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MDQSRPDRIMAIGAGYGPSKVLLTAVGLGLFTELGDRAMTAQALAELLGLVPRPATDFLDALVSLDLLAR DGDGPDARYRNTAETARYLDEASPEYQGGLLKIWDQRNYRFWADLTDALQTGKPQNEIKQTGRPFFETVY ADPRRLEVFLGAMDSASRRNCELLVKRFPFQRYGSLCDVGGANGLLSRTAAAAHPHLQCISFDLPAVTDI TRRKLSEQGLGDRVRAVSGDFFADPLPSADVITMGQILHDWNLDGKQRLIAKAYEALPEGGAFTAIETLI DDARRKNTAGLMMSLNMLIEFGDAFDYTGADFRKWCGAAGFRSFEVIALAAGSSAAVAYK
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. ulcerans Agy99 | MUL_0686 | - | - | 100% (340) | methyltransferase/methylase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0582 | - | 1e-156 | 79.40% (335) | methyltransferase/methylase |
| M. gilvum PYR-GCK | Mflv_3940 | - | 6e-24 | 26.96% (319) | O-methyltransferase family protein |
| M. tuberculosis H37Rv | Rv0567 | - | 1e-157 | 79.70% (335) | methyltransferase/methylase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | - | - | - | - | - |
| M. marinum M | MMAR_0934 | - | 0.0 | 99.12% (340) | methyltransferase/methylase |
| M. avium 104 | - | - | - | - | - |
| M. smegmatis MC2 155 | MSMEG_0367 | - | 4e-22 | 27.33% (311) | O-demethylpuromycin-O-methyltransferase |
| M. thermoresistible (build 8) | TH_3167 | - | 4e-28 | 29.06% (320) | PUTATIVE hydroxyneurosporene-O-methyltransferase |
| M. vanbaalenii PYR-1 | Mvan_2460 | - | 2e-22 | 26.59% (331) | O-methyltransferase family protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_3940|M.gilvum_PYR-GCK -----------------MTHTSTPRGSAARSAPNRVPPVRLIRAVDRLRA
Mvan_2460|M.vanbaalenii_PYR-1 ----------------------------MRTMLMTPPPVVLA-AVGRFRG
MSMEG_0367|M.smegmatis_MC2_155 -----------------------------------MPPARLVRAVERARH
TH_3167|M.thermoresistible__bu LQTEYVEVTRIAPVRSRRYDPITRSGGVVMSARVRVPPARIARTADAARH
MUL_0686|M.ulcerans_Agy99 --------------------------------------------------
MMAR_0934|M.marinum_M --------------------------------------------------
Mb0582|M.bovis_AF2122/97 --------------------------------------------------
Rv0567|M.tuberculosis_H37Rv --------------------------------------------------
Mflv_3940|M.gilvum_PYR-GCK GLQRLHRSTAPGNVALMELATGAWTTQVLYVAATLGIPDELADGPAHAAD
Mvan_2460|M.vanbaalenii_PYR-1 LLDRLHTLTAPSHIAVLELSLGSWFTAALYATVRLGIADALADGPLRADD
MSMEG_0367|M.smegmatis_MC2_155 HVRRLWLRSVPPEAAMLELLLGAWLAQGITAAAQLGVADALSGGPLRADE
TH_3167|M.thermoresistible__bu YLLRLQQKLTAPQAVMLEMILAGWTSQALTTAADLGVADALADGPLAIGD
MUL_0686|M.ulcerans_Agy99 -------MDQSRPDRIMAIGAGYGPSKVLLTAVGLGLFTELGDRAMTAQA
MMAR_0934|M.marinum_M -------MDQSSPDRIMAIGAGYGPSKVLLTAVGLGLFTELGDRAMTAQA
Mb0582|M.bovis_AF2122/97 -------MELS-PDRIMAIGGGYGPSKVLLTAVGLGLFTELGDEAMTAEA
Rv0567|M.tuberculosis_H37Rv -------MELS-PDRIMAIGGGYGPSKVLLTAVGLGLFTELGDEAMTAEA
. :: : . : : .:. **: *.. .
Mflv_3940|M.gilvum_PYR-GCK VATRVGADAGAVYRLMRAMVSRGALREERDG---RFALTPVGDALRTDSE
Mvan_2460|M.vanbaalenii_PYR-1 VARKVGADPEATYRLMRALASRSVLKLRRDG---RFALTRLGHALRVDHP
MSMEG_0367|M.smegmatis_MC2_155 LARRVGADADALDRLMRALVGEGVFRRTRDG---RYALNPLGDTLRTDAQ
TH_3167|M.thermoresistible__bu LARKVDADPERLARLMCALTSRGVFRQRRDG---RYALNALATTLRSDAS
MUL_0686|M.ulcerans_Agy99 LAELLGLVPRPATDFLDALVSLDLLARDGDGPDARYRNTAETARYLDEAS
MMAR_0934|M.marinum_M IAELLGLVPRPATDFLDALVSLDLLARDGDGPDARYRNTAETARYLDEAS
Mb0582|M.bovis_AF2122/97 IADRLGLLKRPAIDFLDALVSLDLLARDGDGPGSHYRNTPETAHFLDEAR
Rv0567|M.tuberculosis_H37Rv IADRLGLLKRPAIDFLDALVSLDLLARDGDGPGSHYRNTPETAHFLDEAR
:* :. :: *:.. . : ** :: . :
Mflv_3940|M.gilvum_PYR-GCK GSLRDMVLFIGHPARWADWGSLEYSVRTGEPAADMLR-GMPFFDYLDTDP
Mvan_2460|M.vanbaalenii_PYR-1 ESMAPLIAFVGSRQHWEHWGELLYSVQTGRTAVEKLR-GSEFFEYLDTDP
MSMEG_0367|M.smegmatis_MC2_155 VSMAGMAKFVGAAQHREHWSHLADAVRTGESAIRTLR-GMEPFDYIASQP
TH_3167|M.thermoresistible__bu ASLAGAARFYGSRLHREHWSMLTDSVRTGKPGVPTLR-GMDWWQFSAANP
MUL_0686|M.ulcerans_Agy99 PEYQGGLLKIWDQRNYRFWADLTDALQTGKPQNEIKQTGRPFFETVYADP
MMAR_0934|M.marinum_M PEYQGGLLKIWDQRNYRFWADLTDALQTGKPQNEIKQTGRPFFETVYADP
Mb0582|M.bovis_AF2122/97 PTYAGGLLKIWNERNYRFWADLTEALKTGKAQSEVKQTGRPFFEALYADP
Rv0567|M.tuberculosis_H37Rv PTYAGGLLKIWNERNYRFWADLTEALKTGKAQSEVKQTGRPFFEALYADP
. *. * :::**.. : * :: ::*
Mflv_3940|M.gilvum_PYR-GCK EFATVFNNAMTAASGLSDDVALQACDFTGARLVVDVGGGHGAVLATILRS
Mvan_2460|M.vanbaalenii_PYR-1 AFAKVFNESMTGGSRAVIENAIPAYDFSDRRLIVDVGGGEGGLLAAILNR
MSMEG_0367|M.smegmatis_MC2_155 ELGTIFNDAMTSMSELAITPLIAAYDFTRFGTIADVGGGHGRLLSAILGS
TH_3167|M.thermoresistible__bu EFGDLFNGAMTSISELSAPVVAAAYDFSPFPTIVDVGGGHGRLLSAILAA
MUL_0686|M.ulcerans_Agy99 RRLEVFLGAMDSASRRNCELLVKRFPFQRYGSLCDVGGANGLLSRTAAAA
MMAR_0934|M.marinum_M RRLEVFLGAMDSASRRNCELLVKRFPFQRYGSLCDVGGANGLLSRTAAAA
Mb0582|M.bovis_AF2122/97 RRLEAFMAAMDAASRRNIELLAKRFPFERYRRLCDVGCADGLLSRIVAAA
Rv0567|M.tuberculosis_H37Rv RRLEAFMAAMDAASRRNIELLAKRFPFERYRRLCDVGCADGLLSRIVAAA
* :* . * * : *** ..* :
Mflv_3940|M.gilvum_PYR-GCK AAGARGILFDLPAVVAGAAPLLADAGVADRCTVSGGSFLESVPAGGDVYV
Mvan_2460|M.vanbaalenii_PYR-1 TPTARGVLFDRPSVVAGADSVLGPAGVAARCRTEGGSFFEAVPAGGDAYV
MSMEG_0367|M.smegmatis_MC2_155 APQAKGVLYDLPNVVEGAPEMLARHGVADRVQVIPGSFFDEVPDGADLYV
TH_3167|M.thermoresistible__bu TPTARGVLFDLPDVVADAPALLRAHGVADRVDIVGGSFFDAVPDG-DAYV
MUL_0686|M.ulcerans_Agy99 HPHLQCISFDLPAVTDITRRKLSEQGLGDRVRAVSGDFFADPLPSADVIT
MMAR_0934|M.marinum_M HPHLQCISFDLPAVTDITRRKLSEQGLGDRVRAVSGDFFADPLPSADVIT
Mb0582|M.bovis_AF2122/97 HPHLQCVSLDLPAVTEIARRKLTAEGLGERVQACAGDFLADPLPAADVIT
Rv0567|M.tuberculosis_H37Rv HPHLQCVSFDLPAVTEIARRKLTAEGLGERVQACAGDFLADPLPAADVIT
. : : * * *. : * *:. * *.*: . * .
Mflv_3940|M.gilvum_PYR-GCK MKNIVHDWDDTDAATILRNVRTAIAEGGKLVLLEMVLPERAS-SFIGHML
Mvan_2460|M.vanbaalenii_PYR-1 MKAIIHDWGDDQSLSILRNVRTAIADDGRLLLFEMVLPERAP-AHLGFMV
MSMEG_0367|M.smegmatis_MC2_155 MKNIIHDWADAPAAEILRNVRAAARTGATLLLVEGVIPDHDR-AFPLKWV
TH_3167|M.thermoresistible__bu LKNVIHDWDDDEALPILGNIRSALSDRGAILLVEMVIPSHHR-EFLGNMV
MUL_0686|M.ulcerans_Agy99 MGQILHDWNLDGKQRLIAKAYEALPEGGAFTAIETLIDDARRKNTAGLMM
MMAR_0934|M.marinum_M MGQILHDWNLDGKQRLIAKAYEALPEGGAFIAIETLIDDARRKNTAGLMM
Mb0582|M.bovis_AF2122/97 MGQILHDWNLDRKQQLVAKAYEALSKEGAFIVIETLIDDARRENTTGLMM
Rv0567|M.tuberculosis_H37Rv MGQILHDWNLDRKQQLVAKAYEALSKEGAFIVIETLIDDARRENTTGLMM
: ::*** :: : * . : .* :: . :
Mflv_3940|M.gilvum_PYR-GCK DLEMLLML-RGKERTRAQYSELLEAAGFQLTRVIPTVSPISVIEARAV
Mvan_2460|M.vanbaalenii_PYR-1 DLEMLVTA-GGRERTASQYAKLLADSGFRMTRVIPTASPLSIVEAVPA
MSMEG_0367|M.smegmatis_MC2_155 DMEMLIGN-AARERTEAQYRKLYTEAGFRLTRVVPTACPYSLIEGVAI
TH_3167|M.thermoresistible__bu DLEMLNGG-NARERTADEYRSLLARANLRMTRVVATAGPYSVIEARAA
MUL_0686|M.ulcerans_Agy99 SLNMLIEFGDAFDYTGADFRKWCGAAGFRSFEVIALAAGSSAAVAYK-
MMAR_0934|M.marinum_M SLNMLIEFGDAFDYTGADFRKWCGAAGFRSFEVIALAAGSSAAVAYK-
Mb0582|M.bovis_AF2122/97 SLNMLIEFGDAFDYSAADFRGWCGEAGFRSFEVIPLAGGSSAAVAYK-
Rv0567|M.tuberculosis_H37Rv SLNMLIEFGDAFDYSAADFRGWCGEAGFRSFEVIPLAGGSSAAVAYK-
.::** . : : :: :.:: .*:. . * .