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MSDVQASIAAKEPAEGGNAGMGAQYLEVRGLTVDFDGFKAVSDVDLTLFQGDLRFLIGPNGAGKTTVIDA ITGLVSASGSVNKSGVELLGKKVNQIARLGVGRTFQTASVFEQLTVLQNLDIAAGAGRSVWTLLRRRNGV LPAIEQALHTTGLTHLADKPAGVLAHGQKQWLEIGMLLVQNADVLLLDEPVAGMSAEEREETGNLLRRIG AERTVVVVEHDMDFMRAFATSVTVLARGQVIAEGSVAEVQANPRVQEVYLGTAAAGADGIELVEENS
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_3801 | - | - | 100% (277) | ABC transporter related |
| M. gilvum PYR-GCK | Mflv_3571 | - | 9e-35 | 37.01% (254) | ABC transporter related |
| M. gilvum PYR-GCK | Mflv_3165 | - | 4e-23 | 30.27% (261) | ABC transporter related |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1270 | sugC | 6e-20 | 27.68% (224) | sugar-transport ATP-binding protein ABC transporter SugC |
| M. tuberculosis H37Rv | Rv1238 | sugC | 6e-20 | 27.68% (224) | sugar-transport ATP-binding protein ABC transporter SugC |
| M. leprae Br4923 | MLBr_01089 | - | 5e-19 | 27.68% (224) | putative ABC-transport protein, ATP-binding component |
| M. abscessus ATCC 19977 | MAB_2623c | - | 3e-33 | 35.50% (262) | branched chain amino acid ABC transporter |
| M. marinum M | MMAR_3715 | cysA1 | 3e-20 | 28.97% (252) | sulfate-transport ATP-binding protein ABC transporter CysA1 |
| M. avium 104 | MAV_1785 | - | 4e-19 | 29.31% (232) | sulfate/thiosulfate import ATP-binding protein CysA |
| M. smegmatis MC2 155 | MSMEG_2979 | - | 1e-131 | 88.89% (270) | ABC transporter ATP-binding protein |
| M. thermoresistible (build 8) | TH_4087 | - | 1e-122 | 88.28% (256) | PUTATIVE ABC transporter ATP-binding protein |
| M. ulcerans Agy99 | MUL_3658 | cysA1 | 3e-20 | 28.97% (252) | sulfate-transport ATP-binding protein ABC transporter CysA1 |
| M. vanbaalenii PYR-1 | Mvan_2593 | - | 1e-146 | 95.31% (277) | ABC transporter-related protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_3801|M.gilvum_PYR-GCK -------------------MSDVQASIAAKEPAEGGNAGMGAQYLEVRGL
Mvan_2593|M.vanbaalenii_PYR-1 -------------------MTEVEASTAGKEPVEGGNAGMGAQYLEVRGL
MSMEG_2979|M.smegmatis_MC2_155 -------------------MTDTET-TAEKEPVAGGNAGMGAEYLEVRGL
TH_4087|M.thermoresistible__bu -------------------MT-----TAAREPVAGGNAGMRAEYLEVRGL
MAB_2623c|M.abscessus_ATCC_199 MTKHRDSSLDDEQDSVEMLQAEIEEGSDEGESGVPVDPGEAEVLLEVKDL
Mb1270|M.bovis_AF2122/97 -----------------------------------------MAEIVLDHV
Rv1238|M.tuberculosis_H37Rv -----------------------------------------MAEIVLDHV
MLBr_01089|M.leprae_Br4923 -----------------------------------------MAEIVLEHV
MMAR_3715|M.marinum_M --------------------------MKKETSLTGPGT--GGHAIVVRDA
MUL_3658|M.ulcerans_Agy99 --------------------------------MTGPGT--GGHAIVVRDA
MAV_1785|M.avium_104 --------------------------------MTDAGTDRGDIAITVRDA
: :
Mflv_3801|M.gilvum_PYR-GCK TVDFDG-FKAVSDVDLTLFQGDLRFLIGPNGAGKTTVIDAITGLVS-ASG
Mvan_2593|M.vanbaalenii_PYR-1 TVDFDG-FKAVSDVDLTLFQGDLRFLIGPNGAGKTTVIDAITGLVP-ATG
MSMEG_2979|M.smegmatis_MC2_155 TVDFDG-FKAVNGVDLTLFQGDLRFLIGPNGAGKTTVIDAITGLVP-ATG
TH_4087|M.thermoresistible__bu TVDFDG-FKAVSGVDLTLFQGDLRFLIGPNGAGKTTVIDAITGLVP-ATG
MAB_2623c|M.abscessus_ATCC_199 TLKFGG-LQALDGVSFDIRRGEILGLVGPNGAGKTTCFNAITGVYKPTSG
Mb1270|M.bovis_AF2122/97 NKSYPDGHTAVRDLNLTIADGEFLILVGPSGCGKTTTLNMIAGLEDISSG
Rv1238|M.tuberculosis_H37Rv NKSYPDGHTAVRDLNLTIADGEFLILVGPSGCGKTTTLNMIAGLEDISSG
MLBr_01089|M.leprae_Br4923 NKNYPNGATAVHDLSITVADGEFLILIGPSGCGKTTTLNMIAGLEDISSG
MMAR_3715|M.marinum_M FKQYGD-FVALDHVDFVVPAGSLTALLGPSGSGKSTLLRTIAGLDQPDSG
MUL_3658|M.ulcerans_Agy99 FKQYGD-FVALDHVDFVVPAGSLTALLGPSGSGKSTLLRTIAGLDQPDSG
MAV_1785|M.avium_104 YKRYGD-FVALDHVDFVVPTGSLTALLGPSGSGKSTLLRTIAGLDQPDTG
: . *: :.: : *.: *:**.*.**:* : *:*: :*
Mflv_3801|M.gilvum_PYR-GCK SVNKSGVELLGKKVNQIARLGVGRTFQTASVFEQLTVLQNLDIAAGAGRS
Mvan_2593|M.vanbaalenii_PYR-1 SVNKSGVELLGKKVHQIARRGVGRTFQTASVFEQLTVLQNLDIAAGAGRS
MSMEG_2979|M.smegmatis_MC2_155 SVNKSGAELLGKKVHQIARLGVGRTFQTASVFEQLTVLQNLDIAAGAGRS
TH_4087|M.thermoresistible__bu SVNKSGVELLGKKVHQIARLGVGRTFQTASVFETLTVLQNLDIAAGAGRS
MAB_2623c|M.abscessus_ATCC_199 SIVFNGKPLRRLRRHQITRRGIARTFQNIRLFGEMTALENVAVGTDARHK
Mb1270|M.bovis_AF2122/97 ELRIAGERVN---EKAPKDRDIAMVFQSYALYPHMTVRQNIAFPLTLAK-
Rv1238|M.tuberculosis_H37Rv ELRIAGERVN---EKAPKDRDIAMVFQSYALYPHMTVRQNIAFPLTLAK-
MLBr_01089|M.leprae_Br4923 ELRIDGDRVN---EKAPKDRDIAMVFQSYALYPHMTVRQNIAFPLMLAK-
MMAR_3715|M.marinum_M NITINGRDVT---RVPPQRRGIGFVFQHYAAFKHLTVRDNVAYGLKIRK-
MUL_3658|M.ulcerans_Agy99 NITINGRDVT---RVPPQRRGIGFVFQHYAAFKHLTVRDNVAYGLKIRK-
MAV_1785|M.avium_104 TVTIYGRDVT---RVPPQRRGIGFVFQHYAAFKHLTVRDNVAYGLKVRK-
: * : .:. .** : :*. :*: :
Mflv_3801|M.gilvum_PYR-GCK VWTL---------LRRRNGVLPAIEQALHTTGLTHLADKPAGVLAHGQKQ
Mvan_2593|M.vanbaalenii_PYR-1 VWTL---------LRRRNGVLPAIEQALHTIGLTHLADKPAGVLAHGQKQ
MSMEG_2979|M.smegmatis_MC2_155 PWSL---------LRRRRGVLPSIEEALETTGLADLADKPAGVLAHGQKQ
TH_4087|M.thermoresistible__bu WRTL---------LRRRGAVLPQITETLQTIGLADLADEPAGTLAHGQKQ
MAB_2623c|M.abscessus_ATCC_199 TSVLGALLRTPRHRREEHYAVDVGMGLLDFVGIADDADVKAKNLPYGSQR
Mb1270|M.bovis_AF2122/97 --------------MRKADIAQKVSETAKILDLTNLLDRKPSQLSGGQRQ
Rv1238|M.tuberculosis_H37Rv --------------MRKADIAQKVSETAKILDLTNLLDRKPSQLSGGQRQ
MLBr_01089|M.leprae_Br4923 --------------VKKAEIAQKVSETAQILDLTDLLDRKPSQLSGGQRQ
MMAR_3715|M.marinum_M --------------RPKAEIRDKVDNLLEVVGLSGFHGRYPNQLSGGQRQ
MUL_3658|M.ulcerans_Agy99 --------------RPKAEIRDKVDNLLEVVGLSGFHGRYPDQLSGGQRQ
MAV_1785|M.avium_104 --------------RPKAEIKAKVDNLLEVVGLSGFQGRYPNQLSGGQRQ
. . .:: . . *. *.::
Mflv_3801|M.gilvum_PYR-GCK WLEIGMLLVQNADVLLLDEPVAGMSAEEREETGNLLRRIGAE--RTVVVV
Mvan_2593|M.vanbaalenii_PYR-1 WLEIGMLLVQNADVLLLDEPVAGMSAEEREETGNLLRRIGAE--RTVVVV
MSMEG_2979|M.smegmatis_MC2_155 WLEIGMLLVQNADVLLLDEPVAGMSHEEREETGNLLRRIGGA--RTVVVV
TH_4087|M.thermoresistible__bu WLEIGMLLVQNADVLLLDEPVAGMSHEEREQTGNLLRRIGGE--RTVVVV
MAB_2623c|M.abscessus_ATCC_199 RLEIARALATEPKLLCLDEPAAGFTPSEKDSLIELIQRIRDYG-YTVLLI
Mb1270|M.bovis_AF2122/97 RVAMGRAIVRHPKAFLMDEPLSNLDAKLRVQMRGEIAQLQRRLGTTTVYV
Rv1238|M.tuberculosis_H37Rv RVAMGRAIVRHPKAFLMDEPLSNLDAKLRVQMRGEIAQLQRRLGTTTVYV
MLBr_01089|M.leprae_Br4923 RVAMGRAIVRHPKAFLMDEPLSNLDAKLRVRTRGEIARLQRRLGATTVYV
MMAR_3715|M.marinum_M RMALARALAVDPEVLLLDEPFGALDAKVREDLRAWLRRLHDEVHVTTVLV
MUL_3658|M.ulcerans_Agy99 RMALARALAVDPEVLLLDEPFGALDAKVREDLRAWLRRLHDEVHVTTVLV
MAV_1785|M.avium_104 RMALARALAVDPQVLLLDEPFGALDAKVREDLRAWLRRLHDEVHVTTVLV
: :. :. ... : :*** . : . : : :: *.: :
Mflv_3801|M.gilvum_PYR-GCK EHDMDFMRAFATSVTVLARGQVIAEGSVAEVQANPRVQEVYLG-------
Mvan_2593|M.vanbaalenii_PYR-1 EHDMDFMRAFATSVTVLARGQVIAEGSVTEVQANPKVQEVYLG-------
MSMEG_2979|M.smegmatis_MC2_155 EHDMDFMRAFATSVTVLARGQVIAEGTVAEVQANPKVQEVYLG-------
TH_4087|M.thermoresistible__bu EHDMDFMRAFATSVTVLARGQVIAEGTVEEVQANPKVQEVYLG-------
MAB_2623c|M.abscessus_ATCC_199 EHDMKLVMGVTDRIVVLEFGRKIADGLPAEVRNDPAVIEAYLG-------
Mb1270|M.bovis_AF2122/97 THDQTEAMTLGDRVVVMYGGIAQQIGTPEELYERPAN--LFVAGFIGSPA
Rv1238|M.tuberculosis_H37Rv THDQTEAMTLGDRVVVMYGGIAQQIGTPEELYERPAN--LFVAGFIGSPA
MLBr_01089|M.leprae_Br4923 THDQTEAMTLGDRVVVMRSGVVQQIGTPDELYERPVN--LFVAGFIGSPV
MMAR_3715|M.marinum_M THDQAEALDVADRIAVLNSGRIEQVGSPTEVYDAPAN--AFVMSFLG---
MUL_3658|M.ulcerans_Agy99 THDQAEALDVADRIAVLNSGRIEQVGSPTEVYDAPTN--AFVMSFLG---
MAV_1785|M.avium_104 THDQAEALDVADRIAVLNQGRIEQIGSPTEVYDAPTN--AFVMSFLG---
** . :.*: * * *: * ::
Mflv_3801|M.gilvum_PYR-GCK -------------------------------------TAAAGADGIELVE
Mvan_2593|M.vanbaalenii_PYR-1 -------------------------------------TAAAGADGIELVE
MSMEG_2979|M.smegmatis_MC2_155 -------------------------------------TAAAGAEGIA---
TH_4087|M.thermoresistible__bu -------------------------------------TAAELPEEAH---
MAB_2623c|M.abscessus_ATCC_199 -------------------------------------VADEDFHGPGWLD
Mb1270|M.bovis_AF2122/97 MNFFPARLTAIGLTLPFGEVTLAPEVQGVIAAHPKPENVIVGVRPEHIQD
Rv1238|M.tuberculosis_H37Rv MNFFPARLTAIGLTLPFGEVTLAPEVQGVIAAHPKPENVIVGVRPEHIQD
MLBr_01089|M.leprae_Br4923 MNFFPAKLTPNGLTLPLGELNLSRDVQAMIGQHPVPDRVIVGVRPEHLTD
MMAR_3715|M.marinum_M -----------AVSALNGALVRPHDIR----VGRTPEMAVAAADGTGEST
MUL_3658|M.ulcerans_Agy99 -----------AVSALNGALVRPHDIR----VGRTPEMAVAAADGTGEST
MAV_1785|M.avium_104 -----------AVSTLNGTLVRPHDIR----VGRTPEMAVAAEDGTAEST
.
Mflv_3801|M.gilvum_PYR-GCK ENS-----------------------------------------------
Mvan_2593|M.vanbaalenii_PYR-1 ENS-----------------------------------------------
MSMEG_2979|M.smegmatis_MC2_155 --------------------------------------------------
TH_4087|M.thermoresistible__bu --------------------------------------------------
MAB_2623c|M.abscessus_ATCC_199 SAPPDSESER----------------------------------------
Mb1270|M.bovis_AF2122/97 AALIDAYQRIRALTFQVKVNLVESLGADKYLYFTTESPAVHSVQLDELAE
Rv1238|M.tuberculosis_H37Rv AALIDAYQRIRALTFQVKVNLVESLGADKYLYFTTESPAVHSVQLDELAE
MLBr_01089|M.leprae_Br4923 AKLIDAHQHGTVLTFKVKVDLVESLGADKYIYFTTTGCDVYSAQLDELAS
MMAR_3715|M.marinum_M GVTRAVVDRIVVLGFEVRVELTSAATGGAFTAQITRG------DAEALAL
MUL_3658|M.ulcerans_Agy99 GVTRAVVDRIVVLGFEVRVELTSAATGGAFTAQITRG------DAEALAL
MAV_1785|M.avium_104 GVARAIVDRVVKLGFEVRVELTSAATGGPFTAQITRG------DAEALAL
Mflv_3801|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_2593|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_2979|M.smegmatis_MC2_155 --------------------------------------------------
TH_4087|M.thermoresistible__bu --------------------------------------------------
MAB_2623c|M.abscessus_ATCC_199 --------------------------------------------------
Mb1270|M.bovis_AF2122/97 VEGESALHENQFVARVPAESKVAIGQSVELAFDTARLAVFDADSGANLTI
Rv1238|M.tuberculosis_H37Rv VEGESALHENQFVARVPAESKVAIGQSVELAFDTARLAVFDADSGANLTI
MLBr_01089|M.leprae_Br4923 ---ELEVRENQFVARVSAESKMAIGESIELAFGTAKIAVFDADSGVNLTV
MMAR_3715|M.marinum_M QEGDTVYVRATRVPPIAGAAPAVPDDGAGSTPSAAQIGVGGQ--------
MUL_3658|M.ulcerans_Agy99 QEGDTVYVRATRVPPIAGAAPAVPDDGAGSTPRAAQIGVGGQ--------
MAV_1785|M.avium_104 REGDTVYVRATRVPPITAGATTVPAVSRDGADEATLTSA-----------
Mflv_3801|M.gilvum_PYR-GCK ------
Mvan_2593|M.vanbaalenii_PYR-1 ------
MSMEG_2979|M.smegmatis_MC2_155 ------
TH_4087|M.thermoresistible__bu ------
MAB_2623c|M.abscessus_ATCC_199 ------
Mb1270|M.bovis_AF2122/97 PHRA--
Rv1238|M.tuberculosis_H37Rv PHRA--
MLBr_01089|M.leprae_Br4923 SAPTDA
MMAR_3715|M.marinum_M ------
MUL_3658|M.ulcerans_Agy99 ------
MAV_1785|M.avium_104 ------