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VAAVLIAEDEPRISALVRKGLSANGFSVTVVPDGPSAYAYAHSGAFDLMVLDTGLPGMDGLSVLRRLRAE GSALPVIVLTTRTTGADTAALLGGADDVIAKPFRLEDLVSRVRTRLSPGRAARTHTLSYGNLRLDLRTRR AHVGDYSVDLSAREFALAEMFLRHPGQVLTRDQLLRQVWGNDYEPGSNVVDVYVRYLRRKLGARRFVTLR GMGYRLEAVH
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_3998 | - | - | 100% (220) | two component transcriptional regulator |
| M. gilvum PYR-GCK | Mflv_1887 | - | 4e-38 | 40.09% (222) | two component transcriptional regulator |
| M. gilvum PYR-GCK | Mflv_1744 | - | 1e-37 | 42.08% (221) | two component transcriptional regulator |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0618c | tcrA | 2e-43 | 44.50% (218) | putative two component DNA binding transcriptional |
| M. tuberculosis H37Rv | Rv0602c | tcrA | 1e-43 | 44.50% (218) | two component DNA binding transcriptional regulatory protein |
| M. leprae Br4923 | MLBr_00174 | - | 9e-40 | 40.72% (221) | putative two-component response regulator |
| M. abscessus ATCC 19977 | MAB_1076 | - | 4e-42 | 42.53% (221) | two component response transcriptional regulatory protein MprA |
| M. marinum M | MMAR_4529 | mprA | 4e-38 | 39.46% (223) | two component response transcriptional regulatory protein |
| M. avium 104 | MAV_1094 | - | 5e-39 | 40.27% (221) | two component response transcriptional regulatory protein MprA |
| M. smegmatis MC2 155 | MSMEG_5662 | prrA | 6e-38 | 42.08% (221) | DNA-binding response regulator PrrA |
| M. thermoresistible (build 8) | TH_4055 | - | 1e-80 | 66.97% (218) | PUTATIVE two component transcriptional regulator, winged helix |
| M. ulcerans Agy99 | MUL_4701 | mprA | 5e-39 | 39.91% (223) | two component response transcriptional regulatory protein |
| M. vanbaalenii PYR-1 | Mvan_2389 | - | 1e-85 | 72.73% (220) | two component transcriptional regulator |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_4529|M.marinum_M --------------------MSVRILVVDDDRAVRESLRRSLSFNGYTVE
MUL_4701|M.ulcerans_Agy99 --------------------MSVRILVVDDDRAVRESLRRSLSFNGYTVE
MAV_1094|M.avium_104 ----------------------MRILVVDDDRAVRESLRRSLSFNGYSVE
MLBr_00174|M.leprae_Br4923 ----------------------MRILAVDDDRAVRESLRRSLSFNGYSVE
MAB_1076|M.abscessus_ATCC_1997 --------------------MPVRILVVDDDRAVRESLRRSLSFNGYSVD
MSMEG_5662|M.smegmatis_MC2_155 ------------MDSTTSGMASPRVLVVDDDPDVLASLERGLRLSGFDVS
Mflv_3998|M.gilvum_PYR-GCK ---------------------MAAVLIAEDEPRISALVRKGLSANGFSVT
Mvan_2389|M.vanbaalenii_PYR-1 ---------------------MTAILIAEDEPRVSSFVRKGLSSNGYSVT
TH_4055|M.thermoresistible__bu ---------------------MARILIVEDEPRISSFIEKGLSANGFTAT
Mb0618c|M.bovis_AF2122/97 MADETTMRAGRGPGRACGRVSGVRILVIEDEPKMTALLARALTEEGHTVD
Rv0602c|M.tuberculosis_H37Rv MADETTMRAGRGPGRACGRVSGVRILVVEDEPKMTALLARALTEEGHTVD
:* :*: : : :.* .*. .
MMAR_4529|M.marinum_M LAHDGVEALEMIASDRPDALVLDVMMPRLDGLEVCRQLRSTGDDLPILVL
MUL_4701|M.ulcerans_Agy99 LAHDGVEALEMIASDRPDALVLDVMMPRLDGLEVCRQLRSTGDDLPILVL
MAV_1094|M.avium_104 LAHDGVEALDMIASDRPDALVLDVMMPRLDGLEVCRQLRSTGDDLPILVL
MLBr_00174|M.leprae_Br4923 LANDGVEALEMVARDRPDALVLDVMMPRLDGLEVCRQLRSTGDDLPILVL
MAB_1076|M.abscessus_ATCC_1997 LAEDGVDALNVIANDRPDALVLDVMMPKLDGLEVCRRLRSTGDDLPILVL
MSMEG_5662|M.smegmatis_MC2_155 TAVDGAEALRSATETRPDAIVLDINMPVLDGVSVVTALRAMDNDVPVCVL
Mflv_3998|M.gilvum_PYR-GCK VVPDGPSAYAYAHSGAFDLMVLDTGLPGMDGLSVLRRLRAEGSALPVIVL
Mvan_2389|M.vanbaalenii_PYR-1 LVTDGRSAYFSARNGGFDLMLLDTDLPGMDGFAVLRRLRADGSPLPVVML
TH_4055|M.thermoresistible__bu TVTDGPTGYDYAMTGGFDLMVLDIGLPSMDGFTVLRKLREDGNQIPVIVL
Mb0618c|M.bovis_AF2122/97 TVADGRHAVAAVDGGDYDAVVLDVMLPGIDGFEVCARLRRQRVWTPVLML
Rv0602c|M.tuberculosis_H37Rv TVADGRHAVAAVDGGDYDAVVLDVMLPGIDGFEVCARLRRQRVWTPVLML
. ** . * ::** :* :**. * ** *: :*
MMAR_4529|M.marinum_M TARDSVSERVAGLDAGADDYLPKPFALEELLARMRALLRRTKPEDDEAAD
MUL_4701|M.ulcerans_Agy99 TARDSVSERVAGLDAGADDYLPKPFALEELLARMRALLRRTKLEDDEAAD
MAV_1094|M.avium_104 TARDSVSERVAGLDAGADDYLPKPFALEELLARMRALLRRTKPEDD--AE
MLBr_00174|M.leprae_Br4923 TARDSVSERVAGLDAGADDYLPKPFALEELLARIRALLRRTKPDDA--AE
MAB_1076|M.abscessus_ATCC_1997 TARDSVSERVAGLDAGADDYLPKPFALEELLARMRALLRRTTIDES--AD
MSMEG_5662|M.smegmatis_MC2_155 SARSSVDDRVAGLEAGADDYLVKPFVLAELVARVKALLRRRGSSAT--FS
Mflv_3998|M.gilvum_PYR-GCK TTRTTGADT-AALLGGADDVIAKPFRLEDLVSRVRTRLSPGR-----AAR
Mvan_2389|M.vanbaalenii_PYR-1 MSRAGVADTTAALEEGADDYVVKPFRFEDLLARVRLRLTAGR-----AAS
TH_4055|M.thermoresistible__bu TARDSVEDTVAGLEGGADDYMPKPFRFEELLARIRLRLTTER-----SAE
Mb0618c|M.bovis_AF2122/97 TARGAVTDRIAGLDGGADDYLTKPFNLDELFARLRALSRRGP-----IPR
Rv0602c|M.tuberculosis_H37Rv TARGAVTDRIAGLDGGADDYLTKPFNLDELFARLRALSRRGP-----IPR
:* : *.* **** : *** : :*.:*::
MMAR_4529|M.marinum_M SVAMTFSDLSLDPVTREVTRGARRISLTRTEFALLEMLIANPRRVLTRSR
MUL_4701|M.ulcerans_Agy99 SVAMTFSDLSLDPVTREVTRGARRISLTRTEFALLEMLIANPRRVLTRSR
MAV_1094|M.avium_104 SVAMTFSDLTLDPVTREVTRGQRRISLTRTEFALLEMLIANPRRVLTRSR
MLBr_00174|M.leprae_Br4923 SVAMSFSDLTLDPVTREVARGQRWISLTRTEFALLEMLIANPRRVLTRSR
MAB_1076|M.abscessus_ATCC_1997 AATLSFGDLTLDPVTREVHRGTRSISLTRTEFALLEMLMANPRRVLTRSR
MSMEG_5662|M.smegmatis_MC2_155 SETIQVGPLEVDIPGRRARVNGVDVDLTKREFDLLAVLAEHKTAVLSRAQ
Mflv_3998|M.gilvum_PYR-GCK THTLSYGNLRLDLRTRRAHVGDYSVDLSAREFALAEMFLRHPGQVLTRDQ
Mvan_2389|M.vanbaalenii_PYR-1 T-TLAYGSLLLDLRTRRAHVGDYAVDLSARECKLAETFLRHPGQVLSREQ
TH_4055|M.thermoresistible__bu LTVLTCGGMQLDLRTRRAKVGDKTVDLSAREFALAETFMRHPGQVLSREQ
Mb0618c|M.bovis_AF2122/97 PPTLEAGDLRLDPSEHRVWRADTEIRLSHKEFTLLEALIRRPGIVHTRAQ
Rv0602c|M.tuberculosis_H37Rv PPTLEAGDLRLDPSEHRVWRADTEIRLSHKEFTLLEALIRRPGIVHTRAQ
.: . : :* :.. : *: * * : . * :* :
MMAR_4529|M.marinum_M ILEEVWGFDFPTSGNALEVYVGYLRRKTEAEGEPRLIHTVRGVGYVLRET
MUL_4701|M.ulcerans_Agy99 ILEEVWGFDFPTSGNALEVYVGYLRRKTEAEGEPRLIHTVRGVGYVLRET
MAV_1094|M.avium_104 ILEEVWGFDFPTSGNALEVYVGYLRRKTEADGEPRLIHTVRGVGYVLRET
MLBr_00174|M.leprae_Br4923 ILEEVWGFDFPTSGNALEVYVGYLRRKTEADGESRLIHTVRGVGYVLRET
MAB_1076|M.abscessus_ATCC_1997 ILEEVWGFDFPTSGNALEVYVGYLRRKTEAEGELRLIHTVRGVGYVLRET
MSMEG_5662|M.smegmatis_MC2_155 LLELVWGYDFAADTNVVDVFIGYLRRKLEAGGAPRLLHTVRGVGFVLRTQ
Mflv_3998|M.gilvum_PYR-GCK LLRQVWGNDYEPGSNVVDVYVRYLR----RKLGARRFVTLRGMGYRLEAV
Mvan_2389|M.vanbaalenii_PYR-1 LLNQVWGRDHETGSNVVDVYVRYLR----RKLGANRFATLRGMGYRLEPI
TH_4055|M.thermoresistible__bu LLSRVWGYDFDPGSNVVDVYVRYLR----RKLGAERFVTVRGMGYRLEEL
Mb0618c|M.bovis_AF2122/97 LLERCWDAAYEARSNIVDVYIRYLRDKIDRPFGVTSLETIRGAGYRLRKD
Rv0602c|M.tuberculosis_H37Rv LLERCWDAAYEARSNIVDVYIRYLRDKIDRPFGVTSLETIRGAGYRLRKD
:* *. . . * ::*:: *** : *:** *: *.
MMAR_4529|M.marinum_M PP------
MUL_4701|M.ulcerans_Agy99 PP------
MAV_1094|M.avium_104 PP------
MLBr_00174|M.leprae_Br4923 PP------
MAB_1076|M.abscessus_ATCC_1997 PP------
MSMEG_5662|M.smegmatis_MC2_155 --------
Mflv_3998|M.gilvum_PYR-GCK H-------
Mvan_2389|M.vanbaalenii_PYR-1 --------
TH_4055|M.thermoresistible__bu P-------
Mb0618c|M.bovis_AF2122/97 GGRHALPR
Rv0602c|M.tuberculosis_H37Rv GGRHALPR