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ADETTMRAGRGPGRACGRVSGVRILVVEDEPKMTALLARALTEEGHTVDTVADGRHAVAAVDGGDYDAVV LDVMLPGIDGFEVCARLRRQRVWTPVLMLTARGAVTDRIAGLDGGADDYLTKPFNLDELFARLRALSRRG PIPRPPTLEAGDLRLDPSEHRVWRADTEIRLSHKEFTLLEALIRRPGIVHTRAQLLERCWDAAYEARSNI VDVYIRYLRDKIDRPFGVTSLETIRGAGYRLRKDGGRHALPR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv0602c | tcrA | - | 100% (253) | PROBABLE TWO COMPONENT DNA BINDING TRANSCRIPTIONAL REGULATORY PROTEIN TCRA |
| M. tuberculosis H37Rv | Rv1033c | trcR | 2e-50 | 46.90% (226) | two component transcriptional regulator TRCR |
| M. tuberculosis H37Rv | Rv3765c | - | 8e-46 | 45.09% (224) | two component transcriptional regulatory protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0618c | tcrA | 1e-145 | 99.60% (253) | putative two component DNA binding transcriptional |
| M. gilvum PYR-GCK | Mflv_1887 | - | 3e-46 | 44.69% (226) | two component transcriptional regulator |
| M. leprae Br4923 | MLBr_00174 | - | 5e-44 | 43.56% (225) | putative two-component response regulator |
| M. abscessus ATCC 19977 | MAB_1076 | - | 2e-47 | 45.78% (225) | two component response transcriptional regulatory protein MprA |
| M. marinum M | MMAR_4455 | trcR | 4e-50 | 46.02% (226) | two-component transcriptional regulator TrcR |
| M. avium 104 | MAV_3406 | - | 3e-58 | 50.91% (220) | TcrA protein |
| M. smegmatis MC2 155 | MSMEG_4990 | - | 2e-46 | 44.13% (247) | DNA-binding response regulator |
| M. thermoresistible (build 8) | TH_1732 | phoP | 4e-45 | 44.89% (225) | DNA-binding response regulator PhoP |
| M. ulcerans Agy99 | MUL_4624 | trcR | 2e-50 | 46.02% (226) | two component transcriptional regulator TrcR |
| M. vanbaalenii PYR-1 | Mvan_4844 | - | 4e-46 | 44.69% (226) | two component transcriptional regulator |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_1887|M.gilvum_PYR-GCK -----------------------------MPVRILVVDDDRAVRESLRRS
Mvan_4844|M.vanbaalenii_PYR-1 -----------------------------MPVRILVVDDDRAVRESLRRS
MLBr_00174|M.leprae_Br4923 -------------------------------MRILAVDDDRAVRESLRRS
TH_1732|M.thermoresistible__bu -----------------------------VAVRILVVDDDRAVRESLRRS
MAB_1076|M.abscessus_ATCC_1997 -----------------------------MPVRILVVDDDRAVRESLRRS
MMAR_4455|M.marinum_M ---MTGSTRTQRPRQAILGQLPRIHRADGSPIRVLLVDDEPALTNLVKMA
MUL_4624|M.ulcerans_Agy99 MKAMTGSTRTQRPRQAILGQLPRIHRADGSPIRVLLVDDEPALTNLVKMA
MSMEG_4990|M.smegmatis_MC2_155 ---MGTANGT-----EIETGRAVMRRADGNPIRVLVVDDEPVLAELVSMA
Rv0602c|M.tuberculosis_H37Rv ---------MADETTMRAGRGPGRACGRVSGVRILVVEDEPKMTALLARA
Mb0618c|M.bovis_AF2122/97 ---------MADETTMRAGRGPGRACGRVSGVRILVIEDEPKMTALLARA
MAV_3406|M.avium_104 -------------------------------MRVLLVEDEPRLAATVARG
:*:* ::*: : : .
Mflv_1887|M.gilvum_PYR-GCK LSFNGYSVELAQDGREALDLIASDRPDAVVLDVMMPRLDGLEVCRQLRST
Mvan_4844|M.vanbaalenii_PYR-1 LSFNGYSVELAQDGREALDLIASDRPDAVVLDVMMPRLDGLEVCRQLRST
MLBr_00174|M.leprae_Br4923 LSFNGYSVELANDGVEALEMVARDRPDALVLDVMMPRLDGLEVCRQLRST
TH_1732|M.thermoresistible__bu LSFNGYSVELAEDGVEALDLIANDRPDAVVLDVMMPRLDGLEVCRQLRST
MAB_1076|M.abscessus_ATCC_1997 LSFNGYSVDLAEDGVDALNVIANDRPDALVLDVMMPKLDGLEVCRRLRST
MMAR_4455|M.marinum_M LHYEGWDVEIAHNGREAISKFDKISPDVLVLDIMLPDVDGLQILQRVRDS
MUL_4624|M.ulcerans_Agy99 LHYEGWDVEIAHNGREAISKFDKISPDVLVLDIMLPDVDGLQILQRVRDS
MSMEG_4990|M.smegmatis_MC2_155 LRYEGWDITTAGDGASAIAAARETPPDVVVLDVMLPDMSGLDVLRKLREQ
Rv0602c|M.tuberculosis_H37Rv LTEEGHTVDTVADGRHAVAAVDGGDYDAVVLDVMLPGIDGFEVCARLRRQ
Mb0618c|M.bovis_AF2122/97 LTEEGHTVDTVADGRHAVAAVDGGDYDAVVLDVMLPGIDGFEVCARLRRQ
MAV_3406|M.avium_104 LKAEGFVVVTVGNGVDGLAEATENPFDVVILDIMLPGRSGYEVLRRMRSN
* :* : . :* .: *.::**:*:* .* :: ::*
Mflv_1887|M.gilvum_PYR-GCK GDDLPILVLTARDSVSERVAGLDAGADDYLPKPFALEELLARMRALLRRT
Mvan_4844|M.vanbaalenii_PYR-1 GDDLPILVLTARDSVSERVAGLDAGADDYLPKPFALEELLARMRALLRRT
MLBr_00174|M.leprae_Br4923 GDDLPILVLTARDSVSERVAGLDAGADDYLPKPFALEELLARIRALLRRT
TH_1732|M.thermoresistible__bu GDDLPILVLTARDSVSERVAGLDAGADDYLPKPFALEELLARLRALLRRT
MAB_1076|M.abscessus_ATCC_1997 GDDLPILVLTARDSVSERVAGLDAGADDYLPKPFALEELLARMRALLRRT
MMAR_4455|M.marinum_M DAYTPTLFLTARDSVMDRVTGLTAGADDYMTKPFSLEELVARLRGLLRRS
MUL_4624|M.ulcerans_Agy99 DAYTPTLFLTARDSVMDRVTGLTAGADDYMTKPFSLEELVARLRGLLRRS
MSMEG_4990|M.smegmatis_MC2_155 IPGLPLLLLTAKDSVEDRIAGLTAGGDDYVTKPFSLEEVVLRLRALLRRT
Rv0602c|M.tuberculosis_H37Rv RVWTPVLMLTARGAVTDRIAGLDGGADDYLTKPFNLDELFARLRALSRRG
Mb0618c|M.bovis_AF2122/97 RVWTPVLMLTARGAVTDRIAGLDGGADDYLTKPFNLDELFARLRALSRRG
MAV_3406|M.avium_104 NVWTPVLMLTAKDGEYDETDAFDLGADDYLTKPFSFRVLVARLRALVRRG
* *.***:.. :. .: *.***:.*** : :. *:*.* **
Mflv_1887|M.gilvum_PYR-GCK SPVDGDGESAAMTFSDLTLDPVTREVTRGNRSISLTRTEFSLLEMLITNP
Mvan_4844|M.vanbaalenii_PYR-1 TPDDGAGESAAMTFSDLSLDPVTREVTRGDRPISLTRTEFSLLEMLIANP
MLBr_00174|M.leprae_Br4923 KPDD-AAESVAMSFSDLTLDPVTREVARGQRWISLTRTEFALLEMLIANP
TH_1732|M.thermoresistible__bu TPDD-AADSQKLTFADLTLDPVTREVTRGNRQISLTRTEFALLELLIANP
MAB_1076|M.abscessus_ATCC_1997 TIDE-SADAATLSFGDLTLDPVTREVHRGTRSISLTRTEFALLEMLMANP
MMAR_4455|M.marinum_M SHLA-PPADESLKVGDLKLDAASREVTRGGTPISLSSTEFELLRFLMRNP
MUL_4624|M.ulcerans_Agy99 SHLA-PPADESLKVGDLKLDAASREVTRGGTPISLSSTEFELLRFLMRNP
MSMEG_4990|M.smegmatis_MC2_155 GVTS-EDGGAKIVVGDLVLDEDSHEVTRGGDPIALTATEFELLRFMMRNA
Rv0602c|M.tuberculosis_H37Rv PIPR----PPTLEAGDLRLDPSEHRVWRADTEIRLSHKEFTLLEALIRRP
Mb0618c|M.bovis_AF2122/97 PIPR----PPTLEAGDLRLDPSEHRVWRADTEIRLSHKEFTLLEALIRRP
MAV_3406|M.avium_104 APER----PVVLTAGSLSLDPARHTVQRGSTPIALTPREYGVLEFLMRNK
: ..* ** : * *. * *: *: :*. :: .
Mflv_1887|M.gilvum_PYR-GCK RRVLTRSRILEEVWGFDFPTSGNALEVYVGYLRRKTEAEGEPRLIHTVRG
Mvan_4844|M.vanbaalenii_PYR-1 RRVLTRSRILEEVWGFDFPTSGNALEVYVGYLRRKTEAEGEPRLIHTVRG
MLBr_00174|M.leprae_Br4923 RRVLTRSRILEEVWGFDFPTSGNALEVYVGYLRRKTEADGESRLIHTVRG
TH_1732|M.thermoresistible__bu RRVLSRSRILEEVWGFDFPTSGNALEVYIGYLRRKTEAEGEPRLIHTVRG
MAB_1076|M.abscessus_ATCC_1997 RRVLTRSRILEEVWGFDFPTSGNALEVYVGYLRRKTEAEGELRLIHTVRG
MMAR_4455|M.marinum_M RRALSRTEILDRVWNYDFAGRTSIVDLYISYLRKKIDADREP-MIHTVRG
MUL_4624|M.ulcerans_Agy99 RRALSRTEILDRVWNYDFAGRTSIVDLYISYLRKKIDADREP-MIHTVRG
MSMEG_4990|M.smegmatis_MC2_155 KRVLSKAQILDRVWSYDFGGRSNIVELYVSYLRKKIDSGREP-MIHTLRG
Rv0602c|M.tuberculosis_H37Rv GIVHTRAQLLERCWDAAYEARSNIVDVYIRYLRDKIDRPFGVTSLETIRG
Mb0618c|M.bovis_AF2122/97 GIVHTRAQLLERCWDAAYEARSNIVDVYIRYLRDKIDRPFGVTSLETIRG
MAV_3406|M.avium_104 DVVVTKADILANVWDAHHHGPDNVVEVYVGYLRRKIDVPFGTNTIETIRG
. ::: :* . *. . . :::*: *** * : :.*:**
Mflv_1887|M.gilvum_PYR-GCK VGYVLRETPP------
Mvan_4844|M.vanbaalenii_PYR-1 VGYVLRETPP------
MLBr_00174|M.leprae_Br4923 VGYVLRETPP------
TH_1732|M.thermoresistible__bu VGYVLRETPP------
MAB_1076|M.abscessus_ATCC_1997 VGYVLRETPP------
MMAR_4455|M.marinum_M IGYMLRPAE-------
MUL_4624|M.ulcerans_Agy99 IGYMLRPAE-------
MSMEG_4990|M.smegmatis_MC2_155 AGYVLRPPR-------
Rv0602c|M.tuberculosis_H37Rv AGYRLRKDGGRHALPR
Mb0618c|M.bovis_AF2122/97 AGYRLRKDGGRHALPR
MAV_3406|M.avium_104 VGYRLLC---------
** *