For questions or suggestions e-mail us at: ioerger@cs.tamu.edu

M. gilvum PYR-GCK Mflv_3794 (-)

annotation: acyl-CoA dehydrogenase domain-containing protein
coordinates: 4049751 - 4051034
length: 427

MTETMTSTESTGTVETVEQFAARARTWLAENMPSIDPDNPPFSVRADQESWDRAKELQKRLYEGGFAGIC
FPREYGGLGLDYAYQRAFNAECRSYEMPLILNVPTFTICAATILDMGTEDQKRDRISAAVRGDEILCQLL
SEPSGGSDLAGVITRADKQGDTWIINGAKTWSTSAFAADYGLLLARTDWTVPKHEGLTMFLVPLDSPGIT
MRRIKEVNGNEEFCEEFFDGLELGADAVVGEVNKGWEVATRQLHHERRAVGGGSEFASGTAAENASEMPP
DHVGLAEATGQSDNPLVQDLAGRALVRRIVKEQLIDHVFRSITDGSLPPNAGTLIRLFHAETTELEVDTA
LAIAGTAGVIDEGSDDAPELSGLLEIGVRYLSRQTGSLGGGSSEMARNVIGERILGFPRELAADKGIPFN
EVKRNKS

Operon Prediction Model: Genebank

Paralogs

species id gene e-value identity (len) annotation
M. gilvum PYR-GCK Mflv_3794 - - 100% (427) acyl-CoA dehydrogenase domain-containing protein
M. gilvum PYR-GCK Mflv_2334 - 1e-49 31.28% (422) acyl-CoA dehydrogenase domain-containing protein
M. gilvum PYR-GCK Mflv_0344 - 3e-48 32.08% (371) acyl-CoA dehydrogenase domain-containing protein

Closest Orthologs (e-value cutoff: 1e-4)

species id gene e-value identity (len) annotation
M. bovis AF2122 / 97 Mb3590c fadE30 4e-46 31.68% (404) acyl-CoA dehydrogenase FADE30
M. tuberculosis H37Rv Rv3560c fadE30 4e-46 31.68% (404) acyl-CoA dehydrogenase FADE30
M. leprae Br4923 MLBr_00737 fadE25 5e-17 25.77% (260) putative acyl-CoA dehydrogenase
M. abscessus ATCC 19977 MAB_3122 - 5e-42 28.92% (415) putative acyl-CoA dehydrogenase
M. marinum M MMAR_3992 - 1e-163 66.91% (411) acyl-CoA dehydrogenase
M. avium 104 MAV_1620 - 1e-169 69.08% (414) acyl-CoA dehydrogenase middle domain-containing protein
M. smegmatis MC2 155 MSMEG_2992 - 0.0 83.10% (426) putative acyl-CoA dehydrogenase
M. thermoresistible (build 8) TH_4121 - 1e-176 69.39% (428) PUTATIVE acyl-CoA dehydrogenase domain protein
M. ulcerans Agy99 MUL_3854 - 1e-159 65.94% (411) acyl-CoA dehydrogenase
M. vanbaalenii PYR-1 Mvan_2600 - 0.0 90.63% (427) acyl-CoA dehydrogenase domain-containing protein

CLUSTAL 2.0.9 multiple sequence alignment


Mb3590c|M.bovis_AF2122/97           ---------------MQDVEEFRAQVRGWLADNLAG----EFAALKGLGG
Rv3560c|M.tuberculosis_H37Rv        ---------------MQDVEEFRAQVRGWLADNLAG----EFAALKGLGG
MAB_3122|M.abscessus_ATCC_1997      ----------------MPVTSSEPSSAGSNALHTSGSSQRDRVAAAAHEV
Mflv_3794|M.gilvum_PYR-GCK          --MTETMTSTESTGTVETVEQFAARARTWLAENMPSID-----PDNPPFS
Mvan_2600|M.vanbaalenii_PYR-1       --MTDTMTSTETT---ESVADFAARARTWLAENMPSID-----PDDPPFS
MSMEG_2992|M.smegmatis_MC2_155      --MTETAVSTGTQ---ESVEDFAARARAWLAGNMPRID-----PDNPPFS
MMAR_3992|M.marinum_M               ------------MTAVESVAEFATRARKWLAANMSQID-----PLSPPEA
MUL_3854|M.ulcerans_Agy99           ------------MTAVESVAEFATRARKWLAANMSQID-----PLSPPEA
MAV_1620|M.avium_104                -------------MTTESVAQFAARARAWLADNMPAID-----RESPPPA
TH_4121|M.thermoresistible__bu      MTETTTTSQGRPAEITETVEEFAARARAWLAESMPRID-----PDNPPNA
MLBr_00737|M.leprae_Br4923          -------MVGWSGNPLFDLFKLPEEHNELRATIRALAE-----KEIAPHA
                                                      : .         *   .               

Mb3590c|M.bovis_AF2122/97           PGREHEAFEERRAWNQRLAAAGLTCLGWPEEHGGRGLSTAHRVAFYEEYA
Rv3560c|M.tuberculosis_H37Rv        PGREHEAFEERRAWNQRLAAAGLTCLGWPEEHGGRGLSTAHRVAFYEEYA
MAB_3122|M.abscessus_ATCC_1997      LAKHPPATTPVTDLLGAVYDAGLAWVHFPVGLGGLDAPPALQAVSDTILR
Mflv_3794|M.gilvum_PYR-GCK          VRADQESWDRAKELQKRLYEGGFAGICFPREYGGLGLDYAYQRAFNAECR
Mvan_2600|M.vanbaalenii_PYR-1       VRAEQSSWDRAMELQKRLYEGGFAGICFPREYGGLGLDHAYQKAFNAECR
MSMEG_2992|M.smegmatis_MC2_155      VRADQESWDRAKELQKRLYQGGFAGICFPREYGGLGLDHAYQRAFNAEAR
MMAR_3992|M.marinum_M               PRDDEASWQRARQLQRRLHDGGFAGICFPREYGGQGLAYEYQRAFDEESL
MUL_3854|M.ulcerans_Agy99           PRDDEASWQRARQLQRRPNDGGFAGICFPREYGGQGLAYEYQRAFDEESL
MAV_1620|M.avium_104                PRDDERAWRRARELQKRLYDGGFAGICFPREYGGLGLDYEYQKAFDAESL
TH_4121|M.thermoresistible__bu      DRGEEEPWLRARELQKRLYEGGFAGICFPREYGGLGLPYEYQKAFDAETA
MLBr_00737|M.leprae_Br4923          ADVDQRARFP-EEALAALNASGFNAIHVPEEYGGQGADSVAACIVIEEVA
                                       .  .             .*:  :  *   ** .              

Mb3590c|M.bovis_AF2122/97           RADAPD--KVNHFGEELLGPTLIAFGTPQQQRRFLPRIRDVTELWCQGYS
Rv3560c|M.tuberculosis_H37Rv        RADAPD--KVNHFGEELLGPTLIAFGTPQQQRRFLPRIRDVTELWCQGYS
MAB_3122|M.abscessus_ATCC_1997      AAGVPDPLFVNVIGYGMAAPTVLAHGQPELIRRILRPLFTGEELWCQLFS
Mflv_3794|M.gilvum_PYR-GCK          SYEMPL--ILNVPTFTICAATILDMGTEDQKRDRISAAVRGDEILCQLLS
Mvan_2600|M.vanbaalenii_PYR-1       CYEMPL--ILNVPTFTICAATILDMGSEAQKRDRISAAIRGDEILCQLLS
MSMEG_2992|M.smegmatis_MC2_155      CYEMPL--ILNTPSFTICAATILDMGSEQQKRDRIGAAIRGEEILVQLLS
MMAR_3992|M.marinum_M               HYEMPL--ILNVPTFTICCATLLDTGSESQKKRHIAAALRGEEVLVQLLS
MUL_3854|M.ulcerans_Agy99           HYEMPL--ILNVPTFTICCATLLDTGSENQKKRHIAAALRGEEVLVQLLS
MAV_1620|M.avium_104                DYEMPL--ILNTPTFTICCATLLDTGSEQQKKQHIAAALRGEEILVQLLS
TH_4121|M.thermoresistible__bu      EYELPL--ILNTPTFTICCATILDTGSEQQKRKHISAAIRGDEVLVQLLS
MLBr_00737|M.leprae_Br4923          RVDASAS--LIPAVNKLGTMGLILRGSEELKKQVLPSLAAEGAMASYALS
                                        .    :      :    ::  *     :  :        :     *

Mb3590c|M.bovis_AF2122/97           EPGAGSDLASVATTAELDGDQWVINGQKVWTSLAHLSQWCFVLARTEKGS
Rv3560c|M.tuberculosis_H37Rv        EPGAGSDLASVATTAELDGDQWVINGQKVWTSLAHLSQWCFVLARTEKGS
MAB_3122|M.abscessus_ATCC_1997      EPGAGSDLAGLATRAVRDGDEWVINGQKVWTSGAHQARWALLVARSNPDV
Mflv_3794|M.gilvum_PYR-GCK          EPSGGSDLAGVITRADKQGDTWIINGAKTWSTSAFAADYGLLLARTDWTV
Mvan_2600|M.vanbaalenii_PYR-1       EPSGGSDLAGVITRAERNGDKWIINGAKTWSTSAFAADYGLLLARTDWTV
MSMEG_2992|M.smegmatis_MC2_155      EPSGGSDLAGVITRADRVGDKWVINGAKTWSTSAFAGDYGLMLARTNWDV
MMAR_3992|M.marinum_M               EPSGGSDLAGVLTRAERQGDRWVINGAKTWSTSAFAADYGLCLARTNWDV
MUL_3854|M.ulcerans_Agy99           EHSGGSDLAGVLTRAERQGDRWVINGAKTWSTSAFAADYGLCLARTNWDV
MAV_1620|M.avium_104                EPSGGSDLAGVLTRAERRGDRWIINGAKTWSTSAFAADYGLCLARTNWDV
TH_4121|M.thermoresistible__bu      EPSGGSDLAGVITRADRRGDKWVINGAKTWSTSAFAADYGLLLARTNWDV
MLBr_00737|M.leprae_Br4923          EREAGSDAASMRTRAKADGDDWILNGFKCWITNGGKSTWYTVMAVTDPD-
                                    *  .*** *.: * *   ** *::** * * : .  . :   :* ::   

Mb3590c|M.bovis_AF2122/97           QRHAGLSYLLVPLDQPGVQIRPIVQITGT--AEFNEVFFDDARTDADLVV
Rv3560c|M.tuberculosis_H37Rv        QRHAGLSYLLVPLDQPGVQIRPIVQITGT--AEFNEVFFDDARTDADLVV
MAB_3122|M.abscessus_ATCC_1997      AKHRGLTYFVVDMTDPGVEVRPLRQMTGD--AEFNEVYLTDVRIPDAHRL
Mflv_3794|M.gilvum_PYR-GCK          PKHEGLTMFLVPLDSPGITMRRIKEVNGN--EEFCEEFFDGLELGADAVV
Mvan_2600|M.vanbaalenii_PYR-1       PKHEGLTMFLVPLNAPGITMRRIKEVNGN--EEFCEEFFDGLELGDDAVV
MSMEG_2992|M.smegmatis_MC2_155      PKHEGLTMFLVPLKAPGITMRRIKEVNGN--EEFCEEFFDNLELGDDAVV
MMAR_3992|M.marinum_M               PKHDGLTMFLVPINHPGITLRRITQVNGS--TEFCEEFLDGVDVGDDAVV
MUL_3854|M.ulcerans_Agy99           PKHDGLTMFLVPINHPGITLRRITQVNGS--TEFCEEFLDSVDVGDDAVV
MAV_1620|M.avium_104                PKHEGLTMFLVPINHPGITLRRITMLSGS--TEFCEEFLDGVDVGDDAVV
TH_4121|M.thermoresistible__bu      PKHEGLTMFLVPLDAPGITMRRIKQVDGG--NEFCEEFFDNVEVGDDAVV
MLBr_00737|M.leprae_Br4923          KGANGISAFIVHKDDEGFSIGPKEKKLGIKGSPTTELYFDKCRIPGDRII
                                        *:: ::*     *. :       *       * ::          :

Mb3590c|M.bovis_AF2122/97           GAPGDGWRVAMATLTFERGVSTLGQQIVYAR-------ELSNLVELARRT
Rv3560c|M.tuberculosis_H37Rv        GAPGDGWRVAMATLTFERGVSTLGQQIVYAR-------ELSNLVELARRT
MAB_3122|M.abscessus_ATCC_1997      GNEGDGWRVSMTTLMNER--SALGGAFDHGRGG----GSIGNALNLWKQR
Mflv_3794|M.gilvum_PYR-GCK          GEVNKGWEVATRQLHHERRAVGGGSEFASGTAAENASEMPPDHVGLAEAT
Mvan_2600|M.vanbaalenii_PYR-1       GEVNKGWEVATRQLHHERRAVGGGSEFASGTAAENASEMPPDHVGLARAT
MSMEG_2992|M.smegmatis_MC2_155      GKVDDGWTVASRQLFHERRAVGGGSEFASGTGAENANEMPPDHVGLAEAL
MMAR_3992|M.marinum_M               GEVNNGWTVASRQLYHERRAVGMGSEFASGAGSEGGHATPVDYVALAETT
MUL_3854|M.ulcerans_Agy99           GEVNNGWTVASRQLYHERRAVGIGSEFASGAGSEGGHATPVDYVALAETT
MAV_1620|M.avium_104                GEVNGGWAVASRQLYHERRAVGQGSEFASGGGSEGGHTIPVDYVSLAEKT
TH_4121|M.thermoresistible__bu      GEVDKGWEVASRQLYHERRAVGGGSEFASGIGAEGSTDQPVDYVALLAAT
MLBr_00737|M.leprae_Br4923          GEPGTGFKTALATLDHTRPTIGAQAVGIAQGALDAAIVYTKDRKQFGESI
                                    *  . *: .:   *   *                       :   :    

Mb3590c|M.bovis_AF2122/97           AAADDPLIRERLTRAWTGLRAMRSYALATMEGPAVEQPGQD--NVSKLLW
Rv3560c|M.tuberculosis_H37Rv        AAADDPLIRERLTRAWTGLRAMRSYALATMEGPAVEQPGQD--NVSKLLW
MAB_3122|M.abscessus_ATCC_1997      PDLHTPELRAKLTNLFVRSEGNRYGTQMRIAAQGDAPMGPEG-SIGKLMG
Mflv_3794|M.gilvum_PYR-GCK          GQSDNPLVQDLAGRALVRRIVKEQLIDHVFRSITDGSLPPNAGTLIRLFH
Mvan_2600|M.vanbaalenii_PYR-1       GQDGDPRVQDLAGRALVRRIVKEQLIDHVFRSIGNGSLPPNAGTLIRLFH
MSMEG_2992|M.smegmatis_MC2_155      GRADDPFVQDLAGRALVRRAVKTQLIDHVTQAIAAGALPPTAGTLIRLFH
MMAR_3992|M.marinum_M               GQAHSDRVREMAGRALVHRAVCEQLIDHVYRSVRDGTLPPAAGTLIRLFH
MUL_3854|M.ulcerans_Agy99           GQAHSDRVREMAGRALVHRAVCEQLIDHVYRSVRDGTLPPAAGTLIRLFH
MAV_1620|M.avium_104                GQADDPRVQEMAGRVLVHRAVAEQLIGHVYRSVRDGALPPAAGTLIRLFH
TH_4121|M.thermoresistible__bu      GQSDSLRAQELAGRALVHRAVQDQLVEHVYHAVNDGTLPPAGGSIIRVTH
MLBr_00737|M.leprae_Br4923          STFQSIQFMLADMAMKVEAARLIVYAAAARAERGEPDLGFIS-AASKCFA
                                                    .                             :   

Mb3590c|M.bovis_AF2122/97           ANWHRNLGELAMDVIGKPGMTMP---------DGEFDEWQRLYLFTRADT
Rv3560c|M.tuberculosis_H37Rv        ANWHRNLGELAMDVIGKPGMTMP---------DGEFDEWQRLYLFTRADT
MAB_3122|M.abscessus_ATCC_1997      AELNQQIYDFCVELLGIEATLYASYDMRRVVEDDRRADTMWAFLRSKANT
Mflv_3794|M.gilvum_PYR-GCK          AETTELEVDTALAIAGTAGVIDEGSDD--APELSGLLEIGVRYLSRQTGS
Mvan_2600|M.vanbaalenii_PYR-1       AETTELEVDTALAIAGTAGVVDEGSDD--APGLTGLMDVGVRYLSRQTGS
MSMEG_2992|M.smegmatis_MC2_155      AETTELEVDTALAIAGTAGVVDEGGD------FDGMLDIGVRYLSRQTGS
MMAR_3992|M.marinum_M               AETVMCEMDTSLAIAGSGGVVGQPGE---------GLQTGLRYLARQSVA
MUL_3854|M.ulcerans_Agy99           AETVMCEMDTSLAIAGSGGVVGQPGE---------GLQTGLRYLARQSVA
MAV_1620|M.avium_104                SETVTTDVDTALAIAGSAGVVGEPGA---------GLETGLRYLSRQTVA
TH_4121|M.thermoresistible__bu      AEHIQVEVDTALALAGSGGVVDDSRD---------LFRFGERYLSRQAAA
MLBr_00737|M.leprae_Br4923          SDIAMEVTTDAVQLFGGAGYTSD-------------FPVERFMRDAKITQ
                                    ::        .: : *  .                           :   

Mb3590c|M.bovis_AF2122/97           IYGGSNEIQRNIIAERVLGLPREAKG------------------
Rv3560c|M.tuberculosis_H37Rv        IYGGSNEIQRNIIAERVLGLPREAKG------------------
MAB_3122|M.abscessus_ATCC_1997      IEGGTSDVMRNIIGERVLGLPGDIRVDTDKAWKDVPRG------
Mflv_3794|M.gilvum_PYR-GCK          LGGGSSEMARNVIGERILGFPRELAADKGIPFNEVKRN----KS
Mvan_2600|M.vanbaalenii_PYR-1       LGGGSSEMARNVISERILGFPRELAADKGIPFNQVKRN----KS
MSMEG_2992|M.smegmatis_MC2_155      LGGGSSEMARNVIGERVLGFPREHAADRGVPFREVKRN----KG
MMAR_3992|M.marinum_M               IGGGTTEMARNVIGERMLNFPREFAADRGVPFNQVRRG--PPR-
MUL_3854|M.ulcerans_Agy99           IGGGPTEMARNVIGERMLNFPREFAADRGVSFNQVRRG--SPR-
MAV_1620|M.avium_104                IGGGTTEMARNVIGERVLGFPREYAADRGVPFNQVRHGQRSDRS
TH_4121|M.thermoresistible__bu      LGGGTTEIARNIIAERILGFPREPAADRGMPFKDVKRN----RG
MLBr_00737|M.leprae_Br4923          IYEGTNQIQRVVMSRALLR-------------------------
                                    :  *..:: * ::.. :*

species	id	gene	e-value	identity (len)	annotation
M. gilvum PYR-GCK	Mflv_3794	-	-	100% (427)	acyl-CoA dehydrogenase domain-containing protein
M. gilvum PYR-GCK	Mflv_2334	-	1e-49	31.28% (422)	acyl-CoA dehydrogenase domain-containing protein
M. gilvum PYR-GCK	Mflv_0344	-	3e-48	32.08% (371)	acyl-CoA dehydrogenase domain-containing protein