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MVVKSGTEGPRNMRLSLRGANAAERLALRAGVVPTAAAEAWGGMALSAVMIAAVRTGLTARLARRPGTAA ELAADLGLDPVPTRLILDCLRSGGHVRCRSGRYRLTRSSRRWLDPASKLSVAQYVAGTADYWSWWANLDE VTRTGRPAAHHDAPPGDPYWQRYIDGQLELARLSAGEVARKLRLPGEPWSLLDLGGGHGWYSAQLCRRYP TLAATVLDLPGSAAVGRRVIADAGMADRVTHRDGDVTTAALGGGYDAVLCFNLLHHLSAEETVALFGRIH QALAPGGTLAVMDAFAEPGHATSAQANVLGLFVYLSSGSQVHPPAQLHEWLRQAGFGVPRRIPILRIPGQ AMYVVAKT
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_3993 | - | - | 100% (358) | methyltransferase type 12 |
| M. gilvum PYR-GCK | Mflv_3940 | - | 7e-22 | 28.19% (337) | O-methyltransferase family protein |
| M. gilvum PYR-GCK | Mflv_2895 | - | 8e-05 | 31.85% (135) | methyltransferase type 11 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0582 | - | 6e-16 | 25.67% (335) | methyltransferase/methylase |
| M. tuberculosis H37Rv | Rv0567 | - | 2e-15 | 25.37% (335) | methyltransferase/methylase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_2704 | - | 3e-08 | 28.99% (169) | hypothetical protein MAB_2704 |
| M. marinum M | MMAR_0934 | - | 1e-19 | 27.39% (314) | methyltransferase/methylase |
| M. avium 104 | MAV_0196 | - | 6e-05 | 30.43% (138) | hypothetical protein MAV_0196 |
| M. smegmatis MC2 155 | MSMEG_0367 | - | 2e-14 | 24.71% (348) | O-demethylpuromycin-O-methyltransferase |
| M. thermoresistible (build 8) | TH_3167 | - | 3e-15 | 26.45% (310) | PUTATIVE hydroxyneurosporene-O-methyltransferase |
| M. ulcerans Agy99 | MUL_0686 | - | 3e-20 | 27.71% (314) | methyltransferase/methylase |
| M. vanbaalenii PYR-1 | Mvan_2460 | - | 1e-18 | 25.80% (314) | O-methyltransferase family protein |
CLUSTAL 2.0.9 multiple sequence alignment
MSMEG_0367|M.smegmatis_MC2_155 -----------------------------------MPPARLVRAVERARH
TH_3167|M.thermoresistible__bu LQTEYVEVTRIAPVRSRRYDPITRSGGVVMSARVRVPPARIARTADAARH
Mvan_2460|M.vanbaalenii_PYR-1 -----------------------------MRTMLMTPPPVVLAAVGRFRG
Mb0582|M.bovis_AF2122/97 --------------------------------------------------
Rv0567|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_0934|M.marinum_M --------------------------------------------------
MUL_0686|M.ulcerans_Agy99 --------------------------------------------------
MAB_2704|M.abscessus_ATCC_1997 --------------------------------------------------
MAV_0196|M.avium_104 --------------------------------------------------
Mflv_3993|M.gilvum_PYR-GCK -----------------------------MVVKSGTEGPRNMRLSLRGAN
MSMEG_0367|M.smegmatis_MC2_155 HVRRLWLRSVPPEAAMLELLLGAWLAQGITAAAQLGVADALSGGPLRADE
TH_3167|M.thermoresistible__bu YLLRLQQKLTAPQAVMLEMILAGWTSQALTTAADLGVADALADGPLAIGD
Mvan_2460|M.vanbaalenii_PYR-1 LLDRLHTLTAPSHIAVLELSLGSWFTAALYATVRLGIADALADGPLRADD
Mb0582|M.bovis_AF2122/97 -------MELS-PDRIMAIGGGYGPSKVLLTAVGLGLFTELGDEAMTAEA
Rv0567|M.tuberculosis_H37Rv -------MELS-PDRIMAIGGGYGPSKVLLTAVGLGLFTELGDEAMTAEA
MMAR_0934|M.marinum_M -------MDQSSPDRIMAIGAGYGPSKVLLTAVGLGLFTELGDRAMTAQA
MUL_0686|M.ulcerans_Agy99 -------MDQSRPDRIMAIGAGYGPSKVLLTAVGLGLFTELGDRAMTAQA
MAB_2704|M.abscessus_ATCC_1997 --------------------------------------------------
MAV_0196|M.avium_104 --------------------------------------------------
Mflv_3993|M.gilvum_PYR-GCK AAERLALRAGVVPTAAAEAWGGMALSAVMIAAVRTGLTARLARRPGTAAE
MSMEG_0367|M.smegmatis_MC2_155 LARRVGADADALDRLMRALVGEGVFRRTRDG---RYALNPLGDTLRTDAQ
TH_3167|M.thermoresistible__bu LARKVDADPERLARLMCALTSRGVFRQRRDG---RYALNALATTLRSDAS
Mvan_2460|M.vanbaalenii_PYR-1 VARKVGADPEATYRLMRALASRSVLKLRRDG---RFALTRLGHALRVDHP
Mb0582|M.bovis_AF2122/97 IADRLGLLKRPAIDFLDALVSLDLLARDGDGPGSHYRNTPETAHFLDEAR
Rv0567|M.tuberculosis_H37Rv IADRLGLLKRPAIDFLDALVSLDLLARDGDGPGSHYRNTPETAHFLDEAR
MMAR_0934|M.marinum_M IAELLGLVPRPATDFLDALVSLDLLARDGDGPDARYRNTAETARYLDEAS
MUL_0686|M.ulcerans_Agy99 LAELLGLVPRPATDFLDALVSLDLLARDGDGPDARYRNTAETARYLDEAS
MAB_2704|M.abscessus_ATCC_1997 --------------------------------------------------
MAV_0196|M.avium_104 --------------------------------------------------
Mflv_3993|M.gilvum_PYR-GCK LAADLGLDPVPTRLILDCLRSGGHVRCRSGR----YRLTRSSRRWLDPAS
MSMEG_0367|M.smegmatis_MC2_155 VSMAGMAKFVGAAQHREHWSHLADAVRTGES-AIRTLRGMEPFDYIASQP
TH_3167|M.thermoresistible__bu ASLAGAARFYGSRLHREHWSMLTDSVRTGKP-GVPTLRGMDWWQFSAANP
Mvan_2460|M.vanbaalenii_PYR-1 ESMAPLIAFVGSRQHWEHWGELLYSVQTGRT-AVEKLRGSEFFEYLDTDP
Mb0582|M.bovis_AF2122/97 PTYAGGLLKIWNERNYRFWADLTEALKTGKAQSEVKQTGRPFFEALYADP
Rv0567|M.tuberculosis_H37Rv PTYAGGLLKIWNERNYRFWADLTEALKTGKAQSEVKQTGRPFFEALYADP
MMAR_0934|M.marinum_M PEYQGGLLKIWDQRNYRFWADLTDALQTGKPQNEIKQTGRPFFETVYADP
MUL_0686|M.ulcerans_Agy99 PEYQGGLLKIWDQRNYRFWADLTDALQTGKPQNEIKQTGRPFFETVYADP
MAB_2704|M.abscessus_ATCC_1997 ---------------------------------------------MWARK
MAV_0196|M.avium_104 ----------------------------MIAMAMNLLHRHRCSSAGWAKE
Mflv_3993|M.gilvum_PYR-GCK -KLSVAQYVAGTADYWSWWANLDEVTRTGRP--------AAHHDAPPGDP
MSMEG_0367|M.smegmatis_MC2_155 ELGTIFNDAMTSMSELAITPLIAAYDFTRFGTIADVGGGHGRLLSAILGS
TH_3167|M.thermoresistible__bu EFGDLFNGAMTSISELSAPVVAAAYDFSPFPTIVDVGGGHGRLLSAILAA
Mvan_2460|M.vanbaalenii_PYR-1 AFAKVFNESMTGGSRAVIENAIPAYDFSDRRLIVDVGGGEGGLLAAILNR
Mb0582|M.bovis_AF2122/97 RRLEAFMAAMDAASRRNIELLAKRFPFERYRRLCDVGCADGLLSRIVAAA
Rv0567|M.tuberculosis_H37Rv RRLEAFMAAMDAASRRNIELLAKRFPFERYRRLCDVGCADGLLSRIVAAA
MMAR_0934|M.marinum_M RRLEVFLGAMDSASRRNCELLVKRFPFQRYGSLCDVGGANGLLSRTAAAA
MUL_0686|M.ulcerans_Agy99 RRLEVFLGAMDSASRRNCELLVKRFPFQRYGSLCDVGGANGLLSRTAAAA
MAB_2704|M.abscessus_ATCC_1997 TESQLLPWALQGVELG--------------ADTLEIGPGYGANLRVLTNR
MAV_0196|M.avium_104 VADELLPWALDGVELG--------------SRTLEIGPGYGATLSALLDR
Mflv_3993|M.gilvum_PYR-GCK YWQRYIDGQLELARLSAGEVARKLRLPGEPWSLLDLGGGHGWYSAQLCRR
: : ::* . *
MSMEG_0367|M.smegmatis_MC2_155 APQAKGVLYDLPNVVEGAPEMLARHGVADRVQVIPG-SFFDEVPDGADLY
TH_3167|M.thermoresistible__bu TPTARGVLFDLPDVVADAPALLRAHGVADRVDIVGG-SFFDAVPDG-DAY
Mvan_2460|M.vanbaalenii_PYR-1 TPTARGVLFDRPSVVAGADSVLGPAGVAARCRTEGG-SFFEAVPAGGDAY
Mb0582|M.bovis_AF2122/97 HPHLQCVSLDLPAVTEIARRKLTAEGLGERVQACAG-DFLADPLPAADVI
Rv0567|M.tuberculosis_H37Rv HPHLQCVSFDLPAVTEIARRKLTAEGLGERVQACAG-DFLADPLPAADVI
MMAR_0934|M.marinum_M HPHLQCISFDLPAVTDITRRKLSEQGLGDRVRAVSG-DFFADPLPSADVI
MUL_0686|M.ulcerans_Agy99 HPHLQCISFDLPAVTDITRRKLSEQGLGDRVRAVSG-DFFADPLPSADVI
MAB_2704|M.abscessus_ATCC_1997 TPQLTAVEID----ETMATRLQRLYGDRATVMQGDG-TKLGFDNDRFSSV
MAV_0196|M.avium_104 TASLTAVELD----PVMADRLQRRYGDRARVIQASG-TETGLPANHFTSV
Mflv_3993|M.gilvum_PYR-GCK YPTLAATVLDLPGSAAVGRRVIADAGMADRVTHRDGDVTTAALGGGYDAV
. * * *
MSMEG_0367|M.smegmatis_MC2_155 VMKNIIHDWAD-APAAEILRNVRAAARTGATLLLVEGVIPDHDR-AFPLK
TH_3167|M.thermoresistible__bu VLKNVIHDWDD-DEALPILGNIRSALSDRGAILLVEMVIPSHHR-EFLGN
Mvan_2460|M.vanbaalenii_PYR-1 VMKAIIHDWGD-DQSLSILRNVRTAIADDGRLLLFEMVLPERAP-AHLGF
Mb0582|M.bovis_AF2122/97 TMGQILHDWNL-DRKQQLVAKAYEALSKEGAFIVIETLIDDARRENTTGL
Rv0567|M.tuberculosis_H37Rv TMGQILHDWNL-DRKQQLVAKAYEALSKEGAFIVIETLIDDARRENTTGL
MMAR_0934|M.marinum_M TMGQILHDWNL-DGKQRLIAKAYEALPEGGAFIAIETLIDDARRKNTAGL
MUL_0686|M.ulcerans_Agy99 TMGQILHDWNL-DGKQRLIAKAYEALPEGGAFTAIETLIDDARRKNTAGL
MAB_2704|M.abscessus_ATCC_1997 VCFTMLHHVPTADLQDQLFAQAHRVLAPGGVFAGSDGVHSTFFR------
MAV_0196|M.avium_104 VCFTMLHHVPSPQLQDQLFAEALRVLQPGGTFAGSDGVPSWVFR------
Mflv_3993|M.gilvum_PYR-GCK LCFNLLHHLSA-EETVALFGRIHQALAPGGTLAVMDAFAEPGHATSAQAN
::*. :. . . . : : .
MSMEG_0367|M.smegmatis_MC2_155 WVDMEMLIGN-AARERTEAQYRKLYTEAGFRLTRVVPTACPYSLIEGVAI
TH_3167|M.thermoresistible__bu MVDLEMLNGG-NARERTADEYRSLLARANLRMTRVVATAGPYSVIEARAA
Mvan_2460|M.vanbaalenii_PYR-1 MVDLEMLVTA-GGRERTASQYAKLLADSGFRMTRVIPTASPLSIVEAVPA
Mb0582|M.bovis_AF2122/97 MMSLNMLIEFGDAFDYSAADFRGWCGEAGFRSFEVIPLAGGSSAAVAYK-
Rv0567|M.tuberculosis_H37Rv MMSLNMLIEFGDAFDYSAADFRGWCGEAGFRSFEVIPLAGGSSAAVAYK-
MMAR_0934|M.marinum_M MMSLNMLIEFGDAFDYTGADFRKWCGAAGFRSFEVIALAAGSSAAVAYK-
MUL_0686|M.ulcerans_Agy99 MMSLNMLIEFGDAFDYTGADFRKWCGAAGFRSFEVIALAAGSSAAVAYK-
MAB_2704|M.abscessus_ATCC_1997 -----LLHIGDTYNPVPTTSLPDRLRAAGFTDIEHHLDGGNQRWRAVKAA
MAV_0196|M.avium_104 -----LLHVADTYNPIAPKDLPGRLAAAGFADIHADARGGRQRWRAVKPI
Mflv_3993|M.gilvum_PYR-GCK VLGLFVYLSS-GSQVHPPAQLHEWLRQAGFGVPRRIPILRIPGQAMYVVA
: . . :.: .
MSMEG_0367|M.smegmatis_MC2_155 --
TH_3167|M.thermoresistible__bu --
Mvan_2460|M.vanbaalenii_PYR-1 --
Mb0582|M.bovis_AF2122/97 --
Rv0567|M.tuberculosis_H37Rv --
MMAR_0934|M.marinum_M --
MUL_0686|M.ulcerans_Agy99 --
MAB_2704|M.abscessus_ATCC_1997 --
MAV_0196|M.avium_104 D-
Mflv_3993|M.gilvum_PYR-GCK KT