mvan_2027|M.vanbaalenii_PYR-1 IAERTVKKDGPHS----LESFRKSIDLNLIGTFNISRLAAWHMSKNDPVD
TH_3183|M.thermoresistible__bu IAERTVKKDGPHS----LESFRQSVDLNLIGTFNISRLAAWHMSKNEPVD
MSMEG_2279|M.smegmatis_MC2_155 IGERTVKKDGPHS----LDSFRSTIDLNLIGTFNVSRLAAWHMSKNDPVD
MLBr_02565|M.leprae_Br4923 TRDKLLANMDDCR-------WDAVLEVNLLAPQRLTEGLVGNGSIS----
: : . . : : :**:.. .: . . :
Mb1176|M.bovis_AF2122/97 E---ERGVIINTASVAAFDGQIGQAAYSASKGGVVGMTLPIARDLASKLI
Rv1144|M.tuberculosis_H37Rv E---ERGVIINTASVAAFDGQIGQAAYSASKGGVVGMTLPIARDLASKLI
MAB_0368|M.abscessus_ATCC_1997 EF-GERGAIVNTASVAAFDGQIGQAAYSASKGGIVGMTLPIARDLSVVGI
MUL_3412|M.ulcerans_Agy99 ---DERGVIINTASIAAFEGQIGQVAYTAAKAGIAGMCLTMARDLGSMGI
MMAR_1624|M.marinum_M ---DERGVIINTASIAAFEGQIGQVAYTAAKAGIAGMCLTMARDLGSMGI
MAV_3936|M.avium_104 ---EERGVIINTASIAAFEGQIGQVAYTAAKAAIAGMCLTMARDLGSVGV
Mflv_4319|M.gilvum_PYR-GCK DEAEERGVIINTASIAAFEGQIGQLAYTASKAAIAGMCLTMARDLGSLGI
Mvan_2027|M.vanbaalenii_PYR-1 DEAEERGVIINTASIAAFEGQIGQVAYTASKAAIAGMCLTMARDLGSLGI
TH_3183|M.thermoresistible__bu DEKEERGVIINTASIAAFEGQIGQVAYTASKAAIAGMCLTMARDLGSLGI
MSMEG_2279|M.smegmatis_MC2_155 AEGEERGVIINTASIAAFEGQIGQVAYTASKAAIAGMSLTMARDLGSLGI
MLBr_02565|M.leprae_Br4923 ----KGGRVIVLSSMAGIAGNRGQTNYATAKAGVIGLTQALAPGLAEKGI
: * :: :*:*.: *: ** *:::*..: *: .:* .*. :
Mb1176|M.bovis_AF2122/97 RVVTIAPGLFDTPLLAS---LPAEAKASLGQQVPHPSRLGNPDEYGALVL
Rv1144|M.tuberculosis_H37Rv RVVTIAPGLFDTPLLAS---LPAEAKASLGQQVPHPSRLGNPDEYGALVL
MAB_0368|M.abscessus_ATCC_1997 RVNTIAPGLIDTPIYGEG-ESAQQFKDRLAPNVLYPQRLGNPEEFASLAL
MUL_3412|M.ulcerans_Agy99 RVLAIAPSLFLTGLTAM---VPDEMAAQLVKDAAFPKRMGRPEEYAKLVA
MMAR_1624|M.marinum_M RVLAIAPSLFLTGLTAM---VPDEMAAQLVKDAAFPKRMGRPEEYAKLVA
MAV_3936|M.avium_104 RVLAIAPSLFATGLTQG---IPDEFATQLTKDAAFPKRLGRPEEYAKLAL
Mflv_4319|M.gilvum_PYR-GCK RALAIAPSLFATGLTEG---IPDEFATVLTKDAAFPKRLGKPEEYAKLAV
Mvan_2027|M.vanbaalenii_PYR-1 RALAIAPSLFATGLTEG---IPDEFASVLTKDAAFPKRLGKPEEYAKLAV
TH_3183|M.thermoresistible__bu RALAIAPSLFATGLTEG---IPDEFAKQLTKDAAFPKRLGKPEEYAKLAL
MSMEG_2279|M.smegmatis_MC2_155 RALAIAPSLFATGLTEG---IPDDFAKVLTKDAAFPKRLGKPDEYARLAL
MLBr_02565|M.leprae_Br4923 TINAVAPGFIETQMTAAIPLATREVGRRLNSLLQGGLPVDVAETIAYFAI
::**.:: * : . : * :. .: . :.
Mb1176|M.bovis_AF2122/97 HIIENPMLNGEVIRLDGAIRMAPR
Rv1144|M.tuberculosis_H37Rv HIIENPMLNGEVIRLDGAIRMAPR
MAB_0368|M.abscessus_ATCC_1997 ELVTNSYMNAETIRIDGGARLQPK
MUL_3412|M.ulcerans_Agy99 AIVDNPMLNGQCLRLDAGQRFAPK
MMAR_1624|M.marinum_M AIVDNPMLNGQCLRLDAGQRFAPK
MAV_3936|M.avium_104 AIVDNPMLNGQCLRLDAGQRFAPK
Mflv_4319|M.gilvum_PYR-GCK AIVENPMLNGQCLRLDAGQRFAPK
Mvan_2027|M.vanbaalenii_PYR-1 AIVENPMLNGQCLRLDAGQRFAPK
TH_3183|M.thermoresistible__bu AIVENPMLNGQCIRLDAGQRFAPK
MSMEG_2279|M.smegmatis_MC2_155 AIVENPMLNGQCIRLDGGQRFAPK
MLBr_02565|M.leprae_Br4923 PASN--AVTGNVIRVCGQAMLGA-
:..: :*: . : .