For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
RTMLMTPPPVVLAAVGRFRGLLDRLHTLTAPSHIAVLELSLGSWFTAALYATVRLGIADALADGPLRADD VARKVGADPEATYRLMRALASRSVLKLRRDGRFALTRLGHALRVDHPESMAPLIAFVGSRQHWEHWGELL YSVQTGRTAVEKLRGSEFFEYLDTDPAFAKVFNESMTGGSRAVIENAIPAYDFSDRRLIVDVGGGEGGLL AAILNRTPTARGVLFDRPSVVAGADSVLGPAGVAARCRTEGGSFFEAVPAGGDAYVMKAIIHDWGDDQSL SILRNVRTAIADDGRLLLFEMVLPERAPAHLGFMVDLEMLVTAGGRERTASQYAKLLADSGFRMTRVIPT ASPLSIVEAVPA*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_2460 | - | - | 100% (363) | O-methyltransferase family protein |
| M. vanbaalenii PYR-1 | Mvan_3149 | - | 1e-22 | 30.94% (320) | methyltransferase type 12 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0582 | - | 2e-22 | 26.42% (318) | methyltransferase/methylase |
| M. gilvum PYR-GCK | Mflv_3940 | - | 1e-110 | 56.09% (353) | O-methyltransferase family protein |
| M. tuberculosis H37Rv | Rv0567 | - | 4e-23 | 26.73% (318) | methyltransferase/methylase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | - | - | - | - | - |
| M. marinum M | MMAR_0934 | - | 5e-23 | 26.59% (331) | methyltransferase/methylase |
| M. avium 104 | - | - | - | - | - |
| M. smegmatis MC2 155 | MSMEG_0367 | - | 3e-89 | 49.15% (354) | O-demethylpuromycin-O-methyltransferase |
| M. thermoresistible (build 8) | TH_3167 | - | 8e-88 | 50.69% (361) | PUTATIVE hydroxyneurosporene-O-methyltransferase |
| M. ulcerans Agy99 | MUL_0686 | - | 1e-22 | 26.59% (331) | methyltransferase/methylase |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_2460|M.vanbaalenii_PYR-1 ----------------------------MRTMLMTPPPVVLA-AVGRFRG
Mflv_3940|M.gilvum_PYR-GCK -----------------MTHTSTPRGSAARSAPNRVPPVRLIRAVDRLRA
MSMEG_0367|M.smegmatis_MC2_155 -----------------------------------MPPARLVRAVERARH
TH_3167|M.thermoresistible__bu LQTEYVEVTRIAPVRSRRYDPITRSGGVVMSARVRVPPARIARTADAARH
Mb0582|M.bovis_AF2122/97 --------------------------------------------------
Rv0567|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_0934|M.marinum_M --------------------------------------------------
MUL_0686|M.ulcerans_Agy99 --------------------------------------------------
Mvan_2460|M.vanbaalenii_PYR-1 LLDRLHTLTAPSHIAVLELSLGSWFTAALYATVRLGIADALADGPLRADD
Mflv_3940|M.gilvum_PYR-GCK GLQRLHRSTAPGNVALMELATGAWTTQVLYVAATLGIPDELADGPAHAAD
MSMEG_0367|M.smegmatis_MC2_155 HVRRLWLRSVPPEAAMLELLLGAWLAQGITAAAQLGVADALSGGPLRADE
TH_3167|M.thermoresistible__bu YLLRLQQKLTAPQAVMLEMILAGWTSQALTTAADLGVADALADGPLAIGD
Mb0582|M.bovis_AF2122/97 -------MELS-PDRIMAIGGGYGPSKVLLTAVGLGLFTELGDEAMTAEA
Rv0567|M.tuberculosis_H37Rv -------MELS-PDRIMAIGGGYGPSKVLLTAVGLGLFTELGDEAMTAEA
MMAR_0934|M.marinum_M -------MDQSSPDRIMAIGAGYGPSKVLLTAVGLGLFTELGDRAMTAQA
MUL_0686|M.ulcerans_Agy99 -------MDQSRPDRIMAIGAGYGPSKVLLTAVGLGLFTELGDRAMTAQA
. :: : . : : .:. **: *.. .
Mvan_2460|M.vanbaalenii_PYR-1 VARKVGADPEATYRLMRALASRSVLKLRRDG---RFALTRLGHALRVDHP
Mflv_3940|M.gilvum_PYR-GCK VATRVGADAGAVYRLMRAMVSRGALREERDG---RFALTPVGDALRTDSE
MSMEG_0367|M.smegmatis_MC2_155 LARRVGADADALDRLMRALVGEGVFRRTRDG---RYALNPLGDTLRTDAQ
TH_3167|M.thermoresistible__bu LARKVDADPERLARLMCALTSRGVFRQRRDG---RYALNALATTLRSDAS
Mb0582|M.bovis_AF2122/97 IADRLGLLKRPAIDFLDALVSLDLLARDGDGPGSHYRNTPETAHFLDEAR
Rv0567|M.tuberculosis_H37Rv IADRLGLLKRPAIDFLDALVSLDLLARDGDGPGSHYRNTPETAHFLDEAR
MMAR_0934|M.marinum_M IAELLGLVPRPATDFLDALVSLDLLARDGDGPDARYRNTAETARYLDEAS
MUL_0686|M.ulcerans_Agy99 LAELLGLVPRPATDFLDALVSLDLLARDGDGPDARYRNTAETARYLDEAS
:* :. :: *:.. . : ** :: . :
Mvan_2460|M.vanbaalenii_PYR-1 ESMAPLIAFVGSRQHWEHWGELLYSVQTGRTAVEKLR-GSEFFEYLDTDP
Mflv_3940|M.gilvum_PYR-GCK GSLRDMVLFIGHPARWADWGSLEYSVRTGEPAADMLR-GMPFFDYLDTDP
MSMEG_0367|M.smegmatis_MC2_155 VSMAGMAKFVGAAQHREHWSHLADAVRTGESAIRTLR-GMEPFDYIASQP
TH_3167|M.thermoresistible__bu ASLAGAARFYGSRLHREHWSMLTDSVRTGKPGVPTLR-GMDWWQFSAANP
Mb0582|M.bovis_AF2122/97 PTYAGGLLKIWNERNYRFWADLTEALKTGKAQSEVKQTGRPFFEALYADP
Rv0567|M.tuberculosis_H37Rv PTYAGGLLKIWNERNYRFWADLTEALKTGKAQSEVKQTGRPFFEALYADP
MMAR_0934|M.marinum_M PEYQGGLLKIWDQRNYRFWADLTDALQTGKPQNEIKQTGRPFFETVYADP
MUL_0686|M.ulcerans_Agy99 PEYQGGLLKIWDQRNYRFWADLTDALQTGKPQNEIKQTGRPFFETVYADP
. *. * :::**.. : * :: ::*
Mvan_2460|M.vanbaalenii_PYR-1 AFAKVFNESMTGGSRAVIENAIPAYDFSDRRLIVDVGGGEGGLLAAILNR
Mflv_3940|M.gilvum_PYR-GCK EFATVFNNAMTAASGLSDDVALQACDFTGARLVVDVGGGHGAVLATILRS
MSMEG_0367|M.smegmatis_MC2_155 ELGTIFNDAMTSMSELAITPLIAAYDFTRFGTIADVGGGHGRLLSAILGS
TH_3167|M.thermoresistible__bu EFGDLFNGAMTSISELSAPVVAAAYDFSPFPTIVDVGGGHGRLLSAILAA
Mb0582|M.bovis_AF2122/97 RRLEAFMAAMDAASRRNIELLAKRFPFERYRRLCDVGCADGLLSRIVAAA
Rv0567|M.tuberculosis_H37Rv RRLEAFMAAMDAASRRNIELLAKRFPFERYRRLCDVGCADGLLSRIVAAA
MMAR_0934|M.marinum_M RRLEVFLGAMDSASRRNCELLVKRFPFQRYGSLCDVGGANGLLSRTAAAA
MUL_0686|M.ulcerans_Agy99 RRLEVFLGAMDSASRRNCELLVKRFPFQRYGSLCDVGGANGLLSRTAAAA
* :* . * * : *** ..* :
Mvan_2460|M.vanbaalenii_PYR-1 TPTARGVLFDRPSVVAGADSVLGPAGVAARCRTEGGSFFEAVPAGGDAYV
Mflv_3940|M.gilvum_PYR-GCK AAGARGILFDLPAVVAGAAPLLADAGVADRCTVSGGSFLESVPAGGDVYV
MSMEG_0367|M.smegmatis_MC2_155 APQAKGVLYDLPNVVEGAPEMLARHGVADRVQVIPGSFFDEVPDGADLYV
TH_3167|M.thermoresistible__bu TPTARGVLFDLPDVVADAPALLRAHGVADRVDIVGGSFFDAVPDG-DAYV
Mb0582|M.bovis_AF2122/97 HPHLQCVSLDLPAVTEIARRKLTAEGLGERVQACAGDFLADPLPAADVIT
Rv0567|M.tuberculosis_H37Rv HPHLQCVSFDLPAVTEIARRKLTAEGLGERVQACAGDFLADPLPAADVIT
MMAR_0934|M.marinum_M HPHLQCISFDLPAVTDITRRKLSEQGLGDRVRAVSGDFFADPLPSADVIT
MUL_0686|M.ulcerans_Agy99 HPHLQCISFDLPAVTDITRRKLSEQGLGDRVRAVSGDFFADPLPSADVIT
. : : * * *. : * *:. * *.*: . * .
Mvan_2460|M.vanbaalenii_PYR-1 MKAIIHDWGDDQSLSILRNVRTAIADDGRLLLFEMVLPERAP-AHLGFMV
Mflv_3940|M.gilvum_PYR-GCK MKNIVHDWDDTDAATILRNVRTAIAEGGKLVLLEMVLPERAS-SFIGHML
MSMEG_0367|M.smegmatis_MC2_155 MKNIIHDWADAPAAEILRNVRAAARTGATLLLVEGVIPDHDR-AFPLKWV
TH_3167|M.thermoresistible__bu LKNVIHDWDDDEALPILGNIRSALSDRGAILLVEMVIPSHHR-EFLGNMV
Mb0582|M.bovis_AF2122/97 MGQILHDWNLDRKQQLVAKAYEALSKEGAFIVIETLIDDARRENTTGLMM
Rv0567|M.tuberculosis_H37Rv MGQILHDWNLDRKQQLVAKAYEALSKEGAFIVIETLIDDARRENTTGLMM
MMAR_0934|M.marinum_M MGQILHDWNLDGKQRLIAKAYEALPEGGAFIAIETLIDDARRKNTAGLMM
MUL_0686|M.ulcerans_Agy99 MGQILHDWNLDGKQRLIAKAYEALPEGGAFTAIETLIDDARRKNTAGLMM
: ::*** :: : * . : .* :: . :
Mvan_2460|M.vanbaalenii_PYR-1 DLEMLVTA-GGRERTASQYAKLLADSGFRMTRVIPTASPLSIVEAVPA
Mflv_3940|M.gilvum_PYR-GCK DLEMLLML-RGKERTRAQYSELLEAAGFQLTRVIPTVSPISVIEARAV
MSMEG_0367|M.smegmatis_MC2_155 DMEMLIGN-AARERTEAQYRKLYTEAGFRLTRVVPTACPYSLIEGVAI
TH_3167|M.thermoresistible__bu DLEMLNGG-NARERTADEYRSLLARANLRMTRVVATAGPYSVIEARAA
Mb0582|M.bovis_AF2122/97 SLNMLIEFGDAFDYSAADFRGWCGEAGFRSFEVIPLAGGSSAAVAYK-
Rv0567|M.tuberculosis_H37Rv SLNMLIEFGDAFDYSAADFRGWCGEAGFRSFEVIPLAGGSSAAVAYK-
MMAR_0934|M.marinum_M SLNMLIEFGDAFDYTGADFRKWCGAAGFRSFEVIALAAGSSAAVAYK-
MUL_0686|M.ulcerans_Agy99 SLNMLIEFGDAFDYTGADFRKWCGAAGFRSFEVIALAAGSSAAVAYK-
.::** . : : :: :.:: .*:. . * .